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The map label for this gene is gltR [H]

Identifier: 89055062

GI number: 89055062

Start: 2578562

End: 2579440

Strand: Reverse

Name: gltR [H]

Synonym: Jann_2571

Alternate gene names: 89055062

Gene position: 2579440-2578562 (Counterclockwise)

Preceding gene: 89055063

Following gene: 89055061

Centisome position: 59.74

GC content: 63.37

Gene sequence:

>879_bases
GTGACCTTTGAACAAATCCGCACCTTTCTCTGGGTCGCGCGCTTGGGCGGCTTTCGCAAAGCCTCCGATCGCTTGAATCT
GTCACAACCCGCCGTGTCGACGCGGATCTCCAACCTTGAGGGCGAGTTGCAGGTGCCACTGTTCGAGCGGGGACCGGGCC
AGTTGATCCTGACCAAGCACGGCCAACAGCTGCTGGCCTATGCGGAGCAGATGCTGTTCGTGGAAGAAGAGATCAAGAAC
CGCGTCGGCAATGCGTCCGAGACCGAAGGGCTCTTTCGCATCGGCGCGTCCGAGACCATTGCCCAGGCCTGGCTGCCGGA
GTTTCTGGAAGCCGTCTCAGAGGCTTACCCGCGCGTGAACGTGGATCTCACCGTGGATATTTCCGGCTCCCTGCGCGACG
CACTGGTGGAGCGGCGCCTGGATCTGGTGTTTCTGATGGGGCCGATCTCGGAGTTTTCCGTGAAGAACACAGCCCTGCCG
CAGTTCGACCTGCACTGGTATCGCGCGGCCCATCTGCACGACGTCAATCTGGGTGAAATCCCAGTGATCTCCTATTCCTC
CAAGACGCGGCCCCACAGGGAACTGACCAGCCAATTGGCCGCCCGCGTTGGCCCGAAGATGCGGGTGTTCTCCTCCGCGT
CGCTCTCCGCCAGCCTGCGCATGATCGCGGCGGGCATTGCCGTGGGGCCGTATCCCCGGGTGCTGGCCACGCCGTTTCTG
GAGGCCGGGCAGGTGGTCGAATTCGACCCCGATTTGCCCCTGTCGCCGCTGGAATTCACCGCGTCCCACCTGGCGGAGCC
CCGCAGTTTTCTGGTGGAAAACAGTGCCGAGATCGCGCGGGATGTGGCCGAGCGCTGGCACCGCGCGCATCCAACATAG

Upstream 100 bases:

>100_bases
GCGTTGACCCGGGTGGCGCAGGATCAGCAAATCCTGGTGTTCACCTGCCGCACGATGGCGTTTCTGAGCCTTGGCGGCAC
ACGGCCGGAGGTCACAATCC

Downstream 100 bases:

>100_bases
CATCCAGAAAATCTATCGCGACATATCCAAAATGATAATTTGATTTAAACGCAACACCCGTGTGAAGCTGCGATTAACCA
AGTGGGGGCTTTGATGGGAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTFEQIRTFLWVARLGGFRKASDRLNLSQPAVSTRISNLEGELQVPLFERGPGQLILTKHGQQLLAYAEQMLFVEEEIKN
RVGNASETEGLFRIGASETIAQAWLPEFLEAVSEAYPRVNVDLTVDISGSLRDALVERRLDLVFLMGPISEFSVKNTALP
QFDLHWYRAAHLHDVNLGEIPVISYSSKTRPHRELTSQLAARVGPKMRVFSSASLSASLRMIAAGIAVGPYPRVLATPFL
EAGQVVEFDPDLPLSPLEFTASHLAEPRSFLVENSAEIARDVAERWHRAHPT

Sequences:

>Translated_292_residues
MTFEQIRTFLWVARLGGFRKASDRLNLSQPAVSTRISNLEGELQVPLFERGPGQLILTKHGQQLLAYAEQMLFVEEEIKN
RVGNASETEGLFRIGASETIAQAWLPEFLEAVSEAYPRVNVDLTVDISGSLRDALVERRLDLVFLMGPISEFSVKNTALP
QFDLHWYRAAHLHDVNLGEIPVISYSSKTRPHRELTSQLAARVGPKMRVFSSASLSASLRMIAAGIAVGPYPRVLATPFL
EAGQVVEFDPDLPLSPLEFTASHLAEPRSFLVENSAEIARDVAERWHRAHPT
>Mature_291_residues
TFEQIRTFLWVARLGGFRKASDRLNLSQPAVSTRISNLEGELQVPLFERGPGQLILTKHGQQLLAYAEQMLFVEEEIKNR
VGNASETEGLFRIGASETIAQAWLPEFLEAVSEAYPRVNVDLTVDISGSLRDALVERRLDLVFLMGPISEFSVKNTALPQ
FDLHWYRAAHLHDVNLGEIPVISYSSKTRPHRELTSQLAARVGPKMRVFSSASLSASLRMIAAGIAVGPYPRVLATPFLE
AGQVVEFDPDLPLSPLEFTASHLAEPRSFLVENSAEIARDVAERWHRAHPT

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=255, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787806, Length=244, Percent_Identity=25, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788481, Length=153, Percent_Identity=33.9869281045752, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082132, Length=254, Percent_Identity=23.6220472440945, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI48994962, Length=175, Percent_Identity=33.1428571428571, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787601, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787128, Length=261, Percent_Identity=25.2873563218391, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693105, Length=256, Percent_Identity=25, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788748, Length=257, Percent_Identity=25.2918287937743, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=150, Percent_Identity=29.3333333333333, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32526; Mature: 32394

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEQIRTFLWVARLGGFRKASDRLNLSQPAVSTRISNLEGELQVPLFERGPGQLILTKH
CCHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHCCCCCEECCEEECCCCEEEEECC
GQQLLAYAEQMLFVEEEIKNRVGNASETEGLFRIGASETIAQAWLPEFLEAVSEAYPRVN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCC
VDLTVDISGSLRDALVERRLDLVFLMGPISEFSVKNTALPQFDLHWYRAAHLHDVNLGEI
EEEEEEECCHHHHHHHHHHHCEEEEECCCHHHCCCCCCCCCCCHHHHHHHEEEECCCCCE
PVISYSSKTRPHRELTSQLAARVGPKMRVFSSASLSASLRMIAAGIAVGPYPRVLATPFL
EEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
EAGQVVEFDPDLPLSPLEFTASHLAEPRSFLVENSAEIARDVAERWHRAHPT
CCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TFEQIRTFLWVARLGGFRKASDRLNLSQPAVSTRISNLEGELQVPLFERGPGQLILTKH
CHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHCCCCCEECCEEECCCCEEEEECC
GQQLLAYAEQMLFVEEEIKNRVGNASETEGLFRIGASETIAQAWLPEFLEAVSEAYPRVN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCC
VDLTVDISGSLRDALVERRLDLVFLMGPISEFSVKNTALPQFDLHWYRAAHLHDVNLGEI
EEEEEEECCHHHHHHHHHHHCEEEEECCCHHHCCCCCCCCCCCHHHHHHHEEEECCCCCE
PVISYSSKTRPHRELTSQLAARVGPKMRVFSSASLSASLRMIAAGIAVGPYPRVLATPFL
EEEECCCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
EAGQVVEFDPDLPLSPLEFTASHLAEPRSFLVENSAEIARDVAERWHRAHPT
CCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]