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The map label for this gene is metC [H]

Identifier: 89054777

GI number: 89054777

Start: 2292289

End: 2293479

Strand: Direct

Name: metC [H]

Synonym: Jann_2286

Alternate gene names: 89054777

Gene position: 2292289-2293479 (Clockwise)

Preceding gene: 89054776

Following gene: 89054779

Centisome position: 53.09

GC content: 64.9

Gene sequence:

>1191_bases
ATGAGCGATGGGCGCAACGAGAAGCCGAGAACATTGGTGCGGCGGGCGGCCCTGCGGGAGGGCGTGAGCCGGGCCGTCGT
GACGCCCATCCAGCCCTCGGTCGTCTATGCCTCGCCGTCCATCGCGACGCTGCATGCGCAGTACGAGGGGCGCGCCCATG
GCTACACTTATGCGCGCGAGGGGCATCCGAACGCGGAGTTGCTGGCCCGCAAGATCGATATGCTGGAGGAGGCTGATGGC
GGCTTGATCCTCGGCTCGGGTATGGCGGCTGTGTCGGCGACCATTCTGGGGCTGTTGGGGCAGGGGGATCATATCGTCGG
GGGCAATCAGCTGTACGGGCGGTCCTTGCGATTGATGCATCAGGATCTGGGGCGGTTCGGCATTGCCACATCCGTGGCCG
ATCCCACAGATGTGGACGCCATGCGCGCCGCCTTGCGGCCTGAGACCAAGATGATCCTGGTGGAGGTGATCTCCAACCCG
ACGTTGCGGGTGGCGGATATGGCCGGGATCATCGCGCTGGCGCGGGAGGTTGGGGTGATCCTGGCCGTGGACAACACCTT
CACCACGCCCGCCGCCTATAGGCCGCTGGTCGAGGGCGCCGATATTACGATCCATTCCGTCACCAAACTGTTGGCGGGAC
ATTCCGATGTGACGCTTGGCTATGTCGCGGCACGGGACGCAGACCAGATGCGCGCGATCTATGATTTCGCGGTGACGGTG
GGCATGACGCCCGCGCCCAATGAGTGTTGGTTGGCGGAACGGGGTCTTTACACCTTCCCCCTGCGGTTTGAGAAGGCGCA
GGCCAATGCGGCAGGATTGGCGGATTACCTGGCGGCGCACCCCAAGGTGGCGCGGGTGCTGTATCCCGGACGTGATGATC
ACCCCGATCACGGGCTTGCCACGGCGCTCGTTGGTCAAGCCTTTGGCAACATGGTGAGTTTTGAACTGAACGATGCCTCG
GAAGCCGCCGCCGACCGCATGGTTCAGGCCGCCCCGGATCTGCCCTTTGCCCCCACCTTGGGCGATGTCGGTACGACGCT
GAGCCATCCGGCCTCCTCCAGTCACCGGGGGCTGACGGCGGAGGGGCGTGCAGCGCTGGGGATCTCGGACGGGTTTTTCC
GGGTCTCCGTCGGGATTGAAGATCTGGACTTGCTGATCGCGGATTTCGAGGCGGGCCTCGCGGCGGTCTAA

Upstream 100 bases:

>100_bases
CAATTCGCGGCTGACGGCGCGTTGGACGGGTTGCGGTAGTGGGGGCCTGCCCCCACACCTCCGGGATATTTATGGAACGA
GGAAGAGGAGGGGGCCTGCG

Downstream 100 bases:

>100_bases
ACCAGATGCAGGGCCGAACTGCCGTCCAGCGCGATCAGATCTACATTCAGATCCGGCGCTTCGGCCAGCACATCGGCGCG
GACCAGGGGAATGTCCGGCA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSDGRNEKPRTLVRRAALREGVSRAVVTPIQPSVVYASPSIATLHAQYEGRAHGYTYAREGHPNAELLARKIDMLEEADG
GLILGSGMAAVSATILGLLGQGDHIVGGNQLYGRSLRLMHQDLGRFGIATSVADPTDVDAMRAALRPETKMILVEVISNP
TLRVADMAGIIALAREVGVILAVDNTFTTPAAYRPLVEGADITIHSVTKLLAGHSDVTLGYVAARDADQMRAIYDFAVTV
GMTPAPNECWLAERGLYTFPLRFEKAQANAAGLADYLAAHPKVARVLYPGRDDHPDHGLATALVGQAFGNMVSFELNDAS
EAAADRMVQAAPDLPFAPTLGDVGTTLSHPASSSHRGLTAEGRAALGISDGFFRVSVGIEDLDLLIADFEAGLAAV

Sequences:

>Translated_396_residues
MSDGRNEKPRTLVRRAALREGVSRAVVTPIQPSVVYASPSIATLHAQYEGRAHGYTYAREGHPNAELLARKIDMLEEADG
GLILGSGMAAVSATILGLLGQGDHIVGGNQLYGRSLRLMHQDLGRFGIATSVADPTDVDAMRAALRPETKMILVEVISNP
TLRVADMAGIIALAREVGVILAVDNTFTTPAAYRPLVEGADITIHSVTKLLAGHSDVTLGYVAARDADQMRAIYDFAVTV
GMTPAPNECWLAERGLYTFPLRFEKAQANAAGLADYLAAHPKVARVLYPGRDDHPDHGLATALVGQAFGNMVSFELNDAS
EAAADRMVQAAPDLPFAPTLGDVGTTLSHPASSSHRGLTAEGRAALGISDGFFRVSVGIEDLDLLIADFEAGLAAV
>Mature_395_residues
SDGRNEKPRTLVRRAALREGVSRAVVTPIQPSVVYASPSIATLHAQYEGRAHGYTYAREGHPNAELLARKIDMLEEADGG
LILGSGMAAVSATILGLLGQGDHIVGGNQLYGRSLRLMHQDLGRFGIATSVADPTDVDAMRAALRPETKMILVEVISNPT
LRVADMAGIIALAREVGVILAVDNTFTTPAAYRPLVEGADITIHSVTKLLAGHSDVTLGYVAARDADQMRAIYDFAVTVG
MTPAPNECWLAERGLYTFPLRFEKAQANAAGLADYLAAHPKVARVLYPGRDDHPDHGLATALVGQAFGNMVSFELNDASE
AAADRMVQAAPDLPFAPTLGDVGTTLSHPASSSHRGLTAEGRAALGISDGFFRVSVGIEDLDLLIADFEAGLAAV

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=361, Percent_Identity=33.7950138504155, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI299473759, Length=361, Percent_Identity=30.1939058171745, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI25453487, Length=360, Percent_Identity=29.4444444444444, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI1790375, Length=371, Percent_Identity=39.0835579514825, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1789383, Length=380, Percent_Identity=27.8947368421053, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71980708, Length=374, Percent_Identity=34.2245989304813, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17538055, Length=359, Percent_Identity=34.2618384401114, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17560056, Length=361, Percent_Identity=35.1800554016621, Blast_Score=207, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6319307, Length=378, Percent_Identity=34.9206349206349, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6323333, Length=413, Percent_Identity=29.0556900726392, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=27.3885350318471, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6321254, Length=374, Percent_Identity=26.7379679144385, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321904, Length=348, Percent_Identity=26.4367816091954, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922554, Length=374, Percent_Identity=35.5614973262032, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41856; Mature: 41725

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDGRNEKPRTLVRRAALREGVSRAVVTPIQPSVVYASPSIATLHAQYEGRAHGYTYARE
CCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEECCCEEEEEEECCCCCCCEEEECC
GHPNAELLARKIDMLEEADGGLILGSGMAAVSATILGLLGQGDHIVGGNQLYGRSLRLMH
CCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHH
QDLGRFGIATSVADPTDVDAMRAALRPETKMILVEVISNPTLRVADMAGIIALAREVGVI
HHHHHHCCCCCCCCCCCHHHHHHHHCCCHHEEEEEECCCCCEEEHHHHHHHHHHHHCCEE
LAVDNTFTTPAAYRPLVEGADITIHSVTKLLAGHSDVTLGYVAARDADQMRAIYDFAVTV
EEECCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHEE
GMTPAPNECWLAERGLYTFPLRFEKAQANAAGLADYLAAHPKVARVLYPGRDDHPDHGLA
CCCCCCCCCEEECCCCEEECEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHH
TALVGQAFGNMVSFELNDASEAAADRMVQAAPDLPFAPTLGDVGTTLSHPASSSHRGLTA
HHHHHHHHCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EGRAALGISDGFFRVSVGIEDLDLLIADFEAGLAAV
CCCEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDGRNEKPRTLVRRAALREGVSRAVVTPIQPSVVYASPSIATLHAQYEGRAHGYTYARE
CCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCEEEECCCEEEEEEECCCCCCCEEEECC
GHPNAELLARKIDMLEEADGGLILGSGMAAVSATILGLLGQGDHIVGGNQLYGRSLRLMH
CCCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHH
QDLGRFGIATSVADPTDVDAMRAALRPETKMILVEVISNPTLRVADMAGIIALAREVGVI
HHHHHHCCCCCCCCCCCHHHHHHHHCCCHHEEEEEECCCCCEEEHHHHHHHHHHHHCCEE
LAVDNTFTTPAAYRPLVEGADITIHSVTKLLAGHSDVTLGYVAARDADQMRAIYDFAVTV
EEECCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHEE
GMTPAPNECWLAERGLYTFPLRFEKAQANAAGLADYLAAHPKVARVLYPGRDDHPDHGLA
CCCCCCCCCEEECCCCEEECEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHH
TALVGQAFGNMVSFELNDASEAAADRMVQAAPDLPFAPTLGDVGTTLSHPASSSHRGLTA
HHHHHHHHCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EGRAALGISDGFFRVSVGIEDLDLLIADFEAGLAAV
CCCEEEEECCCEEEEEECCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]