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The map label for this gene is garR [H]

Identifier: 89054085

GI number: 89054085

Start: 1576263

End: 1577207

Strand: Direct

Name: garR [H]

Synonym: Jann_1594

Alternate gene names: 89054085

Gene position: 1576263-1577207 (Clockwise)

Preceding gene: 89054077

Following gene: 89054087

Centisome position: 36.5

GC content: 64.55

Gene sequence:

>945_bases
ATGCAGGTGGGATTTATCGGATTGGGGTCGGTTGGCGGAAAGCTTGCGGGCTCTCTCCTGCGCAACGGGGTGGATCTGTC
GGTCCATGATCTGGACGCGGCAGCGGTGGCGGAGTTTGTCGCGCGCGGCGCACGGGCGGGGGGCAGTGCTGCGGCGTTGA
TGCGCGATTGCGACGTGGTGATCACCTGCCTGCCGTCGCCCGCGGCCTCTGCGGCCGTTGTGGACCAGATGCTGCCGGAG
GTGGCCCCGGGCAAGATCTGGATGGAGATGTCGACCACCGATGCGGCCGAGGTTCTGCGACTGGCCCCCCTGGTGGAGGC
GGCAGGCGGCGCGGTTGCCGAATGCCCCGTCTCGGGCGGGTGCCACCGGGCGGCGACAGGCAATATCGCGATCTACATGA
GCGGCGCGCGGGAGGTCTTCGACCGCGTCTTCTCGTTGCTCGCCAAAATGGGCCGCCGGGTGTTGCATACGGGACCGTTG
GGGGCGGCTTCCACGCTGAAGGTGATGACGAATTACCTGGCCACGACGCATCTTCTGGCGCTGTGCGAGAGCCTTGCGGT
GATGCGCGCGGCGGGTGTTGATCTGGGCGTGGCTTATGAGGCAATCGCCGTGTCCTCGGGCAATTCTTTCGTGCATGAGA
CCGAAAGTCAGCTGATCTTATCGGGATCGCGTGACGTGAACTTCACGCTGGACCTGATCCAGAAAGATGTGGGCCTGTTT
CAGGCCACCGCAGAGCGCAATGGCGTGCCGCTGGAGCTGTCGCCCAAGGTGATCGAGATGCTGACGGAGGGGCAGAGGGT
GCTGGGGGATACGGCCCAGAGCGACCGGATGATTGAGTTGTTGGAGACGGCCACTGGCCTTGACGTGCGGGCCGACGGGT
TCCCGATGGAATTGATTGACGATGAGCCGGAGGCGCAGGGATATGAAGTTGTGGTTCAGCGGTGA

Upstream 100 bases:

>100_bases
GTCGCCTTTGCCCGATGGGATACGGGGTCGTGTCGGAAACAGAAGGGCGCAGCCGTGCGAGCGCCGCAAACCTGCTGCAA
TACAGCAGAGGAGCAGGACG

Downstream 100 bases:

>100_bases
CGTCGCGCCATGTCGGGGATGGGCGGGCCTGCCCACCCACCCCATTTGGGGGCATGGCCCCCTGGCCCCCCGGGATCAGG
CTTGTGATGGGTGCAAGAGA

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQVGFIGLGSVGGKLAGSLLRNGVDLSVHDLDAAAVAEFVARGARAGGSAAALMRDCDVVITCLPSPAASAAVVDQMLPE
VAPGKIWMEMSTTDAAEVLRLAPLVEAAGGAVAECPVSGGCHRAATGNIAIYMSGAREVFDRVFSLLAKMGRRVLHTGPL
GAASTLKVMTNYLATTHLLALCESLAVMRAAGVDLGVAYEAIAVSSGNSFVHETESQLILSGSRDVNFTLDLIQKDVGLF
QATAERNGVPLELSPKVIEMLTEGQRVLGDTAQSDRMIELLETATGLDVRADGFPMELIDDEPEAQGYEVVVQR

Sequences:

>Translated_314_residues
MQVGFIGLGSVGGKLAGSLLRNGVDLSVHDLDAAAVAEFVARGARAGGSAAALMRDCDVVITCLPSPAASAAVVDQMLPE
VAPGKIWMEMSTTDAAEVLRLAPLVEAAGGAVAECPVSGGCHRAATGNIAIYMSGAREVFDRVFSLLAKMGRRVLHTGPL
GAASTLKVMTNYLATTHLLALCESLAVMRAAGVDLGVAYEAIAVSSGNSFVHETESQLILSGSRDVNFTLDLIQKDVGLF
QATAERNGVPLELSPKVIEMLTEGQRVLGDTAQSDRMIELLETATGLDVRADGFPMELIDDEPEAQGYEVVVQR
>Mature_314_residues
MQVGFIGLGSVGGKLAGSLLRNGVDLSVHDLDAAAVAEFVARGARAGGSAAALMRDCDVVITCLPSPAASAAVVDQMLPE
VAPGKIWMEMSTTDAAEVLRLAPLVEAAGGAVAECPVSGGCHRAATGNIAIYMSGAREVFDRVFSLLAKMGRRVLHTGPL
GAASTLKVMTNYLATTHLLALCESLAVMRAAGVDLGVAYEAIAVSSGNSFVHETESQLILSGSRDVNFTLDLIQKDVGLF
QATAERNGVPLELSPKVIEMLTEGQRVLGDTAQSDRMIELLETATGLDVRADGFPMELIDDEPEAQGYEVVVQR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=241, Percent_Identity=28.2157676348548, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI23308751, Length=263, Percent_Identity=29.6577946768061, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI145693186, Length=264, Percent_Identity=29.9242424242424, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789092, Length=275, Percent_Identity=28.7272727272727, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1790315, Length=268, Percent_Identity=26.4925373134328, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786719, Length=242, Percent_Identity=27.6859504132231, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=219, Percent_Identity=30.1369863013699, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=28.2051282051282, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=28.2051282051282, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 32769; Mature: 32769

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVGFIGLGSVGGKLAGSLLRNGVDLSVHDLDAAAVAEFVARGARAGGSAAALMRDCDVV
CEEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHCCCEE
ITCLPSPAASAAVVDQMLPEVAPGKIWMEMSTTDAAEVLRLAPLVEAAGGAVAECPVSGG
EEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCC
CHRAATGNIAIYMSGAREVFDRVFSLLAKMGRRVLHTGPLGAASTLKVMTNYLATTHLLA
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
LCESLAVMRAAGVDLGVAYEAIAVSSGNSFVHETESQLILSGSRDVNFTLDLIQKDVGLF
HHHHHHHHHHCCCCCCEEEEEEEEECCCCCEECCCCEEEEECCCCCEEHHHHHHHHHHHH
QATAERNGVPLELSPKVIEMLTEGQRVLGDTAQSDRMIELLETATGLDVRADGFPMELID
HHHHHCCCCCEEECHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCEEECCCCCHHEEC
DEPEAQGYEVVVQR
CCCCCCCCEEEEEC
>Mature Secondary Structure
MQVGFIGLGSVGGKLAGSLLRNGVDLSVHDLDAAAVAEFVARGARAGGSAAALMRDCDVV
CEEEEEECCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCHHHHHHHCCCEE
ITCLPSPAASAAVVDQMLPEVAPGKIWMEMSTTDAAEVLRLAPLVEAAGGAVAECPVSGG
EEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCC
CHRAATGNIAIYMSGAREVFDRVFSLLAKMGRRVLHTGPLGAASTLKVMTNYLATTHLLA
CCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
LCESLAVMRAAGVDLGVAYEAIAVSSGNSFVHETESQLILSGSRDVNFTLDLIQKDVGLF
HHHHHHHHHHCCCCCCEEEEEEEEECCCCCEECCCCEEEEECCCCCEEHHHHHHHHHHHH
QATAERNGVPLELSPKVIEMLTEGQRVLGDTAQSDRMIELLETATGLDVRADGFPMELID
HHHHHCCCCCEEECHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCEEECCCCCHHEEC
DEPEAQGYEVVVQR
CCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]