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The map label for this gene is gcvT [H]

Identifier: 89054087

GI number: 89054087

Start: 1578433

End: 1580898

Strand: Direct

Name: gcvT [H]

Synonym: Jann_1596

Alternate gene names: 89054087

Gene position: 1578433-1580898 (Clockwise)

Preceding gene: 89054085

Following gene: 89054088

Centisome position: 36.55

GC content: 62.53

Gene sequence:

>2466_bases
ATGGCGGATCTGCCAAACACGGCACGGGTTGTCATCATCGGGGGCGGGGTCGTCGGAACCTCGGCCCTCTACCATTTGGC
GATGGGCGGTTGGACGGATTGTGTTCTGTTGGAGAAGAATGAGCTGACGGCGGGCAGTACGTGGCACGCGGCGGGCAATT
GTCCGAATTTCTCGACATCGTGGGCGGTACTGAACATGCAGCGCTATTCGTTGGAGATGTACCGGACGTTGGCCGAAAAG
GTCGACTATCCGATGAATTACCACGTCACGGGCTCGTTGCGTTTGGGCCACACCAAGGAGCGCGCGCAGGAATTCAAGCG
CGTGCTGGGTATGGCCGAATATCAGGGCATCGACATGCGGATGCTGTCGAATGACGAGGCCAGGAGCATGTATCCGTTCC
TGCAAACCCACGACCTGAGCGGCATTCTCTACGACCCCTATGACGGGGACATTGACCCGGCGCAATTGACCCAGGCCATG
GCCAAGGGGGCGCGCGATCTGGGCGCGCAGATCCATCGGTTCACCCCTGCCACCGGCGTGCGACGCGACGTTTCTGGCAA
GACCGGGGGCGAGTGGATTGTAGAGACGGGGAAGGGCGAGATCCGCTGCGAATTCGTGGTGAATGCCGCCGGATATTACG
CGCAGCGCGTGGGCGAATGGTTCAAGCCCCACGGGGGCCGCACGGTGCCGATGGTCGTCATGTCCCACCAGTATTTCCTG
ACCGAGGAAATCGGCGCGGTGAAGGACTGGACGGAGCAGAATGGCAAGAAGCTGCCGCTGATCCGTGACGTGGATTCGTC
TTACTACCTGCGACAGGACAAAAACGGGCTGAACCTGGGACCCTATGAACGCAACTGCAAAGCCCATTGGATCACGCCCG
ACGATCCGATGCCCGAGGATTTCAGTTTCCAGTTGTATCCTGACGATCTAGACCGGCTGGAATGGTATATCGAGGACGCA
ATGGAGCGCGTGCCGCTTCTGGGTGAAGGCGGCGTGGGGCGCAACATCAACGGCCCCATCCCCTACGCGCCCGATGGCCT
GCCAATGGTGGGGCCCATGCCCGGCGTGACCAACGCGTTTGAAGCGCATTCCTTCACCTTCGGCATTGTGCAGGGGGGCG
GCGCGGGCAAGGTTCTGTCGGAGTGGATCATGCATGGCGAGACGGAGTGGGACATGTGGGCCGTCGATCCGCGCCGCTAC
ACCGATTACGCCGATCATTCTTACTGTCTGGACAAGGCGTTAGAGACCTACGGGCATGAATACGGCATGCATTTCCCGTG
GAAAAGCTGGCCCGCCGGGCGCGACAAGAAGCTGTCTCCGGTGGACGCGAAGGTGCGCGAATTGGGCGGCCAGATGGGGG
CCTATGCGGGGTGGGAACGGGCCAACTGGTTCGCCAAGCCAGGCGATGACACGTCCATAGAGGCAACGGAAACCTGGGGC
CGCAATGGCCCGTGGGAGCCGCGTGTGAAGGCGGAATGCGAAGCGGTGCGGGACGGGGTTGGCGTGCTGGACCTGCCGGG
GTTCTCTCGGTTCAATCTGTCAGGGGAGGGGGCCGCAGAATGGCTGCGGGGCCGCATCGCAGGCGCTTTGCCCAAGGTGG
GGCGGATGAACCTGGGCTATTTTCCGGACACGCGGGGCCGCATCCTGACGGAGATGTCGCTGATCCGCCACGAGGAGGAT
CACTTCACCCTGATCACCGCCGCGCCCGCCCAATGGCACGATTTCGAAGTGCTCTGGCGCGATGGCTTGCCCGATGGCGT
CAGCCTGACAGATCATACGACTGAGTTCTCGACCCTCATCGTGACTGGCCCCAAGGCGCGGGATCTGTTTGAGACAATCG
GAACCGATGCCGATCTTTCGTTGGGCTGGCTGACGCATCAGACCGCGACAGTTGCCGGGACACCAGCGTTTCTGGCGCGC
GTGTCCTTTGCGGGAGAGCTGGGGTGGGAAATCCACGCCGCCACGGCTGACATGCCCGCAATCTACGATGCCGTGCTGGC
CGCCGGGGCCACCCCCTTCGGGATGTTCGCGCTCAACGCGCTGCGGATCGAGAAGGGATATCGCGCTTGGAAGGGCGATC
TGTCGACCGATTATACCCTGCTGGAAGGGGGGCTGGAGCGGTTCATCAAATTCGACAAGCCGCAGGATTTCCCCGGCAAG
GCGGCGTTGCTGTCGGAAAAGCAATCGGGCGTGAAGAAGCGCTTCGTTGTCCTTAACGTGGATGCGGGCGAGGCCGACGC
GCCCTATATGTCGACGATCACCCATGGCGGCGATGTGGTGGGCGAGACGACATCGGGGGCCTGGGGCTACCGCGTCGGCC
ATTCCGTGGCGCTGGCCATGGTCCGCGCTGACCTGAGCGCGCCCGGAACCGAGCTGAACGTCAACATCTTTGGCGAGGTC
TGCAAAGCCACGGTGCAGGGCGATGGCCCGATCTGGGATCCCACAAATGAGAGGATCCGCGCGTGA

Upstream 100 bases:

>100_bases
TGCGGCGTGCGAATTGAAGTCTTTCCTGTCCGATACGATACTTGCCCGCGAACGCAGACATGGGCGCGCTTTTGGTGGCG
AGCCTTGAGGGGAGAGTTTC

Downstream 100 bases:

>100_bases
TCGGAGCTCGCCCATGAGCGTAGAGGTCTACCTTCTTTATCTGGGCGTTCTCGTCGCGTTTTTCGCGACCCCGCCCGATA
CGTCTCAACTATTGATCATG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 821; Mature: 820

Protein sequence:

>821_residues
MADLPNTARVVIIGGGVVGTSALYHLAMGGWTDCVLLEKNELTAGSTWHAAGNCPNFSTSWAVLNMQRYSLEMYRTLAEK
VDYPMNYHVTGSLRLGHTKERAQEFKRVLGMAEYQGIDMRMLSNDEARSMYPFLQTHDLSGILYDPYDGDIDPAQLTQAM
AKGARDLGAQIHRFTPATGVRRDVSGKTGGEWIVETGKGEIRCEFVVNAAGYYAQRVGEWFKPHGGRTVPMVVMSHQYFL
TEEIGAVKDWTEQNGKKLPLIRDVDSSYYLRQDKNGLNLGPYERNCKAHWITPDDPMPEDFSFQLYPDDLDRLEWYIEDA
MERVPLLGEGGVGRNINGPIPYAPDGLPMVGPMPGVTNAFEAHSFTFGIVQGGGAGKVLSEWIMHGETEWDMWAVDPRRY
TDYADHSYCLDKALETYGHEYGMHFPWKSWPAGRDKKLSPVDAKVRELGGQMGAYAGWERANWFAKPGDDTSIEATETWG
RNGPWEPRVKAECEAVRDGVGVLDLPGFSRFNLSGEGAAEWLRGRIAGALPKVGRMNLGYFPDTRGRILTEMSLIRHEED
HFTLITAAPAQWHDFEVLWRDGLPDGVSLTDHTTEFSTLIVTGPKARDLFETIGTDADLSLGWLTHQTATVAGTPAFLAR
VSFAGELGWEIHAATADMPAIYDAVLAAGATPFGMFALNALRIEKGYRAWKGDLSTDYTLLEGGLERFIKFDKPQDFPGK
AALLSEKQSGVKKRFVVLNVDAGEADAPYMSTITHGGDVVGETTSGAWGYRVGHSVALAMVRADLSAPGTELNVNIFGEV
CKATVQGDGPIWDPTNERIRA

Sequences:

>Translated_821_residues
MADLPNTARVVIIGGGVVGTSALYHLAMGGWTDCVLLEKNELTAGSTWHAAGNCPNFSTSWAVLNMQRYSLEMYRTLAEK
VDYPMNYHVTGSLRLGHTKERAQEFKRVLGMAEYQGIDMRMLSNDEARSMYPFLQTHDLSGILYDPYDGDIDPAQLTQAM
AKGARDLGAQIHRFTPATGVRRDVSGKTGGEWIVETGKGEIRCEFVVNAAGYYAQRVGEWFKPHGGRTVPMVVMSHQYFL
TEEIGAVKDWTEQNGKKLPLIRDVDSSYYLRQDKNGLNLGPYERNCKAHWITPDDPMPEDFSFQLYPDDLDRLEWYIEDA
MERVPLLGEGGVGRNINGPIPYAPDGLPMVGPMPGVTNAFEAHSFTFGIVQGGGAGKVLSEWIMHGETEWDMWAVDPRRY
TDYADHSYCLDKALETYGHEYGMHFPWKSWPAGRDKKLSPVDAKVRELGGQMGAYAGWERANWFAKPGDDTSIEATETWG
RNGPWEPRVKAECEAVRDGVGVLDLPGFSRFNLSGEGAAEWLRGRIAGALPKVGRMNLGYFPDTRGRILTEMSLIRHEED
HFTLITAAPAQWHDFEVLWRDGLPDGVSLTDHTTEFSTLIVTGPKARDLFETIGTDADLSLGWLTHQTATVAGTPAFLAR
VSFAGELGWEIHAATADMPAIYDAVLAAGATPFGMFALNALRIEKGYRAWKGDLSTDYTLLEGGLERFIKFDKPQDFPGK
AALLSEKQSGVKKRFVVLNVDAGEADAPYMSTITHGGDVVGETTSGAWGYRVGHSVALAMVRADLSAPGTELNVNIFGEV
CKATVQGDGPIWDPTNERIRA
>Mature_820_residues
ADLPNTARVVIIGGGVVGTSALYHLAMGGWTDCVLLEKNELTAGSTWHAAGNCPNFSTSWAVLNMQRYSLEMYRTLAEKV
DYPMNYHVTGSLRLGHTKERAQEFKRVLGMAEYQGIDMRMLSNDEARSMYPFLQTHDLSGILYDPYDGDIDPAQLTQAMA
KGARDLGAQIHRFTPATGVRRDVSGKTGGEWIVETGKGEIRCEFVVNAAGYYAQRVGEWFKPHGGRTVPMVVMSHQYFLT
EEIGAVKDWTEQNGKKLPLIRDVDSSYYLRQDKNGLNLGPYERNCKAHWITPDDPMPEDFSFQLYPDDLDRLEWYIEDAM
ERVPLLGEGGVGRNINGPIPYAPDGLPMVGPMPGVTNAFEAHSFTFGIVQGGGAGKVLSEWIMHGETEWDMWAVDPRRYT
DYADHSYCLDKALETYGHEYGMHFPWKSWPAGRDKKLSPVDAKVRELGGQMGAYAGWERANWFAKPGDDTSIEATETWGR
NGPWEPRVKAECEAVRDGVGVLDLPGFSRFNLSGEGAAEWLRGRIAGALPKVGRMNLGYFPDTRGRILTEMSLIRHEEDH
FTLITAAPAQWHDFEVLWRDGLPDGVSLTDHTTEFSTLIVTGPKARDLFETIGTDADLSLGWLTHQTATVAGTPAFLARV
SFAGELGWEIHAATADMPAIYDAVLAAGATPFGMFALNALRIEKGYRAWKGDLSTDYTLLEGGLERFIKFDKPQDFPGKA
ALLSEKQSGVKKRFVVLNVDAGEADAPYMSTITHGGDVVGETTSGAWGYRVGHSVALAMVRADLSAPGTELNVNIFGEVC
KATVQGDGPIWDPTNERIRA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=829, Percent_Identity=37.1531966224367, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI197927446, Length=886, Percent_Identity=30.0225733634311, Blast_Score=355, Evalue=7e-98,
Organism=Homo sapiens, GI21361378, Length=886, Percent_Identity=30.0225733634311, Blast_Score=355, Evalue=7e-98,
Organism=Homo sapiens, GI194306651, Length=802, Percent_Identity=27.930174563591, Blast_Score=273, Evalue=6e-73,
Organism=Escherichia coli, GI1789272, Length=296, Percent_Identity=24.6621621621622, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71994045, Length=807, Percent_Identity=26.7657992565056, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI71994052, Length=814, Percent_Identity=26.2899262899263, Blast_Score=239, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI32563613, Length=810, Percent_Identity=27.6543209876543, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20130091, Length=877, Percent_Identity=28.0501710376283, Blast_Score=304, Evalue=2e-82,
Organism=Drosophila melanogaster, GI28571104, Length=761, Percent_Identity=27.9894875164258, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI20129441, Length=286, Percent_Identity=25.8741258741259, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 90669; Mature: 90538

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLPNTARVVIIGGGVVGTSALYHLAMGGWTDCVLLEKNELTAGSTWHAAGNCPNFSTS
CCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCCCCCCCC
WAVLNMQRYSLEMYRTLAEKVDYPMNYHVTGSLRLGHTKERAQEFKRVLGMAEYQGIDMR
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHCHHHHCCCEEE
MLSNDEARSMYPFLQTHDLSGILYDPYDGDIDPAQLTQAMAKGARDLGAQIHRFTPATGV
EECCCCHHHHCCHHEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RRDVSGKTGGEWIVETGKGEIRCEFVVNAAGYYAQRVGEWFKPHGGRTVPMVVMSHQYFL
CCCCCCCCCCCEEEECCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCEEEEEEEECCCHH
TEEIGAVKDWTEQNGKKLPLIRDVDSSYYLRQDKNGLNLGPYERNCKAHWITPDDPMPED
HHHHCHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCC
FSFQLYPDDLDRLEWYIEDAMERVPLLGEGGVGRNINGPIPYAPDGLPMVGPMPGVTNAF
CEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
EAHSFTFGIVQGGGAGKVLSEWIMHGETEWDMWAVDPRRYTDYADHSYCLDKALETYGHE
HCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCHHHCCCCCHHHHHHHHHHHCCHH
YGMHFPWKSWPAGRDKKLSPVDAKVRELGGQMGAYAGWERANWFAKPGDDTSIEATETWG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHCCCCCCHHCCCCCCCCCCCCEEEHHCCC
RNGPWEPRVKAECEAVRDGVGVLDLPGFSRFNLSGEGAAEWLRGRIAGALPKVGRMNLGY
CCCCCCCCHHHHHHHHHCCCCEEECCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCC
FPDTRGRILTEMSLIRHEEDHFTLITAAPAQWHDFEVLWRDGLPDGVSLTDHTTEFSTLI
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
VTGPKARDLFETIGTDADLSLGWLTHQTATVAGTPAFLARVSFAGELGWEIHAATADMPA
EECCCHHHHHHHHCCCCCCEEEEEEECCEEECCCHHHHHHHHHCCCCCCEEEECCCCCHH
IYDAVLAAGATPFGMFALNALRIEKGYRAWKGDLSTDYTLLEGGLERFIKFDKPQDFPGK
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
AALLSEKQSGVKKRFVVLNVDAGEADAPYMSTITHGGDVVGETTSGAWGYRVGHSVALAM
HHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHH
VRADLSAPGTELNVNIFGEVCKATVQGDGPIWDPTNERIRA
HHHHCCCCCCEEEEEEEEHHHHHEECCCCCCCCCCCHHHCC
>Mature Secondary Structure 
ADLPNTARVVIIGGGVVGTSALYHLAMGGWTDCVLLEKNELTAGSTWHAAGNCPNFSTS
CCCCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCCCCCCCC
WAVLNMQRYSLEMYRTLAEKVDYPMNYHVTGSLRLGHTKERAQEFKRVLGMAEYQGIDMR
EEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHCHHHHCCCEEE
MLSNDEARSMYPFLQTHDLSGILYDPYDGDIDPAQLTQAMAKGARDLGAQIHRFTPATGV
EECCCCHHHHCCHHEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RRDVSGKTGGEWIVETGKGEIRCEFVVNAAGYYAQRVGEWFKPHGGRTVPMVVMSHQYFL
CCCCCCCCCCCEEEECCCCCEEEEEEEECHHHHHHHHHHHHCCCCCCEEEEEEEECCCHH
TEEIGAVKDWTEQNGKKLPLIRDVDSSYYLRQDKNGLNLGPYERNCKAHWITPDDPMPED
HHHHCHHHHHHHCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCC
FSFQLYPDDLDRLEWYIEDAMERVPLLGEGGVGRNINGPIPYAPDGLPMVGPMPGVTNAF
CEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
EAHSFTFGIVQGGGAGKVLSEWIMHGETEWDMWAVDPRRYTDYADHSYCLDKALETYGHE
HCCCEEEEEEECCCCHHHHHHHHHCCCCCCCEEEECCHHHCCCCCHHHHHHHHHHHCCHH
YGMHFPWKSWPAGRDKKLSPVDAKVRELGGQMGAYAGWERANWFAKPGDDTSIEATETWG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHCCCCCCHHCCCCCCCCCCCCEEEHHCCC
RNGPWEPRVKAECEAVRDGVGVLDLPGFSRFNLSGEGAAEWLRGRIAGALPKVGRMNLGY
CCCCCCCCHHHHHHHHHCCCCEEECCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCC
FPDTRGRILTEMSLIRHEEDHFTLITAAPAQWHDFEVLWRDGLPDGVSLTDHTTEFSTLI
CCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
VTGPKARDLFETIGTDADLSLGWLTHQTATVAGTPAFLARVSFAGELGWEIHAATADMPA
EECCCHHHHHHHHCCCCCCEEEEEEECCEEECCCHHHHHHHHHCCCCCCEEEECCCCCHH
IYDAVLAAGATPFGMFALNALRIEKGYRAWKGDLSTDYTLLEGGLERFIKFDKPQDFPGK
HHHHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
AALLSEKQSGVKKRFVVLNVDAGEADAPYMSTITHGGDVVGETTSGAWGYRVGHSVALAM
HHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHH
VRADLSAPGTELNVNIFGEVCKATVQGDGPIWDPTNERIRA
HHHHCCCCCCEEEEEEEEHHHHHEECCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA