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The map label for this gene is pfpI [H]

Identifier: 89054358

GI number: 89054358

Start: 1854735

End: 1855295

Strand: Direct

Name: pfpI [H]

Synonym: Jann_1867

Alternate gene names: 89054358

Gene position: 1854735-1855295 (Clockwise)

Preceding gene: 89054353

Following gene: 89054359

Centisome position: 42.95

GC content: 63.1

Gene sequence:

>561_bases
ATGCCCAACATCGACCAGTCCAAGATCCTGATCCTGTCCACCCATGGCTTCGAGCAATCCGAGCTGGAAGTGCCGCTGGA
ACAGCTGCGCGCCGCCGGTGCGACGGTCCATGTCGCTTCGCCCGAGAGCGGGGAGATCAAGGGATGGGACGGGGGCGATT
GGGGCGCGTCTGTCCCGGTCGACCTGCCGCTGTCGGATGTGAATGCCTACGATTATGACGCGCTGGTGCTGCCGGGCGGC
CAGATCAATCCCGACATCCTGCGCACCCATGAGGGTGCGGTCGATATCATCCGCACGTTTGTGGATTCGGGCCGCATCGT
CGCCGCCATCTGCCACGCCCCGTGGTTGCTGATCGAAGCGGGCGTGGTCGAGGGGCGCGAGATGACCTCCTACCCCTCCA
TCAAGACCGACATGATCAATGCCGGTGCCAAGTGGGAAGACAGCGAAGTCGCCATCTCCAACGGCATCATCACCAGCCGC
AATCCCGATGATCTGGACGCGTTCGTCGCCAAGATCATCGAGGAGGTGAAAGAGGGCAAGCACGAGCGGGACGCTGCGTG
A

Upstream 100 bases:

>100_bases
CAGGGGGGAGGGAACCCGATGCAGGGGGCGCGTGTTGGTTCATTGGAACAAGCGGCCACCGAGGTGGTCGCGCAATGGAA
CACACATATGGAGGCATCCC

Downstream 100 bases:

>100_bases
TCCAGCCCCCGCGCGATTCGTTAACCGATCGATGTTAACGGTAAGCATGCCCTGAAACCGCCGCCCCGGACCTGCCACCC
GGGGCGGCGGTTTTGCTGTT

Product: peptidase C56, PfpI

Products: NA

Alternate protein names: Intracellular protease I [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MPNIDQSKILILSTHGFEQSELEVPLEQLRAAGATVHVASPESGEIKGWDGGDWGASVPVDLPLSDVNAYDYDALVLPGG
QINPDILRTHEGAVDIIRTFVDSGRIVAAICHAPWLLIEAGVVEGREMTSYPSIKTDMINAGAKWEDSEVAISNGIITSR
NPDDLDAFVAKIIEEVKEGKHERDAA

Sequences:

>Translated_186_residues
MPNIDQSKILILSTHGFEQSELEVPLEQLRAAGATVHVASPESGEIKGWDGGDWGASVPVDLPLSDVNAYDYDALVLPGG
QINPDILRTHEGAVDIIRTFVDSGRIVAAICHAPWLLIEAGVVEGREMTSYPSIKTDMINAGAKWEDSEVAISNGIITSR
NPDDLDAFVAKIIEEVKEGKHERDAA
>Mature_185_residues
PNIDQSKILILSTHGFEQSELEVPLEQLRAAGATVHVASPESGEIKGWDGGDWGASVPVDLPLSDVNAYDYDALVLPGGQ
INPDILRTHEGAVDIIRTFVDSGRIVAAICHAPWLLIEAGVVEGREMTSYPSIKTDMINAGAKWEDSEVAISNGIITSRN
PDDLDAFVAKIIEEVKEGKHERDAA

Specific function: Highly stable protease. Although the physiological function is unclear it is the dominant protease in P.furiosus [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PfpI endopeptidase domain [H]

Homologues:

Organism=Escherichia coli, GI87082219, Length=164, Percent_Identity=43.2926829268293, Blast_Score=121, Evalue=2e-29,
Organism=Escherichia coli, GI87081736, Length=183, Percent_Identity=32.2404371584699, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531319, Length=185, Percent_Identity=32.4324324324324, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17558714, Length=183, Percent_Identity=29.5081967213115, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571932, Length=174, Percent_Identity=32.183908045977, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24653499, Length=106, Percent_Identity=34.9056603773585, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006286
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 20041; Mature: 19909

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIDQSKILILSTHGFEQSELEVPLEQLRAAGATVHVASPESGEIKGWDGGDWGASVPV
CCCCCCCEEEEEEECCCCCCHHHCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCC
DLPLSDVNAYDYDALVLPGGQINPDILRTHEGAVDIIRTFVDSGRIVAAICHAPWLLIEA
CCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEHHCCEEEEEC
GVVEGREMTSYPSIKTDMINAGAKWEDSEVAISNGIITSRNPDDLDAFVAKIIEEVKEGK
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHCCC
HERDAA
CCCCCC
>Mature Secondary Structure 
PNIDQSKILILSTHGFEQSELEVPLEQLRAAGATVHVASPESGEIKGWDGGDWGASVPV
CCCCCCEEEEEEECCCCCCHHHCCHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCC
DLPLSDVNAYDYDALVLPGGQINPDILRTHEGAVDIIRTFVDSGRIVAAICHAPWLLIEA
CCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEHHCCEEEEEC
GVVEGREMTSYPSIKTDMINAGAKWEDSEVAISNGIITSRNPDDLDAFVAKIIEEVKEGK
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHHCCC
HERDAA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626329 [H]