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The map label for this gene is fmt

Identifier: 89052960

GI number: 89052960

Start: 467482

End: 468387

Strand: Direct

Name: fmt

Synonym: Jann_0469

Alternate gene names: 89052960

Gene position: 467482-468387 (Clockwise)

Preceding gene: 89052959

Following gene: 89052961

Centisome position: 10.83

GC content: 64.46

Gene sequence:

>906_bases
ATGCGGATCATCTTCATGGGGACGCCCGACTTTTCCGTCCCGGTTCTGGACGCGCTGGTGGCCGCAGAGCATGAGGTCGT
CGCGGTCTATTCGCAACCTCCACGCCCCGCGGGACGCGGCAAGAGGGACCGCCCCAGTCCTGTGCAGGCGCGGGCAGAGA
CCTTGGGGCTAACCGTGCGGAATCCGGTCAGCCTGAAAAGCACAGAAGAGCAGTCGGCTCTTGCAGACTTGAACGCGGAT
GTCGCGGTCGTCGTGGCCTACGGCCTGATCCTGCCGCAAGCGGTGCTTGATGCACCCGCGCGTGGGTGTCTCAATATCCA
CGCCTCCCTGCTCCCGCGCTGGCGTGGGGCCGCGCCCATTCATCGGGCGATCATGGCAGGCGATACCATGACAGGCGTGT
GTATCATGCAGATGGAAGCCGGCCTTGATACGGGTCCCGTCCTGCTGCGCCGCGAGACATCCATTGGGGCGGAGGACACA
ACCGGCACGCTCCACGACAGGCTTTCGGCCATAGGGGCAAAGGCAATCGTGGACGCGCTCTCTCAACTGGACGAGCTGAC
CCCCAAACCGCAGCCGGACGATGGCGTCACCTATGCCACAAAGATTGATAAATCCGAGGCAAAGGTGGATTGGACCGCCC
CGGCCCCCCATATCAATCGTCAGATCCTTGGCCTGTCGCCCTTCCCGGGTGCCTGGACCATGGCGGGCGGCAAGCGCCTG
AAACTGTTGCAGAGCCGCGTTGCGAACGGCACGGGCGCCCTTGGTGAGGTGTTGCACGGGCTAACCGTGGCCTGCGGCGA
CGGAGCGGTGGAGATCTCGCGCGTTCAGCCTGAGGGCAAAGGCGCGATGGATGCGAAAGACTGGCTCTTGGGTGCGCGGA
TCGCGCCGGGGACGGTTTTGGAGTAA

Upstream 100 bases:

>100_bases
TCCAGCACCAGATCGACCATCTGGCGGGCAAAGTGTATGTCGATCACCTCAGCCGAACGAAGCGCGAGATGGTGATCAAG
AAATCCCGGAGGGGCAGCTG

Downstream 100 bases:

>100_bases
GATGGGCTGCGGCCCGACGTTCAATTGGGGCTGAACACCCCGGGCAATCGGAGGACCCCATGGTTCTGTTTTCCTTTTTC
GGATCCCTGATGATCGCAGG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRIIFMGTPDFSVPVLDALVAAEHEVVAVYSQPPRPAGRGKRDRPSPVQARAETLGLTVRNPVSLKSTEEQSALADLNAD
VAVVVAYGLILPQAVLDAPARGCLNIHASLLPRWRGAAPIHRAIMAGDTMTGVCIMQMEAGLDTGPVLLRRETSIGAEDT
TGTLHDRLSAIGAKAIVDALSQLDELTPKPQPDDGVTYATKIDKSEAKVDWTAPAPHINRQILGLSPFPGAWTMAGGKRL
KLLQSRVANGTGALGEVLHGLTVACGDGAVEISRVQPEGKGAMDAKDWLLGARIAPGTVLE

Sequences:

>Translated_301_residues
MRIIFMGTPDFSVPVLDALVAAEHEVVAVYSQPPRPAGRGKRDRPSPVQARAETLGLTVRNPVSLKSTEEQSALADLNAD
VAVVVAYGLILPQAVLDAPARGCLNIHASLLPRWRGAAPIHRAIMAGDTMTGVCIMQMEAGLDTGPVLLRRETSIGAEDT
TGTLHDRLSAIGAKAIVDALSQLDELTPKPQPDDGVTYATKIDKSEAKVDWTAPAPHINRQILGLSPFPGAWTMAGGKRL
KLLQSRVANGTGALGEVLHGLTVACGDGAVEISRVQPEGKGAMDAKDWLLGARIAPGTVLE
>Mature_301_residues
MRIIFMGTPDFSVPVLDALVAAEHEVVAVYSQPPRPAGRGKRDRPSPVQARAETLGLTVRNPVSLKSTEEQSALADLNAD
VAVVVAYGLILPQAVLDAPARGCLNIHASLLPRWRGAAPIHRAIMAGDTMTGVCIMQMEAGLDTGPVLLRRETSIGAEDT
TGTLHDRLSAIGAKAIVDALSQLDELTPKPQPDDGVTYATKIDKSEAKVDWTAPAPHINRQILGLSPFPGAWTMAGGKRL
KLLQSRVANGTGALGEVLHGLTVACGDGAVEISRVQPEGKGAMDAKDWLLGARIAPGTVLE

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=266, Percent_Identity=33.8345864661654, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI238814322, Length=267, Percent_Identity=31.0861423220974, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI164663775, Length=318, Percent_Identity=30.188679245283, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1789683, Length=311, Percent_Identity=49.1961414790997, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788589, Length=279, Percent_Identity=25.4480286738351, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI133930964, Length=263, Percent_Identity=26.9961977186312, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319458, Length=264, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45550868, Length=301, Percent_Identity=30.2325581395349, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28571984, Length=222, Percent_Identity=32.8828828828829, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24585660, Length=319, Percent_Identity=29.153605015674, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_JANSC (Q28V76)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508411.1
- ProteinModelPortal:   Q28V76
- SMR:   Q28V76
- STRING:   Q28V76
- GeneID:   3932910
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0469
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- PhylomeDB:   Q28V76
- ProtClustDB:   CLSK934096
- BioCyc:   JSP290400:JANN_0469-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 31671; Mature: 31671

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFMGTPDFSVPVLDALVAAEHEVVAVYSQPPRPAGRGKRDRPSPVQARAETLGLTVR
CEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCEEEC
NPVSLKSTEEQSALADLNADVAVVVAYGLILPQAVLDAPARGCLNIHASLLPRWRGAAPI
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHH
HRAIMAGDTMTGVCIMQMEAGLDTGPVLLRRETSIGAEDTTGTLHDRLSAIGAKAIVDAL
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SQLDELTPKPQPDDGVTYATKIDKSEAKVDWTAPAPHINRQILGLSPFPGAWTMAGGKRL
HHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCEECCCCHHH
KLLQSRVANGTGALGEVLHGLTVACGDGAVEISRVQPEGKGAMDAKDWLLGARIAPGTVL
HHHHHHHCCCCCHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCHHHHHEECCCCCCCCC
E
C
>Mature Secondary Structure
MRIIFMGTPDFSVPVLDALVAAEHEVVAVYSQPPRPAGRGKRDRPSPVQARAETLGLTVR
CEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCEEEC
NPVSLKSTEEQSALADLNADVAVVVAYGLILPQAVLDAPARGCLNIHASLLPRWRGAAPI
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHH
HRAIMAGDTMTGVCIMQMEAGLDTGPVLLRRETSIGAEDTTGTLHDRLSAIGAKAIVDAL
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SQLDELTPKPQPDDGVTYATKIDKSEAKVDWTAPAPHINRQILGLSPFPGAWTMAGGKRL
HHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCEEEECCCCCCCEECCCCHHH
KLLQSRVANGTGALGEVLHGLTVACGDGAVEISRVQPEGKGAMDAKDWLLGARIAPGTVL
HHHHHHHCCCCCHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCHHHHHEECCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA