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The map label for this gene is mltA [H]

Identifier: 89052681

GI number: 89052681

Start: 182851

End: 183867

Strand: Reverse

Name: mltA [H]

Synonym: Jann_0190

Alternate gene names: 89052681

Gene position: 183867-182851 (Counterclockwise)

Preceding gene: 89052682

Following gene: 89052680

Centisome position: 4.26

GC content: 59.59

Gene sequence:

>1017_bases
ATGGGACGGCTTGCGGTTGTCTTTGCCCTATTGATGACGGCGAGTGTCGCTGTGGCCGATGAGCCCGTGCAACTTCTTGG
ATTTGATGATCTGGACGGATGGGCTGCGGATGATCACTCCGCGGCCCTTTCCGTGTTTCGGAACACCTGTATGGATCTTG
ATGGGTCGGACTGGGCGGCGCTGTGCGAAGTGGCAGACACGGCGCGGGACGCCCGCACCTTCTTTGAGCTGTTCTTTCAG
CCCGTCCTCATTGGTGGCGAAAACCCGGCCTTGTTTACGGGGTATTACGAGCCCGAACTGACCGGTTCGCGCACGCGCAC
CAGCCGATATCGCTTCCCTGTCTATCGGATGCCTCCGGAAGTGTCTGGCCGCTGGCTGTCTCGCGAAGAGATCGAGGAAA
CACGGGTGTTGGAAGGCCGCGGACTGGAGATTGCTTGGGTTGATGACCCGGTTGAGTTGTTTTTCCTGCAAATTCAAGGC
TCTGGTCGGATCAGAATGATGGATGGCAGTTTCATCCGCGTCGGGTATGGCGGGCGGAATGGGCACGAATACCGATCCGT
TGGGCAGGAGCTTGTGCGGCGCGGTGTGTATCATGCCCATCAGGTCTCTGCGCAGGTCATTCAGTCCTGGGTGCGCCGAA
ATCCGTCTGCCGGGCGGGATCTTCTGCACCACAATCCCAGCTATGTGTTCTTCCGCGAGGTTGAGATCACAGATCCCGAT
CTCGGGCCGCTTGGCGCGATGAACCGAAACATCACGCCCCACCGCACCATCGCTGTCGATCCGGACCACACACCTCTTGG
CGCGCCTGTTTGGATTGAGAAAGATGGAAACGGCCCGATACGACGCCTGATGATTGCCCAAGACACGGGTGGCGCGATTC
AAGGCGCACAGCGTGCTGATATCTTCTTTGGGTTTGGCGACGATGCGGGCGAGGCTGCCGGCGTCATCCGGGATCCTGGC
CGTATGATCGTGCTGCTTCCGATCGAGCGGGCGCACCAACTTATCCCGGACGCATGA

Upstream 100 bases:

>100_bases
CGCAACAGAGATCAAACGCCAACGCGATGTCTGGACCTTTGCCCGTAAAATGGGCGCCGATGATCCGAACTGGGCCCTGG
TGGCAACCGACGGATGATCC

Downstream 100 bases:

>100_bases
TCCATGGCGCGGCGTGGCAAACGGGGTCTGTCGGCGGACGACAAGGCGATTTGGGAGAAGGTTGCGGCGACGGCGACGCC
CATGGATCGCTCTGGCGTAC

Product: MltA

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MGRLAVVFALLMTASVAVADEPVQLLGFDDLDGWAADDHSAALSVFRNTCMDLDGSDWAALCEVADTARDARTFFELFFQ
PVLIGGENPALFTGYYEPELTGSRTRTSRYRFPVYRMPPEVSGRWLSREEIEETRVLEGRGLEIAWVDDPVELFFLQIQG
SGRIRMMDGSFIRVGYGGRNGHEYRSVGQELVRRGVYHAHQVSAQVIQSWVRRNPSAGRDLLHHNPSYVFFREVEITDPD
LGPLGAMNRNITPHRTIAVDPDHTPLGAPVWIEKDGNGPIRRLMIAQDTGGAIQGAQRADIFFGFGDDAGEAAGVIRDPG
RMIVLLPIERAHQLIPDA

Sequences:

>Translated_338_residues
MGRLAVVFALLMTASVAVADEPVQLLGFDDLDGWAADDHSAALSVFRNTCMDLDGSDWAALCEVADTARDARTFFELFFQ
PVLIGGENPALFTGYYEPELTGSRTRTSRYRFPVYRMPPEVSGRWLSREEIEETRVLEGRGLEIAWVDDPVELFFLQIQG
SGRIRMMDGSFIRVGYGGRNGHEYRSVGQELVRRGVYHAHQVSAQVIQSWVRRNPSAGRDLLHHNPSYVFFREVEITDPD
LGPLGAMNRNITPHRTIAVDPDHTPLGAPVWIEKDGNGPIRRLMIAQDTGGAIQGAQRADIFFGFGDDAGEAAGVIRDPG
RMIVLLPIERAHQLIPDA
>Mature_337_residues
GRLAVVFALLMTASVAVADEPVQLLGFDDLDGWAADDHSAALSVFRNTCMDLDGSDWAALCEVADTARDARTFFELFFQP
VLIGGENPALFTGYYEPELTGSRTRTSRYRFPVYRMPPEVSGRWLSREEIEETRVLEGRGLEIAWVDDPVELFFLQIQGS
GRIRMMDGSFIRVGYGGRNGHEYRSVGQELVRRGVYHAHQVSAQVIQSWVRRNPSAGRDLLHHNPSYVFFREVEITDPDL
GPLGAMNRNITPHRTIAVDPDHTPLGAPVWIEKDGNGPIRRLMIAQDTGGAIQGAQRADIFFGFGDDAGEAAGVIRDPGR
MIVLLPIERAHQLIPDA

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=245, Percent_Identity=37.1428571428571, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 37548; Mature: 37417

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLAVVFALLMTASVAVADEPVQLLGFDDLDGWAADDHSAALSVFRNTCMDLDGSDWAA
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
LCEVADTARDARTFFELFFQPVLIGGENPALFTGYYEPELTGSRTRTSRYRFPVYRMPPE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCEEECCEEECCCC
VSGRWLSREEIEETRVLEGRGLEIAWVDDPVELFFLQIQGSGRIRMMDGSFIRVGYGGRN
CCCCCCCHHHHHHHHEECCCCCEEEEECCCEEEEEEEEECCCEEEEECCCEEEEECCCCC
GHEYRSVGQELVRRGVYHAHQVSAQVIQSWVRRNPSAGRDLLHHNPSYVFFREVEITDPD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEEECCCC
LGPLGAMNRNITPHRTIAVDPDHTPLGAPVWIEKDGNGPIRRLMIAQDTGGAIQGAQRAD
CCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCEEE
IFFGFGDDAGEAAGVIRDPGRMIVLLPIERAHQLIPDA
EEEEECCCCCCCCCEEECCCCEEEEEECHHHHHHCCCC
>Mature Secondary Structure 
GRLAVVFALLMTASVAVADEPVQLLGFDDLDGWAADDHSAALSVFRNTCMDLDGSDWAA
CHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHH
LCEVADTARDARTFFELFFQPVLIGGENPALFTGYYEPELTGSRTRTSRYRFPVYRMPPE
HHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCCCCCCCEEECCEEECCCC
VSGRWLSREEIEETRVLEGRGLEIAWVDDPVELFFLQIQGSGRIRMMDGSFIRVGYGGRN
CCCCCCCHHHHHHHHEECCCCCEEEEECCCEEEEEEEEECCCEEEEECCCEEEEECCCCC
GHEYRSVGQELVRRGVYHAHQVSAQVIQSWVRRNPSAGRDLLHHNPSYVFFREVEITDPD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEEEEECCCC
LGPLGAMNRNITPHRTIAVDPDHTPLGAPVWIEKDGNGPIRRLMIAQDTGGAIQGAQRAD
CCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCCEEE
IFFGFGDDAGEAAGVIRDPGRMIVLLPIERAHQLIPDA
EEEEECCCCCCCCCEEECCCCEEEEEECHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]