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The map label for this gene is serS

Identifier: 89053561

GI number: 89053561

Start: 1031167

End: 1032459

Strand: Reverse

Name: serS

Synonym: Jann_1070

Alternate gene names: 89053561

Gene position: 1032459-1031167 (Counterclockwise)

Preceding gene: 89053562

Following gene: 89053560

Centisome position: 23.91

GC content: 63.73

Gene sequence:

>1293_bases
ATGCATGATATCCGCGCGATCCGCGAGACCCCTGCTGCTTTTGACGCCGCTCTGGCGCTTCGGGGATTGTCCGCTGCCTC
CGCCGACATTCTGGCGATTGACGAGGCGCGCCGCGCCGCGATCACCCAGGCTGAAACGGCTCAGGCAGACCGCAACGCAG
CCTCGAAAGAGGTCGGAAAAGCCAAGGCTTCGGGCGATGAGGCGGAGTTTGAACGCCTGCGCGCGCTGGTCTCCACCAAG
AAGGATGAGATCGCCCGGCTGGACGAGGAAGCCAAGGCAAAAGACGCTGAACTGACCGCGATTCTGGAGGCGCTGCCCAA
CCTGCCGTCGCCAGATGTGCCCGCAGGCGCCGATGAAGATGACAACGTGGAGCAGCATCGTCGCGGCACCCCGCGCGCCT
TTGATTTCAAACCCTTAGAGCATTTCGACATTCCCGGCATTGCCGCGTCGATGGACTTCGAGACGGCCGCAAAACTCTCC
GGTGCGCGCTTCGTGACGCTGAAGGGCGCGGTCGCCCGTGTGCACCGCGCGCTGGCGCAATTCATGCTCGATACCCATAC
CGAAGAGAACGGCCTGACCGAGATCAACGCGCCCGTGCTGGTGCGCGATGAGACGATGTACGGCACCGGCCAGCTGCCCA
AGTTTGCCGAGGACAGCTACCAGACGACCAATGGCTGGTGGCTGATCCCCACGTCCGAAGTCACGCTGACCTCGCTGGAC
AGCGGCAATATTGTGGACGAGGCGACCCTGCCTCACCGCTACGCCGCCCATTCGCTGTGCTTCCGGTCAGAGGCAGGCAG
CGCAGGCCGCGACACGGCAGGCATGCTGCGCCAGCACCAGTTCGAGAAGGTCGAAATGGTCTCCGTCACCCACCCCGACC
AGTCGAATGCGGAACAACAGCGCATGCTCGCCTGCGCCGAAGGCATCCTCGACAAGCTGGAAATCCCTTACCGCACAGTG
CTTTTGTGTGCGGGCGACATGGGCTTTGGCGCAACGCGAACCTATGACATCGAAGCCTGGCTGCCGGGGCAGGACACTTA
CCGCGAAATCTCCTCGGTCTCCACCTGTGGTGCGTTCCAGGCCCGTCGCATGAATGCGCGTTTCAAGCCGTCCGACGGCG
GCAAGCCCGAGTTTGTCCACACCCTCAACGGCTCAGGCCTCGCCGTGGGCCGCTGCTTGATTGCGGTGCTGGAAAATGGG
CAAAACGCCGACGGATCTGTCACCCTGCCCGCCGCCCTGCACCCCTGGCTCGGCGGCAAAACCCGGATCACAGCGGAGGG
CAATCTTGCCTGA

Upstream 100 bases:

>100_bases
AGTTTCACGACAGGATAATTACACCGCGAAACCGGCCTCTTCCCCCGCGCCCGGCTTTGCGGCATACCCCGCGCATCACA
CGCAATGACGGAGGCTCCCC

Downstream 100 bases:

>100_bases
TCTCAGCCCAAAACTGATGGCAGCGCTGGTCCTGCTGGCCGCCATCGCCTTCGCCCTCTCGCCGGTCCTGTCCGAGCCAT
TCACCGGCTTCAACCCCGAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MHDIRAIRETPAAFDAALALRGLSAASADILAIDEARRAAITQAETAQADRNAASKEVGKAKASGDEAEFERLRALVSTK
KDEIARLDEEAKAKDAELTAILEALPNLPSPDVPAGADEDDNVEQHRRGTPRAFDFKPLEHFDIPGIAASMDFETAAKLS
GARFVTLKGAVARVHRALAQFMLDTHTEENGLTEINAPVLVRDETMYGTGQLPKFAEDSYQTTNGWWLIPTSEVTLTSLD
SGNIVDEATLPHRYAAHSLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSVTHPDQSNAEQQRMLACAEGILDKLEIPYRTV
LLCAGDMGFGATRTYDIEAWLPGQDTYREISSVSTCGAFQARRMNARFKPSDGGKPEFVHTLNGSGLAVGRCLIAVLENG
QNADGSVTLPAALHPWLGGKTRITAEGNLA

Sequences:

>Translated_430_residues
MHDIRAIRETPAAFDAALALRGLSAASADILAIDEARRAAITQAETAQADRNAASKEVGKAKASGDEAEFERLRALVSTK
KDEIARLDEEAKAKDAELTAILEALPNLPSPDVPAGADEDDNVEQHRRGTPRAFDFKPLEHFDIPGIAASMDFETAAKLS
GARFVTLKGAVARVHRALAQFMLDTHTEENGLTEINAPVLVRDETMYGTGQLPKFAEDSYQTTNGWWLIPTSEVTLTSLD
SGNIVDEATLPHRYAAHSLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSVTHPDQSNAEQQRMLACAEGILDKLEIPYRTV
LLCAGDMGFGATRTYDIEAWLPGQDTYREISSVSTCGAFQARRMNARFKPSDGGKPEFVHTLNGSGLAVGRCLIAVLENG
QNADGSVTLPAALHPWLGGKTRITAEGNLA
>Mature_430_residues
MHDIRAIRETPAAFDAALALRGLSAASADILAIDEARRAAITQAETAQADRNAASKEVGKAKASGDEAEFERLRALVSTK
KDEIARLDEEAKAKDAELTAILEALPNLPSPDVPAGADEDDNVEQHRRGTPRAFDFKPLEHFDIPGIAASMDFETAAKLS
GARFVTLKGAVARVHRALAQFMLDTHTEENGLTEINAPVLVRDETMYGTGQLPKFAEDSYQTTNGWWLIPTSEVTLTSLD
SGNIVDEATLPHRYAAHSLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSVTHPDQSNAEQQRMLACAEGILDKLEIPYRTV
LLCAGDMGFGATRTYDIEAWLPGQDTYREISSVSTCGAFQARRMNARFKPSDGGKPEFVHTLNGSGLAVGRCLIAVLENG
QNADGSVTLPAALHPWLGGKTRITAEGNLA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=369, Percent_Identity=33.6043360433604, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI8923421, Length=441, Percent_Identity=31.2925170068027, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI225579074, Length=445, Percent_Identity=31.0112359550562, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=48.9461358313817, Blast_Score=413, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539260, Length=430, Percent_Identity=28.3720930232558, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17542084, Length=267, Percent_Identity=33.7078651685393, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=392, Percent_Identity=31.6326530612245, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321799, Length=435, Percent_Identity=26.6666666666667, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581334, Length=330, Percent_Identity=33.030303030303, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17737985, Length=345, Percent_Identity=31.5942028985507, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_JANSC (Q28TH5)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509012.1
- ProteinModelPortal:   Q28TH5
- SMR:   Q28TH5
- STRING:   Q28TH5
- GeneID:   3933514
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1070
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q28TH5
- ProtClustDB:   PRK05431
- BioCyc:   JSP290400:JANN_1070-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46428; Mature: 46428

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRAIRETPAAFDAALALRGLSAASADILAIDEARRAAITQAETAQADRNAASKEVGK
CCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
AKASGDEAEFERLRALVSTKKDEIARLDEEAKAKDAELTAILEALPNLPSPDVPAGADED
HHCCCCHHHHHHHHHHHHCCHHHHHHCCHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCC
DNVEQHRRGTPRAFDFKPLEHFDIPGIAASMDFETAAKLSGARFVTLKGAVARVHRALAQ
CCHHHHHCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHCCCCEEEEEHHHHHHHHHHHHH
FMLDTHTEENGLTEINAPVLVRDETMYGTGQLPKFAEDSYQTTNGWWLIPTSEVTLTSLD
HHHHCCCCCCCCEECCCCEEEECCCEECCCCCCCHHCCCCCCCCCEEEEECCCEEEEECC
SGNIVDEATLPHRYAAHSLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSVTHPDQSNAEQQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHH
RMLACAEGILDKLEIPYRTVLLCAGDMGFGATRTYDIEAWLPGQDTYREISSVSTCGAFQ
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
ARRMNARFKPSDGGKPEFVHTLNGSGLAVGRCLIAVLENGQNADGSVTLPAALHPWLGGK
HHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEECHHHCCCCCCC
TRITAEGNLA
EEEEECCCCC
>Mature Secondary Structure
MHDIRAIRETPAAFDAALALRGLSAASADILAIDEARRAAITQAETAQADRNAASKEVGK
CCCHHHHHHCCHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
AKASGDEAEFERLRALVSTKKDEIARLDEEAKAKDAELTAILEALPNLPSPDVPAGADED
HHCCCCHHHHHHHHHHHHCCHHHHHHCCHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCC
DNVEQHRRGTPRAFDFKPLEHFDIPGIAASMDFETAAKLSGARFVTLKGAVARVHRALAQ
CCHHHHHCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHCCCCEEEEEHHHHHHHHHHHHH
FMLDTHTEENGLTEINAPVLVRDETMYGTGQLPKFAEDSYQTTNGWWLIPTSEVTLTSLD
HHHHCCCCCCCCEECCCCEEEECCCEECCCCCCCHHCCCCCCCCCEEEEECCCEEEEECC
SGNIVDEATLPHRYAAHSLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSVTHPDQSNAEQQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHH
RMLACAEGILDKLEIPYRTVLLCAGDMGFGATRTYDIEAWLPGQDTYREISSVSTCGAFQ
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHH
ARRMNARFKPSDGGKPEFVHTLNGSGLAVGRCLIAVLENGQNADGSVTLPAALHPWLGGK
HHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEECHHHCCCCCCC
TRITAEGNLA
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA