Click here to switch to the map view.

The map label for this gene is rsh [H]

Identifier: 89053005

GI number: 89053005

Start: 507462

End: 509630

Strand: Direct

Name: rsh [H]

Synonym: Jann_0514

Alternate gene names: 89053005

Gene position: 507462-509630 (Clockwise)

Preceding gene: 89053004

Following gene: 89053006

Centisome position: 11.75

GC content: 62.1

Gene sequence:

>2169_bases
GTGGCGGCGGATGGCAGGCCAGCAGACGAGACGGTCGCAGAGGATGCGATTACCGTCGACGATCTGCTAAGCCTCGTCCG
CAACTACAACCCCAAAGCCCGTGAAAGCCTGATCCGTGACGCCTTCGCCTATGGCGCGCGGATGCATGACGGGCAGACCC
GCCATTCCGGTGAGCCGTATTTCACCCACCCCGTGGCCGTCGCCGCCATCCTGACAGAGCAGCAGCTGGACGATGCCACC
ATCGTCACGGCTCTTCTGCACGACACGATTGAAGACACGCGGTCGACCTACGGGGAAGTGGCCAAGCATTTCGGGCCCGA
GATCGCAGAGCTGATCGACGGCGTCACGAAGCTGACAAACCTGCAATTGAGCAACCGCGAGAGCAAGCAGGCGGAAAATT
TCCGCAAGCTGTTCATGGCGATGTCCAAGGATCTGCGGGTCATCCTGGTGAAGCTGGCCGACCGGCTGCACAACATGCGC
ACGATCCGCCACATGCGCCCCGACAAGCAGAAGCAGAAGGCGCAGGAGACGATGGATATCTATGCGCCGCTGGCCGGTCG
TATGGGTATGCACTGGATGCGCGAAGAGTTGGAGGACCTGTCGTTTCGGGTCCTGAACCCGGAGGCGCGATCATCGATCC
TGCGCCGCTTCATCACGCTGCAAAAGGAAACCGGCGACGCGATCCCGAAGATCAGCGACGACATTGAGACGGTACTGAAC
AAACGCGGCGTACACGCGGACGTTTATGGCCGTGCGAAAAAGCCCTATTCGATCTGGCGCAAGATGCAGGAGAAGAAGCT
GGCCTTCTCGCGCCTGTCGGACATCTACGGCTTCCGCGTGATCACCGAGACCGAAGATGACTGCTACCGGGTGCTTGGCG
CTATTCACCAGCGGTGGAAATCCGTGCCGGGGCGGTTCAAGGATTACATCAGCCAGCCGAAGTCGAACGGCTATCGCTCC
ATCCACACCACGGTCAGCGGGCGCGATGGCAAGCGGGTGGAGGTGCAGATCCGCACCTATCAGATGCATGAAGTAGCCGA
GGCGGGCGTGGCCGCCCATTGGGCGTACCGTGACGGTGTGCGGACCCAGAACCCTTTCGCGGTCGATCCCACCAAGTGGC
TGGAAAGCCTGACCGAGCGGTTCGAGAACGCCGAGGACACCAACGAGTTCCTCGAACATGTGAAGCTGGAAATGTACTCG
GACCAAGTGTTCTGCTTCACGCCCAAAGGCGACGTGGTCAAGCTGCCGCGCGGGGCGACGCCAATTGATTTCGCTTATTC
GATCCACACGCGGATCGGGCATTCCTGCGTCGGTGCAAAGGTGGATGGGCTGCGCGTGCCCCTGTGGACGCGGCTGAAGA
ACGGGCAATCGGTCGATATCATCACTGCGGAGGGGCAGACGCCGCAAGCGACCTGGATCGATATTGCCACCACGGGCCGC
GCCAAGGCGGCGATCCGGCGGTCTCTGCGCGAGGTGGACCGGGATCGCTACATCAAGCTGGGGCGGGAATTGGCCCGCGT
CGCGTTTGAACAGATCGGCAAGAAAGCCACGGACAAGGCTTTGGCAACAGCGGCCAAAGCCCTAGTACTGAGTGACGGGG
ATGAGGTGCTGGCGCGCATCGGTTCGGCTGAACTGAGCGCGCGGCAGGTGGTGGCGGAGCTGTATCCGGAGCTGGCCAAT
CCCGACGATGCGTCGGCCATTGAAGGCGCCCGCGCCGTCATCGGCCTGCCGCCCGGCGCGCGCATCCTTCGCGCCCAATG
CTGCCAGCCGGTGCCCGGAGAGCGGATCGTGGGCATTACGTACCACGGCAAGGGGCCGATCCTGCATTCCATCGACTGCC
CCGCCTTGGCCGCGTTCGACGACCAGCCGGACCGCTGGATTGACCTGCACTGGACCGAAGGCCGCCACGCGTCGATCCAC
AACGTCACGGCGAATGTGACGCTGTCGAATGAGAATGGCGTGCTGGGGCGCATTTGCACCCTGATCGGGGAGCAGAACGC
GAATATCTCGGACCTGCACTTCATTGACCGCAAGCCGGATTTCTTCCGTATTCTCATTGATATGGACGTCCGGGACGCCG
AACATCTGCACGCCGTGATGATGGCCGTGGAGGCAGATTCGGATGTTGCCGCATTAGATCGCTTCCGTGATCTGGACCGG
AGGCCCTAA

Upstream 100 bases:

>100_bases
GCTTCTGCAAGGCGTGGAGCAGGATCGCCCTGCCCAGGACGACATGAGCGAAGAGCAGATGCTGCGCGCGCTGATGGAAG
CGCAGGGTCAGAAGTAAAGC

Downstream 100 bases:

>100_bases
GAGGTCCATATCTACGCAAGAGCGCCGGGATGGGACGACTGGCGCGAAGGGGCTGGCCCGCGACGGGCAGTCAGAGGAGG
CTCAACGCGCGTGTTCAGAC

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MAADGRPADETVAEDAITVDDLLSLVRNYNPKARESLIRDAFAYGARMHDGQTRHSGEPYFTHPVAVAAILTEQQLDDAT
IVTALLHDTIEDTRSTYGEVAKHFGPEIAELIDGVTKLTNLQLSNRESKQAENFRKLFMAMSKDLRVILVKLADRLHNMR
TIRHMRPDKQKQKAQETMDIYAPLAGRMGMHWMREELEDLSFRVLNPEARSSILRRFITLQKETGDAIPKISDDIETVLN
KRGVHADVYGRAKKPYSIWRKMQEKKLAFSRLSDIYGFRVITETEDDCYRVLGAIHQRWKSVPGRFKDYISQPKSNGYRS
IHTTVSGRDGKRVEVQIRTYQMHEVAEAGVAAHWAYRDGVRTQNPFAVDPTKWLESLTERFENAEDTNEFLEHVKLEMYS
DQVFCFTPKGDVVKLPRGATPIDFAYSIHTRIGHSCVGAKVDGLRVPLWTRLKNGQSVDIITAEGQTPQATWIDIATTGR
AKAAIRRSLREVDRDRYIKLGRELARVAFEQIGKKATDKALATAAKALVLSDGDEVLARIGSAELSARQVVAELYPELAN
PDDASAIEGARAVIGLPPGARILRAQCCQPVPGERIVGITYHGKGPILHSIDCPALAAFDDQPDRWIDLHWTEGRHASIH
NVTANVTLSNENGVLGRICTLIGEQNANISDLHFIDRKPDFFRILIDMDVRDAEHLHAVMMAVEADSDVAALDRFRDLDR
RP

Sequences:

>Translated_722_residues
MAADGRPADETVAEDAITVDDLLSLVRNYNPKARESLIRDAFAYGARMHDGQTRHSGEPYFTHPVAVAAILTEQQLDDAT
IVTALLHDTIEDTRSTYGEVAKHFGPEIAELIDGVTKLTNLQLSNRESKQAENFRKLFMAMSKDLRVILVKLADRLHNMR
TIRHMRPDKQKQKAQETMDIYAPLAGRMGMHWMREELEDLSFRVLNPEARSSILRRFITLQKETGDAIPKISDDIETVLN
KRGVHADVYGRAKKPYSIWRKMQEKKLAFSRLSDIYGFRVITETEDDCYRVLGAIHQRWKSVPGRFKDYISQPKSNGYRS
IHTTVSGRDGKRVEVQIRTYQMHEVAEAGVAAHWAYRDGVRTQNPFAVDPTKWLESLTERFENAEDTNEFLEHVKLEMYS
DQVFCFTPKGDVVKLPRGATPIDFAYSIHTRIGHSCVGAKVDGLRVPLWTRLKNGQSVDIITAEGQTPQATWIDIATTGR
AKAAIRRSLREVDRDRYIKLGRELARVAFEQIGKKATDKALATAAKALVLSDGDEVLARIGSAELSARQVVAELYPELAN
PDDASAIEGARAVIGLPPGARILRAQCCQPVPGERIVGITYHGKGPILHSIDCPALAAFDDQPDRWIDLHWTEGRHASIH
NVTANVTLSNENGVLGRICTLIGEQNANISDLHFIDRKPDFFRILIDMDVRDAEHLHAVMMAVEADSDVAALDRFRDLDR
RP
>Mature_721_residues
AADGRPADETVAEDAITVDDLLSLVRNYNPKARESLIRDAFAYGARMHDGQTRHSGEPYFTHPVAVAAILTEQQLDDATI
VTALLHDTIEDTRSTYGEVAKHFGPEIAELIDGVTKLTNLQLSNRESKQAENFRKLFMAMSKDLRVILVKLADRLHNMRT
IRHMRPDKQKQKAQETMDIYAPLAGRMGMHWMREELEDLSFRVLNPEARSSILRRFITLQKETGDAIPKISDDIETVLNK
RGVHADVYGRAKKPYSIWRKMQEKKLAFSRLSDIYGFRVITETEDDCYRVLGAIHQRWKSVPGRFKDYISQPKSNGYRSI
HTTVSGRDGKRVEVQIRTYQMHEVAEAGVAAHWAYRDGVRTQNPFAVDPTKWLESLTERFENAEDTNEFLEHVKLEMYSD
QVFCFTPKGDVVKLPRGATPIDFAYSIHTRIGHSCVGAKVDGLRVPLWTRLKNGQSVDIITAEGQTPQATWIDIATTGRA
KAAIRRSLREVDRDRYIKLGRELARVAFEQIGKKATDKALATAAKALVLSDGDEVLARIGSAELSARQVVAELYPELANP
DDASAIEGARAVIGLPPGARILRAQCCQPVPGERIVGITYHGKGPILHSIDCPALAAFDDQPDRWIDLHWTEGRHASIHN
VTANVTLSNENGVLGRICTLIGEQNANISDLHFIDRKPDFFRILIDMDVRDAEHLHAVMMAVEADSDVAALDRFRDLDRR
P

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=137, Percent_Identity=37.2262773722628, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790082, Length=704, Percent_Identity=39.7727272727273, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789147, Length=641, Percent_Identity=34.789391575663, Blast_Score=380, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI25143118, Length=135, Percent_Identity=34.0740740740741, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650996, Length=147, Percent_Identity=31.2925170068027, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81194; Mature: 81063

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADGRPADETVAEDAITVDDLLSLVRNYNPKARESLIRDAFAYGARMHDGQTRHSGEPY
CCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FTHPVAVAAILTEQQLDDATIVTALLHDTIEDTRSTYGEVAKHFGPEIAELIDGVTKLTN
EECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
LQLSNRESKQAENFRKLFMAMSKDLRVILVKLADRLHNMRTIRHMRPDKQKQKAQETMDI
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YAPLAGRMGMHWMREELEDLSFRVLNPEARSSILRRFITLQKETGDAIPKISDDIETVLN
HHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
KRGVHADVYGRAKKPYSIWRKMQEKKLAFSRLSDIYGFRVITETEDDCYRVLGAIHQRWK
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHH
SVPGRFKDYISQPKSNGYRSIHTTVSGRDGKRVEVQIRTYQMHEVAEAGVAAHWAYRDGV
HCCHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEEEEHHHHHHHHCCHHHHHHHHCCC
RTQNPFAVDPTKWLESLTERFENAEDTNEFLEHVKLEMYSDQVFCFTPKGDVVKLPRGAT
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCEEEEECCCCCEEECCCCCC
PIDFAYSIHTRIGHSCVGAKVDGLRVPLWTRLKNGQSVDIITAEGQTPQATWIDIATTGR
CCHHHEEHHHHHCCHHCCCCCCCEECCHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCH
AKAAIRRSLREVDRDRYIKLGRELARVAFEQIGKKATDKALATAAKALVLSDGDEVLARI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHH
GSAELSARQVVAELYPELANPDDASAIEGARAVIGLPPGARILRAQCCQPVPGERIVGIT
CCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEECCCCHHHHHHHCCCCCCCCEEEEEE
YHGKGPILHSIDCPALAAFDDQPDRWIDLHWTEGRHASIHNVTANVTLSNENGVLGRICT
EECCCCEEECCCCCCEECCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCHHHHHHH
LIGEQNANISDLHFIDRKPDFFRILIDMDVRDAEHLHAVMMAVEADSDVAALDRFRDLDR
HHCCCCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
RP
CC
>Mature Secondary Structure 
AADGRPADETVAEDAITVDDLLSLVRNYNPKARESLIRDAFAYGARMHDGQTRHSGEPY
CCCCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
FTHPVAVAAILTEQQLDDATIVTALLHDTIEDTRSTYGEVAKHFGPEIAELIDGVTKLTN
EECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHC
LQLSNRESKQAENFRKLFMAMSKDLRVILVKLADRLHNMRTIRHMRPDKQKQKAQETMDI
CCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
YAPLAGRMGMHWMREELEDLSFRVLNPEARSSILRRFITLQKETGDAIPKISDDIETVLN
HHHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
KRGVHADVYGRAKKPYSIWRKMQEKKLAFSRLSDIYGFRVITETEDDCYRVLGAIHQRWK
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHH
SVPGRFKDYISQPKSNGYRSIHTTVSGRDGKRVEVQIRTYQMHEVAEAGVAAHWAYRDGV
HCCHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEEEEHHHHHHHHCCHHHHHHHHCCC
RTQNPFAVDPTKWLESLTERFENAEDTNEFLEHVKLEMYSDQVFCFTPKGDVVKLPRGAT
CCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCEEEEECCCCCEEECCCCCC
PIDFAYSIHTRIGHSCVGAKVDGLRVPLWTRLKNGQSVDIITAEGQTPQATWIDIATTGR
CCHHHEEHHHHHCCHHCCCCCCCEECCHHHHCCCCCEEEEEEECCCCCCCEEEEEECCCH
AKAAIRRSLREVDRDRYIKLGRELARVAFEQIGKKATDKALATAAKALVLSDGDEVLARI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHH
GSAELSARQVVAELYPELANPDDASAIEGARAVIGLPPGARILRAQCCQPVPGERIVGIT
CCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEEECCCCHHHHHHHCCCCCCCCEEEEEE
YHGKGPILHSIDCPALAAFDDQPDRWIDLHWTEGRHASIHNVTANVTLSNENGVLGRICT
EECCCCEEECCCCCCEECCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCHHHHHHH
LIGEQNANISDLHFIDRKPDFFRILIDMDVRDAEHLHAVMMAVEADSDVAALDRFRDLDR
HHCCCCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCC
RP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA