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The map label for this gene is rnhA

Identifier: 89052993

GI number: 89052993

Start: 499515

End: 499988

Strand: Reverse

Name: rnhA

Synonym: Jann_0502

Alternate gene names: 89052993

Gene position: 499988-499515 (Counterclockwise)

Preceding gene: 89052994

Following gene: 89052992

Centisome position: 11.58

GC content: 61.81

Gene sequence:

>474_bases
ATGCCTGATCTCGTTGCCTATACCGATGGTGCCTGTTCCGGCAATCCAGGTCCCGGTGGCTGGGGGGCGCTGATGCGCGC
CAAGGACGGCGATACGATCCTGAAGGAGCGGGAGCTGAAGGGCGGTGAGGCCGACACCACCAACAACCGGATGGAGCTTC
TGGCCGCGATCTCGGCGCTGGAAGCTCTCGATCGCCCCTCCACGCTCACGATCATTACCGACAGCGCCTATGTCAAAAAC
GGGATCACCGGCTGGATGCACGGCTGGAAGCGCAACGGCTGGAAGACCTCCACCAGGAAGCCCGTCAAGAACGTGGATCT
GTGGCAACGGCTGGATGAGGCGCAGTCCCGTCACACTGTGACATGGGAATGGATCAAGGGTCACGCGGGCCATGAGGGCA
ATGAGAAGGCAGATGAACTTGCCCGCGCAGGCATGGCGCCCTTCAAGACGGGCAAGCGGGGCAAAGATGGATAA

Upstream 100 bases:

>100_bases
CTGGAAGACGCGGGCCTGCGTGTGACCCAAACCGTCACCGGCCGTGGCAAAGGCCTGTCCGGCTCAGACGATACCTATGC
CCTTGTGCACGCGGTCCGCG

Downstream 100 bases:

>100_bases
GGTCTGTCCGGTGGTCCTGCGCCCGGGGCGGAGAGTTCTGGCGTTCAGGCATCCCCAGGCAGGACTTCAACTGGTGAAGG
GCGGCATCGAGTCCAATGAA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MPDLVAYTDGACSGNPGPGGWGALMRAKDGDTILKERELKGGEADTTNNRMELLAAISALEALDRPSTLTIITDSAYVKN
GITGWMHGWKRNGWKTSTRKPVKNVDLWQRLDEAQSRHTVTWEWIKGHAGHEGNEKADELARAGMAPFKTGKRGKDG

Sequences:

>Translated_157_residues
MPDLVAYTDGACSGNPGPGGWGALMRAKDGDTILKERELKGGEADTTNNRMELLAAISALEALDRPSTLTIITDSAYVKN
GITGWMHGWKRNGWKTSTRKPVKNVDLWQRLDEAQSRHTVTWEWIKGHAGHEGNEKADELARAGMAPFKTGKRGKDG
>Mature_156_residues
PDLVAYTDGACSGNPGPGGWGALMRAKDGDTILKERELKGGEADTTNNRMELLAAISALEALDRPSTLTIITDSAYVKNG
ITGWMHGWKRNGWKTSTRKPVKNVDLWQRLDEAQSRHTVTWEWIKGHAGHEGNEKADELARAGMAPFKTGKRGKDG

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=150, Percent_Identity=38.6666666666667, Blast_Score=85, Evalue=3e-17,
Organism=Escherichia coli, GI1786408, Length=144, Percent_Identity=55.5555555555556, Blast_Score=174, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI115532542, Length=149, Percent_Identity=42.2818791946309, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45552509, Length=153, Percent_Identity=39.8692810457516, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137476, Length=153, Percent_Identity=39.8692810457516, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_JANSC (Q28V43)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508444.1
- ProteinModelPortal:   Q28V43
- STRING:   Q28V43
- GeneID:   3932943
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0502
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- PhylomeDB:   Q28V43
- ProtClustDB:   PRK00203
- BioCyc:   JSP290400:JANN_0502-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 17173; Mature: 17042

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLVAYTDGACSGNPGPGGWGALMRAKDGDTILKERELKGGEADTTNNRMELLAAISAL
CCCCCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EALDRPSTLTIITDSAYVKNGITGWMHGWKRNGWKTSTRKPVKNVDLWQRLDEAQSRHTV
HHHCCCCEEEEEECCHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
TWEWIKGHAGHEGNEKADELARAGMAPFKTGKRGKDG
EEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDLVAYTDGACSGNPGPGGWGALMRAKDGDTILKERELKGGEADTTNNRMELLAAISAL
CCCCCCCCCCCCCCCCCCCHHHEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EALDRPSTLTIITDSAYVKNGITGWMHGWKRNGWKTSTRKPVKNVDLWQRLDEAQSRHTV
HHHCCCCEEEEEECCHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCE
TWEWIKGHAGHEGNEKADELARAGMAPFKTGKRGKDG
EEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA