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The map label for this gene is phbA [H]

Identifier: 89052753

GI number: 89052753

Start: 263930

End: 265105

Strand: Direct

Name: phbA [H]

Synonym: Jann_0262

Alternate gene names: 89052753

Gene position: 263930-265105 (Clockwise)

Preceding gene: 89052752

Following gene: 89052756

Centisome position: 6.11

GC content: 62.84

Gene sequence:

>1176_bases
ATGGACGATATCGTCATTCTGTCGGGCGCACGCACGGCCATTGGGACGTTTGGGGGCAGCCTTGCGGGCACGGCCCCGAT
CGAGACAGGCACAATCGTTGCGAAAGCAGCGTTGGAGCGTGCAGAGGTTGAGGGTGGTCAAATCGGCCACGTCGTCTTCG
GTCACGTCATCAACACCGAACCCCGCGATATGTACCTGAGCCGTGTGGCGGCGATGCAGGCGGGCGTACCCGAGACGGTG
CCTGCGATGAATGTGAACCGCCTTTGCGGATCCGGCGCACAGGCGATTGTGTCGGTCATTCAATCGCTCGCCATGGGCGA
TGCGGATTTCGGGTTGGCAGGCGGTGCGGAAAGCATGTCGCGCTCCCCTTATATCTCCTCGGCGACCCGGTTCGGGCAGA
AGATGGGCGATGTGAAGACGCTCGACATGATGCTTGGGGCGCTGAACTGTCCGTTCGGCACTGGGCACATGGGTGTCACG
GCAGAGAATGTCGCGGTTGAGCATGACGTGACGCGCGCGCAGATGGATGCCTTTGCCATGGCGTCTCAGGAACGGGCCGC
CCACGCGATTGAGCAAGGGTACTTTGCCGAGCAGATCGTGCCCGTCGACGTCCGCGTGAAGCGCGACATGATGCCGTTTG
AGGTGGACGAACATCCCAAGGCAACGTCCGTCGACGCGCTGGGCGGGCTGCGGGCCGTGTTCAAGAAAGACGGCCGTGTC
ACGGCTGGCAATGCGTCGGGCATCAACGACGGGGCTGCGGCGCTGGTTCTGGCGCGCGCTGATGCGGCAGAGGCCGCCGG
TCTGCCCCCCCGCGCCCGTATTTTGGGCTATGCCCACGCTGGTGTACGGCCTGAGGTCATGGGGATCGGTCCGGTTCCCG
CTGTAGAAAATTTGCTGTCGAAGACGGGGCTTTCGGTAAGAGATTTTGATGTGATCGAATCCAATGAGGCCTTTGCCGCA
CAGGCCCTGGCGGTGAACAAAGGCCTGGGGTTGGATAGCGCGAAGGTGAATCCGAACGGCGGCGCGATTGCTTTGGGCCA
CCCCGTCGGCGCCACGGGCGCGATCATCACTGTAAAAGCGCTTTACGAGCTGGAGCGGACTGGCGGCAAGCGCGCGCTGA
TCACGATGTGTATTGGCGGGGGACAGGGGATCGCCTTGGCGATTGAGCGGCTCTAA

Upstream 100 bases:

>100_bases
GAAGCCGCTTCAGTTCGCCGCCGCGTAACGCCGCGTTGCCATAGCTTTGTGGCGTCTAAGCTGCTCTAACCCTCCGTGAG
ACATTGCGGAGGGTTATTTC

Downstream 100 bases:

>100_bases
CACGCAGGTTAGAGCCTAGTTTGAGACCTCTACAGCGCGACTTTCCGCCAGGCCTGTTGCGTCGATGACGGTGAGTTCCC
CGAACCCTAAATCCGCCTCA

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDDIVILSGARTAIGTFGGSLAGTAPIETGTIVAKAALERAEVEGGQIGHVVFGHVINTEPRDMYLSRVAAMQAGVPETV
PAMNVNRLCGSGAQAIVSVIQSLAMGDADFGLAGGAESMSRSPYISSATRFGQKMGDVKTLDMMLGALNCPFGTGHMGVT
AENVAVEHDVTRAQMDAFAMASQERAAHAIEQGYFAEQIVPVDVRVKRDMMPFEVDEHPKATSVDALGGLRAVFKKDGRV
TAGNASGINDGAAALVLARADAAEAAGLPPRARILGYAHAGVRPEVMGIGPVPAVENLLSKTGLSVRDFDVIESNEAFAA
QALAVNKGLGLDSAKVNPNGGAIALGHPVGATGAIITVKALYELERTGGKRALITMCIGGGQGIALAIERL

Sequences:

>Translated_391_residues
MDDIVILSGARTAIGTFGGSLAGTAPIETGTIVAKAALERAEVEGGQIGHVVFGHVINTEPRDMYLSRVAAMQAGVPETV
PAMNVNRLCGSGAQAIVSVIQSLAMGDADFGLAGGAESMSRSPYISSATRFGQKMGDVKTLDMMLGALNCPFGTGHMGVT
AENVAVEHDVTRAQMDAFAMASQERAAHAIEQGYFAEQIVPVDVRVKRDMMPFEVDEHPKATSVDALGGLRAVFKKDGRV
TAGNASGINDGAAALVLARADAAEAAGLPPRARILGYAHAGVRPEVMGIGPVPAVENLLSKTGLSVRDFDVIESNEAFAA
QALAVNKGLGLDSAKVNPNGGAIALGHPVGATGAIITVKALYELERTGGKRALITMCIGGGQGIALAIERL
>Mature_391_residues
MDDIVILSGARTAIGTFGGSLAGTAPIETGTIVAKAALERAEVEGGQIGHVVFGHVINTEPRDMYLSRVAAMQAGVPETV
PAMNVNRLCGSGAQAIVSVIQSLAMGDADFGLAGGAESMSRSPYISSATRFGQKMGDVKTLDMMLGALNCPFGTGHMGVT
AENVAVEHDVTRAQMDAFAMASQERAAHAIEQGYFAEQIVPVDVRVKRDMMPFEVDEHPKATSVDALGGLRAVFKKDGRV
TAGNASGINDGAAALVLARADAAEAAGLPPRARILGYAHAGVRPEVMGIGPVPAVENLLSKTGLSVRDFDVIESNEAFAA
QALAVNKGLGLDSAKVNPNGGAIALGHPVGATGAIITVKALYELERTGGKRALITMCIGGGQGIALAIERL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=43.8144329896907, Blast_Score=334, Evalue=9e-92,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=43.2569974554707, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=40.3022670025189, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=38.3458646616541, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=29.0780141843972, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=30.6122448979592, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=50, Blast_Score=343, Evalue=8e-96,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=42.8571428571429, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=43.8118811881188, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=38.8613861386139, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=31.5533980582524, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=44.4730077120823, Blast_Score=343, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=34.8837209302326, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=35.6234096692112, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=30.1176470588235, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=27.8061224489796, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=37.1212121212121, Blast_Score=225, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=36.1596009975062, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=45.8015267175573, Blast_Score=338, Evalue=5e-93,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=44.7300771208226, Blast_Score=318, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=37.3737373737374, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17137578, Length=433, Percent_Identity=30.715935334873, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40168; Mature: 40168

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDIVILSGARTAIGTFGGSLAGTAPIETGTIVAKAALERAEVEGGQIGHVVFGHVINTE
CCCEEEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
PRDMYLSRVAAMQAGVPETVPAMNVNRLCGSGAQAIVSVIQSLAMGDADFGLAGGAESMS
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHC
RSPYISSATRFGQKMGDVKTLDMMLGALNCPFGTGHMGVTAENVAVEHDVTRAQMDAFAM
CCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEECCEEEHHHHHHHHHHHHHH
ASQERAAHAIEQGYFAEQIVPVDVRVKRDMMPFEVDEHPKATSVDALGGLRAVFKKDGRV
HHHHHHHHHHHHCCHHHEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
TAGNASGINDGAAALVLARADAAEAAGLPPRARILGYAHAGVRPEVMGIGPVPAVENLLS
EECCCCCCCCCCEEEEEEECCHHHHCCCCCHHHEEEEECCCCCCEEEECCCCHHHHHHHH
KTGLSVRDFDVIESNEAFAAQALAVNKGLGLDSAKVNPNGGAIALGHPVGATGAIITVKA
HCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCCCCCCCEEEHHH
LYELERTGGKRALITMCIGGGQGIALAIERL
HHHHHHCCCCEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MDDIVILSGARTAIGTFGGSLAGTAPIETGTIVAKAALERAEVEGGQIGHVVFGHVINTE
CCCEEEECCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
PRDMYLSRVAAMQAGVPETVPAMNVNRLCGSGAQAIVSVIQSLAMGDADFGLAGGAESMS
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHC
RSPYISSATRFGQKMGDVKTLDMMLGALNCPFGTGHMGVTAENVAVEHDVTRAQMDAFAM
CCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEECCEEEHHHHHHHHHHHHHH
ASQERAAHAIEQGYFAEQIVPVDVRVKRDMMPFEVDEHPKATSVDALGGLRAVFKKDGRV
HHHHHHHHHHHHCCHHHEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCE
TAGNASGINDGAAALVLARADAAEAAGLPPRARILGYAHAGVRPEVMGIGPVPAVENLLS
EECCCCCCCCCCEEEEEEECCHHHHCCCCCHHHEEEEECCCCCCEEEECCCCHHHHHHHH
KTGLSVRDFDVIESNEAFAAQALAVNKGLGLDSAKVNPNGGAIALGHPVGATGAIITVKA
HCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCEECCCCCEEEECCCCCCCCCEEEHHH
LYELERTGGKRALITMCIGGGQGIALAIERL
HHHHHHCCCCEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]