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The map label for this gene is murB

Identifier: 89055245

GI number: 89055245

Start: 2770870

End: 2771799

Strand: Reverse

Name: murB

Synonym: Jann_2754

Alternate gene names: 89055245

Gene position: 2771799-2770870 (Counterclockwise)

Preceding gene: 89055246

Following gene: 89055244

Centisome position: 64.19

GC content: 63.01

Gene sequence:

>930_bases
ATGACGCAAGACTTACCCACGCCCCGTGGCCGGTTGACGCCGGACAAAGACCTGTCCGGCCTTACGTGGCTGCGCGTCGG
CGGTCCGGCGGACTGGCTGTTCCAGCCCGCTGATGTCGATGATCTCTGCGCGTTCATGGCGGAACTGGACCCCGCTGTGC
CTGTCTTCCCCATGGGCGTCGGCTCCAACCTTATCGTGCGCGATGGGGGGCTGCGCGGTGTGGTGATCAAATTGGGCCGC
CCGTTCATGGATATCTCGGTGGAGGGGGACCGGATCACTGCCGGGGCAGCCGTGCTGGACGCCCGCTTGGCGAAAGAGGC
GGCAGATGCGGGCGTTGACCTGACCTTCCTGCGCACGATCCCGGGATCTCTTGGCGGCGCACTCAAGATGAATGCGGGCT
GCTATGGGTCATATGTCGCCGATCACTTCGTCGGCGCCCAAGCCGTCCTGCGCGATGGCACACAGGTGACGTTGACCCGG
GACGACATCACATTCGCCTACCGCCAAACAGATATCCCCGAGGGAGTGACCATCACCTCCGTCACGCTTCAGGGCAACCG
CGAGGACAGCCGCGTGCTTCACACGCGGATGGAGGAGCAGTTGGCCAAACGCGACGCAACCCAACCCACAAAGGCGCTGA
CGGCGGGCTCCACGTTCCGCAACCCGGCGGGCTTCTCCTCCACGGGCCAGGCCGATGACACCCACGAGTTGAAAGCCTGG
AAGGTCATCGACGACGCGGGCATGCGCGGCGCGACCCGCGGCGGCGCACAGATGAGCGAGATGCATTCCAACTTCCTCGT
TAACAAGGGTGGCGCAACTGCCGCAGATTTGGAGGGATTGGGAGAAGAAGTCAGAAAAAGGGTTTTCCAAACCCAGGGCA
TAGATTTAGTGTGGGAAATCATGCGGGTCGGTGTACCCGAAGAGACCTAA

Upstream 100 bases:

>100_bases
TGGTTCTCTATGGTGTTCTCATGCCGTTCAGTGCCTGTGTGATTGTTGCAAGTCTGATCGGCACCGTCGTGCGGAAGGTC
CTCGGTGCCAGAGGAGTGTC

Downstream 100 bases:

>100_bases
GCGCAGCCCGAAAAGTGGGAACCGGTTTTCGGATCAAGCTGCGCGATGAAGACAAGGGTGCAGCCCGAAAAGTGGGAACC
GGTTTTCGGATCAAGCTGCG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTQDLPTPRGRLTPDKDLSGLTWLRVGGPADWLFQPADVDDLCAFMAELDPAVPVFPMGVGSNLIVRDGGLRGVVIKLGR
PFMDISVEGDRITAGAAVLDARLAKEAADAGVDLTFLRTIPGSLGGALKMNAGCYGSYVADHFVGAQAVLRDGTQVTLTR
DDITFAYRQTDIPEGVTITSVTLQGNREDSRVLHTRMEEQLAKRDATQPTKALTAGSTFRNPAGFSSTGQADDTHELKAW
KVIDDAGMRGATRGGAQMSEMHSNFLVNKGGATAADLEGLGEEVRKRVFQTQGIDLVWEIMRVGVPEET

Sequences:

>Translated_309_residues
MTQDLPTPRGRLTPDKDLSGLTWLRVGGPADWLFQPADVDDLCAFMAELDPAVPVFPMGVGSNLIVRDGGLRGVVIKLGR
PFMDISVEGDRITAGAAVLDARLAKEAADAGVDLTFLRTIPGSLGGALKMNAGCYGSYVADHFVGAQAVLRDGTQVTLTR
DDITFAYRQTDIPEGVTITSVTLQGNREDSRVLHTRMEEQLAKRDATQPTKALTAGSTFRNPAGFSSTGQADDTHELKAW
KVIDDAGMRGATRGGAQMSEMHSNFLVNKGGATAADLEGLGEEVRKRVFQTQGIDLVWEIMRVGVPEET
>Mature_308_residues
TQDLPTPRGRLTPDKDLSGLTWLRVGGPADWLFQPADVDDLCAFMAELDPAVPVFPMGVGSNLIVRDGGLRGVVIKLGRP
FMDISVEGDRITAGAAVLDARLAKEAADAGVDLTFLRTIPGSLGGALKMNAGCYGSYVADHFVGAQAVLRDGTQVTLTRD
DITFAYRQTDIPEGVTITSVTLQGNREDSRVLHTRMEEQLAKRDATQPTKALTAGSTFRNPAGFSSTGQADDTHELKAWK
VIDDAGMRGATRGGAQMSEMHSNFLVNKGGATAADLEGLGEEVRKRVFQTQGIDLVWEIMRVGVPEET

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_JANSC (Q28NP1)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510696.1
- ProteinModelPortal:   Q28NP1
- SMR:   Q28NP1
- STRING:   Q28NP1
- GeneID:   3935218
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2754
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- BioCyc:   JSP290400:JANN_2754-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33119; Mature: 32988

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 168-168 ACT_SITE 217-217 ACT_SITE 299-299

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDLPTPRGRLTPDKDLSGLTWLRVGGPADWLFQPADVDDLCAFMAELDPAVPVFPMGV
CCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCCCEEECCC
GSNLIVRDGGLRGVVIKLGRPFMDISVEGDRITAGAAVLDARLAKEAADAGVDLTFLRTI
CCEEEEECCCCCEEEEECCCCEEEEEECCCEEECHHHHHHHHHHHHHHHCCCCEEEEECC
PGSLGGALKMNAGCYGSYVADHFVGAQAVLRDGTQVTLTRDDITFAYRQTDIPEGVTITS
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCCCEEEEE
VTLQGNREDSRVLHTRMEEQLAKRDATQPTKALTAGSTFRNPAGFSSTGQADDTHELKAW
EEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
KVIDDAGMRGATRGGAQMSEMHSNFLVNKGGATAADLEGLGEEVRKRVFQTQGIDLVWEI
EEECCCCCCCCCCCCHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
MRVGVPEET
HHCCCCCCC
>Mature Secondary Structure 
TQDLPTPRGRLTPDKDLSGLTWLRVGGPADWLFQPADVDDLCAFMAELDPAVPVFPMGV
CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHCCCCCCHHHHHHHHHHCCCCCCEEECCC
GSNLIVRDGGLRGVVIKLGRPFMDISVEGDRITAGAAVLDARLAKEAADAGVDLTFLRTI
CCEEEEECCCCCEEEEECCCCEEEEEECCCEEECHHHHHHHHHHHHHHHCCCCEEEEECC
PGSLGGALKMNAGCYGSYVADHFVGAQAVLRDGTQVTLTRDDITFAYRQTDIPEGVTITS
CCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCCCEEEEE
VTLQGNREDSRVLHTRMEEQLAKRDATQPTKALTAGSTFRNPAGFSSTGQADDTHELKAW
EEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
KVIDDAGMRGATRGGAQMSEMHSNFLVNKGGATAADLEGLGEEVRKRVFQTQGIDLVWEI
EEECCCCCCCCCCCCHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
MRVGVPEET
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA