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The map label for this gene is ilvD [H]

Identifier: 89052553

GI number: 89052553

Start: 57092

End: 58855

Strand: Direct

Name: ilvD [H]

Synonym: Jann_0062

Alternate gene names: 89052553

Gene position: 57092-58855 (Clockwise)

Preceding gene: 89052547

Following gene: 89052554

Centisome position: 1.32

GC content: 62.87

Gene sequence:

>1764_bases
ATGACCGCCAACAGGCCAGACAAATCCAGATTGCCCAGTCGCCATGTGACCGAAGGACCCGAGCGCGCGCCGCATCGGTC
GTATTTCTACGCCATGGACCTGACACAGGAGCAGATCGACCAGCCATTCGTCGGCGTCGCCACCTGCTGGAACGAAGCGG
CCCCTTGCAACATCGCGCTCAACTGGCAGGCGCAATCGGTGAAACGCGGTGTGGGTGAGGCGAACGGTACGCCGAGGGAA
TTCACCACGATCACCGTCACCGACGGCATTGCGATGGGGCATGAAGGGATGCGGTCCTCGCTGGCGTCGCGCGATGCGAT
CACCGACACGGTGGAACTGACGATGCGCGGCCACTGCTATGACGCATTGGTCGGGCTTGCCGGGTGCGACAAGTCCCTGC
CCGGCATGATGATGGCCATGGTGCGCCTGAACGTGCCGTCCGTCTTCATCTATGGCGGCACGATCCTTCCCGGCAAAGCG
CCTGAAGTTGCCGACATTCCCGCCGAGTTTGCCAACCGTGACCTGACCGTGCAGGACATGTTCGAGGCCGTGGGCAAGTA
CCAGTCCGGCCAATTGAGCGAAGCCGCCCTGGAAGTTCTGGAACGCGTTGCCTGCCCGTCTGCGGGCGCCTGTGGCGGTC
AGTTCACCGCCAACACCATGGCATGTGTGTCCGAGGCGATTGGTCTGGCAATGCTCAACTCCTCCGGGATGCCTGCGCCT
TACGAGGGGCGGAAGGAATTCGGCGAGGCAAGCGGTCGCGCGGTGATGAACCTGCTTGAAAAGAACATCCGCGCCCGTGA
CGTCGTCACCCGCAAAGCGTTGGAGAATGCGGCCCGTGTTGTGGCGTGTACCGGGGGCTCCACCAATGCAGGTCTGCACC
TTCCCGCGATTGCCCATGAGGCCGGAATCGACTTCGACCTCTTTGACGTCTGCGACATCTTCAAGGACACGCCCTACTTC
GTCGACATGAAACCCGGCGGTCAGTATGTGGCGAAAGACCTCTATGAGGTGGGCGGCGTGCCAGTCGTGATGAAGGAGCT
GTTGAAAGAGGGGCTGTTGCACGGCGATTGCCTCACTGCCTCTGGCGAGACGATGGAAGAGGCGCTCGACAAGATCCAGG
GCACGCCCGATGGCCGTGTGGTCCATACGGTCCAGAACCCGATCACCAGCACCGGCGGCGTGGTCGGCCTGCGCGGCAAT
CTCGCCGAAGAGGGTGCGATCGTGAAAGTTGCGGGCATGGATGAGGCAAGCCAGGTCTTCACCGGACCCGCGCGCGTGTT
TGAATGCGAAGAAGACGCCTTTGCCGCCGTGAAGGCGCGCGGCTACGAGGAAGGCGAAGTCATTGTCATCCGCAATGAAG
GGCCAAAGGGCGGCCCGGGCATGCGGGAAATGTTGGCGACGACGGCGGCATTGTCGGGTCAGGGCATGGGCAAGAAGGTG
GCCCTGATCACCGACGGCCGGTTCTCTGGTGCAACGCGGGGCTTCTGCGTCGGTCACGTGGGACCTGAGGCGGCTGTTGG
CGGACCGATTGGTCTGCTGGAGAACAGCGACATGATCACCATCAATGCGCTGACGGGGGAACTGTCGGTTGCCTTGACCG
AGGCGGAATTGGCCGAGCGTCGGAAGGCCTGGGCCGGTCCGCGTGAGACAATGTACGCCTCTGGCGCGTTGTGGAAATAC
GCGCAATTGGTGGGAGAGGCGCGCTATGGCGCGGTGACCCATCCCGGCGGGGCCAAGGAAAAGCACGTCTATGCGGACAT
CTAG

Upstream 100 bases:

>100_bases
TTGGAGCGCGGTGCGCGGATCTCTCGAATGGCCGTCTCTCTTGCCCCTTCTGACGGGGCGCACTATCCCCAGACAAAGCC
AAGTTTCAGGGAGACGCGCC

Downstream 100 bases:

>100_bases
GCGGCTTCGCCGCGGGGCGCTGCTCCTCGGGCCTGCGGCCCTCCTCGCGGCGTGCGTGGGGCTCGGGGGCGGAGACGACG
CGCCCCGTGAGGTGCAGGTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MTANRPDKSRLPSRHVTEGPERAPHRSYFYAMDLTQEQIDQPFVGVATCWNEAAPCNIALNWQAQSVKRGVGEANGTPRE
FTTITVTDGIAMGHEGMRSSLASRDAITDTVELTMRGHCYDALVGLAGCDKSLPGMMMAMVRLNVPSVFIYGGTILPGKA
PEVADIPAEFANRDLTVQDMFEAVGKYQSGQLSEAALEVLERVACPSAGACGGQFTANTMACVSEAIGLAMLNSSGMPAP
YEGRKEFGEASGRAVMNLLEKNIRARDVVTRKALENAARVVACTGGSTNAGLHLPAIAHEAGIDFDLFDVCDIFKDTPYF
VDMKPGGQYVAKDLYEVGGVPVVMKELLKEGLLHGDCLTASGETMEEALDKIQGTPDGRVVHTVQNPITSTGGVVGLRGN
LAEEGAIVKVAGMDEASQVFTGPARVFECEEDAFAAVKARGYEEGEVIVIRNEGPKGGPGMREMLATTAALSGQGMGKKV
ALITDGRFSGATRGFCVGHVGPEAAVGGPIGLLENSDMITINALTGELSVALTEAELAERRKAWAGPRETMYASGALWKY
AQLVGEARYGAVTHPGGAKEKHVYADI

Sequences:

>Translated_587_residues
MTANRPDKSRLPSRHVTEGPERAPHRSYFYAMDLTQEQIDQPFVGVATCWNEAAPCNIALNWQAQSVKRGVGEANGTPRE
FTTITVTDGIAMGHEGMRSSLASRDAITDTVELTMRGHCYDALVGLAGCDKSLPGMMMAMVRLNVPSVFIYGGTILPGKA
PEVADIPAEFANRDLTVQDMFEAVGKYQSGQLSEAALEVLERVACPSAGACGGQFTANTMACVSEAIGLAMLNSSGMPAP
YEGRKEFGEASGRAVMNLLEKNIRARDVVTRKALENAARVVACTGGSTNAGLHLPAIAHEAGIDFDLFDVCDIFKDTPYF
VDMKPGGQYVAKDLYEVGGVPVVMKELLKEGLLHGDCLTASGETMEEALDKIQGTPDGRVVHTVQNPITSTGGVVGLRGN
LAEEGAIVKVAGMDEASQVFTGPARVFECEEDAFAAVKARGYEEGEVIVIRNEGPKGGPGMREMLATTAALSGQGMGKKV
ALITDGRFSGATRGFCVGHVGPEAAVGGPIGLLENSDMITINALTGELSVALTEAELAERRKAWAGPRETMYASGALWKY
AQLVGEARYGAVTHPGGAKEKHVYADI
>Mature_586_residues
TANRPDKSRLPSRHVTEGPERAPHRSYFYAMDLTQEQIDQPFVGVATCWNEAAPCNIALNWQAQSVKRGVGEANGTPREF
TTITVTDGIAMGHEGMRSSLASRDAITDTVELTMRGHCYDALVGLAGCDKSLPGMMMAMVRLNVPSVFIYGGTILPGKAP
EVADIPAEFANRDLTVQDMFEAVGKYQSGQLSEAALEVLERVACPSAGACGGQFTANTMACVSEAIGLAMLNSSGMPAPY
EGRKEFGEASGRAVMNLLEKNIRARDVVTRKALENAARVVACTGGSTNAGLHLPAIAHEAGIDFDLFDVCDIFKDTPYFV
DMKPGGQYVAKDLYEVGGVPVVMKELLKEGLLHGDCLTASGETMEEALDKIQGTPDGRVVHTVQNPITSTGGVVGLRGNL
AEEGAIVKVAGMDEASQVFTGPARVFECEEDAFAAVKARGYEEGEVIVIRNEGPKGGPGMREMLATTAALSGQGMGKKVA
LITDGRFSGATRGFCVGHVGPEAAVGGPIGLLENSDMITINALTGELSVALTEAELAERRKAWAGPRETMYASGALWKYA
QLVGEARYGAVTHPGGAKEKHVYADI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=612, Percent_Identity=36.6013071895425, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI2367371, Length=478, Percent_Identity=36.6108786610879, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1786464, Length=496, Percent_Identity=34.8790322580645, Blast_Score=215, Evalue=7e-57,
Organism=Escherichia coli, GI1788157, Length=518, Percent_Identity=28.7644787644788, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=561, Percent_Identity=41.5329768270945, Blast_Score=418, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62129; Mature: 61998

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANRPDKSRLPSRHVTEGPERAPHRSYFYAMDLTQEQIDQPFVGVATCWNEAAPCNIAL
CCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCEEHHHHCCCCCCCEEEE
NWQAQSVKRGVGEANGTPREFTTITVTDGIAMGHEGMRSSLASRDAITDTVELTMRGHCY
ECCHHHHHHCCCCCCCCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHCCEEEEEECCCHH
DALVGLAGCDKSLPGMMMAMVRLNVPSVFIYGGTILPGKAPEVADIPAEFANRDLTVQDM
HHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCEECCCCCCCHHCCCHHHCCCCCCHHHH
FEAVGKYQSGQLSEAALEVLERVACPSAGACGGQFTANTMACVSEAIGLAMLNSSGMPAP
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCC
YEGRKEFGEASGRAVMNLLEKNIRARDVVTRKALENAARVVACTGGSTNAGLHLPAIAHE
CCCHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEECCHHHHH
AGIDFDLFDVCDIFKDTPYFVDMKPGGQYVAKDLYEVGGVPVVMKELLKEGLLHGDCLTA
CCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECC
SGETMEEALDKIQGTPDGRVVHTVQNPITSTGGVVGLRGNLAEEGAIVKVAGMDEASQVF
CCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCEEEEECCCCHHHHH
TGPARVFECEEDAFAAVKARGYEEGEVIVIRNEGPKGGPGMREMLATTAALSGQGMGKKV
CCCHHEEECCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEE
ALITDGRFSGATRGFCVGHVGPEAAVGGPIGLLENSDMITINALTGELSVALTEAELAER
EEEECCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCEEEEEEHHHHHHH
RKAWAGPRETMYASGALWKYAQLVGEARYGAVTHPGGAKEKHVYADI
HHHCCCCHHHHEECCHHHHHHHHHHHHHCCCEECCCCCCCCCEEECC
>Mature Secondary Structure 
TANRPDKSRLPSRHVTEGPERAPHRSYFYAMDLTQEQIDQPFVGVATCWNEAAPCNIAL
CCCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCEEHHHHCCCCCCCEEEE
NWQAQSVKRGVGEANGTPREFTTITVTDGIAMGHEGMRSSLASRDAITDTVELTMRGHCY
ECCHHHHHHCCCCCCCCCCEEEEEEEECCCHHCCHHHHHHHHHHHHHCCEEEEEECCCHH
DALVGLAGCDKSLPGMMMAMVRLNVPSVFIYGGTILPGKAPEVADIPAEFANRDLTVQDM
HHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCEECCCCCCCHHCCCHHHCCCCCCHHHH
FEAVGKYQSGQLSEAALEVLERVACPSAGACGGQFTANTMACVSEAIGLAMLNSSGMPAP
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCC
YEGRKEFGEASGRAVMNLLEKNIRARDVVTRKALENAARVVACTGGSTNAGLHLPAIAHE
CCCHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEECCHHHHH
AGIDFDLFDVCDIFKDTPYFVDMKPGGQYVAKDLYEVGGVPVVMKELLKEGLLHGDCLTA
CCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEECC
SGETMEEALDKIQGTPDGRVVHTVQNPITSTGGVVGLRGNLAEEGAIVKVAGMDEASQVF
CCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCCCCCCEEEEECCCCHHHHH
TGPARVFECEEDAFAAVKARGYEEGEVIVIRNEGPKGGPGMREMLATTAALSGQGMGKKV
CCCHHEEECCHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEE
ALITDGRFSGATRGFCVGHVGPEAAVGGPIGLLENSDMITINALTGELSVALTEAELAER
EEEECCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCEEEEEEECCCEEEEEEHHHHHHH
RKAWAGPRETMYASGALWKYAQLVGEARYGAVTHPGGAKEKHVYADI
HHHCCCCHHHHEECCHHHHHHHHHHHHHCCCEECCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA