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The map label for this gene is ribA [H]

Identifier: 89052907

GI number: 89052907

Start: 419272

End: 420345

Strand: Reverse

Name: ribA [H]

Synonym: Jann_0416

Alternate gene names: 89052907

Gene position: 420345-419272 (Counterclockwise)

Preceding gene: 89052910

Following gene: 89052906

Centisome position: 9.73

GC content: 65.27

Gene sequence:

>1074_bases
ATGAGTTTGTTGCCCTCCATATCGGACCTTGTGGCGCGCGCCCGCAGTGACCTGCGCGTGGGACTGCCCGTTGTGCTGGA
CCGCGACGGTACGGGGCTGATCGTGCTGGCCTGCGAAACGGCAAGCGATGCGCGGCTGGAGGCCCTGCGTGCCCTCGGCC
CAGTCACCGCCGCGATCACCGGGTGGCGGGCCGAGACGTTGAAGATCCGCATCTATGACGGCGACATTGCCCGGATCACG
ATGCCCGCCGATGCGGGCGCGCGGTGGTTGGCAGAGCTGGCCGACCCGGCCTGTGACCTGTCCGCCCCGATGCGTGGCCC
GTTCAGGGAGGATCGCGATGGCGATGCCAGCCTTCACCGGATTGCCCTTGATCTGACGAAATCCGCCCAGCTTCTGCCCG
CAATCGCAGGCGTCGAGGTGAGCGCTTGGCCGGAGGGACTGACGATTCTGCCCGCCGACCTGGCCGCCCAGGATTTGGCG
ATGTCCGCGCCCCTGTCACCGGTGGCCGCCGCGCGTCTTCCGATGGCGCTGGCGGGTGCCGGGCGTCTGCACATCTTCCG
CCCCGACAATGCCGGGATCGAACACTACGCCATCGAGGTCGGCCGCCCGGACCGCTCCAGGCCTGTTTTGGCGCGGCTGC
ATTCCGCCTGTTTCACCGGCGATGTCCTTGGGTCATTGAAATGCGATTGCGGCCCCCAGCTGCACGCCGCTTTGGCCGAG
ATGGGGCGGATCGGGGAAGGCGTGCTGCTATACCTCAACCAGGAGGGGCGCGGGATCGGGCTGGCCAACAAGATGCGCGC
CTATGCGTTGCAGGATCAGGGGTTTGACACGGTCGAGGCCAATCACCGTCTTGGCTTTGAGGATGATGAACGCGACTTCC
GCATCGGCGCGGATCTTCTACGCCGCATGGGGTTCGACGCCGTGCGCCTGATGACCAACAATCCCCGCAAGGTCGAGATG
ATGGATGCGGAAGGCATAGATGTGGCCGAGCGCGTGCCGCTGATCATTGACCCTAACCGGCACAATGCCGACTATTTGCA
GGTGAAACGCACCAAATCAGGGCATTTGCTGTAA

Upstream 100 bases:

>100_bases
TGGATGTAACCATGCCTCACGGCCCTGTGTCGGCGCGTGAGGGAATGTTTCAATTCCGCCATTCTTCCAATTCCGGGACT
TTGCGGGCTATGTGTGGGCG

Downstream 100 bases:

>100_bases
GGTCCTGGCAAAATGCGGGGCTGCGAGGAGAGTACGATGGCCAAAGGCCACATCATCGCCCACGATATGGACCGGATCGC
CCGCTTTGGCGACGCCTCCG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSLLPSISDLVARARSDLRVGLPVVLDRDGTGLIVLACETASDARLEALRALGPVTAAITGWRAETLKIRIYDGDIARIT
MPADAGARWLAELADPACDLSAPMRGPFREDRDGDASLHRIALDLTKSAQLLPAIAGVEVSAWPEGLTILPADLAAQDLA
MSAPLSPVAAARLPMALAGAGRLHIFRPDNAGIEHYAIEVGRPDRSRPVLARLHSACFTGDVLGSLKCDCGPQLHAALAE
MGRIGEGVLLYLNQEGRGIGLANKMRAYALQDQGFDTVEANHRLGFEDDERDFRIGADLLRRMGFDAVRLMTNNPRKVEM
MDAEGIDVAERVPLIIDPNRHNADYLQVKRTKSGHLL

Sequences:

>Translated_357_residues
MSLLPSISDLVARARSDLRVGLPVVLDRDGTGLIVLACETASDARLEALRALGPVTAAITGWRAETLKIRIYDGDIARIT
MPADAGARWLAELADPACDLSAPMRGPFREDRDGDASLHRIALDLTKSAQLLPAIAGVEVSAWPEGLTILPADLAAQDLA
MSAPLSPVAAARLPMALAGAGRLHIFRPDNAGIEHYAIEVGRPDRSRPVLARLHSACFTGDVLGSLKCDCGPQLHAALAE
MGRIGEGVLLYLNQEGRGIGLANKMRAYALQDQGFDTVEANHRLGFEDDERDFRIGADLLRRMGFDAVRLMTNNPRKVEM
MDAEGIDVAERVPLIIDPNRHNADYLQVKRTKSGHLL
>Mature_356_residues
SLLPSISDLVARARSDLRVGLPVVLDRDGTGLIVLACETASDARLEALRALGPVTAAITGWRAETLKIRIYDGDIARITM
PADAGARWLAELADPACDLSAPMRGPFREDRDGDASLHRIALDLTKSAQLLPAIAGVEVSAWPEGLTILPADLAAQDLAM
SAPLSPVAAARLPMALAGAGRLHIFRPDNAGIEHYAIEVGRPDRSRPVLARLHSACFTGDVLGSLKCDCGPQLHAALAEM
GRIGEGVLLYLNQEGRGIGLANKMRAYALQDQGFDTVEANHRLGFEDDERDFRIGADLLRRMGFDAVRLMTNNPRKVEMM
DAEGIDVAERVPLIIDPNRHNADYLQVKRTKSGHLL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=53.8860103626943, Blast_Score=201, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6319438, Length=176, Percent_Identity=40.9090909090909, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 38539; Mature: 38408

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLPSISDLVARARSDLRVGLPVVLDRDGTGLIVLACETASDARLEALRALGPVTAAIT
CCCCCCHHHHHHHHHCCCEECCCEEECCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHEE
GWRAETLKIRIYDGDIARITMPADAGARWLAELADPACDLSAPMRGPFREDRDGDASLHR
CCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHEE
IALDLTKSAQLLPAIAGVEVSAWPEGLTILPADLAAQDLAMSAPLSPVAAARLPMALAGA
EEEECCCCHHHHHHHHCCEEECCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHCCCEEECC
GRLHIFRPDNAGIEHYAIEVGRPDRSRPVLARLHSACFTGDVLGSLKCDCGPQLHAALAE
CEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHH
MGRIGEGVLLYLNQEGRGIGLANKMRAYALQDQGFDTVEANHRLGFEDDERDFRIGADLL
HCCCCCCEEEEECCCCCCCCCHHHHHHEEECCCCCCEEECCCCCCCCCCCCHHHHHHHHH
RRMGFDAVRLMTNNPRKVEMMDAEGIDVAERVPLIIDPNRHNADYLQVKRTKSGHLL
HHCCCCEEEEECCCCCEEEEECCCCCCHHHCCCEEECCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SLLPSISDLVARARSDLRVGLPVVLDRDGTGLIVLACETASDARLEALRALGPVTAAIT
CCCCCHHHHHHHHHCCCEECCCEEECCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHEE
GWRAETLKIRIYDGDIARITMPADAGARWLAELADPACDLSAPMRGPFREDRDGDASLHR
CCEEEEEEEEEEECCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHEE
IALDLTKSAQLLPAIAGVEVSAWPEGLTILPADLAAQDLAMSAPLSPVAAARLPMALAGA
EEEECCCCHHHHHHHHCCEEECCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHCCCEEECC
GRLHIFRPDNAGIEHYAIEVGRPDRSRPVLARLHSACFTGDVLGSLKCDCGPQLHAALAE
CEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHH
MGRIGEGVLLYLNQEGRGIGLANKMRAYALQDQGFDTVEANHRLGFEDDERDFRIGADLL
HCCCCCCEEEEECCCCCCCCCHHHHHHEEECCCCCCEEECCCCCCCCCCCCHHHHHHHHH
RRMGFDAVRLMTNNPRKVEMMDAEGIDVAERVPLIIDPNRHNADYLQVKRTKSGHLL
HHCCCCEEEEECCCCCEEEEECCCCCCHHHCCCEEECCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]