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The map label for this gene is cobC [H]

Identifier: 89052860

GI number: 89052860

Start: 371855

End: 372832

Strand: Direct

Name: cobC [H]

Synonym: Jann_0369

Alternate gene names: 89052860

Gene position: 371855-372832 (Clockwise)

Preceding gene: 89052859

Following gene: 89052861

Centisome position: 8.61

GC content: 65.54

Gene sequence:

>978_bases
ATGAACGTCCCGTTTCCAAAACGCGACCACGGGGGTGGTCTGGATGCCGCAGCCGCTGAATATGGCGGTGATCTGGAGGC
GTGGCTGGATCTGTCGACCGGCATCAACCCCAACGCCTATCCGGTGGGGCAATTGCCGCAGGACATCTGGGGTCGCCTGC
CCGATGAAGGCGCGATGGCGCGGTTGCTGGACGCCGCGCGCAGCTTCTGGTCGGTCCCCGATGGGGTGGAGGTCATTGCC
GCCGCCGGGGCCTCTCCGCTGATCGCGCGGATGCCGGATATGACGGCCTTCTCGGGCGCGTATATCCCGGTGCCCACCTA
TAACGAATACGCGGCGGCCTTTGCGGCGCGGGGGCGGCTGAACGACCCGCTGAACCCCCAAAATCCCGTGCATGTCTACG
TACATCCCAACAATCCTGATGGGCGCATGTGGCCGGGATCGGTCATTGGCGGGCGGCCCCTGACGATCATCGACGAAAGT
TTCTGCGATACCGTCCCGGACAAGACCCACATGGCCCGCGCGGCAGAGCCCGGGGTGATTATCCTCAAGAGTTTCGGCAA
ATTCTGGGGTCTCGCGGGCCTGCGCCTTGGGTTCGCGATTGCAGCGCCCGAGACGTTTGCGCGGTCGTCGTCATCCGCGT
CGTTGCAGGAGCTGATGGGGCCGTGGTCCGTCTCCGGCCCCGCGCTGGAGATCGGGGCGCGTGCCTTGCAGGACCACGCC
TGGGCCGAGGCGACGCGGGTGCGTCTGGGTCACGATGCCGCCCGGCTCGATGATATGCTGCTATCCGCTGGGGCGGAGAT
CGTGGGCGGCACGACGCTGTTTCGCACCTATGCATGGGAGCAGGGGGCAGAGGTCTGGCAAAAACGTCTGGCCGAGCATC
GCATCTGGTCACGCATTTTCCCCTATTCCACCAATTGGATGCGCCTGGGTCTTCCCGCCACGGATGAGGATTGGGCGCGC
CTGGACGCGGCCCTTTGA

Upstream 100 bases:

>100_bases
CATCCCAATCAACCCGCAGATCGACTGGACCGCGCCCCATGGTCGCTCTGATCGGTGAAGCGGATTGCGGGCGGCGTAAT
TTCGGGTATCAAAAGGGGTC

Downstream 100 bases:

>100_bases
TCGCCACCGCTGGGTTGCTGTTTGCTGCGATGATCCTGGATGCGCTGGTGGGCGAGCCCCGGTGGCTGTGGTCCCGGATC
CCGCATCCGATCGTGCTGAT

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MNVPFPKRDHGGGLDAAAAEYGGDLEAWLDLSTGINPNAYPVGQLPQDIWGRLPDEGAMARLLDAARSFWSVPDGVEVIA
AAGASPLIARMPDMTAFSGAYIPVPTYNEYAAAFAARGRLNDPLNPQNPVHVYVHPNNPDGRMWPGSVIGGRPLTIIDES
FCDTVPDKTHMARAAEPGVIILKSFGKFWGLAGLRLGFAIAAPETFARSSSSASLQELMGPWSVSGPALEIGARALQDHA
WAEATRVRLGHDAARLDDMLLSAGAEIVGGTTLFRTYAWEQGAEVWQKRLAEHRIWSRIFPYSTNWMRLGLPATDEDWAR
LDAAL

Sequences:

>Translated_325_residues
MNVPFPKRDHGGGLDAAAAEYGGDLEAWLDLSTGINPNAYPVGQLPQDIWGRLPDEGAMARLLDAARSFWSVPDGVEVIA
AAGASPLIARMPDMTAFSGAYIPVPTYNEYAAAFAARGRLNDPLNPQNPVHVYVHPNNPDGRMWPGSVIGGRPLTIIDES
FCDTVPDKTHMARAAEPGVIILKSFGKFWGLAGLRLGFAIAAPETFARSSSSASLQELMGPWSVSGPALEIGARALQDHA
WAEATRVRLGHDAARLDDMLLSAGAEIVGGTTLFRTYAWEQGAEVWQKRLAEHRIWSRIFPYSTNWMRLGLPATDEDWAR
LDAAL
>Mature_325_residues
MNVPFPKRDHGGGLDAAAAEYGGDLEAWLDLSTGINPNAYPVGQLPQDIWGRLPDEGAMARLLDAARSFWSVPDGVEVIA
AAGASPLIARMPDMTAFSGAYIPVPTYNEYAAAFAARGRLNDPLNPQNPVHVYVHPNNPDGRMWPGSVIGGRPLTIIDES
FCDTVPDKTHMARAAEPGVIILKSFGKFWGLAGLRLGFAIAAPETFARSSSSASLQELMGPWSVSGPALEIGARALQDHA
WAEATRVRLGHDAARLDDMLLSAGAEIVGGTTLFRTYAWEQGAEVWQKRLAEHRIWSRIFPYSTNWMRLGLPATDEDWAR
LDAAL

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35187; Mature: 35187

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVPFPKRDHGGGLDAAAAEYGGDLEAWLDLSTGINPNAYPVGQLPQDIWGRLPDEGAMA
CCCCCCCCCCCCCCCHHHHHHCCCHHEEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHH
RLLDAARSFWSVPDGVEVIAAAGASPLIARMPDMTAFSGAYIPVPTYNEYAAAFAARGRL
HHHHHHHHHCCCCCCHHHHHHCCCCCHHHHCCCCCCCCCCEECCCCCHHHHHHHHHCCCC
NDPLNPQNPVHVYVHPNNPDGRMWPGSVIGGRPLTIIDESFCDTVPDKTHMARAAEPGVI
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECHHHHCCCCCHHHHHHCCCCCEE
ILKSFGKFWGLAGLRLGFAIAAPETFARSSSSASLQELMGPWSVSGPALEIGARALQDHA
EEEHHHHHHHHHHHHHHEEEECCHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
WAEATRVRLGHDAARLDDMLLSAGAEIVGGTTLFRTYAWEQGAEVWQKRLAEHRIWSRIF
HHHHHHHHHCCHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PYSTNWMRLGLPATDEDWARLDAAL
CCCCCEEEECCCCCCHHHHHHHCCC
>Mature Secondary Structure
MNVPFPKRDHGGGLDAAAAEYGGDLEAWLDLSTGINPNAYPVGQLPQDIWGRLPDEGAMA
CCCCCCCCCCCCCCCHHHHHHCCCHHEEEECCCCCCCCCCCCCCCCHHHHCCCCCCHHHH
RLLDAARSFWSVPDGVEVIAAAGASPLIARMPDMTAFSGAYIPVPTYNEYAAAFAARGRL
HHHHHHHHHCCCCCCHHHHHHCCCCCHHHHCCCCCCCCCCEECCCCCHHHHHHHHHCCCC
NDPLNPQNPVHVYVHPNNPDGRMWPGSVIGGRPLTIIDESFCDTVPDKTHMARAAEPGVI
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECHHHHCCCCCHHHHHHCCCCCEE
ILKSFGKFWGLAGLRLGFAIAAPETFARSSSSASLQELMGPWSVSGPALEIGARALQDHA
EEEHHHHHHHHHHHHHHEEEECCHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
WAEATRVRLGHDAARLDDMLLSAGAEIVGGTTLFRTYAWEQGAEVWQKRLAEHRIWSRIF
HHHHHHHHHCCHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PYSTNWMRLGLPATDEDWARLDAAL
CCCCCEEEECCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]