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The map label for this gene is ilvC [H]

Identifier: 89053729

GI number: 89053729

Start: 1193557

End: 1194579

Strand: Reverse

Name: ilvC [H]

Synonym: Jann_1238

Alternate gene names: 89053729

Gene position: 1194579-1193557 (Counterclockwise)

Preceding gene: 89053733

Following gene: 89053728

Centisome position: 27.67

GC content: 61.0

Gene sequence:

>1023_bases
ATGCGCGTTTACTATGATCGCGATTGCGATGTGAACCTGATCAAGGACATGAAAGTGGCGATCCTGGGCTATGGATCCCA
AGGCCACGCCCATGCGCTGAACCTGCGCGACAGCGGTGCCAAGAACGTGGTCGTGGCCCTGCGCGAAGGCTCCGCCTCTG
CCGCCAAGGCTGAGGGTGAGGGCCTAAAAGTCATGGGCATCGCAGAGGCCGCCGCCTGGTGCGACGTCATCATGTTCACC
ATGCCCGACGAATTGCAGGCGGAGACGTATAAGAAATACGTCCACGACAACCTGAAAGACGGCGCGGCGATTGCCTTTGC
CCACGGGTTGAACGTCCACTTCGGTCTGATCGAGCCCAAGCCCGGCGTTGACGTCATCATGATGGCCCCCAAGGGTCCCG
GCCACACGGTGCGCGGCGAATACACCAAAGGCGGCGGCGTGCCGTGTCTGGTCGCGGTGCACCAGAACGCGTCGGACCGG
GCGCTGGAAATCGGCCTGTCCTATTGCTCCGCCATCGGTGGCGGGCGCTCTGGTATCATCGAGACGAACTTCCGCGAGGA
ATGCGAGACCGATCTGTTCGGGGAACAGGCGGTTCTGTGCGGCGGCCTGGTTGAACTGATCCGCATGGGCTTTGAGACGT
TGGTGGAAGCAGGCTACGCACCCGAGATGGCCTATTTCGAGTGCCTGCACGAGGTGAAGCTGATCGTGGACCTGATCTAC
GAGGGCGGCATCGCGAATATGAACTACTCGATCTCCAACACCGCCGAATATGGCGAATATGTCTCGGGCCCGCGCATCCT
GCCCTACGACGAGACCAAGGCGCGGATGAAAGCGGTCCTTCGCGACATCCAGACCGGTGCCTTCGTGCGCGACTTCATGC
AGGAAAATCAGGCCGGCCAGCCCTACTTCAAAGGCACGCGCCGCCTGAACGACGAGCATCAGATTGAGCAGGTTGGTGAG
ACCCTGCGCGGCATGATGCCGTGGATCTCCGAGGGCAAGATGGTCGACAAAGCCAAGAACTGA

Upstream 100 bases:

>100_bases
ATTTTCTCAGTTATCATTCATTTTCATCCAAGTCGAACAGCGATTTTCACGCAGAAGCCCGCCATGGTCGCCACAAATCA
CGCATCAAAGGAGAGAGACC

Downstream 100 bases:

>100_bases
GCCCGCCCTGATACACGAAAGCGGGGCCCGATGCGGCCCCGCTTTTGCGGTCAGCTCTTCACGTTGACGTCACCATTGCC
CACACGCGGCGCAGTCACCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRVYYDRDCDVNLIKDMKVAILGYGSQGHAHALNLRDSGAKNVVVALREGSASAAKAEGEGLKVMGIAEAAAWCDVIMFT
MPDELQAETYKKYVHDNLKDGAAIAFAHGLNVHFGLIEPKPGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQNASDR
ALEIGLSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRMGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVSGPRILPYDETKARMKAVLRDIQTGAFVRDFMQENQAGQPYFKGTRRLNDEHQIEQVGE
TLRGMMPWISEGKMVDKAKN

Sequences:

>Translated_340_residues
MRVYYDRDCDVNLIKDMKVAILGYGSQGHAHALNLRDSGAKNVVVALREGSASAAKAEGEGLKVMGIAEAAAWCDVIMFT
MPDELQAETYKKYVHDNLKDGAAIAFAHGLNVHFGLIEPKPGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQNASDR
ALEIGLSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRMGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVSGPRILPYDETKARMKAVLRDIQTGAFVRDFMQENQAGQPYFKGTRRLNDEHQIEQVGE
TLRGMMPWISEGKMVDKAKN
>Mature_340_residues
MRVYYDRDCDVNLIKDMKVAILGYGSQGHAHALNLRDSGAKNVVVALREGSASAAKAEGEGLKVMGIAEAAAWCDVIMFT
MPDELQAETYKKYVHDNLKDGAAIAFAHGLNVHFGLIEPKPGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQNASDR
ALEIGLSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRMGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
EGGIANMNYSISNTAEYGEYVSGPRILPYDETKARMKAVLRDIQTGAFVRDFMQENQAGQPYFKGTRRLNDEHQIEQVGE
TLRGMMPWISEGKMVDKAKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=252, Percent_Identity=36.9047619047619, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323387, Length=350, Percent_Identity=29.4285714285714, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37202; Mature: 37202

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDCDVNLIKDMKVAILGYGSQGHAHALNLRDSGAKNVVVALREGSASAAKAEGE
CCEEECCCCCCCHHCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
GLKVMGIAEAAAWCDVIMFTMPDELQAETYKKYVHDNLKDGAAIAFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEEEEECCC
PGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQNASDRALEIGLSYCSAIGGGRSGII
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEE
ETNFREECETDLFGEQAVLCGGLVELIRMGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVSGPRILPYDETKARMKAVLRDIQTGAFVRDFMQENQAGQ
CCCCCCCCCCCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYFKGTRRLNDEHQIEQVGETLRGMMPWISEGKMVDKAKN
CHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCC
>Mature Secondary Structure
MRVYYDRDCDVNLIKDMKVAILGYGSQGHAHALNLRDSGAKNVVVALREGSASAAKAEGE
CCEEECCCCCCCHHCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
GLKVMGIAEAAAWCDVIMFTMPDELQAETYKKYVHDNLKDGAAIAFAHGLNVHFGLIEPK
CEEEEEHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCEEEEEEECCC
PGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQNASDRALEIGLSYCSAIGGGRSGII
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEE
ETNFREECETDLFGEQAVLCGGLVELIRMGFETLVEAGYAPEMAYFECLHEVKLIVDLIY
ECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGIANMNYSISNTAEYGEYVSGPRILPYDETKARMKAVLRDIQTGAFVRDFMQENQAGQ
CCCCCCCCCCCCCCHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PYFKGTRRLNDEHQIEQVGETLRGMMPWISEGKMVDKAKN
CHHHHHHCCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA