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The map label for this gene is prs [H]

Identifier: 89053544

GI number: 89053544

Start: 1006980

End: 1008008

Strand: Reverse

Name: prs [H]

Synonym: Jann_1053

Alternate gene names: 89053544

Gene position: 1008008-1006980 (Counterclockwise)

Preceding gene: 89053552

Following gene: 89053533

Centisome position: 23.34

GC content: 61.13

Gene sequence:

>1029_bases
ATGGCTGCACAAGATCCGAAACTGATTTCCGGCAATGCGAACAAGAACTTGGCCGACGCCATCGCGCGGCGCATGTCGAT
GCATCGCGGCATGCAGGTGGGTCTTGTCGACGCGCGTGTCGAGCGGTTCAATGACGGTGAAATTTTCGTTGAGGTTTATG
AAAATGTCCGGGGGGAGGACATGTTCATCATCCAGCCCACGTCCAAGCCCGCAAACGACAACCTGATGGAGCTGTTGATC
ATGGCCGACGCGCTGCGCCGCTCCTCGGCCGCACGGATCACGGCGGTGATCCCCTATTTCGGCTATGCCCGGCAGGACAG
GCGCACCAAGGCGCGCACGCCGATCACCGCCAAGCTGGTCGCCAATATGATTGCCTCCGGCGGGATCGAGCGGGTGCTGA
CGATGGACCTGCACGCGGCTCAGATCCAGGGCTTCTTTGATATGCCCGTCGACAACCTCTATGCCTCGCCGATCTTTGCG
CTGGATATCCTGCACCAGTTCGGCGGCGATATGAGCGATGTGATGGTCGTCTCTCCCGATGTTGGCGGCGTGGCGCGCGC
GCGGGAACTGGCGACGCGGATCGGCGCGCCTTTGTCTATCGTAGACAAGCGACGGGAGAAGGTTGGCGAGGTTTCGGACA
TGACGGTGATCGGGGATGTGACCGGCAAGAAATGCGTCATCATCGACGACATCGTGGATACCGCAGGCACCCTGTGCAAG
GCCGCCGAGGTCCTGACGGAAGCGGGCGCGACGGAAGTCCATTCCTATATCACCCACGGCGTCATGTCGGGCCCGGCCGT
TGAGCGGATCGAAAAATCAGTGATGAAATCGCTGGTCCTGACCGACACGATAGAGGCCACCGACGCTGTCGCGGCCTGTT
CCAGCATCCGCGTCGTGCCCACCGCGCCGATGTTCGCGCAATCGATCCTGAATATCTGGAACGGAACGTCGGTGTCGTCG
CTGTTTGACACGGCGTCCCTGGTCCCGATCTACGAAAGCCTCTATCCCAACGGCATGTGGGGCCGGTAG

Upstream 100 bases:

>100_bases
AACTTTGCGTGGCCGCGGGGCCAGTGCTAGGGGGAGGCCAGTGTTTGAGGGGTGGCCGCGTGGGGACGGGTCTGGCCCCG
CATCTTGGGGACGAAAGACC

Downstream 100 bases:

>100_bases
ATCCATCAGACCTTGCGCGGCGCCACCGTAAAAATAGTCAGGATGATCGCCTGCCAGCCAACGTAAAGGGCTGCCAACCC
TGGAATTTCCAGCGCGTCGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAAQDPKLISGNANKNLADAIARRMSMHRGMQVGLVDARVERFNDGEIFVEVYENVRGEDMFIIQPTSKPANDNLMELLI
MADALRRSSAARITAVIPYFGYARQDRRTKARTPITAKLVANMIASGGIERVLTMDLHAAQIQGFFDMPVDNLYASPIFA
LDILHQFGGDMSDVMVVSPDVGGVARARELATRIGAPLSIVDKRREKVGEVSDMTVIGDVTGKKCVIIDDIVDTAGTLCK
AAEVLTEAGATEVHSYITHGVMSGPAVERIEKSVMKSLVLTDTIEATDAVAACSSIRVVPTAPMFAQSILNIWNGTSVSS
LFDTASLVPIYESLYPNGMWGR

Sequences:

>Translated_342_residues
MAAQDPKLISGNANKNLADAIARRMSMHRGMQVGLVDARVERFNDGEIFVEVYENVRGEDMFIIQPTSKPANDNLMELLI
MADALRRSSAARITAVIPYFGYARQDRRTKARTPITAKLVANMIASGGIERVLTMDLHAAQIQGFFDMPVDNLYASPIFA
LDILHQFGGDMSDVMVVSPDVGGVARARELATRIGAPLSIVDKRREKVGEVSDMTVIGDVTGKKCVIIDDIVDTAGTLCK
AAEVLTEAGATEVHSYITHGVMSGPAVERIEKSVMKSLVLTDTIEATDAVAACSSIRVVPTAPMFAQSILNIWNGTSVSS
LFDTASLVPIYESLYPNGMWGR
>Mature_341_residues
AAQDPKLISGNANKNLADAIARRMSMHRGMQVGLVDARVERFNDGEIFVEVYENVRGEDMFIIQPTSKPANDNLMELLIM
ADALRRSSAARITAVIPYFGYARQDRRTKARTPITAKLVANMIASGGIERVLTMDLHAAQIQGFFDMPVDNLYASPIFAL
DILHQFGGDMSDVMVVSPDVGGVARARELATRIGAPLSIVDKRREKVGEVSDMTVIGDVTGKKCVIIDDIVDTAGTLCKA
AEVLTEAGATEVHSYITHGVMSGPAVERIEKSVMKSLVLTDTIEATDAVAACSSIRVVPTAPMFAQSILNIWNGTSVSSL
FDTASLVPIYESLYPNGMWGR

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=324, Percent_Identity=44.4444444444444, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI4506129, Length=323, Percent_Identity=43.9628482972136, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI84875539, Length=326, Percent_Identity=43.558282208589, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI28557709, Length=324, Percent_Identity=43.2098765432099, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI4506133, Length=351, Percent_Identity=34.4729344729345, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI194018537, Length=346, Percent_Identity=33.5260115606936, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=32.6530612244898, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=32.6530612244898, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=32.6530612244898, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=32.6530612244898, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1787458, Length=321, Percent_Identity=51.0903426791277, Blast_Score=319, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI17554704, Length=325, Percent_Identity=42.7692307692308, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17554702, Length=324, Percent_Identity=42.9012345679012, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI25149168, Length=324, Percent_Identity=42.9012345679012, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71989924, Length=324, Percent_Identity=42.9012345679012, Blast_Score=277, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=347, Percent_Identity=30.5475504322767, Blast_Score=171, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321776, Length=328, Percent_Identity=43.5975609756098, Blast_Score=269, Evalue=5e-73,
Organism=Saccharomyces cerevisiae, GI6319403, Length=327, Percent_Identity=42.5076452599388, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320946, Length=327, Percent_Identity=41.8960244648318, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322667, Length=203, Percent_Identity=37.9310344827586, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=37.3913043478261, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=44.3037974683544, Blast_Score=280, Evalue=8e-76,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=41.2979351032448, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24651458, Length=363, Percent_Identity=33.0578512396694, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24651456, Length=363, Percent_Identity=33.0578512396694, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI281362873, Length=363, Percent_Identity=33.0578512396694, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24651454, Length=363, Percent_Identity=33.0578512396694, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24651462, Length=200, Percent_Identity=39, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24651464, Length=200, Percent_Identity=39, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45552010, Length=194, Percent_Identity=40.2061855670103, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 37011; Mature: 36880

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQDPKLISGNANKNLADAIARRMSMHRGMQVGLVDARVERFNDGEIFVEVYENVRGED
CCCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCEEHEEHHCCCCCE
MFIIQPTSKPANDNLMELLIMADALRRSSAARITAVIPYFGYARQDRRTKARTPITAKLV
EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECHHCCHHHHHHHHCCCCHHHHHH
ANMIASGGIERVLTMDLHAAQIQGFFDMPVDNLYASPIFALDILHQFGGDMSDVMVVSPD
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCEEEECCC
VGGVARARELATRIGAPLSIVDKRREKVGEVSDMTVIGDVTGKKCVIIDDIVDTAGTLCK
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHH
AAEVLTEAGATEVHSYITHGVMSGPAVERIEKSVMKSLVLTDTIEATDAVAACSSIRVVP
HHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
TAPMFAQSILNIWNGTSVSSLFDTASLVPIYESLYPNGMWGR
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AAQDPKLISGNANKNLADAIARRMSMHRGMQVGLVDARVERFNDGEIFVEVYENVRGED
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCEEHEEHHCCCCCE
MFIIQPTSKPANDNLMELLIMADALRRSSAARITAVIPYFGYARQDRRTKARTPITAKLV
EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECHHCCHHHHHHHHCCCCHHHHHH
ANMIASGGIERVLTMDLHAAQIQGFFDMPVDNLYASPIFALDILHQFGGDMSDVMVVSPD
HHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCEEEECCC
VGGVARARELATRIGAPLSIVDKRREKVGEVSDMTVIGDVTGKKCVIIDDIVDTAGTLCK
CCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHH
AAEVLTEAGATEVHSYITHGVMSGPAVERIEKSVMKSLVLTDTIEATDAVAACSSIRVVP
HHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
TAPMFAQSILNIWNGTSVSSLFDTASLVPIYESLYPNGMWGR
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA