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The map label for this gene is folK [H]

Identifier: 89053003

GI number: 89053003

Start: 506413

End: 507000

Strand: Direct

Name: folK [H]

Synonym: Jann_0512

Alternate gene names: 89053003

Gene position: 506413-507000 (Clockwise)

Preceding gene: 89053001

Following gene: 89053004

Centisome position: 11.73

GC content: 65.99

Gene sequence:

>588_bases
ATGTATACAAATGACGCGAGGGCAGGCCTAATTGCGCTGGGTGCAAACCTGCCTTCCGGCGGATTGCCGCCGGAAATCAG
CGTACCGAAGGCAATGGCCCGGTTGGTGGAGCGAGTGGGCGGCCCCCACAGTCAAAGCCGCTTGTTTCACACGCCTGCCT
TCCCGCCGGGGTCGGGGCCGCAATTCGTCAATGCGGCTGTAAAGATCGAGTGGCGCGGCCATGCCGGGGAACTTCTGGCC
CTGCTCCACGAGATTGAAGAGGAATTTGGTCGGACCCGCGCCCATCGTTGGGAGGCGCGGGTGATGGATCTGGATCTGAT
CGGCCTGGGCGATGCGATCCTGCCGGATGCGGCCACGCGGGCCAATTGGGCGAATCTGCCGCCGGAGCGGGCGGCGCAGG
TGGTGCCCGATCAGCTGATTCTCCCCCATCCGCGTTTGGCAGAGCGGGGATTCGTGCTGGTGCCCCTGGCCGATATCGCG
CCCGAATGGGTGGATCCGGCCACCGGCCTGACCGTGGCCGAGATGCTGGCGGCGCGTCCCCATGCCGAGCTGGCGGGGAT
CCATCCGGTGCCTGTCGCAGCGGAATAA

Upstream 100 bases:

>100_bases
GTATTGCACCGTTGGCCTAAAAATTCCGGTCCCATCCGGCGGCCTCCAGTGCGAGCTGGCAAGTTTGTATGTAACGCTGA
TGTGACAGGTTCAAGCCAAG

Downstream 100 bases:

>100_bases
GGCCTGAAACTGCTGCAATGGCCGCGAATCCCATTGTCAATACGCCCATCGGCGCATATGTAGCGCCTTTAACCCCTTAA
GGTTTCTAGAGTCTGGAGTG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MYTNDARAGLIALGANLPSGGLPPEISVPKAMARLVERVGGPHSQSRLFHTPAFPPGSGPQFVNAAVKIEWRGHAGELLA
LLHEIEEEFGRTRAHRWEARVMDLDLIGLGDAILPDAATRANWANLPPERAAQVVPDQLILPHPRLAERGFVLVPLADIA
PEWVDPATGLTVAEMLAARPHAELAGIHPVPVAAE

Sequences:

>Translated_195_residues
MYTNDARAGLIALGANLPSGGLPPEISVPKAMARLVERVGGPHSQSRLFHTPAFPPGSGPQFVNAAVKIEWRGHAGELLA
LLHEIEEEFGRTRAHRWEARVMDLDLIGLGDAILPDAATRANWANLPPERAAQVVPDQLILPHPRLAERGFVLVPLADIA
PEWVDPATGLTVAEMLAARPHAELAGIHPVPVAAE
>Mature_195_residues
MYTNDARAGLIALGANLPSGGLPPEISVPKAMARLVERVGGPHSQSRLFHTPAFPPGSGPQFVNAAVKIEWRGHAGELLA
LLHEIEEEFGRTRAHRWEARVMDLDLIGLGDAILPDAATRANWANLPPERAAQVVPDQLILPHPRLAERGFVLVPLADIA
PEWVDPATGLTVAEMLAARPHAELAGIHPVPVAAE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=177, Percent_Identity=31.638418079096, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20874; Mature: 20874

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTNDARAGLIALGANLPSGGLPPEISVPKAMARLVERVGGPHSQSRLFHTPAFPPGSGP
CCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
QFVNAAVKIEWRGHAGELLALLHEIEEEFGRTRAHRWEARVMDLDLIGLGDAILPDAATR
CEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHCCCCCCC
ANWANLPPERAAQVVPDQLILPHPRLAERGFVLVPLADIAPEWVDPATGLTVAEMLAARP
CCCCCCCHHHHHHHCCCCCCCCCCCHHHCCEEEEEHHHHCCCCCCCCCCHHHHHHHHCCC
HAELAGIHPVPVAAE
CCHHCCCCCCCCCCC
>Mature Secondary Structure
MYTNDARAGLIALGANLPSGGLPPEISVPKAMARLVERVGGPHSQSRLFHTPAFPPGSGP
CCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
QFVNAAVKIEWRGHAGELLALLHEIEEEFGRTRAHRWEARVMDLDLIGLGDAILPDAATR
CEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHCCCCCCC
ANWANLPPERAAQVVPDQLILPHPRLAERGFVLVPLADIAPEWVDPATGLTVAEMLAARP
CCCCCCCHHHHHHHCCCCCCCCCCCHHHCCEEEEEHHHHCCCCCCCCCCHHHHHHHHCCC
HAELAGIHPVPVAAE
CCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]