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The map label for this gene is degA [H]

Identifier: 89053888

GI number: 89053888

Start: 1366968

End: 1367990

Strand: Reverse

Name: degA [H]

Synonym: Jann_1397

Alternate gene names: 89053888

Gene position: 1367990-1366968 (Counterclockwise)

Preceding gene: 89053895

Following gene: 89053882

Centisome position: 31.68

GC content: 64.13

Gene sequence:

>1023_bases
ATGACAGCATCTCGCCCCACCCCCACGTTGCATGACGTTGCAGAGCTTTCCGGGTTTTCGACGGCGACGGTGTCTCGCTG
CCTGAACTTCCCGAAGCAAGTCTCGGACAAGACACGAGACAAGGTCATGTCCGCAATTGCGGAGCTGGGGTATTCGCCCA
ACTTTGGGGCCCGCGCGATGGCTGCGCAACGCACAAACACCATCGGCGCGATTATTCCGACGATGGAGAACGCGATTTTC
GCCCGAGGCATTCAGGCCTTTCAGGAAGAGTTGGACGACCACGGCTATAACCTGATGGTGGCGTCCTCCTCCTACCGCGC
GGATCTGGAGGAGCGTCAGATCCGGTCTCTTGTGGCACGGGGCGCCGATGCGCTGCTGCTGGTCGGGCATCAACGGGACC
CCGCCATCTATCAGTTTCTGGAGGCGCAGCGCGTCCCGATCCTGGTGACATGGGCCTACACACCCGATGCGCCCCGGCCG
TCCATCGGTTTCGACAACCGCCGTTCCATGGCGAAACTCGCAGCCGAGGTTTTGCGCCTCGGGCATCGGCGTCTGGGAAT
GATTTCAGCTGAGGTCAGCACCAACGACCGCGCCGCCGCGCGCCTGCAGGGGATCCGCGACGCGATGGCAGAGGCAGGCC
TCCAAGCCGACACACTGGCAGTGATTGAGGCGCCCTATGGCATCGACACGGGCGCGGAGGCGTTTGCGCAATTGATGCAA
TCCAGCGAACCGCCCACAGCGGTGCTCTGCGGAAACGACGTCTTGGCCGTGGGGGCCCTGGGCCGCGCCCGGGACCTGGG
CCTGGACGTGCCACGCGACGTGTCGATCCTGGGCTTCGACGATATCGAGTTGGCCCAGGTGGCCTTCCCTAAACTGTCAA
CCGTCCACGTCCCGCACCGGGACATGGGCCGCGCCGCCGCCCGCGCGCTGATCCGGACCCTGCAAGACGGATCTCCGATC
ACGGGCCAGGAATTGCCCGCTGACGTTTATCTGCGCGACAGCCTGGGTCCTGCACCAAATTAA

Upstream 100 bases:

>100_bases
GATGCGCGATTCCGTTAACGTGTGTGTAAGCCCTTACATTACGTCGATGCAAGCCATTACAATTGCGGTCGCCACTCCGT
AGCCTTATGGTCCCAGACAG

Downstream 100 bases:

>100_bases
GCATTGGACTGGATCAGCCGCGCGGTCCCAACCGCCGCCTCCCCTTCAAGCGCGGAGGTCAACGGCATGCCAAGCACACG
CTCGCGGATCTTGGTCCAGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTASRPTPTLHDVAELSGFSTATVSRCLNFPKQVSDKTRDKVMSAIAELGYSPNFGARAMAAQRTNTIGAIIPTMENAIF
ARGIQAFQEELDDHGYNLMVASSSYRADLEERQIRSLVARGADALLLVGHQRDPAIYQFLEAQRVPILVTWAYTPDAPRP
SIGFDNRRSMAKLAAEVLRLGHRRLGMISAEVSTNDRAAARLQGIRDAMAEAGLQADTLAVIEAPYGIDTGAEAFAQLMQ
SSEPPTAVLCGNDVLAVGALGRARDLGLDVPRDVSILGFDDIELAQVAFPKLSTVHVPHRDMGRAAARALIRTLQDGSPI
TGQELPADVYLRDSLGPAPN

Sequences:

>Translated_340_residues
MTASRPTPTLHDVAELSGFSTATVSRCLNFPKQVSDKTRDKVMSAIAELGYSPNFGARAMAAQRTNTIGAIIPTMENAIF
ARGIQAFQEELDDHGYNLMVASSSYRADLEERQIRSLVARGADALLLVGHQRDPAIYQFLEAQRVPILVTWAYTPDAPRP
SIGFDNRRSMAKLAAEVLRLGHRRLGMISAEVSTNDRAAARLQGIRDAMAEAGLQADTLAVIEAPYGIDTGAEAFAQLMQ
SSEPPTAVLCGNDVLAVGALGRARDLGLDVPRDVSILGFDDIELAQVAFPKLSTVHVPHRDMGRAAARALIRTLQDGSPI
TGQELPADVYLRDSLGPAPN
>Mature_339_residues
TASRPTPTLHDVAELSGFSTATVSRCLNFPKQVSDKTRDKVMSAIAELGYSPNFGARAMAAQRTNTIGAIIPTMENAIFA
RGIQAFQEELDDHGYNLMVASSSYRADLEERQIRSLVARGADALLLVGHQRDPAIYQFLEAQRVPILVTWAYTPDAPRPS
IGFDNRRSMAKLAAEVLRLGHRRLGMISAEVSTNDRAAARLQGIRDAMAEAGLQADTLAVIEAPYGIDTGAEAFAQLMQS
SEPPTAVLCGNDVLAVGALGRARDLGLDVPRDVSILGFDDIELAQVAFPKLSTVHVPHRDMGRAAARALIRTLQDGSPIT
GQELPADVYLRDSLGPAPN

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=308, Percent_Identity=32.1428571428571, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI48994940, Length=308, Percent_Identity=29.8701298701299, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787948, Length=305, Percent_Identity=30.8196721311475, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789202, Length=291, Percent_Identity=32.9896907216495, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790194, Length=309, Percent_Identity=31.3915857605178, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1790715, Length=311, Percent_Identity=27.3311897106109, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1789068, Length=336, Percent_Identity=28.2738095238095, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788474, Length=312, Percent_Identity=32.3717948717949, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786540, Length=335, Percent_Identity=28.3582089552239, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787580, Length=322, Percent_Identity=23.9130434782609, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790689, Length=332, Percent_Identity=25.9036144578313, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787906, Length=315, Percent_Identity=24.4444444444444, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786268, Length=323, Percent_Identity=25.6965944272446, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789456, Length=323, Percent_Identity=23.2198142414861, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36587; Mature: 36456

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASRPTPTLHDVAELSGFSTATVSRCLNFPKQVSDKTRDKVMSAIAELGYSPNFGARAM
CCCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAQRTNTIGAIIPTMENAIFARGIQAFQEELDDHGYNLMVASSSYRADLEERQIRSLVAR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCHHHHHHHHHHHC
GADALLLVGHQRDPAIYQFLEAQRVPILVTWAYTPDAPRPSIGFDNRRSMAKLAAEVLRL
CCCEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
GHRRLGMISAEVSTNDRAAARLQGIRDAMAEAGLQADTLAVIEAPYGIDTGAEAFAQLMQ
HHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHH
SSEPPTAVLCGNDVLAVGALGRARDLGLDVPRDVSILGFDDIELAQVAFPKLSTVHVPHR
CCCCCEEEEECCCEEEECCCCCHHHCCCCCCCCCEEECCCCCHHHHHHCCCCCEEECCCH
DMGRAAARALIRTLQDGSPITGQELPADVYLRDSLGPAPN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TASRPTPTLHDVAELSGFSTATVSRCLNFPKQVSDKTRDKVMSAIAELGYSPNFGARAM
CCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
AAQRTNTIGAIIPTMENAIFARGIQAFQEELDDHGYNLMVASSSYRADLEERQIRSLVAR
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCCHHHHHHHHHHHC
GADALLLVGHQRDPAIYQFLEAQRVPILVTWAYTPDAPRPSIGFDNRRSMAKLAAEVLRL
CCCEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
GHRRLGMISAEVSTNDRAAARLQGIRDAMAEAGLQADTLAVIEAPYGIDTGAEAFAQLMQ
HHHHHCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHH
SSEPPTAVLCGNDVLAVGALGRARDLGLDVPRDVSILGFDDIELAQVAFPKLSTVHVPHR
CCCCCEEEEECCCEEEECCCCCHHHCCCCCCCCCEEECCCCCHHHHHHCCCCCEEECCCH
DMGRAAARALIRTLQDGSPITGQELPADVYLRDSLGPAPN
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]