Click here to switch to the map view.

The map label for this gene is ccmE

Identifier: 89054826

GI number: 89054826

Start: 2342874

End: 2343332

Strand: Reverse

Name: ccmE

Synonym: Jann_2335

Alternate gene names: 89054826

Gene position: 2343332-2342874 (Counterclockwise)

Preceding gene: 89054827

Following gene: 89054825

Centisome position: 54.27

GC content: 63.83

Gene sequence:

>459_bases
ATGCGCGGGTTGAAGAAGCAACGCAGGATCCAGATCCTGATCGTCGCGGCGGTGGCGCTGACCCTGTCGTCCGTGCTGAT
CGGGTATGCGCTTCGCGATGGCATCAACTTCTTCCGTCCGCCCGCCGAGGTGGCCGAAAACCCGCCACCGCCCTCGGAGG
TTTTCCGCATTGGCGGCATGGTGGAGGAGGGAACGCTGGTGCGCGGGCAGGGTGAGACGATCACCTTCAACGTCACCGAT
TTCGCCGCCTCGATCCCCGTATCCTACACGGGCGTCTTGCCCGATCTCTTCGGCGAAGGTGAAGGCATGGTCGGCACCGG
GCGTCTGGTGAACGGCACGTTTGAGGCGACGGAAATTCTTGCCCGCCATGATGAGACCTATATGCCCGCCGAAGTGACTG
AAGCGCTGGAGGCGCAGGGATACTCGCCGGACGGCTACGCCCGCGACGGCGATAGCTGA

Upstream 100 bases:

>100_bases
TCCAGCGGGCAGGCGGTGCAGAACGCCAACCTGATGCTGGGGCTGGAGGAGACAGCGGGCCTGTTGGGTCTGGGTGTGTT
CCCCTGAGGGAGACGACGCG

Downstream 100 bases:

>100_bases
GGGCGCAAACGCTCCTCCGCTGCCGCGTCCTCGCCGTTTGGCTCTCCGACAACTTTGTCGAAAGATGTTAGGGATTTGTT
AACCCCGCCAGTGTTCTCTC

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MRGLKKQRRIQILIVAAVALTLSSVLIGYALRDGINFFRPPAEVAENPPPPSEVFRIGGMVEEGTLVRGQGETITFNVTD
FAASIPVSYTGVLPDLFGEGEGMVGTGRLVNGTFEATEILARHDETYMPAEVTEALEAQGYSPDGYARDGDS

Sequences:

>Translated_152_residues
MRGLKKQRRIQILIVAAVALTLSSVLIGYALRDGINFFRPPAEVAENPPPPSEVFRIGGMVEEGTLVRGQGETITFNVTD
FAASIPVSYTGVLPDLFGEGEGMVGTGRLVNGTFEATEILARHDETYMPAEVTEALEAQGYSPDGYARDGDS
>Mature_152_residues
MRGLKKQRRIQILIVAAVALTLSSVLIGYALRDGINFFRPPAEVAENPPPPSEVFRIGGMVEEGTLVRGQGETITFNVTD
FAASIPVSYTGVLPDLFGEGEGMVGTGRLVNGTFEATEILARHDETYMPAEVTEALEAQGYSPDGYARDGDS

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=155, Percent_Identity=36.7741935483871, Blast_Score=99, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_JANSC (Q28PW0)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510277.1
- ProteinModelPortal:   Q28PW0
- SMR:   Q28PW0
- STRING:   Q28PW0
- GeneID:   3934791
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2335
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q28PW0
- ProtClustDB:   PRK13254
- BioCyc:   JSP290400:JANN_2335-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16307; Mature: 16307

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

HASH(0xf424414)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLKKQRRIQILIVAAVALTLSSVLIGYALRDGINFFRPPAEVAENPPPPSEVFRIGGM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHCCE
VEEGTLVRGQGETITFNVTDFAASIPVSYTGVLPDLFGEGEGMVGTGRLVNGTFEATEIL
ECCCEEEECCCCEEEEEEHHHHHHCCCCCCCCCHHHHCCCCCCEECCEEECCCHHHHHHH
ARHDETYMPAEVTEALEAQGYSPDGYARDGDS
HHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
>Mature Secondary Structure
MRGLKKQRRIQILIVAAVALTLSSVLIGYALRDGINFFRPPAEVAENPPPPSEVFRIGGM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHCCE
VEEGTLVRGQGETITFNVTDFAASIPVSYTGVLPDLFGEGEGMVGTGRLVNGTFEATEIL
ECCCEEEECCCCEEEEEEHHHHHHCCCCCCCCCHHHHCCCCCCEECCEEECCCHHHHHHH
ARHDETYMPAEVTEALEAQGYSPDGYARDGDS
HHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA