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The map label for this gene is folE2

Identifier: 89054348

GI number: 89054348

Start: 1844107

End: 1845195

Strand: Direct

Name: folE2

Synonym: Jann_1857

Alternate gene names: 89054348

Gene position: 1844107-1845195 (Clockwise)

Preceding gene: 89054347

Following gene: 89054350

Centisome position: 42.71

GC content: 61.34

Gene sequence:

>1089_bases
ATGAATGTGCATGTTAAGACCGCCGATCAAACGCCATCTACCGTGCAGGCTCAGGATGCCCTCGCCATCCTGAGTGCCTG
GGCGTCCGAGGCATCTGCTGATCAGATCGACGCATTGGATCCCGGCATCGCGCGTCTTGTGCGCGTGCAGGCCTATCCGG
ACCTGCGGGCTGAGTATCCAGGCGACTTCACCGTCGATGAGGCCTACCGCGCCACGCTGCCGGACCTGCAAAACGGCCCG
GCCTCCCTGATCAAAGGCGCGAACCGGCGCATCCAGCATGTGGGGATTTCCAACTTCCGCCTGCCGATCCGCTACGCCGT
GCAGGATGGATCCGAGGTGATGCTGGAAACCTCCGTCACCGGCACCGTTAGCCTGGAGGCCGACCAGAAGGGCATCAACA
TGAGCCGCATCATGCGGTCGTTCTACAAGCACGCCGATGCGTCGTTTGGGTTTGATGTGATCGAGGCCGCACTGGATGAT
TACAAGGCCGATCTGGGCAGTTTTGACGCCCGTATCCAGATGCGCCTGAGTTACCCGATGAAGGTCGATAGCCTCCGCTC
GGGCCTGTCGGGGTGGCAATATTACGACATTGCTCTGGAACTGGTGGAACGGGGCGGTGTGCGACAGCGTATCGTGCATC
TCGACTATGTCTATTCGTCGACCTGCCCGTGTTCGCTGGAACTGAGCGAGCACGCCCGCGCCACCCGTGGTCAGCTGGCG
ACGCCGCACTCGCAGCGATCCGTCGCGCGGATCAGCGTGGAATTGCAGGGGCAGGGCGTCTGGTTTGAGGACCTGATCGA
GATGGCCCGTTCAGGCGTGCCGACCGAAACGCAGGTGATGGTCAAACGTGAGGATGAACAGGCCTTCGCGGAACTCAACG
CCGCCAACCCGATCTTCGTGGAGGACGCCGCGCGTCTCTTCGCCGAGCAGTTGCAGGCCCATAGCGGTGTCGGAGATTTC
CGCGTCATGGCCAGCCATCAAGAAAGCCTGCACAGCCACGATGCTGTCAGTCTCTTAACGGAGGGTGACACCTTTGCCGA
GGTTAGCCTGGACCCTAAGCTGTTCCCGTCCCTCATCCACGTTGGCTAA

Upstream 100 bases:

>100_bases
GTAACCCTTGGCCTACATAACCCCCTGGACAAATCTTTCCTTGGGTTTCCCGGCCGCCGCTCCATATGATTAAATACATC
ATTAAAGGGAGGGGTGGCAC

Downstream 100 bases:

>100_bases
AGTGTTACTTTAACGCTGCCGCGCAACCTATAGATAATAAAAGCCCCCGTAGATATGCGAGGGCTTTTCTCGATCCGTAT
GAACCCGAGGTCAGTAATAG

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MNVHVKTADQTPSTVQAQDALAILSAWASEASADQIDALDPGIARLVRVQAYPDLRAEYPGDFTVDEAYRATLPDLQNGP
ASLIKGANRRIQHVGISNFRLPIRYAVQDGSEVMLETSVTGTVSLEADQKGINMSRIMRSFYKHADASFGFDVIEAALDD
YKADLGSFDARIQMRLSYPMKVDSLRSGLSGWQYYDIALELVERGGVRQRIVHLDYVYSSTCPCSLELSEHARATRGQLA
TPHSQRSVARISVELQGQGVWFEDLIEMARSGVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFAEQLQAHSGVGDF
RVMASHQESLHSHDAVSLLTEGDTFAEVSLDPKLFPSLIHVG

Sequences:

>Translated_362_residues
MNVHVKTADQTPSTVQAQDALAILSAWASEASADQIDALDPGIARLVRVQAYPDLRAEYPGDFTVDEAYRATLPDLQNGP
ASLIKGANRRIQHVGISNFRLPIRYAVQDGSEVMLETSVTGTVSLEADQKGINMSRIMRSFYKHADASFGFDVIEAALDD
YKADLGSFDARIQMRLSYPMKVDSLRSGLSGWQYYDIALELVERGGVRQRIVHLDYVYSSTCPCSLELSEHARATRGQLA
TPHSQRSVARISVELQGQGVWFEDLIEMARSGVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFAEQLQAHSGVGDF
RVMASHQESLHSHDAVSLLTEGDTFAEVSLDPKLFPSLIHVG
>Mature_362_residues
MNVHVKTADQTPSTVQAQDALAILSAWASEASADQIDALDPGIARLVRVQAYPDLRAEYPGDFTVDEAYRATLPDLQNGP
ASLIKGANRRIQHVGISNFRLPIRYAVQDGSEVMLETSVTGTVSLEADQKGINMSRIMRSFYKHADASFGFDVIEAALDD
YKADLGSFDARIQMRLSYPMKVDSLRSGLSGWQYYDIALELVERGGVRQRIVHLDYVYSSTCPCSLELSEHARATRGQLA
TPHSQRSVARISVELQGQGVWFEDLIEMARSGVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFAEQLQAHSGVGDF
RVMASHQESLHSHDAVSLLTEGDTFAEVSLDPKLFPSLIHVG

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_JANSC (Q28R88)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509799.1
- ProteinModelPortal:   Q28R88
- SMR:   Q28R88
- STRING:   Q28R88
- GeneID:   3934308
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1857
- eggNOG:   COG1469
- HOGENOM:   HBG466315
- OMA:   GLSGWQY
- ProtClustDB:   PRK13674
- BioCyc:   JSP290400:JANN_1857-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 39886; Mature: 39886

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHVKTADQTPSTVQAQDALAILSAWASEASADQIDALDPGIARLVRVQAYPDLRAEYP
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHEEHCCCCCCCCCCC
GDFTVDEAYRATLPDLQNGPASLIKGANRRIQHVGISNFRLPIRYAVQDGSEVMLETSVT
CCCCHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCEEEEEEECC
GTVSLEADQKGINMSRIMRSFYKHADASFGFDVIEAALDDYKADLGSFDARIQMRLSYPM
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
KVDSLRSGLSGWQYYDIALELVERGGVRQRIVHLDYVYSSTCPCSLELSEHARATRGQLA
CHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHEEEEEHCCCCCCCEEEHHHHHHHHCCCCC
TPHSQRSVARISVELQGQGVWFEDLIEMARSGVPTETQVMVKREDEQAFAELNAANPIFV
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHCCCCCEEH
EDAARLFAEQLQAHSGVGDFRVMASHQESLHSHDAVSLLTEGDTFAEVSLDPKLFPSLIH
HHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHC
VG
CC
>Mature Secondary Structure
MNVHVKTADQTPSTVQAQDALAILSAWASEASADQIDALDPGIARLVRVQAYPDLRAEYP
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHEEHCCCCCCCCCCC
GDFTVDEAYRATLPDLQNGPASLIKGANRRIQHVGISNFRLPIRYAVQDGSEVMLETSVT
CCCCHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCEEEEEEECC
GTVSLEADQKGINMSRIMRSFYKHADASFGFDVIEAALDDYKADLGSFDARIQMRLSYPM
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEECCC
KVDSLRSGLSGWQYYDIALELVERGGVRQRIVHLDYVYSSTCPCSLELSEHARATRGQLA
CHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHEEEEEHCCCCCCCEEEHHHHHHHHCCCCC
TPHSQRSVARISVELQGQGVWFEDLIEMARSGVPTETQVMVKREDEQAFAELNAANPIFV
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHCCCCCEEH
EDAARLFAEQLQAHSGVGDFRVMASHQESLHSHDAVSLLTEGDTFAEVSLDPKLFPSLIH
HHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHHHC
VG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA