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The map label for this gene is gcvT [H]

Identifier: 89053972

GI number: 89053972

Start: 1450215

End: 1452620

Strand: Reverse

Name: gcvT [H]

Synonym: Jann_1481

Alternate gene names: 89053972

Gene position: 1452620-1450215 (Counterclockwise)

Preceding gene: 89053973

Following gene: 89053971

Centisome position: 33.64

GC content: 60.31

Gene sequence:

>2406_bases
ATGAAAACCCATTACAGAGCGGTCGTGATCGGCGGCGGGGTAGTTGGCTCCTCGGTGCTCTATCATCTGGCGAAGTTTGG
CTGGACAGACGTCTGCATGCTCGAACGCAGTGTTTTGACCGCAGGTTCAAGCTGGCACGCGGCGGGCGGCATTCACGCAT
TGAACGCCGACCCCAACATGGCGGCTTTGCAAGCCTATACCATTGATCTGCTGTCAGAAATTGAAGCTGAATCCGGCCAG
AACATCGGACTACACATGACCGGCGGACTGACGCTCGCCGGCACGCCGGAGCGGTGGGAATGGCTGCAATCGGCCTACCG
CACCTTCCAGGCCATCGGCATCACCGACTGCCATCTGATGACCCCGGACGAGGCAAAACAGGCCTGCCCGATCATGTCCA
CCGACGGCGTCATCGGCGCCCTTTGGGCGGATCGGGAGGGATACGTGGACACCACGGGCACCGTCCACGCCTATGCGACC
GCCGCCAAACTGCGCGGCGCGGAGTATTATGAGCACACCAAGGTGGAAGAACTGATCCAGACCAAGGACGGTTGGAAGAT
CGTCACCGACAAGGGCACGATCACCTGTGACCATGTGGTGAATGCGGGCGGTCTTTGGGCCAAGCAAGTGGGCCGCATGG
CAGGGATTGAGCTGCCGGTTTCGCCACTGAAGCATCATTATCTGATCTCTGACACCATCCCCGAGCTGGAGGCATTGGAC
TTTGAAGTGCCGATGACCGTCGACCTTGAGGGCTTCACGTATATGCGACAAGACCAGAAGGGCCTGCTTCTGGGGATCTA
CGAGGTGAACCATGAGCACTGGGCGATGGATGGTGCGCCTTGGGATTACGGGATGGAGCTGTTTCAGGAACAGACCGACC
GGATCGAGAATGAGCTGATCTTGGGGTTTGAGCGCTACCCCGCCCTGCAAACCACCGGCGTGAAGACCTGGGTGAATGGT
GCGTTTACGTTCTCGCCCGATGGAAACCCATTGGTGGGACCGGTTAACGGCGTTAACGGCTACTGGTGCGCCTGTGCGGT
CATGGCAGGCTTCCTGCAGGGCGGCGGCGTGGGCAAGTCGCTCGCGGAATGGATGATCTATGGCGAGACGGAGGCCGACA
CCTACTCCATGGACGTCGCGCGCTACGGCAAGTTTGCCGAGAACCGCGAGTATATTCGGCAGACGACAGGTCAGTTCTAC
TCCCGCCGGTTCGTGATGTCCTACGCCAACGAACAGCTTACCGCCGGGCGCCCATTGAAACGCGCACCCGCCTATGAGGG
TATGACAAGGGCGGGTTGCCGGTGGGGCCAATCCTGGGATCTGGAGGTGCCCCTCTATTTCGCACCGTCAGAAGATTTCG
TTGAAAATCTTACCCTTAAACGCTCCAACGCTCACGGTATCGTGGCTGAGGAATGTCGCGCGGTTCGTGAGGGTGTGGCG
CTTCTGGACATTACCGGCTTCTCTCGGTTCGAAGTCACGGGCCCTGAGGCGGAGCGCTGGCTGGACCGGATGATGGCCTC
CAAACTCCCCGGGCGAGGTCGTGCGAAACTGGCCCCGATGCTGGGGGACAGCGGTCGTCTGATGGGTGATCTGACGGTGT
TCAACTGGGGCGATGGCACATGGTGGGTCATGGGCAGCTACTACCTGCGCGCGTGGCATATGCGGTGGTTTGACGATCAT
TTGGTTAACGGCGTTAACGTCCGCGATCTGGGGGAAGAGATTTGCGGGTTTTCCCTTGCTGGCCCGAAATCCACCTCGGT
GCTGCAAAAGCTGGTGACATATGACCTCGCACCGATGCCGTTCATGGGATGCGCAACATTTGACGTCGGCCTGATCGAGG
CAAAGGTCGCCCGAATGAGCGTGACCGGCGAGCGCGGGTACGAGATCAACTGCCGCTACGGAGACCACATCACATTGCGA
GACATGCTCCTGGAAGCAGGGGCCGACGATCGCATCCGCGAGGTCGGGTTCAACGCCCTTCTATCGACACGTCTGGAAAA
ATCCTTCGGCATCTGGTCCGCTGAATTCACCCAGGGCTACACACCCGCCCAGACCGGAATGGACCGCTGGATTGACTGGG
AAAAGGACTTCATCGGCAAGGCAGGCGCGGTGGCTGAGCGCGACGGAAACGGGCCTGCACAACGGCTTGTCACCTTGGAA
ATTGACGCCGATGGCGCAGACCCCGTCGGCTATGAGCCGGTCTGGCATAGCGGAGACATCGTGGGCTTCGTGACGTCGGG
TGGCTACGGCCATACGGTCCAGAAATCCCTTGCGATGGCGATGGTTAGGGCGGACCTGGCCGCGGATGGAACCGATCTGT
CCGTCCATGTCGTGGGCAGTGAACGCGCCGCGAAAGTGATCCCTCCGTCGCCCTATGATTCCTCGGGCACAGCGATGCGG
GGATGA

Upstream 100 bases:

>100_bases
GTCGTAGGCAGACACGGAAATTGTCGCGAACGTAATGGACAGATCTGTCCAGAGCGCCCTAGCCTTGCGCCTGATCGTTC
AAACACCGGAGGCCCACCCT

Downstream 100 bases:

>100_bases
GCAACAGACGTCGCAACCGCAATGCTCCGCGGGCTTCGGCGCGGGTGACGCAGTACGGCCAACTCCGCAATCCCTTCCCA
CCGATGAATGTGTTCCCGGC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 801; Mature: 801

Protein sequence:

>801_residues
MKTHYRAVVIGGGVVGSSVLYHLAKFGWTDVCMLERSVLTAGSSWHAAGGIHALNADPNMAALQAYTIDLLSEIEAESGQ
NIGLHMTGGLTLAGTPERWEWLQSAYRTFQAIGITDCHLMTPDEAKQACPIMSTDGVIGALWADREGYVDTTGTVHAYAT
AAKLRGAEYYEHTKVEELIQTKDGWKIVTDKGTITCDHVVNAGGLWAKQVGRMAGIELPVSPLKHHYLISDTIPELEALD
FEVPMTVDLEGFTYMRQDQKGLLLGIYEVNHEHWAMDGAPWDYGMELFQEQTDRIENELILGFERYPALQTTGVKTWVNG
AFTFSPDGNPLVGPVNGVNGYWCACAVMAGFLQGGGVGKSLAEWMIYGETEADTYSMDVARYGKFAENREYIRQTTGQFY
SRRFVMSYANEQLTAGRPLKRAPAYEGMTRAGCRWGQSWDLEVPLYFAPSEDFVENLTLKRSNAHGIVAEECRAVREGVA
LLDITGFSRFEVTGPEAERWLDRMMASKLPGRGRAKLAPMLGDSGRLMGDLTVFNWGDGTWWVMGSYYLRAWHMRWFDDH
LVNGVNVRDLGEEICGFSLAGPKSTSVLQKLVTYDLAPMPFMGCATFDVGLIEAKVARMSVTGERGYEINCRYGDHITLR
DMLLEAGADDRIREVGFNALLSTRLEKSFGIWSAEFTQGYTPAQTGMDRWIDWEKDFIGKAGAVAERDGNGPAQRLVTLE
IDADGADPVGYEPVWHSGDIVGFVTSGGYGHTVQKSLAMAMVRADLAADGTDLSVHVVGSERAAKVIPPSPYDSSGTAMR
G

Sequences:

>Translated_801_residues
MKTHYRAVVIGGGVVGSSVLYHLAKFGWTDVCMLERSVLTAGSSWHAAGGIHALNADPNMAALQAYTIDLLSEIEAESGQ
NIGLHMTGGLTLAGTPERWEWLQSAYRTFQAIGITDCHLMTPDEAKQACPIMSTDGVIGALWADREGYVDTTGTVHAYAT
AAKLRGAEYYEHTKVEELIQTKDGWKIVTDKGTITCDHVVNAGGLWAKQVGRMAGIELPVSPLKHHYLISDTIPELEALD
FEVPMTVDLEGFTYMRQDQKGLLLGIYEVNHEHWAMDGAPWDYGMELFQEQTDRIENELILGFERYPALQTTGVKTWVNG
AFTFSPDGNPLVGPVNGVNGYWCACAVMAGFLQGGGVGKSLAEWMIYGETEADTYSMDVARYGKFAENREYIRQTTGQFY
SRRFVMSYANEQLTAGRPLKRAPAYEGMTRAGCRWGQSWDLEVPLYFAPSEDFVENLTLKRSNAHGIVAEECRAVREGVA
LLDITGFSRFEVTGPEAERWLDRMMASKLPGRGRAKLAPMLGDSGRLMGDLTVFNWGDGTWWVMGSYYLRAWHMRWFDDH
LVNGVNVRDLGEEICGFSLAGPKSTSVLQKLVTYDLAPMPFMGCATFDVGLIEAKVARMSVTGERGYEINCRYGDHITLR
DMLLEAGADDRIREVGFNALLSTRLEKSFGIWSAEFTQGYTPAQTGMDRWIDWEKDFIGKAGAVAERDGNGPAQRLVTLE
IDADGADPVGYEPVWHSGDIVGFVTSGGYGHTVQKSLAMAMVRADLAADGTDLSVHVVGSERAAKVIPPSPYDSSGTAMR
G
>Mature_801_residues
MKTHYRAVVIGGGVVGSSVLYHLAKFGWTDVCMLERSVLTAGSSWHAAGGIHALNADPNMAALQAYTIDLLSEIEAESGQ
NIGLHMTGGLTLAGTPERWEWLQSAYRTFQAIGITDCHLMTPDEAKQACPIMSTDGVIGALWADREGYVDTTGTVHAYAT
AAKLRGAEYYEHTKVEELIQTKDGWKIVTDKGTITCDHVVNAGGLWAKQVGRMAGIELPVSPLKHHYLISDTIPELEALD
FEVPMTVDLEGFTYMRQDQKGLLLGIYEVNHEHWAMDGAPWDYGMELFQEQTDRIENELILGFERYPALQTTGVKTWVNG
AFTFSPDGNPLVGPVNGVNGYWCACAVMAGFLQGGGVGKSLAEWMIYGETEADTYSMDVARYGKFAENREYIRQTTGQFY
SRRFVMSYANEQLTAGRPLKRAPAYEGMTRAGCRWGQSWDLEVPLYFAPSEDFVENLTLKRSNAHGIVAEECRAVREGVA
LLDITGFSRFEVTGPEAERWLDRMMASKLPGRGRAKLAPMLGDSGRLMGDLTVFNWGDGTWWVMGSYYLRAWHMRWFDDH
LVNGVNVRDLGEEICGFSLAGPKSTSVLQKLVTYDLAPMPFMGCATFDVGLIEAKVARMSVTGERGYEINCRYGDHITLR
DMLLEAGADDRIREVGFNALLSTRLEKSFGIWSAEFTQGYTPAQTGMDRWIDWEKDFIGKAGAVAERDGNGPAQRLVTLE
IDADGADPVGYEPVWHSGDIVGFVTSGGYGHTVQKSLAMAMVRADLAADGTDLSVHVVGSERAAKVIPPSPYDSSGTAMR
G

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0665

COG function: function code E; Glycine/D-amino acid oxidases (deaminating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=800, Percent_Identity=33.625, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI197927446, Length=864, Percent_Identity=27.1990740740741, Blast_Score=307, Evalue=3e-83,
Organism=Homo sapiens, GI21361378, Length=864, Percent_Identity=27.1990740740741, Blast_Score=307, Evalue=3e-83,
Organism=Homo sapiens, GI194306651, Length=786, Percent_Identity=27.35368956743, Blast_Score=289, Evalue=7e-78,
Organism=Homo sapiens, GI44662838, Length=332, Percent_Identity=24.3975903614458, Blast_Score=81, Evalue=5e-15,
Organism=Homo sapiens, GI257796258, Length=317, Percent_Identity=24.2902208201893, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI257796256, Length=275, Percent_Identity=26.5454545454545, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI257796254, Length=229, Percent_Identity=27.9475982532751, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789272, Length=388, Percent_Identity=23.4536082474227, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994045, Length=832, Percent_Identity=28.2451923076923, Blast_Score=271, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI71994052, Length=839, Percent_Identity=27.8903456495828, Blast_Score=269, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI32563613, Length=793, Percent_Identity=24.7162673392182, Blast_Score=195, Evalue=9e-50,
Organism=Drosophila melanogaster, GI20130091, Length=861, Percent_Identity=27.5261324041812, Blast_Score=283, Evalue=5e-76,
Organism=Drosophila melanogaster, GI28571104, Length=804, Percent_Identity=26.3681592039801, Blast_Score=256, Evalue=3e-68,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 88146; Mature: 88146

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHYRAVVIGGGVVGSSVLYHLAKFGWTDVCMLERSVLTAGSSWHAAGGIHALNADPNM
CCCEEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCH
AALQAYTIDLLSEIEAESGQNIGLHMTGGLTLAGTPERWEWLQSAYRTFQAIGITDCHLM
HHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEE
TPDEAKQACPIMSTDGVIGALWADREGYVDTTGTVHAYATAAKLRGAEYYEHTKVEELIQ
CCHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHH
TKDGWKIVTDKGTITCDHVVNAGGLWAKQVGRMAGIELPVSPLKHHYLISDTIPELEALD
CCCCCEEEECCCCEEEHHCCCCCCHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCHHHCC
FEVPMTVDLEGFTYMRQDQKGLLLGIYEVNHEHWAMDGAPWDYGMELFQEQTDRIENELI
CCCCEEEECCCCEEEECCCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHCHHEE
LGFERYPALQTTGVKTWVNGAFTFSPDGNPLVGPVNGVNGYWCACAVMAGFLQGGGVGKS
EEHHHCCCCEECCCCEEECCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCHH
LAEWMIYGETEADTYSMDVARYGKFAENREYIRQTTGQFYSRRFVMSYANEQLTAGRPLK
HHHHEEECCCCCCEEEHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RAPAYEGMTRAGCRWGQSWDLEVPLYFAPSEDFVENLTLKRSNAHGIVAEECRAVREGVA
CCCCCCCCHHHCCCCCCCCCCEEEEEECCCHHHHHCCEEECCCCCCCHHHHHHHHHCCCE
LLDITGFSRFEVTGPEAERWLDRMMASKLPGRGRAKLAPMLGDSGRLMGDLTVFNWGDGT
EEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEEEECCCCE
WWVMGSYYLRAWHMRWFDDHLVNGVNVRDLGEEICGFSLAGPKSTSVLQKLVTYDLAPMP
EEEECCEEEHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
FMGCATFDVGLIEAKVARMSVTGERGYEINCRYGDHITLRDMLLEAGADDRIREVGFNAL
CCCCCHHCCHHHHHEEHEEEECCCCCCEEEEEECCEEEHHHHHHHCCCCHHHHHHHHHHH
LSTRLEKSFGIWSAEFTQGYTPAQTGMDRWIDWEKDFIGKAGAVAERDGNGPAQRLVTLE
HHHHHHHHCCCEEHHHHCCCCCHHHCHHHHCCCCHHHCCCCCCCCCCCCCCCHHEEEEEE
IDADGADPVGYEPVWHSGDIVGFVTSGGYGHTVQKSLAMAMVRADLAADGTDLSVHVVGS
ECCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
ERAAKVIPPSPYDSSGTAMRG
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTHYRAVVIGGGVVGSSVLYHLAKFGWTDVCMLERSVLTAGSSWHAAGGIHALNADPNM
CCCEEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCH
AALQAYTIDLLSEIEAESGQNIGLHMTGGLTLAGTPERWEWLQSAYRTFQAIGITDCHLM
HHHHHHHHHHHHHHHHCCCCCEEEEEECCEEECCCCHHHHHHHHHHHHHHHCCCCEEEEE
TPDEAKQACPIMSTDGVIGALWADREGYVDTTGTVHAYATAAKLRGAEYYEHTKVEELIQ
CCHHHHHCCCCEECCCCEEEEECCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHHH
TKDGWKIVTDKGTITCDHVVNAGGLWAKQVGRMAGIELPVSPLKHHYLISDTIPELEALD
CCCCCEEEECCCCEEEHHCCCCCCHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCHHHCC
FEVPMTVDLEGFTYMRQDQKGLLLGIYEVNHEHWAMDGAPWDYGMELFQEQTDRIENELI
CCCCEEEECCCCEEEECCCCCEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHCHHEE
LGFERYPALQTTGVKTWVNGAFTFSPDGNPLVGPVNGVNGYWCACAVMAGFLQGGGVGKS
EEHHHCCCCEECCCCEEECCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCHH
LAEWMIYGETEADTYSMDVARYGKFAENREYIRQTTGQFYSRRFVMSYANEQLTAGRPLK
HHHHEEECCCCCCEEEHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RAPAYEGMTRAGCRWGQSWDLEVPLYFAPSEDFVENLTLKRSNAHGIVAEECRAVREGVA
CCCCCCCCHHHCCCCCCCCCCEEEEEECCCHHHHHCCEEECCCCCCCHHHHHHHHHCCCE
LLDITGFSRFEVTGPEAERWLDRMMASKLPGRGRAKLAPMLGDSGRLMGDLTVFNWGDGT
EEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEEEEEEECCCCE
WWVMGSYYLRAWHMRWFDDHLVNGVNVRDLGEEICGFSLAGPKSTSVLQKLVTYDLAPMP
EEEECCEEEHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCC
FMGCATFDVGLIEAKVARMSVTGERGYEINCRYGDHITLRDMLLEAGADDRIREVGFNAL
CCCCCHHCCHHHHHEEHEEEECCCCCCEEEEEECCEEEHHHHHHHCCCCHHHHHHHHHHH
LSTRLEKSFGIWSAEFTQGYTPAQTGMDRWIDWEKDFIGKAGAVAERDGNGPAQRLVTLE
HHHHHHHHCCCEEHHHHCCCCCHHHCHHHHCCCCHHHCCCCCCCCCCCCCCCHHEEEEEE
IDADGADPVGYEPVWHSGDIVGFVTSGGYGHTVQKSLAMAMVRADLAADGTDLSVHVVGS
ECCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
ERAAKVIPPSPYDSSGTAMRG
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA