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The map label for this gene is serA [H]

Identifier: 89052752

GI number: 89052752

Start: 262262

End: 263857

Strand: Direct

Name: serA [H]

Synonym: Jann_0261

Alternate gene names: 89052752

Gene position: 262262-263857 (Clockwise)

Preceding gene: 89052751

Following gene: 89052753

Centisome position: 6.07

GC content: 59.46

Gene sequence:

>1596_bases
ATGGCCCCCAAAGTTCTCGTCTCCGACAAACTCTCGGAAACCGCCGTTCAGATCTTTCGCGATCGCGGCATTGACGTCAC
CTTCGACCCGACGATTGGCAAGGATAAGGAAAAACTCCTGTCCGTGATCGATCAATATGACGGCCTCGCCATTCGCTCCG
CCACAAAGGTGACGGAGAAGATTATCGCCGCAGCCACGAACCTCAAGGTCGTGGGTCGTGCCGGGATCGGGGTCGACAAC
GTCGATATCCCCGCCGCGTCCAAGAAGGGCATCATCGTGATGAACACGCCTTTCGGCAACTCCATCACCACGGCGGAGCA
CGCTATCGCGATGATGTTCGCGGTTGCCCGTCAGATCCCGGAGGCGAGCACGTCGACCCATGATGGCAAGTGGGAGAAGT
CGAAATTCATGGGGGTGGAGCTGACGGCCAAGACCCTCGGTGTGATCGGTGCGGGTAACATTGGGTCCATCGTGATCTCC
CGCGCCTTGGGGCTGAAGATGAAAGTGATCGCCTATGATCCGTTCCTGTCGGAAGAACGTGCAAAGGAAATCGGCTGCCA
GAAGGTCGAACTCGATGAGCTGCTGAAGCGCGCGGATTTCATCACCATGCATGTGCCGTTCACGGAGAAGACGGCGAATA
TCCTGTCCGCGGAAAACCTCGCCAAAACCAAGAAGGGTGTGCGGATCGTGAACTGCGCGCGCGGCGGTCTGGTGGATGAA
GCGGCCCTTGCGGAGCTGCTGAAATCCGGCCACGTCGCCGGGGCTGCCTTCGACGTCTTCGCGCAGGAACCCGCGACCGA
GAACCCGCTGTTCCATCTGCCCAATGTCGTCGTGACGCCTCATCTGGGGGCTGCCACGACGGAAGCGCAGGAAAACGTCG
CCCTGCAAGTGGCCGAACAGATGTCGGATTTTCTGCTATCCGGTGCCGTGTCCAACGCGCTCAACATGCCGTCTGTCACC
GCAGAGGAAGCGGCGATCATGGGCCCGTGGGTCAAACTGGCCGAGCATCTGGGCGCCTTCGTCGGGCAGCTCACTGAAGA
GCCGATCCAAAGCATCGACGTGGTCTACAATGGTGTGGTTACCGGCATGAACCTAAAGGCGCTGGATTGCGCCGCGATTG
CCGGTGTGATGAAGGCGACAAATCCGGACGTAAATATGGTCTCCGCCCCCGTGATCGCCAAAGAACGCGGCATCGACCTG
TCCCAGACGACGCAAGACAAGACGGGCGTGTTCGATGGCTACATCCGCTTGGTGGTGAAGACCGACAAGCGCGAACGGTC
GATTGCGGGCACTGTCTTCAGCGACGGCAAGCCGCGGTTCATCCAGATCAAGGGCATCAACATCGATGCCGAGATCGGGG
AGCATATGCTCTACACCACGAACCACGACATTCCCGGCATTATCGGCACATTGGGCCAGACGATGGGTGAAAACGGCGTG
AATATCGCTAACTTTACCCTCGGTCGATCTGGGCGTGACGGGGAAGCGATCGCGCTGCTCTACCTTGACGAACAGCCGCC
CGCTGACGTCTTGGGCAAGCTGATGGAGACGGGGTTGTTCGAATCCGTGAAGCCGCTTCAGTTCGCCGCCGCGTAA

Upstream 100 bases:

>100_bases
AGCGCAGGCCTAACCACCTGCTCCCCTCTTCATCTTGGTCATTACAACTCAATCCCACGGCAGGCCTAATGCGCCGCCGA
CTACCAAAGGAGCGCCAAAC

Downstream 100 bases:

>100_bases
CGCCGCGTTGCCATAGCTTTGTGGCGTCTAAGCTGCTCTAACCCTCCGTGAGACATTGCGGAGGGTTATTTCATGGACGA
TATCGTCATTCTGTCGGGCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAPKVLVSDKLSETAVQIFRDRGIDVTFDPTIGKDKEKLLSVIDQYDGLAIRSATKVTEKIIAAATNLKVVGRAGIGVDN
VDIPAASKKGIIVMNTPFGNSITTAEHAIAMMFAVARQIPEASTSTHDGKWEKSKFMGVELTAKTLGVIGAGNIGSIVIS
RALGLKMKVIAYDPFLSEERAKEIGCQKVELDELLKRADFITMHVPFTEKTANILSAENLAKTKKGVRIVNCARGGLVDE
AALAELLKSGHVAGAAFDVFAQEPATENPLFHLPNVVVTPHLGAATTEAQENVALQVAEQMSDFLLSGAVSNALNMPSVT
AEEAAIMGPWVKLAEHLGAFVGQLTEEPIQSIDVVYNGVVTGMNLKALDCAAIAGVMKATNPDVNMVSAPVIAKERGIDL
SQTTQDKTGVFDGYIRLVVKTDKRERSIAGTVFSDGKPRFIQIKGINIDAEIGEHMLYTTNHDIPGIIGTLGQTMGENGV
NIANFTLGRSGRDGEAIALLYLDEQPPADVLGKLMETGLFESVKPLQFAAA

Sequences:

>Translated_531_residues
MAPKVLVSDKLSETAVQIFRDRGIDVTFDPTIGKDKEKLLSVIDQYDGLAIRSATKVTEKIIAAATNLKVVGRAGIGVDN
VDIPAASKKGIIVMNTPFGNSITTAEHAIAMMFAVARQIPEASTSTHDGKWEKSKFMGVELTAKTLGVIGAGNIGSIVIS
RALGLKMKVIAYDPFLSEERAKEIGCQKVELDELLKRADFITMHVPFTEKTANILSAENLAKTKKGVRIVNCARGGLVDE
AALAELLKSGHVAGAAFDVFAQEPATENPLFHLPNVVVTPHLGAATTEAQENVALQVAEQMSDFLLSGAVSNALNMPSVT
AEEAAIMGPWVKLAEHLGAFVGQLTEEPIQSIDVVYNGVVTGMNLKALDCAAIAGVMKATNPDVNMVSAPVIAKERGIDL
SQTTQDKTGVFDGYIRLVVKTDKRERSIAGTVFSDGKPRFIQIKGINIDAEIGEHMLYTTNHDIPGIIGTLGQTMGENGV
NIANFTLGRSGRDGEAIALLYLDEQPPADVLGKLMETGLFESVKPLQFAAA
>Mature_530_residues
APKVLVSDKLSETAVQIFRDRGIDVTFDPTIGKDKEKLLSVIDQYDGLAIRSATKVTEKIIAAATNLKVVGRAGIGVDNV
DIPAASKKGIIVMNTPFGNSITTAEHAIAMMFAVARQIPEASTSTHDGKWEKSKFMGVELTAKTLGVIGAGNIGSIVISR
ALGLKMKVIAYDPFLSEERAKEIGCQKVELDELLKRADFITMHVPFTEKTANILSAENLAKTKKGVRIVNCARGGLVDEA
ALAELLKSGHVAGAAFDVFAQEPATENPLFHLPNVVVTPHLGAATTEAQENVALQVAEQMSDFLLSGAVSNALNMPSVTA
EEAAIMGPWVKLAEHLGAFVGQLTEEPIQSIDVVYNGVVTGMNLKALDCAAIAGVMKATNPDVNMVSAPVIAKERGIDLS
QTTQDKTGVFDGYIRLVVKTDKRERSIAGTVFSDGKPRFIQIKGINIDAEIGEHMLYTTNHDIPGIIGTLGQTMGENGVN
IANFTLGRSGRDGEAIALLYLDEQPPADVLGKLMETGLFESVKPLQFAAA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=402, Percent_Identity=43.0348258706468, Blast_Score=332, Evalue=7e-91,
Organism=Homo sapiens, GI61743967, Length=317, Percent_Identity=30.5993690851735, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4557497, Length=317, Percent_Identity=30.5993690851735, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI145580578, Length=306, Percent_Identity=30.718954248366, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4557499, Length=306, Percent_Identity=30.718954248366, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=34.5528455284553, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI6912396, Length=265, Percent_Identity=31.6981132075472, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=35.9133126934984, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=28.125, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=30.2788844621514, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI87081824, Length=263, Percent_Identity=27.3764258555133, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=28.8973384030418, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=45.6953642384106, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI25147481, Length=250, Percent_Identity=32.8, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=36.3363363363363, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6320925, Length=333, Percent_Identity=35.7357357357357, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=28.3088235294118, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=26.5454545454545, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=115, Percent_Identity=35.6521739130435, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=45.0331125827815, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=32.2314049586777, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585516, Length=304, Percent_Identity=26.9736842105263, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=32.258064516129, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=32.258064516129, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=32.258064516129, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=32.258064516129, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=32.258064516129, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28571528, Length=290, Percent_Identity=30, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574284, Length=242, Percent_Identity=29.7520661157025, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24585514, Length=242, Percent_Identity=29.7520661157025, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28574282, Length=242, Percent_Identity=29.7520661157025, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45551003, Length=242, Percent_Identity=29.7520661157025, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45552429, Length=242, Percent_Identity=29.7520661157025, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56533; Mature: 56402

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKVLVSDKLSETAVQIFRDRGIDVTFDPTIGKDKEKLLSVIDQYDGLAIRSATKVTEK
CCCCEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHH
IIAAATNLKVVGRAGIGVDNVDIPAASKKGIIVMNTPFGNSITTAEHAIAMMFAVARQIP
HHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EASTSTHDGKWEKSKFMGVELTAKTLGVIGAGNIGSIVISRALGLKMKVIAYDPFLSEER
CCCCCCCCCCCCHHHEEEEEEEHHHHCEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHH
AKEIGCQKVELDELLKRADFITMHVPFTEKTANILSAENLAKTKKGVRIVNCARGGLVDE
HHHHCCCEECHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCH
AALAELLKSGHVAGAAFDVFAQEPATENPLFHLPNVVVTPHLGAATTEAQENVALQVAEQ
HHHHHHHHCCCCCCEEHHHHHCCCCCCCCCEECCCEEEECCCCCCCCHHHHHHHHHHHHH
MSDFLLSGAVSNALNMPSVTAEEAAIMGPWVKLAEHLGAFVGQLTEEPIQSIDVVYNGVV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
TGMNLKALDCAAIAGVMKATNPDVNMVSAPVIAKERGIDLSQTTQDKTGVFDGYIRLVVK
ECCCCCHHHHHHHHHHHHCCCCCCCEEECCEEHHHCCCCCCCCCCCCCCCCCEEEEEEEE
TDKRERSIAGTVFSDGKPRFIQIKGINIDAEIGEHMLYTTNHDIPGIIGTLGQTMGENGV
CCCCCCCEEEEEECCCCCCEEEEEECEEEHHHCCEEEEECCCCCCHHHHHHHHHHCCCCC
NIANFTLGRSGRDGEAIALLYLDEQPPADVLGKLMETGLFESVKPLQFAAA
EEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
APKVLVSDKLSETAVQIFRDRGIDVTFDPTIGKDKEKLLSVIDQYDGLAIRSATKVTEK
CCCEEHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHH
IIAAATNLKVVGRAGIGVDNVDIPAASKKGIIVMNTPFGNSITTAEHAIAMMFAVARQIP
HHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
EASTSTHDGKWEKSKFMGVELTAKTLGVIGAGNIGSIVISRALGLKMKVIAYDPFLSEER
CCCCCCCCCCCCHHHEEEEEEEHHHHCEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHH
AKEIGCQKVELDELLKRADFITMHVPFTEKTANILSAENLAKTKKGVRIVNCARGGLVDE
HHHHCCCEECHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCH
AALAELLKSGHVAGAAFDVFAQEPATENPLFHLPNVVVTPHLGAATTEAQENVALQVAEQ
HHHHHHHHCCCCCCEEHHHHHCCCCCCCCCEECCCEEEECCCCCCCCHHHHHHHHHHHHH
MSDFLLSGAVSNALNMPSVTAEEAAIMGPWVKLAEHLGAFVGQLTEEPIQSIDVVYNGVV
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEE
TGMNLKALDCAAIAGVMKATNPDVNMVSAPVIAKERGIDLSQTTQDKTGVFDGYIRLVVK
ECCCCCHHHHHHHHHHHHCCCCCCCEEECCEEHHHCCCCCCCCCCCCCCCCCEEEEEEEE
TDKRERSIAGTVFSDGKPRFIQIKGINIDAEIGEHMLYTTNHDIPGIIGTLGQTMGENGV
CCCCCCCEEEEEECCCCCCEEEEEECEEEHHHCCEEEEECCCCCCHHHHHHHHHHCCCCC
NIANFTLGRSGRDGEAIALLYLDEQPPADVLGKLMETGLFESVKPLQFAAA
EEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]