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The map label for this gene is thyX [H]

Identifier: 88658661

GI number: 88658661

Start: 305301

End: 306062

Strand: Direct

Name: thyX [H]

Synonym: ECH_0317

Alternate gene names: 88658661

Gene position: 305301-306062 (Clockwise)

Preceding gene: 88657846

Following gene: 88658142

Centisome position: 25.96

GC content: 33.33

Gene sequence:

>762_bases
TTGATTGATTATATGGGATCTGATGAATCTATAGTGCAGGCTGCTAGGATATCTTATGGCAGGGGTACTAAGAGTGTCAG
TCAAGATGCTGCATTGATTAATTATTTGATGCGACATTCACATACTACTCCATTTGAGATGTGTGAAATTAAGTTTCATA
TTAAGTTACCTATATTTGTTGCAAGGCAGTGGGTACGTCATCGTACTGCAAATGTAAATGAATATTCTGCAAGGTATTCT
GTGTTAGATCATGAATTCTATATTCCGGAGCATAGTCAAGTGGCAATGCAGTCTGAAGATAATGCTCAGGGTAGGGGGAA
TAATTTATCTGATGAGGATGCAAAGTATGTTGCTGATCTTTTAACACGTGATTCTGATATGGTATATGAAACTTATAATA
AATTTTTGGAGAAAGGTGTTTCTAGAGAGATAGCACGTGTTAACCTTACTTTGAATTATTATACTGAATGGTATTGGAAA
ATAGATTTACATAATTTATTACACTTCTTGAAATTAAGGTCTGAGATGAATGCTCAATATGAAATTAGAGTATATGCAGA
AACTATGTTGGATATTGTAAAAAAATGGGTTCCATTAACTTATGCAGCTTTTGTTGAGTATTGTTTAAAATCGCAAAACT
TTTCAAGAAGTGCATTAGATGTTGTAAAGAAGTTAATTGTTGGAGAAAAAGTAGTTCAAGAAGATACTAATATTGGAAAA
AGAGAGTGGAGGGAACTGATGGCTATTTTAAAGCCTGAATGA

Upstream 100 bases:

>100_bases
GGGAATTATGGAATCAGCAGTTACAAAACGTATAGTTGTCCCTGAGTTGGAAGAAATCCTTTATAAGGAATATAAAGTTT
TAGACAAAGGATTTGTTAGG

Downstream 100 bases:

>100_bases
GTTTTTTTGGATTAGTATCAGTAAATTCTTAGTTATTATGTAAACGTCTGTTAAGGTTTAATACTTTATAGTTTTCAAGT
ACTTGAGATTTTTAGTTTAT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIDYMGSDESIVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFVARQWVRHRTANVNEYSARYS
VLDHEFYIPEHSQVAMQSEDNAQGRGNNLSDEDAKYVADLLTRDSDMVYETYNKFLEKGVSREIARVNLTLNYYTEWYWK
IDLHNLLHFLKLRSEMNAQYEIRVYAETMLDIVKKWVPLTYAAFVEYCLKSQNFSRSALDVVKKLIVGEKVVQEDTNIGK
REWRELMAILKPE

Sequences:

>Translated_253_residues
MIDYMGSDESIVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFVARQWVRHRTANVNEYSARYS
VLDHEFYIPEHSQVAMQSEDNAQGRGNNLSDEDAKYVADLLTRDSDMVYETYNKFLEKGVSREIARVNLTLNYYTEWYWK
IDLHNLLHFLKLRSEMNAQYEIRVYAETMLDIVKKWVPLTYAAFVEYCLKSQNFSRSALDVVKKLIVGEKVVQEDTNIGK
REWRELMAILKPE
>Mature_253_residues
MIDYMGSDESIVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFVARQWVRHRTANVNEYSARYS
VLDHEFYIPEHSQVAMQSEDNAQGRGNNLSDEDAKYVADLLTRDSDMVYETYNKFLEKGVSREIARVNLTLNYYTEWYWK
IDLHNLLHFLKLRSEMNAQYEIRVYAETMLDIVKKWVPLTYAAFVEYCLKSQNFSRSALDVVKKLIVGEKVVQEDTNIGK
REWRELMAILKPE

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 29714; Mature: 29714

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYMGSDESIVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFV
CCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECHHHH
ARQWVRHRTANVNEYSARYSVLDHEFYIPEHSQVAMQSEDNAQGRGNNLSDEDAKYVADL
HHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHH
LTRDSDMVYETYNKFLEKGVSREIARVNLTLNYYTEWYWKIDLHNLLHFLKLRSEMNAQY
HHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEEEEEHHHHHHHHHHHHHCCCEE
EIRVYAETMLDIVKKWVPLTYAAFVEYCLKSQNFSRSALDVVKKLIVGEKVVQEDTNIGK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
REWRELMAILKPE
HHHHHHHHHHCCC
>Mature Secondary Structure
MIDYMGSDESIVQAARISYGRGTKSVSQDAALINYLMRHSHTTPFEMCEIKFHIKLPIFV
CCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHEEEEEEEEECHHHH
ARQWVRHRTANVNEYSARYSVLDHEFYIPEHSQVAMQSEDNAQGRGNNLSDEDAKYVADL
HHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHH
LTRDSDMVYETYNKFLEKGVSREIARVNLTLNYYTEWYWKIDLHNLLHFLKLRSEMNAQY
HHCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEEEEEEHHHHHHHHHHHHHCCCEE
EIRVYAETMLDIVKKWVPLTYAAFVEYCLKSQNFSRSALDVVKKLIVGEKVVQEDTNIGK
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
REWRELMAILKPE
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA