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The map label for this gene is trkH [H]

Identifier: 89054734

GI number: 89054734

Start: 2250756

End: 2252273

Strand: Direct

Name: trkH [H]

Synonym: Jann_2243

Alternate gene names: 89054734

Gene position: 2250756-2252273 (Clockwise)

Preceding gene: 89054733

Following gene: 89054735

Centisome position: 52.13

GC content: 64.76

Gene sequence:

>1518_bases
ATGGCCGCTTATTTCCGCAATCTGCCCTTCTTCGTGATCCTGATTTTCGTGGCGGGCGGGGCGATGCTGGCCCCATCTGC
GGTGGCGCTGGCGTGGAAGGATTACGGCACGGCGCGGGTGTTTCTCTATACCGGGTTGATGGTTCTGATGGCCGCCGTAC
TTCTGGGGTTCGCCAGCCAAACCCCGCGCAGGCCCCCGTCCGAGCGGAGCCATTTGGCGTCGCTGTTTCTGGCCTATCTG
TGGTTGCCGCTGGTTCTGGGGATGCCGATGGATCAGGCGGTTGGAAATACGCGGTTTATCAACGTCTATCTCGACATGGT
GTCGGCCCTCACGACCACCGGGGCGGAGGTGTTTGATCCCGGCCGCCTGAGCCCGGCGGTGCATCTCTGGCGCGGTCTGG
TGGGGTGGTTTGGCGGCCTGCTGATCTGGATCACGGCCTTCGCGGTTCTCGCGCCCCTGAACCTGGGCGGGTATGAGGTG
ACGTCGGAGGCTGTCGTGCAAGGCAAGGTCGTGAATGCACGCGGCCAGATGCGGGCGGCGGATGCGTCCAACAGATTGCG
CAAGCATGCCGCGCGCCTGACGCCGATCTATGCAGGTCTGACCATCGCCCTGACCGCGGCCCTGGCGGCGGCAGGCGAAG
AGCCGCTTGTCGCCGTGATCCACGCCATGTCGACGCTGGCCACGTCGGGCATCAGCCCCGCAGGCGGGCTGGAGGGCCGG
CCCATCGGCCTGTTTGGCGAGGTGTTGATTTTCATCTTCTTTCTGTTCGCGCTGTCGCGCCGCACCTATTCCAGCGGCAT
CGGGCGAGAGTTTCGCGAGCGTCTGACCAAGGACCGGGAGATCCGGCTGGCGCTGTTTGCGGGCATCGTGCTGCCGACCC
TGCTATTCGCACGCCATTGGGTCGGCGCGTTGGAGGTTGATGATCTGGCAGATGGGCGCGCGGCATTTTCGGCGCTGTGG
GGGTCGGTCTTCACGGTCTTCTCGTTCCTGACCACCACCGGGTTTGTCAGCGATGCCTGGGGCGATGCGCGGGCCTGGTC
GGGCCTGCAGACGCCGGGGTTACTGCTGGTGGGCCTTGTGCTGATGGGCGGTGGCGTCGCCACGACAGCGGGGGGCGTGA
AGCTGCTGCGGGTCTATGCGCTCTACAAACATGGCACCCGCGAGATGGGCAAACTGATCTATCCCAACTCGGTCGCCGGG
GCAGGGCGGCTTGGGCGCCGCATCCGCCGGGAGGGGGCTTACATCGCGTGGATCGTTTTCATGCTTTTGGTCTTGTCGAT
CGCGACCGTGATGACCGCGCTGGCAGCCACGGGGCTGGATTTCGAATCGGCCACGATCCTGGCGATTTCCAGCCTGACGA
CGACGGGCCCGCTGGCCTCTGTCGCGGGCGCGCAGCCGATTGATTATTTCACGCTGTCGGACATGGCCAAGCTGATTTGC
GCCGCCGCGATGATCGTGGGGCGGATCGAGACATTGGTGATGATTGCGCTTCTGAACCCGGGCTTCTGGCGCGATTAA

Upstream 100 bases:

>100_bases
AGGAGGGCGACGTCGTGGTCATCTTCGCGCTGGCCCCCGATGTGCCAGCGGTTGAGGCGCTTCTGCAAGTCTCCATCGAC
TTTTTCTGACCGCCCGCGCC

Downstream 100 bases:

>100_bases
GCCACGGGTTTGCGGCTGTCGCGCCCGGGGGGGTAGAAATCCAAGCAGAATCGAGGACATAGTGCCCAGGCACGCATGCA
ACCGGACGAAACTCCGGGTG

Product: cation transporter

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MAAYFRNLPFFVILIFVAGGAMLAPSAVALAWKDYGTARVFLYTGLMVLMAAVLLGFASQTPRRPPSERSHLASLFLAYL
WLPLVLGMPMDQAVGNTRFINVYLDMVSALTTTGAEVFDPGRLSPAVHLWRGLVGWFGGLLIWITAFAVLAPLNLGGYEV
TSEAVVQGKVVNARGQMRAADASNRLRKHAARLTPIYAGLTIALTAALAAAGEEPLVAVIHAMSTLATSGISPAGGLEGR
PIGLFGEVLIFIFFLFALSRRTYSSGIGREFRERLTKDREIRLALFAGIVLPTLLFARHWVGALEVDDLADGRAAFSALW
GSVFTVFSFLTTTGFVSDAWGDARAWSGLQTPGLLLVGLVLMGGGVATTAGGVKLLRVYALYKHGTREMGKLIYPNSVAG
AGRLGRRIRREGAYIAWIVFMLLVLSIATVMTALAATGLDFESATILAISSLTTTGPLASVAGAQPIDYFTLSDMAKLIC
AAAMIVGRIETLVMIALLNPGFWRD

Sequences:

>Translated_505_residues
MAAYFRNLPFFVILIFVAGGAMLAPSAVALAWKDYGTARVFLYTGLMVLMAAVLLGFASQTPRRPPSERSHLASLFLAYL
WLPLVLGMPMDQAVGNTRFINVYLDMVSALTTTGAEVFDPGRLSPAVHLWRGLVGWFGGLLIWITAFAVLAPLNLGGYEV
TSEAVVQGKVVNARGQMRAADASNRLRKHAARLTPIYAGLTIALTAALAAAGEEPLVAVIHAMSTLATSGISPAGGLEGR
PIGLFGEVLIFIFFLFALSRRTYSSGIGREFRERLTKDREIRLALFAGIVLPTLLFARHWVGALEVDDLADGRAAFSALW
GSVFTVFSFLTTTGFVSDAWGDARAWSGLQTPGLLLVGLVLMGGGVATTAGGVKLLRVYALYKHGTREMGKLIYPNSVAG
AGRLGRRIRREGAYIAWIVFMLLVLSIATVMTALAATGLDFESATILAISSLTTTGPLASVAGAQPIDYFTLSDMAKLIC
AAAMIVGRIETLVMIALLNPGFWRD
>Mature_504_residues
AAYFRNLPFFVILIFVAGGAMLAPSAVALAWKDYGTARVFLYTGLMVLMAAVLLGFASQTPRRPPSERSHLASLFLAYLW
LPLVLGMPMDQAVGNTRFINVYLDMVSALTTTGAEVFDPGRLSPAVHLWRGLVGWFGGLLIWITAFAVLAPLNLGGYEVT
SEAVVQGKVVNARGQMRAADASNRLRKHAARLTPIYAGLTIALTAALAAAGEEPLVAVIHAMSTLATSGISPAGGLEGRP
IGLFGEVLIFIFFLFALSRRTYSSGIGREFRERLTKDREIRLALFAGIVLPTLLFARHWVGALEVDDLADGRAAFSALWG
SVFTVFSFLTTTGFVSDAWGDARAWSGLQTPGLLLVGLVLMGGGVATTAGGVKLLRVYALYKHGTREMGKLIYPNSVAGA
GRLGRRIRREGAYIAWIVFMLLVLSIATVMTALAATGLDFESATILAISSLTTTGPLASVAGAQPIDYFTLSDMAKLICA
AAMIVGRIETLVMIALLNPGFWRD

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity [H]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI48994987, Length=510, Percent_Identity=29.2156862745098, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787626, Length=416, Percent_Identity=26.9230769230769, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445
- InterPro:   IPR004772 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 53971; Mature: 53840

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYFRNLPFFVILIFVAGGAMLAPSAVALAWKDYGTARVFLYTGLMVLMAAVLLGFASQ
CCCHHHCCHHHHHHHHHHCCHHHCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
TPRRPPSERSHLASLFLAYLWLPLVLGMPMDQAVGNTRFINVYLDMVSALTTTGAEVFDP
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHHHHHHHCCCHHCCC
GRLSPAVHLWRGLVGWFGGLLIWITAFAVLAPLNLGGYEVTSEAVVQGKVVNARGQMRAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECCCCCCHHH
DASNRLRKHAARLTPIYAGLTIALTAALAAAGEEPLVAVIHAMSTLATSGISPAGGLEGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
PIGLFGEVLIFIFFLFALSRRTYSSGIGREFRERLTKDREIRLALFAGIVLPTLLFARHW
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VGALEVDDLADGRAAFSALWGSVFTVFSFLTTTGFVSDAWGDARAWSGLQTPGLLLVGLV
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHCCCCCCCHHHHHHHH
LMGGGVATTAGGVKLLRVYALYKHGTREMGKLIYPNSVAGAGRLGRRIRREGAYIAWIVF
HHCCCHHHHHHHHHHHHHHHHHHHCHHHHCCEECCCCCCCHHHHHHHHHHCCCHHHHHHH
MLLVLSIATVMTALAATGLDFESATILAISSLTTTGPLASVAGAQPIDYFTLSDMAKLIC
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCCHHHHCCCCCCCHHHHHHHHHHHH
AAAMIVGRIETLVMIALLNPGFWRD
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AAYFRNLPFFVILIFVAGGAMLAPSAVALAWKDYGTARVFLYTGLMVLMAAVLLGFASQ
CCHHHCCHHHHHHHHHHCCHHHCCHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCC
TPRRPPSERSHLASLFLAYLWLPLVLGMPMDQAVGNTRFINVYLDMVSALTTTGAEVFDP
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHHHHHHHCCCHHCCC
GRLSPAVHLWRGLVGWFGGLLIWITAFAVLAPLNLGGYEVTSEAVVQGKVVNARGQMRAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECCCCCCHHH
DASNRLRKHAARLTPIYAGLTIALTAALAAAGEEPLVAVIHAMSTLATSGISPAGGLEGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
PIGLFGEVLIFIFFLFALSRRTYSSGIGREFRERLTKDREIRLALFAGIVLPTLLFARHW
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VGALEVDDLADGRAAFSALWGSVFTVFSFLTTTGFVSDAWGDARAWSGLQTPGLLLVGLV
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHCCCCCCCHHHHHHHH
LMGGGVATTAGGVKLLRVYALYKHGTREMGKLIYPNSVAGAGRLGRRIRREGAYIAWIVF
HHCCCHHHHHHHHHHHHHHHHHHHCHHHHCCEECCCCCCCHHHHHHHHHHCCCHHHHHHH
MLLVLSIATVMTALAATGLDFESATILAISSLTTTGPLASVAGAQPIDYFTLSDMAKLIC
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHCCCCCHHHHCCCCCCCHHHHHHHHHHHH
AAAMIVGRIETLVMIALLNPGFWRD
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]