Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 89054779

GI number: 89054779

Start: 2294101

End: 2295141

Strand: Direct

Name: phoR [H]

Synonym: Jann_2288

Alternate gene names: 89054779

Gene position: 2294101-2295141 (Clockwise)

Preceding gene: 89054777

Following gene: 89054780

Centisome position: 53.13

GC content: 65.51

Gene sequence:

>1041_bases
ATGACCTACAGCGCAATTCACTCCCTCATCGATGCCGTGCCCGATCCGATGGTGCTGATCGCGCCGGATGGCACAATCGG
GCACGCCAATGCGGGCGCGACGGCGCTTTTTGGGGGATGGATCATCGGGCGCAGCCACGGGCTCGCGTTGCGCCACCCTG
CACTTCTGGAGCAGATTGATGCCGTTCGGTCGGGGGAGGCCTCGGCCAAGCTGCGCATCGAGCGGTCTGAGCAGGCGGGC
GTCACGCAATACAAGGTCCGCATCTCGGCACTAACCGGGGGCGCTGCGGGCGCATTGGTGCTGCATTTCACCGACATCAC
CCATCTGCGCGAGACCGAAGAGATGCGCCGCGATTTCGTGGCCAATGTGTCCCACGAGCTGCGGACGCCGCTGACATCCG
TGATGGGGTTCATCGAGACGCTGCGCGGCCCCGCCCGCAATGACCCGGCGGCGCAGGACCGATTCCTGGGCATCATGGAG
GCCGAGGCGGGGCGGATGAACCGCCTGATCTCGGACCTTCTGTCCCTGAGCAAGGTGGAGGCGGCGGAGCGCAAGCGCCC
CACGGAGCAGGTCGACCTCGCCGTCCTTCTGGAGGAGGTGATCGCAGCTCTGCGGCCCCGGGCGGACGATGCGGGCAATC
GGCTAGAGCTGATCCACGACGACGCGCCTGCGTTGGTGCGAGGGGATCACGATCAACTGATGCAGGTGTTCCTGAATCTG
GCCGAGAATGCGCTGAAGTATGGCGGGCCGGGACAGCCCGTGACGCTGCGCCTGTCACGGGGCCAGGGCGGTGGGATCAA
CGGCAGGGCGATGATCCGCGTCGATGTCACCGATCAGGGGCCGGGCATCGACTCGCAACATCTGCCGCGCCTGACGGAGC
GATTCTACCGCGTCGATGCCCACAGATCGCGGGAAATGGGGGGGACGGGGCTGGGGCTGGCGATTGTGAAGCACATCGTC
AATCGCCACCGGGGGCGGCTGAAAATCACGTCACAACAGGGACATGGCAGCACATTTTCCGTGCAGCTTCCTGTGGAGTA
A

Upstream 100 bases:

>100_bases
GCACAAATGAAGGAAGGTGAATATTGGCAGGGTCTATCAGTTGCGGCGCGGGGCAGAATCGCCCCACACCCACCGGGGAA
TTCGGAAAGGGGCAGGGGGC

Downstream 100 bases:

>100_bases
ATGCCTGGGGCATGTCGTGTCATAAAACCGTTACACAAGCGTCACAAAAGCTTGGCCAACGGTGCGTAGTCCAAGCCTCA
AGCGCGAGGCAGACGCCCTG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTYSAIHSLIDAVPDPMVLIAPDGTIGHANAGATALFGGWIIGRSHGLALRHPALLEQIDAVRSGEASAKLRIERSEQAG
VTQYKVRISALTGGAAGALVLHFTDITHLRETEEMRRDFVANVSHELRTPLTSVMGFIETLRGPARNDPAAQDRFLGIME
AEAGRMNRLISDLLSLSKVEAAERKRPTEQVDLAVLLEEVIAALRPRADDAGNRLELIHDDAPALVRGDHDQLMQVFLNL
AENALKYGGPGQPVTLRLSRGQGGGINGRAMIRVDVTDQGPGIDSQHLPRLTERFYRVDAHRSREMGGTGLGLAIVKHIV
NRHRGRLKITSQQGHGSTFSVQLPVE

Sequences:

>Translated_346_residues
MTYSAIHSLIDAVPDPMVLIAPDGTIGHANAGATALFGGWIIGRSHGLALRHPALLEQIDAVRSGEASAKLRIERSEQAG
VTQYKVRISALTGGAAGALVLHFTDITHLRETEEMRRDFVANVSHELRTPLTSVMGFIETLRGPARNDPAAQDRFLGIME
AEAGRMNRLISDLLSLSKVEAAERKRPTEQVDLAVLLEEVIAALRPRADDAGNRLELIHDDAPALVRGDHDQLMQVFLNL
AENALKYGGPGQPVTLRLSRGQGGGINGRAMIRVDVTDQGPGIDSQHLPRLTERFYRVDAHRSREMGGTGLGLAIVKHIV
NRHRGRLKITSQQGHGSTFSVQLPVE
>Mature_345_residues
TYSAIHSLIDAVPDPMVLIAPDGTIGHANAGATALFGGWIIGRSHGLALRHPALLEQIDAVRSGEASAKLRIERSEQAGV
TQYKVRISALTGGAAGALVLHFTDITHLRETEEMRRDFVANVSHELRTPLTSVMGFIETLRGPARNDPAAQDRFLGIMEA
EAGRMNRLISDLLSLSKVEAAERKRPTEQVDLAVLLEEVIAALRPRADDAGNRLELIHDDAPALVRGDHDQLMQVFLNLA
ENALKYGGPGQPVTLRLSRGQGGGINGRAMIRVDVTDQGPGIDSQHLPRLTERFYRVDAHRSREMGGTGLGLAIVKHIVN
RHRGRLKITSQQGHGSTFSVQLPVE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=337, Percent_Identity=34.4213649851632, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=33.4519572953737, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=35.7446808510638, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=31.9838056680162, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=31.5789473684211, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788549, Length=362, Percent_Identity=27.0718232044199, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI145693157, Length=228, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=28.2700421940928, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=29.4372294372294, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790346, Length=251, Percent_Identity=29.0836653386454, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790300, Length=236, Percent_Identity=33.4745762711864, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=32.9004329004329, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=28.0334728033473, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=258, Percent_Identity=28.2945736434109, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790551, Length=237, Percent_Identity=30.379746835443, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=27.7056277056277, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=29.6137339055794, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=207, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37561; Mature: 37430

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSAIHSLIDAVPDPMVLIAPDGTIGHANAGATALFGGWIIGRSHGLALRHPALLEQID
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHCEEEECCCCCEECCHHHHHHHH
AVRSGEASAKLRIERSEQAGVTQYKVRISALTGGAAGALVLHFTDITHLRETEEMRRDFV
HHHCCCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHH
ANVSHELRTPLTSVMGFIETLRGPARNDPAAQDRFLGIMEAEAGRMNRLISDLLSLSKVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAERKRPTEQVDLAVLLEEVIAALRPRADDAGNRLELIHDDAPALVRGDHDQLMQVFLNL
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHH
AENALKYGGPGQPVTLRLSRGQGGGINGRAMIRVDVTDQGPGIDSQHLPRLTERFYRVDA
HHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HRSREMGGTGLGLAIVKHIVNRHRGRLKITSQQGHGSTFSVQLPVE
HHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCC
>Mature Secondary Structure 
TYSAIHSLIDAVPDPMVLIAPDGTIGHANAGATALFGGWIIGRSHGLALRHPALLEQID
CHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHCEEEECCCCCEECCHHHHHHHH
AVRSGEASAKLRIERSEQAGVTQYKVRISALTGGAAGALVLHFTDITHLRETEEMRRDFV
HHHCCCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHH
ANVSHELRTPLTSVMGFIETLRGPARNDPAAQDRFLGIMEAEAGRMNRLISDLLSLSKVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAERKRPTEQVDLAVLLEEVIAALRPRADDAGNRLELIHDDAPALVRGDHDQLMQVFLNL
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHH
AENALKYGGPGQPVTLRLSRGQGGGINGRAMIRVDVTDQGPGIDSQHLPRLTERFYRVDA
HHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHH
HRSREMGGTGLGLAIVKHIVNRHRGRLKITSQQGHGSTFSVQLPVE
HHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]