Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 89054334

GI number: 89054334

Start: 1829133

End: 1831253

Strand: Direct

Name: comEC [H]

Synonym: Jann_1843

Alternate gene names: 89054334

Gene position: 1829133-1831253 (Clockwise)

Preceding gene: 89054331

Following gene: 89054335

Centisome position: 42.36

GC content: 68.55

Gene sequence:

>2121_bases
TTGATCTTACGCGCGGCCAATGCGGTCCAGCAGGGGCAACGGGGCGCGTTGATGCCCTGGACCGCCGTGGCGTTGGGCTG
CGGCGTTGGCCTTTACTTTTCCCTATCGGTGGAACCCGGCGTCCTCGCCTATGGCGCAGCGATCGGGGTGGCCATCCTCG
CGGCGGCAATCGGATTTTGGCGGCGGGAGGTGCTTGGCCCCCTCGGCCTGGCGGTGGTCCTGGTCGCGGTCGGCTTCTGC
CTTGCGGGCCTGCGCGCCCATTCGGTGGCAGGACCGGTCATCGATTTCCGCTATTATGGCGCGATTGAAGGCCGGATCGT
TGGTATCGACCGGTCGTCCTCCGATGCCGTGCGCCTGACACTGGATCAGGTGCGTCTGGATGACGTGCGAAATACGCCCC
TGCGCGTGCGCATCGCGCTGCACGGAGATCAGGGCTTCATGGACCCGCAGCCGGGCGCGATTATCTTCACCACGGGCCAT
CTGTCGCCCCCCGGCGGCGCGGCGGAGCCCGGAGGGTTCGATTTCCAGCGCCATGCGTGGTTCCAGTCAATCGGCGGCGT
GGGCTACACCCGCACGCCGGTGTTGTTGCTGGAGCCGCCCGCCGATGGGGTGGCCCCGCTGTTTACCCTGCGCATGCGCA
TGTCAGCTGCCGTCCAGGCGCAGATCCCCGGCCAGCCCGGGGCTTTTGCTGCAGCAGTCCTGACCGGCGACCGCTCCGGC
CTGTCGCAAGGCTCCACCCAGGATATGCGGGACAGCAACATCGCGCATTTGCTGGCAATCTCGGGCCTGCATATGGGGCT
TCTGACCGGCTTCGTCTACGCCGCCCTGCGCACAGCTCTCGCGCTGATCCCCGCCATCGCGCTGCGCTACCCGATCCGCA
AATGGGCGGCTGTGGCGGCGCTGGTCTCCGGCGCGTTCTATCTGGCGCTGTCGGGCGGCAATGTTGCGACAGAGCGCGCC
TTCATCCAGGTCGCGGTGATGTTCACCGCCGTCCTGCTGGACCGCCGCGCCATCACGCTCCGCTCCGTCGCCATCGCCGC
GATCATCGTGTTGTTGCACCGGCCCGAGACGTTGATGTCCCCCGGCTTCCAGATGTCCTTCGCCGCCACCACGGCGCTTG
TAGCCGCGTTCACCGGGCTGCAAGGGGCCGAATGGATGCGCAACTGGCCCAAATGGGTGAAGGGCGCCTGGGCTTTGCTG
ACCTCTTCGGTGATTGCGGGGGCCGCCACTGCGCCCTTCGCCGCCGCCCATTTCAACCGGCTGGCGGTTTACGGGCTGAT
CGCCAACCTTCTGACCGTCCCTGCCATGGGCTCGGTTGTCATCCCCTTTGCCGTCCTGGCGCTGATGCTGGCCCCCTTTG
GCCTGTCATGGGTGGCCTTCTGGATCATGGAACTGGCGTTGGAATGGATCCTTGCGGTGGCGGCCCGTGTGGCCGATATC
CCCGGCGCGGTGCGCATGGTGGCCAGTCCGCCGCATCTGGTTCTTCCGTTGATCGGCGTGGGTGGCATTGCCCTGTGCAT
CTGGTCGGGGCGGGGGCGATGGATCGCGCTGACGCCCATGGCTGCGGGCCTGATCCTGTGGCAATGGGCCGAGCGTCCGA
TGTTGCTGATATCCGAGCCCGGTGGCCTCGTGGGCCTGACAACGGACCAGGGCCGCGCCCTCAGCCGGCCCCGGGGCGAT
GGCTTCGTGGCGGGCATCTGGCTGGAGAATGATGGCGACCTGATCACCCAGGAGGACGCCGCCGCGCGCCCCGCCTGGGC
AGATGCAGACCCCGGGCGCACAACGCAGCTTGGCGAGGTGACGCTTTGGCACGGCACGGGCCGCGCGGCCTCCCGCGTGG
TGGATGCGGCCTGCGCGCGACACGACATTGTCGTCACCAACCTCGCGCCGGAAGATCCAAGCGCGACCCTTACCCAGGCC
GAACGCGACACGCGCGCCCGGCTGACGGCACCTCCCCCCGCCACCGGTGCGGCCAATGCTGCGACCGCCACGCCCTGCCT
GCTGCTGACCCCGCGCGTCCTGTCGGCCACCGGCTCCATCGCGCTCTCCGCCCAGGACGGCGCGCTCCAGATCGACACTG
CGCGCGCCCATCAAGGCACCCGTCTGTGGTCCCGCGACTAA

Upstream 100 bases:

>100_bases
CCTTTTGGAAACCATGATCTGGCATCTTCAAGGCTAGGTATCTTGGGCAAGGGACCCGAGCAAGGCCCGGCGCTCAGTTG
CGTTGGGGAAGGCGGATGAT

Downstream 100 bases:

>100_bases
GCTCCCTCTTCCTCACGCCCCCACCACCTTATTCGCGCCACCCCTCAATTCCCCGTTCTTCAAATATCCCCGCCGGAGGC
ATCGCACCCCCTCGACCCGC

Product: ComEC/Rec2-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MILRAANAVQQGQRGALMPWTAVALGCGVGLYFSLSVEPGVLAYGAAIGVAILAAAIGFWRREVLGPLGLAVVLVAVGFC
LAGLRAHSVAGPVIDFRYYGAIEGRIVGIDRSSSDAVRLTLDQVRLDDVRNTPLRVRIALHGDQGFMDPQPGAIIFTTGH
LSPPGGAAEPGGFDFQRHAWFQSIGGVGYTRTPVLLLEPPADGVAPLFTLRMRMSAAVQAQIPGQPGAFAAAVLTGDRSG
LSQGSTQDMRDSNIAHLLAISGLHMGLLTGFVYAALRTALALIPAIALRYPIRKWAAVAALVSGAFYLALSGGNVATERA
FIQVAVMFTAVLLDRRAITLRSVAIAAIIVLLHRPETLMSPGFQMSFAATTALVAAFTGLQGAEWMRNWPKWVKGAWALL
TSSVIAGAATAPFAAAHFNRLAVYGLIANLLTVPAMGSVVIPFAVLALMLAPFGLSWVAFWIMELALEWILAVAARVADI
PGAVRMVASPPHLVLPLIGVGGIALCIWSGRGRWIALTPMAAGLILWQWAERPMLLISEPGGLVGLTTDQGRALSRPRGD
GFVAGIWLENDGDLITQEDAAARPAWADADPGRTTQLGEVTLWHGTGRAASRVVDAACARHDIVVTNLAPEDPSATLTQA
ERDTRARLTAPPPATGAANAATATPCLLLTPRVLSATGSIALSAQDGALQIDTARAHQGTRLWSRD

Sequences:

>Translated_706_residues
MILRAANAVQQGQRGALMPWTAVALGCGVGLYFSLSVEPGVLAYGAAIGVAILAAAIGFWRREVLGPLGLAVVLVAVGFC
LAGLRAHSVAGPVIDFRYYGAIEGRIVGIDRSSSDAVRLTLDQVRLDDVRNTPLRVRIALHGDQGFMDPQPGAIIFTTGH
LSPPGGAAEPGGFDFQRHAWFQSIGGVGYTRTPVLLLEPPADGVAPLFTLRMRMSAAVQAQIPGQPGAFAAAVLTGDRSG
LSQGSTQDMRDSNIAHLLAISGLHMGLLTGFVYAALRTALALIPAIALRYPIRKWAAVAALVSGAFYLALSGGNVATERA
FIQVAVMFTAVLLDRRAITLRSVAIAAIIVLLHRPETLMSPGFQMSFAATTALVAAFTGLQGAEWMRNWPKWVKGAWALL
TSSVIAGAATAPFAAAHFNRLAVYGLIANLLTVPAMGSVVIPFAVLALMLAPFGLSWVAFWIMELALEWILAVAARVADI
PGAVRMVASPPHLVLPLIGVGGIALCIWSGRGRWIALTPMAAGLILWQWAERPMLLISEPGGLVGLTTDQGRALSRPRGD
GFVAGIWLENDGDLITQEDAAARPAWADADPGRTTQLGEVTLWHGTGRAASRVVDAACARHDIVVTNLAPEDPSATLTQA
ERDTRARLTAPPPATGAANAATATPCLLLTPRVLSATGSIALSAQDGALQIDTARAHQGTRLWSRD
>Mature_706_residues
MILRAANAVQQGQRGALMPWTAVALGCGVGLYFSLSVEPGVLAYGAAIGVAILAAAIGFWRREVLGPLGLAVVLVAVGFC
LAGLRAHSVAGPVIDFRYYGAIEGRIVGIDRSSSDAVRLTLDQVRLDDVRNTPLRVRIALHGDQGFMDPQPGAIIFTTGH
LSPPGGAAEPGGFDFQRHAWFQSIGGVGYTRTPVLLLEPPADGVAPLFTLRMRMSAAVQAQIPGQPGAFAAAVLTGDRSG
LSQGSTQDMRDSNIAHLLAISGLHMGLLTGFVYAALRTALALIPAIALRYPIRKWAAVAALVSGAFYLALSGGNVATERA
FIQVAVMFTAVLLDRRAITLRSVAIAAIIVLLHRPETLMSPGFQMSFAATTALVAAFTGLQGAEWMRNWPKWVKGAWALL
TSSVIAGAATAPFAAAHFNRLAVYGLIANLLTVPAMGSVVIPFAVLALMLAPFGLSWVAFWIMELALEWILAVAARVADI
PGAVRMVASPPHLVLPLIGVGGIALCIWSGRGRWIALTPMAAGLILWQWAERPMLLISEPGGLVGLTTDQGRALSRPRGD
GFVAGIWLENDGDLITQEDAAARPAWADADPGRTTQLGEVTLWHGTGRAASRVVDAACARHDIVVTNLAPEDPSATLTQA
ERDTRARLTAPPPATGAANAATATPCLLLTPRVLSATGSIALSAQDGALQIDTARAHQGTRLWSRD

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=289, Percent_Identity=24.5674740484429, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 74112; Mature: 74112

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILRAANAVQQGQRGALMPWTAVALGCGVGLYFSLSVEPGVLAYGAAIGVAILAAAIGFW
CEECCCHHHHCCCCCCCCCHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RREVLGPLGLAVVLVAVGFCLAGLRAHSVAGPVIDFRYYGAIEGRIVGIDRSSSDAVRLT
HHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEE
LDQVRLDDVRNTPLRVRIALHGDQGFMDPQPGAIIFTTGHLSPPGGAAEPGGFDFQRHAW
EHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
FQSIGGVGYTRTPVLLLEPPADGVAPLFTLRMRMSAAVQAQIPGQPGAFAAAVLTGDRSG
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCCC
LSQGSTQDMRDSNIAHLLAISGLHMGLLTGFVYAALRTALALIPAIALRYPIRKWAAVAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSGAFYLALSGGNVATERAFIQVAVMFTAVLLDRRAITLRSVAIAAIIVLLHRPETLMS
HHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHC
PGFQMSFAATTALVAAFTGLQGAEWMRNWPKWVKGAWALLTSSVIAGAATAPFAAAHFNR
CCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAVYGLIANLLTVPAMGSVVIPFAVLALMLAPFGLSWVAFWIMELALEWILAVAARVADI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PGAVRMVASPPHLVLPLIGVGGIALCIWSGRGRWIALTPMAAGLILWQWAERPMLLISEP
CCCEEEECCCCCEEEEHHCCCCEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEECC
GGLVGLTTDQGRALSRPRGDGFVAGIWLENDGDLITQEDAAARPAWADADPGRTTQLGEV
CCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCEECEE
TLWHGTGRAASRVVDAACARHDIVVTNLAPEDPSATLTQAERDTRARLTAPPPATGAANA
EEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCC
ATATPCLLLTPRVLSATGSIALSAQDGALQIDTARAHQGTRLWSRD
CCCCCEEEECCHHHCCCCCEEEEECCCCEEEEEHHCCCCCCCCCCC
>Mature Secondary Structure
MILRAANAVQQGQRGALMPWTAVALGCGVGLYFSLSVEPGVLAYGAAIGVAILAAAIGFW
CEECCCHHHHCCCCCCCCCHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
RREVLGPLGLAVVLVAVGFCLAGLRAHSVAGPVIDFRYYGAIEGRIVGIDRSSSDAVRLT
HHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCEEEEE
LDQVRLDDVRNTPLRVRIALHGDQGFMDPQPGAIIFTTGHLSPPGGAAEPGGFDFQRHAW
EHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
FQSIGGVGYTRTPVLLLEPPADGVAPLFTLRMRMSAAVQAQIPGQPGAFAAAVLTGDRSG
HHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHEEEECCCCCCCEEEEEEECCCCC
LSQGSTQDMRDSNIAHLLAISGLHMGLLTGFVYAALRTALALIPAIALRYPIRKWAAVAA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSGAFYLALSGGNVATERAFIQVAVMFTAVLLDRRAITLRSVAIAAIIVLLHRPETLMS
HHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHC
PGFQMSFAATTALVAAFTGLQGAEWMRNWPKWVKGAWALLTSSVIAGAATAPFAAAHFNR
CCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LAVYGLIANLLTVPAMGSVVIPFAVLALMLAPFGLSWVAFWIMELALEWILAVAARVADI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PGAVRMVASPPHLVLPLIGVGGIALCIWSGRGRWIALTPMAAGLILWQWAERPMLLISEP
CCCEEEECCCCCEEEEHHCCCCEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEECC
GGLVGLTTDQGRALSRPRGDGFVAGIWLENDGDLITQEDAAARPAWADADPGRTTQLGEV
CCEEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCEECEE
TLWHGTGRAASRVVDAACARHDIVVTNLAPEDPSATLTQAERDTRARLTAPPPATGAANA
EEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHCCCCCCEECCCCCCCCCCCC
ATATPCLLLTPRVLSATGSIALSAQDGALQIDTARAHQGTRLWSRD
CCCCCEEEECCHHHCCCCCEEEEECCCCEEEEEHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]