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The map label for this gene is dmdA

Identifier: 89054870

GI number: 89054870

Start: 2383058

End: 2384161

Strand: Reverse

Name: dmdA

Synonym: Jann_2379

Alternate gene names: 89054870

Gene position: 2384161-2383058 (Counterclockwise)

Preceding gene: 89054873

Following gene: 89054869

Centisome position: 55.21

GC content: 63.41

Gene sequence:

>1104_bases
ATGGCCCTGATCTCTCCGTCCCGCCGCCTGCGCCGCACCCCCTTTTCTGATGGGGTGGAGGCGTCCGGGGTAAAAGCCTA
CACGATCTATAACCGGATGCTCCTGCCCACCCTGTTTCGTACAGTGGAGGAGGATTACGCCCACCTGAAATCCGCCGTGC
AACTCTGGGATGTCTCGGTGGAGCGGCAGGTGGAGGTGCGTGGCCCCGATGCGGGGCGTCTGGTGCAGATGCTTACCCCC
CGCGACCTGCGCGGCATGTTGCCCGGCCAATGCTATTACATGCCCGTCGTGGATGAGACGGGGGGCATGCTCAACGATCC
CGTTGTCCTGAAACTGGCCGAGGACCGTTGGTGGATCTCCATCGCGGACAGTGATTTATTGTTGTGGGTCAAGGGGGTGG
CGCAGGGCTACCGTCTGGACGTATTGGTCGATGAACCCGATGTGTCACCCCTGGCCGTGCAGGGCCCCAAGGCCGATGAG
CTGATGGCGCGGGTCTTCGGCGACAGCATCCGCGACGTGCGCTTCTTCCGCTTCGGCTGGTTCGACTTTCAGGGCCACGA
TATGGTCATTGCGCGTTCTGGCTATTCCAAGCAGGGCGGGTTCGAGATCTATGTGGAGGGCTGGGATGTCGGGATGCCGC
TGTGGAACGCGCTGATGGAGGCCGGGCGCGATCTGGATGTCCACGCCGGTTGCCCCAATAATATCGAGCGGATTGAGGGC
GGATTGCTCAGCTACGGCAACGACATGACCGATGACAACACGCCCCACGAATGCGGGTTGGGCCGGTTCTGCAACACCGC
CACCGCCGTGGGCTGTATCGGGCGCGACGCGCTGTTGCGGGTGGCCAAGGAAGGTCCGGTGCAGCAGGTGCGCGCCATCG
CGATTGATGCGGATGTCCTGCCCAGTTGCGACCGGGCCTGGCCGCTGATGGCGGGCAAGAAGCGCGTGGGGCAGTTGACC
TCCGCCGCCTATAGCCCCGACTACAGCGAAGGGGTGGCCATCGGCATGGTGCGCATGACCCATTGGGATCCGGGCACGCA
GCTGCATGTCCAGACGCCCGATGGCCTGATGCCCGCAGAGGTGCGTGAGAAATTTTGGATTTGA

Upstream 100 bases:

>100_bases
TGATCCGCATTCCTGTTTCACGACCGGCACTCCTCTGGGCTGCTGCCCGCAAGTCTAACCGCAATCCCCGCACTCCGCCA
AGGTAAGGAGACCCTCACAC

Downstream 100 bases:

>100_bases
TTACAGCACTTTGCGCTGCGATCTTAACGCGATACTGAAGGAGAGAGACGCGATGACGTTCAATGCATTGGTCGTTGAGA
AAAATGATGAGGGCAAGACC

Product: putative dimethyl sulfoniopropionate demethylase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MALISPSRRLRRTPFSDGVEASGVKAYTIYNRMLLPTLFRTVEEDYAHLKSAVQLWDVSVERQVEVRGPDAGRLVQMLTP
RDLRGMLPGQCYYMPVVDETGGMLNDPVVLKLAEDRWWISIADSDLLLWVKGVAQGYRLDVLVDEPDVSPLAVQGPKADE
LMARVFGDSIRDVRFFRFGWFDFQGHDMVIARSGYSKQGGFEIYVEGWDVGMPLWNALMEAGRDLDVHAGCPNNIERIEG
GLLSYGNDMTDDNTPHECGLGRFCNTATAVGCIGRDALLRVAKEGPVQQVRAIAIDADVLPSCDRAWPLMAGKKRVGQLT
SAAYSPDYSEGVAIGMVRMTHWDPGTQLHVQTPDGLMPAEVREKFWI

Sequences:

>Translated_367_residues
MALISPSRRLRRTPFSDGVEASGVKAYTIYNRMLLPTLFRTVEEDYAHLKSAVQLWDVSVERQVEVRGPDAGRLVQMLTP
RDLRGMLPGQCYYMPVVDETGGMLNDPVVLKLAEDRWWISIADSDLLLWVKGVAQGYRLDVLVDEPDVSPLAVQGPKADE
LMARVFGDSIRDVRFFRFGWFDFQGHDMVIARSGYSKQGGFEIYVEGWDVGMPLWNALMEAGRDLDVHAGCPNNIERIEG
GLLSYGNDMTDDNTPHECGLGRFCNTATAVGCIGRDALLRVAKEGPVQQVRAIAIDADVLPSCDRAWPLMAGKKRVGQLT
SAAYSPDYSEGVAIGMVRMTHWDPGTQLHVQTPDGLMPAEVREKFWI
>Mature_366_residues
ALISPSRRLRRTPFSDGVEASGVKAYTIYNRMLLPTLFRTVEEDYAHLKSAVQLWDVSVERQVEVRGPDAGRLVQMLTPR
DLRGMLPGQCYYMPVVDETGGMLNDPVVLKLAEDRWWISIADSDLLLWVKGVAQGYRLDVLVDEPDVSPLAVQGPKADEL
MARVFGDSIRDVRFFRFGWFDFQGHDMVIARSGYSKQGGFEIYVEGWDVGMPLWNALMEAGRDLDVHAGCPNNIERIEGG
LLSYGNDMTDDNTPHECGLGRFCNTATAVGCIGRDALLRVAKEGPVQQVRAIAIDADVLPSCDRAWPLMAGKKRVGQLTS
AAYSPDYSEGVAIGMVRMTHWDPGTQLHVQTPDGLMPAEVREKFWI

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=26.3305322128852, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI44662838, Length=353, Percent_Identity=26.0623229461756, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI257796256, Length=303, Percent_Identity=25.7425742574257, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789272, Length=340, Percent_Identity=24.1176470588235, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994045, Length=336, Percent_Identity=24.702380952381, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994052, Length=336, Percent_Identity=24.702380952381, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129441, Length=338, Percent_Identity=25.7396449704142, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40853; Mature: 40722

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISPSRRLRRTPFSDGVEASGVKAYTIYNRMLLPTLFRTVEEDYAHLKSAVQLWDVSV
CCCCCCCHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ERQVEVRGPDAGRLVQMLTPRDLRGMLPGQCYYMPVVDETGGMLNDPVVLKLAEDRWWIS
EEEEEECCCCHHHHEECCCCHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCEEEE
IADSDLLLWVKGVAQGYRLDVLVDEPDVSPLAVQGPKADELMARVFGDSIRDVRFFRFGW
ECCCCEEEEEEHHCCCEEEEEEECCCCCCCEEECCCCHHHHHHHHHCCHHHHEEEEEEEE
FDFQGHDMVIARSGYSKQGGFEIYVEGWDVGMPLWNALMEAGRDLDVHAGCPNNIERIEG
EEECCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHCC
GLLSYGNDMTDDNTPHECGLGRFCNTATAVGCIGRDALLRVAKEGPVQQVRAIAIDADVL
CHHHCCCCCCCCCCCCCCCCCHHHCHHHHHHHCCHHHHHHHHCCCCHHHHHEEEECCCCC
PSCDRAWPLMAGKKRVGQLTSAAYSPDYSEGVAIGMVRMTHWDPGTQLHVQTPDGLMPAE
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCHH
VREKFWI
HHHHCCC
>Mature Secondary Structure 
ALISPSRRLRRTPFSDGVEASGVKAYTIYNRMLLPTLFRTVEEDYAHLKSAVQLWDVSV
CCCCCCHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
ERQVEVRGPDAGRLVQMLTPRDLRGMLPGQCYYMPVVDETGGMLNDPVVLKLAEDRWWIS
EEEEEECCCCHHHHEECCCCHHHCCCCCCCEEEEEEECCCCCCCCCCEEEEEECCCEEEE
IADSDLLLWVKGVAQGYRLDVLVDEPDVSPLAVQGPKADELMARVFGDSIRDVRFFRFGW
ECCCCEEEEEEHHCCCEEEEEEECCCCCCCEEECCCCHHHHHHHHHCCHHHHEEEEEEEE
FDFQGHDMVIARSGYSKQGGFEIYVEGWDVGMPLWNALMEAGRDLDVHAGCPNNIERIEG
EEECCCEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCHHHHCC
GLLSYGNDMTDDNTPHECGLGRFCNTATAVGCIGRDALLRVAKEGPVQQVRAIAIDADVL
CHHHCCCCCCCCCCCCCCCCCHHHCHHHHHHHCCHHHHHHHHCCCCHHHHHEEEECCCCC
PSCDRAWPLMAGKKRVGQLTSAAYSPDYSEGVAIGMVRMTHWDPGTQLHVQTPDGLMPAE
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCHH
VREKFWI
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA