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The map label for this gene is barA [H]

Identifier: 89052756

GI number: 89052756

Start: 272732

End: 274882

Strand: Direct

Name: barA [H]

Synonym: Jann_0265

Alternate gene names: 89052756

Gene position: 272732-274882 (Clockwise)

Preceding gene: 89052753

Following gene: 89052758

Centisome position: 6.32

GC content: 59.88

Gene sequence:

>2151_bases
ATGGCTGCGATAAACCTCAACGACCGGATGGCGCAGGAGAGACGCGCGCGCCTGCAGGCCGAGCAGTTGCTCGCCCTGCG
GTCGGAGGAGCTGTATTCCGCCAACCGCAAGCTTGCCGAACATGCCACCGCGCTGTCCACTCAGGTCATCGAACAGAGAG
AGGAGAACGAACTTCTCAAGGGTAAAACCCAGAAGACCGAGGTTGAACTTGAGGTCGTGACCGAGCGGGCCCTGATGGCG
CAGCGACGGCTTTGGGACGCGCTGACTGCTACGGAGGACGGCTTTGCAATCTTTGATCGCGATTGGCGTCTGGTGGCCGC
CAACCCCGCGTTCTTCCTGATCTTTGACGGGATTTCCGATGTGACCGAGGGGGCCACTTATGAGGCGATCCTGCGCGTCG
CGACCGAGGAGGGCATCGTTGATCTGCAAGGGCAGAACGCCGACGATTGGGTGGAGGAAATGGTCGCGCGTTGGGAGAAG
GTCCCCATTCCCAACGTGGATGTGAAGCTATGGAACGGCGCGTATATCCGGCTGAATGACAAGCAGACGCCCCAGGGGGA
TTTCGTGTCCCTCAGCGTTGACATCACGCCCAACATCCGCCGCGAGCGGGAGTTGAGTGAGGCGCGCGATGCAGCCGAGG
CGGCCAACCGCGCGAAGTCGCATTTCCTCGCCAATATGAGCCACGAGATTCGCACACCGATGAATGGCGTCGTCTCCATG
GCAGAGCTTTTGCGCGATACGGCCCTGGACGAAGAACAGCAGATGTATGCCGATACAATCCGCAGCTCCGGCGAGGCGCT
GTTGGTGATTATCAACGACATTCTGGACTTCTCCAAGATCGAAGCGGGCAAGCTGGAACTTCATGAGGAGACATTTGACC
TCAACGCCATGGTCGGCGAGATTTTCCGCCTGATCCAACCCGGGATTGCCTCCAAGGATCTGGAGCTGCGGCTGGACTAC
GACATCTTCCTGCCACCGCTTTTGATCGGCGATCGGGGTCGGATGCGCCAGATCCTGACCAACCTGATCGGCAACGCCGT
GAAGTTCACCGAGAAAGGACATGTGACGGTTCGGGTCTTGTCCGTGCCGCCGATGGATCAACCTGACGCACTCGGTATTT
CCATCGTCGTGGAAGACAGCGGTGTTGGTATCGCGCCCGACCAGCAGGAGCATGTGTTCGGAGAGTTCAATCAGGTGGAA
GATGAGGCTAACCGCCGCCACGATGGCACGGGTCTGGGTCTTGCGATCACCAAACGCCTGATCAGTTTGATGGGCGGGAA
GATGTGGCTTGAATCGGAGGTTGGGCGCGGTTCGGCCTTTGGGTTCACGATCAGTATGAAGGTGGATCCGGACTGCGGTT
CCGGCCCCGTGGCGGGCCTGCCTGCGGGACAATCCAGAGTGCTGTTGATTGGCCACGGGGAGGGTCGGTCCGAGCCCTTG
TTCGACGCTCTTGGTCGATTGCACGCGGAAACAACGCAGATCCGCCGGGTGCCAAACCCGCAGGATCTGGCAGAAACGGT
GGGTGTTATCCTGTGCGATCCGGCAATGGATGTTGCCGGGATTGCCGCTTCGTTGACAGAGGCGGACTTCAATGGTGCCC
GTTTGGCGTGGCTTGGACGGAGCGAATTGCCCGACGGATTTGAGGTTTGCGCGCTTGATCAGGGTCTTGCCGCGCTGCGT
GCGCAACTTCTGATGCCCGCGCCTGACACGCTGCATCCCGCTGAACTGGCCTCACCACCCCCACCTGAGCCTGAGGAAGA
GCCCGCCGCGCTGCCGCGCCTTCTGGCGGCGGAGGACAACAAGACCAATCAGATGGTGTTCAAGGCCATGCTCAAGGGGT
TGAGGCTGAACTTGGAGATCACCAACAACGGTCTGGAGTTGGTGGAGGCCTATAAGCGGGAGGTGCCGGATCTCGTGATG
ACCGATATCTCCATGCCTGAAATGGATGGGCTGGAAGCTGCCGCCAAGATCCGCGCCTATGAGGAGGAACAGGGTCTGCC
GCGGGTGACCATCATCGCCATGACAGCCCATGCCGTCGAAGGTGATCGAGAACGCATTCTGGCGGCGGGGTTGGACGATT
ATGTCACCAAACCGCTGAAAAAGGCTCTGATCCACGAAAAAATCGCGGACGGCCTGCCTTCAGATTCGTAA

Upstream 100 bases:

>100_bases
ATGATTCCCACACCGGGAAGCATGCGCAATGGAGGATTAACGCCATATTCACGGCCACGGGGCCAATCTGCCGCCACCGA
TTCCGACAGAGCTTGGCCCC

Downstream 100 bases:

>100_bases
CCCGCTGAGGGCGTCGGCAATACGGTAGTGGCCAGTCTCAATCCCGTTCCAGTTGCGGATCGGGCCGTGGGTGAAGGCCT
GCGCTTCGGGATGGTTCGGA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 716; Mature: 715

Protein sequence:

>716_residues
MAAINLNDRMAQERRARLQAEQLLALRSEELYSANRKLAEHATALSTQVIEQREENELLKGKTQKTEVELEVVTERALMA
QRRLWDALTATEDGFAIFDRDWRLVAANPAFFLIFDGISDVTEGATYEAILRVATEEGIVDLQGQNADDWVEEMVARWEK
VPIPNVDVKLWNGAYIRLNDKQTPQGDFVSLSVDITPNIRRERELSEARDAAEAANRAKSHFLANMSHEIRTPMNGVVSM
AELLRDTALDEEQQMYADTIRSSGEALLVIINDILDFSKIEAGKLELHEETFDLNAMVGEIFRLIQPGIASKDLELRLDY
DIFLPPLLIGDRGRMRQILTNLIGNAVKFTEKGHVTVRVLSVPPMDQPDALGISIVVEDSGVGIAPDQQEHVFGEFNQVE
DEANRRHDGTGLGLAITKRLISLMGGKMWLESEVGRGSAFGFTISMKVDPDCGSGPVAGLPAGQSRVLLIGHGEGRSEPL
FDALGRLHAETTQIRRVPNPQDLAETVGVILCDPAMDVAGIAASLTEADFNGARLAWLGRSELPDGFEVCALDQGLAALR
AQLLMPAPDTLHPAELASPPPPEPEEEPAALPRLLAAEDNKTNQMVFKAMLKGLRLNLEITNNGLELVEAYKREVPDLVM
TDISMPEMDGLEAAAKIRAYEEEQGLPRVTIIAMTAHAVEGDRERILAAGLDDYVTKPLKKALIHEKIADGLPSDS

Sequences:

>Translated_716_residues
MAAINLNDRMAQERRARLQAEQLLALRSEELYSANRKLAEHATALSTQVIEQREENELLKGKTQKTEVELEVVTERALMA
QRRLWDALTATEDGFAIFDRDWRLVAANPAFFLIFDGISDVTEGATYEAILRVATEEGIVDLQGQNADDWVEEMVARWEK
VPIPNVDVKLWNGAYIRLNDKQTPQGDFVSLSVDITPNIRRERELSEARDAAEAANRAKSHFLANMSHEIRTPMNGVVSM
AELLRDTALDEEQQMYADTIRSSGEALLVIINDILDFSKIEAGKLELHEETFDLNAMVGEIFRLIQPGIASKDLELRLDY
DIFLPPLLIGDRGRMRQILTNLIGNAVKFTEKGHVTVRVLSVPPMDQPDALGISIVVEDSGVGIAPDQQEHVFGEFNQVE
DEANRRHDGTGLGLAITKRLISLMGGKMWLESEVGRGSAFGFTISMKVDPDCGSGPVAGLPAGQSRVLLIGHGEGRSEPL
FDALGRLHAETTQIRRVPNPQDLAETVGVILCDPAMDVAGIAASLTEADFNGARLAWLGRSELPDGFEVCALDQGLAALR
AQLLMPAPDTLHPAELASPPPPEPEEEPAALPRLLAAEDNKTNQMVFKAMLKGLRLNLEITNNGLELVEAYKREVPDLVM
TDISMPEMDGLEAAAKIRAYEEEQGLPRVTIIAMTAHAVEGDRERILAAGLDDYVTKPLKKALIHEKIADGLPSDS
>Mature_715_residues
AAINLNDRMAQERRARLQAEQLLALRSEELYSANRKLAEHATALSTQVIEQREENELLKGKTQKTEVELEVVTERALMAQ
RRLWDALTATEDGFAIFDRDWRLVAANPAFFLIFDGISDVTEGATYEAILRVATEEGIVDLQGQNADDWVEEMVARWEKV
PIPNVDVKLWNGAYIRLNDKQTPQGDFVSLSVDITPNIRRERELSEARDAAEAANRAKSHFLANMSHEIRTPMNGVVSMA
ELLRDTALDEEQQMYADTIRSSGEALLVIINDILDFSKIEAGKLELHEETFDLNAMVGEIFRLIQPGIASKDLELRLDYD
IFLPPLLIGDRGRMRQILTNLIGNAVKFTEKGHVTVRVLSVPPMDQPDALGISIVVEDSGVGIAPDQQEHVFGEFNQVED
EANRRHDGTGLGLAITKRLISLMGGKMWLESEVGRGSAFGFTISMKVDPDCGSGPVAGLPAGQSRVLLIGHGEGRSEPLF
DALGRLHAETTQIRRVPNPQDLAETVGVILCDPAMDVAGIAASLTEADFNGARLAWLGRSELPDGFEVCALDQGLAALRA
QLLMPAPDTLHPAELASPPPPEPEEEPAALPRLLAAEDNKTNQMVFKAMLKGLRLNLEITNNGLELVEAYKREVPDLVMT
DISMPEMDGLEAAAKIRAYEEEQGLPRVTIIAMTAHAVEGDRERILAAGLDDYVTKPLKKALIHEKIADGLPSDS

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=517, Percent_Identity=34.4294003868472, Blast_Score=254, Evalue=2e-68,
Organism=Escherichia coli, GI145693157, Length=540, Percent_Identity=29.4444444444444, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=41.0569105691057, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=37.6518218623482, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=35.15625, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1786600, Length=258, Percent_Identity=30.6201550387597, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=27.8260869565217, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=27.3504273504274, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1788549, Length=266, Percent_Identity=25.187969924812, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=26.1044176706827, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1789808, Length=289, Percent_Identity=26.643598615917, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=27.3127753303965, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=25.296442687747, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=27.5, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=25.974025974026, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=83, Percent_Identity=48.1927710843374, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323034, Length=167, Percent_Identity=26.9461077844311, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78779; Mature: 78647

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAINLNDRMAQERRARLQAEQLLALRSEELYSANRKLAEHATALSTQVIEQREENELLK
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKTQKTEVELEVVTERALMAQRRLWDALTATEDGFAIFDRDWRLVAANPAFFLIFDGISD
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCEEEEEECCCHH
VTEGATYEAILRVATEEGIVDLQGQNADDWVEEMVARWEKVPIPNVDVKLWNGAYIRLND
HHCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEECC
KQTPQGDFVSLSVDITPNIRRERELSEARDAAEAANRAKSHFLANMSHEIRTPMNGVVSM
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHH
AELLRDTALDEEQQMYADTIRSSGEALLVIINDILDFSKIEAGKLELHEETFDLNAMVGE
HHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
IFRLIQPGIASKDLELRLDYDIFLPPLLIGDRGRMRQILTNLIGNAVKFTEKGHVTVRVL
HHHHHCCCCCCCCEEEEECCCEECCCEEECCCHHHHHHHHHHHCCCEEEECCCCEEEEEE
SVPPMDQPDALGISIVVEDSGVGIAPDQQEHVFGEFNQVEDEANRRHDGTGLGLAITKRL
ECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ISLMGGKMWLESEVGRGSAFGFTISMKVDPDCGSGPVAGLPAGQSRVLLIGHGEGRSEPL
HHHHCCCEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
FDALGRLHAETTQIRRVPNPQDLAETVGVILCDPAMDVAGIAASLTEADFNGARLAWLGR
HHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECC
SELPDGFEVCALDQGLAALRAQLLMPAPDTLHPAELASPPPPEPEEEPAALPRLLAAEDN
CCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHCCCC
KTNQMVFKAMLKGLRLNLEITNNGLELVEAYKREVPDLVMTDISMPEMDGLEAAAKIRAY
CHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCHHEECCCCCCCCCCHHHHHHHHHH
EEEQGLPRVTIIAMTAHAVEGDRERILAAGLDDYVTKPLKKALIHEKIADGLPSDS
HHHCCCCEEEEEEEEHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AAINLNDRMAQERRARLQAEQLLALRSEELYSANRKLAEHATALSTQVIEQREENELLK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKTQKTEVELEVVTERALMAQRRLWDALTATEDGFAIFDRDWRLVAANPAFFLIFDGISD
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCEEEEEECCCHH
VTEGATYEAILRVATEEGIVDLQGQNADDWVEEMVARWEKVPIPNVDVKLWNGAYIRLND
HHCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEECC
KQTPQGDFVSLSVDITPNIRRERELSEARDAAEAANRAKSHFLANMSHEIRTPMNGVVSM
CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHH
AELLRDTALDEEQQMYADTIRSSGEALLVIINDILDFSKIEAGKLELHEETFDLNAMVGE
HHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCEEEEHHHHHHHHHHHH
IFRLIQPGIASKDLELRLDYDIFLPPLLIGDRGRMRQILTNLIGNAVKFTEKGHVTVRVL
HHHHHCCCCCCCCEEEEECCCEECCCEEECCCHHHHHHHHHHHCCCEEEECCCCEEEEEE
SVPPMDQPDALGISIVVEDSGVGIAPDQQEHVFGEFNQVEDEANRRHDGTGLGLAITKRL
ECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ISLMGGKMWLESEVGRGSAFGFTISMKVDPDCGSGPVAGLPAGQSRVLLIGHGEGRSEPL
HHHHCCCEEEECCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
FDALGRLHAETTQIRRVPNPQDLAETVGVILCDPAMDVAGIAASLTEADFNGARLAWLGR
HHHHHHHHHHHHHHHCCCCHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECC
SELPDGFEVCALDQGLAALRAQLLMPAPDTLHPAELASPPPPEPEEEPAALPRLLAAEDN
CCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHCCCC
KTNQMVFKAMLKGLRLNLEITNNGLELVEAYKREVPDLVMTDISMPEMDGLEAAAKIRAY
CHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHCCHHEECCCCCCCCCCHHHHHHHHHH
EEEQGLPRVTIIAMTAHAVEGDRERILAAGLDDYVTKPLKKALIHEKIADGLPSDS
HHHCCCCEEEEEEEEHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]