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The map label for this gene is mazG

Identifier: 89054835

GI number: 89054835

Start: 2351098

End: 2351895

Strand: Direct

Name: mazG

Synonym: Jann_2344

Alternate gene names: 89054835

Gene position: 2351098-2351895 (Clockwise)

Preceding gene: 89054832

Following gene: 89054836

Centisome position: 54.45

GC content: 63.16

Gene sequence:

>798_bases
ATGGAAGACCTCCCGCAAGACCCCATGACCCGTCTGCGTGCCATCATGGCGCGGCTTCGCGACCCGGAGCGCGGCTGCCC
GTGGGATGTGGAGCAGACCTTCGCCTCCATCGCGCCCTACACGATCGAGGAGGCCTATGAGGTCGCCGATGCGATTGAAC
GCGGCGACATGGCGGAGTTGCAGGGTGAATTGGGGGATCTGCTGTTCCAGTCCGTGTTCCACGCGCAGATGGCCGAGGAT
GGTGGGCATTTCGATTTCGACGATGTGGCCCGCGCCATCGGCGACAAGATGATTGCCCGCCACCCCCATGTTTTCGGAGA
CGAGAGCAACGCCAAATCCGCCACACAGCAGGTGCAGGATTGGGAGACGGTGAAGGCCGCCGAGCGCGCCTCCCGGTCCA
AAGGCGGGGTGCTGGACGATGTCGCGTTGGGGCTGCCCGCCCTGATGCGGGCCGAGAAGTTGCAAAAACGCGCCGCCCGC
GTTGGCTTTGACTGGCCCCACATCGCCATGGTGATCGCCAAGATCGCCGAGGAAGCGGAGGAATTGGCGGAGGCGCGCGA
GACGCTGCCGCAGGAGAAGATCGCGGAAGAGATGGGGGATCTGCTGTTTGTCATGGCCAACCTCGCGCGGCACCTGAAGG
TCGACCCGGAGGTGGCGCTGCGCGGCGCAAACGCTAAGTTTGTGAGGCGATTTTCATATATAGAGCAACAGCTTGCAGCG
CGTTCTTCAAGTCCTGAAGGCAGTACATTGGAGGAAATGGACGCGCTGTGGGATGCCGCGAAGGCCAAGGGCCTGTGA

Upstream 100 bases:

>100_bases
GGACCTCCTGAGGGTGCGGCGCCCGACCACTTTGGGCCGCGAGGCCGGTCGGAGCAAGGACCACTTGCCCTTACCCGCGC
CATGGCGCATCCCTTGGACC

Downstream 100 bases:

>100_bases
CATTCCCTGCCCGCCGGACCCCGCCTGTTCACCGGTTCAAGTGGCGGCCAACATGACCGACACTCCGACCACCGTGCCGG
ACCTGCCCGCGTCCAACGTC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MEDLPQDPMTRLRAIMARLRDPERGCPWDVEQTFASIAPYTIEEAYEVADAIERGDMAELQGELGDLLFQSVFHAQMAED
GGHFDFDDVARAIGDKMIARHPHVFGDESNAKSATQQVQDWETVKAAERASRSKGGVLDDVALGLPALMRAEKLQKRAAR
VGFDWPHIAMVIAKIAEEAEELAEARETLPQEKIAEEMGDLLFVMANLARHLKVDPEVALRGANAKFVRRFSYIEQQLAA
RSSSPEGSTLEEMDALWDAAKAKGL

Sequences:

>Translated_265_residues
MEDLPQDPMTRLRAIMARLRDPERGCPWDVEQTFASIAPYTIEEAYEVADAIERGDMAELQGELGDLLFQSVFHAQMAED
GGHFDFDDVARAIGDKMIARHPHVFGDESNAKSATQQVQDWETVKAAERASRSKGGVLDDVALGLPALMRAEKLQKRAAR
VGFDWPHIAMVIAKIAEEAEELAEARETLPQEKIAEEMGDLLFVMANLARHLKVDPEVALRGANAKFVRRFSYIEQQLAA
RSSSPEGSTLEEMDALWDAAKAKGL
>Mature_265_residues
MEDLPQDPMTRLRAIMARLRDPERGCPWDVEQTFASIAPYTIEEAYEVADAIERGDMAELQGELGDLLFQSVFHAQMAED
GGHFDFDDVARAIGDKMIARHPHVFGDESNAKSATQQVQDWETVKAAERASRSKGGVLDDVALGLPALMRAEKLQKRAAR
VGFDWPHIAMVIAKIAEEAEELAEARETLPQEKIAEEMGDLLFVMANLARHLKVDPEVALRGANAKFVRRFSYIEQQLAA
RSSSPEGSTLEEMDALWDAAKAKGL

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=257, Percent_Identity=54.0856031128405, Blast_Score=277, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 29407; Mature: 29407

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLPQDPMTRLRAIMARLRDPERGCPWDVEQTFASIAPYTIEEAYEVADAIERGDMAEL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHH
QGELGDLLFQSVFHAQMAEDGGHFDFDDVARAIGDKMIARHPHVFGDESNAKSATQQVQD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
WETVKAAERASRSKGGVLDDVALGLPALMRAEKLQKRAARVGFDWPHIAMVIAKIAEEAE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ELAEARETLPQEKIAEEMGDLLFVMANLARHLKVDPEVALRGANAKFVRRFSYIEQQLAA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHH
RSSSPEGSTLEEMDALWDAAKAKGL
HCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDLPQDPMTRLRAIMARLRDPERGCPWDVEQTFASIAPYTIEEAYEVADAIERGDMAEL
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHH
QGELGDLLFQSVFHAQMAEDGGHFDFDDVARAIGDKMIARHPHVFGDESNAKSATQQVQD
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
WETVKAAERASRSKGGVLDDVALGLPALMRAEKLQKRAARVGFDWPHIAMVIAKIAEEAE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
ELAEARETLPQEKIAEEMGDLLFVMANLARHLKVDPEVALRGANAKFVRRFSYIEQQLAA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHH
RSSSPEGSTLEEMDALWDAAKAKGL
HCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]