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The map label for this gene is sdhB [H]

Identifier: 88657846

GI number: 88657846

Start: 304044

End: 304820

Strand: Direct

Name: sdhB [H]

Synonym: ECH_0316

Alternate gene names: 88657846

Gene position: 304044-304820 (Clockwise)

Preceding gene: 88658480

Following gene: 88658661

Centisome position: 25.85

GC content: 31.15

Gene sequence:

>777_bases
ATGGTTCAATTTTTTTTACCTAAGAATTCTAAAGTTAATAAGAACGGTAAGGTTCATCATGCTCGTAAAGGGGCAAAAAA
TGTAAAATGTTTTAAAATATATAGATGGTCTCCAGATGATGATGAAAATCCAAGGATTGATACATTCTTTATAGATCTTG
ATGAATGTGGACAAATGGTGCTTGATGCTTTAATAAAGATCAAAAATGAAGTTGATTCTACATTAACATTCAGAAGATCA
TGTAGAGAAGGTATATGTGGTTCATGTGCGATGAACATTGATGGTACTAACACTTTAGCTTGTACAAAAGCAATATCAGA
TATTAAATCAGATGTAAATATTTATCCTTTACCACATATGCATGTGATAAAAGATTTAGTACCTGATTTAAGTAATTTTT
ATAAACAATATGAATCAGTTACTCCGTGGATACAAGCTGAAGAACCTAATCATAATAAAGAAAGGTTACAAACAATAGAA
GATAGAAGCAAGTTAGATGGAATATATGACTGTATATTGTGTGCATGTTGTAGTACTAGTTGTCCTAGTTATTGGTGGAA
TTCAGATAAATATTTAGGGCCAGCAGCTTTATTGCAAGCTTATAGATGGCTTATTGATAGTAGGGATGAAGCATCAGATA
GTAGGTTAGATGTACTTGATGATGCATTTAAATTGTATCGTTGTCATACTATTATGAACTGTACTAAAACTTGTCCTAAA
GGGTTAAATCCGGCAAAAGCAATTGCACATATAAAACAAATGATGGTAAGAAGATAA

Upstream 100 bases:

>100_bases
AAGCAACTTTAACAGATGATGTTCAGTATTTTCCTCCACAAAAAAGAGTATATTAATACTATCTATATAGTTATATGGTG
GTTATTTAAAAGGTTTGACT

Downstream 100 bases:

>100_bases
ATGCCGTTAAAGTTATATTTCAATGGTTAATCAATTCATAGTGAAATAAAGTTATTGGTATATGTGGTTTGCACAATTGT
ATTTTTGACATGTATTGTGA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MVQFFLPKNSKVNKNGKVHHARKGAKNVKCFKIYRWSPDDDENPRIDTFFIDLDECGQMVLDALIKIKNEVDSTLTFRRS
CREGICGSCAMNIDGTNTLACTKAISDIKSDVNIYPLPHMHVIKDLVPDLSNFYKQYESVTPWIQAEEPNHNKERLQTIE
DRSKLDGIYDCILCACCSTSCPSYWWNSDKYLGPAALLQAYRWLIDSRDEASDSRLDVLDDAFKLYRCHTIMNCTKTCPK
GLNPAKAIAHIKQMMVRR

Sequences:

>Translated_258_residues
MVQFFLPKNSKVNKNGKVHHARKGAKNVKCFKIYRWSPDDDENPRIDTFFIDLDECGQMVLDALIKIKNEVDSTLTFRRS
CREGICGSCAMNIDGTNTLACTKAISDIKSDVNIYPLPHMHVIKDLVPDLSNFYKQYESVTPWIQAEEPNHNKERLQTIE
DRSKLDGIYDCILCACCSTSCPSYWWNSDKYLGPAALLQAYRWLIDSRDEASDSRLDVLDDAFKLYRCHTIMNCTKTCPK
GLNPAKAIAHIKQMMVRR
>Mature_258_residues
MVQFFLPKNSKVNKNGKVHHARKGAKNVKCFKIYRWSPDDDENPRIDTFFIDLDECGQMVLDALIKIKNEVDSTLTFRRS
CREGICGSCAMNIDGTNTLACTKAISDIKSDVNIYPLPHMHVIKDLVPDLSNFYKQYESVTPWIQAEEPNHNKERLQTIE
DRSKLDGIYDCILCACCSTSCPSYWWNSDKYLGPAALLQAYRWLIDSRDEASDSRLDVLDDAFKLYRCHTIMNCTKTCPK
GLNPAKAIAHIKQMMVRR

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=243, Percent_Identity=66.2551440329218, Blast_Score=344, Evalue=6e-95,
Organism=Escherichia coli, GI1786943, Length=233, Percent_Identity=55.3648068669528, Blast_Score=271, Evalue=2e-74,
Organism=Escherichia coli, GI1790596, Length=228, Percent_Identity=30.7017543859649, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17533915, Length=239, Percent_Identity=61.9246861924686, Blast_Score=319, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=64.2241379310345, Blast_Score=325, Evalue=4e-90,
Organism=Drosophila melanogaster, GI17137106, Length=235, Percent_Identity=65.531914893617, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=64.3776824034335, Blast_Score=330, Evalue=6e-91,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29583; Mature: 29583

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQFFLPKNSKVNKNGKVHHARKGAKNVKCFKIYRWSPDDDENPRIDTFFIDLDECGQMV
CEEEECCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEEEEHHHHHHHH
LDALIKIKNEVDSTLTFRRSCREGICGSCAMNIDGTNTLACTKAISDIKSDVNIYPLPHM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHCCEECCCCHH
HVIKDLVPDLSNFYKQYESVTPWIQAEEPNHNKERLQTIEDRSKLDGIYDCILCACCSTS
HHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CPSYWWNSDKYLGPAALLQAYRWLIDSRDEASDSRLDVLDDAFKLYRCHTIMNCTKTCPK
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GLNPAKAIAHIKQMMVRR
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVQFFLPKNSKVNKNGKVHHARKGAKNVKCFKIYRWSPDDDENPRIDTFFIDLDECGQMV
CEEEECCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEEEEHHHHHHHH
LDALIKIKNEVDSTLTFRRSCREGICGSCAMNIDGTNTLACTKAISDIKSDVNIYPLPHM
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHCCEECCCCHH
HVIKDLVPDLSNFYKQYESVTPWIQAEEPNHNKERLQTIEDRSKLDGIYDCILCACCSTS
HHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CPSYWWNSDKYLGPAALLQAYRWLIDSRDEASDSRLDVLDDAFKLYRCHTIMNCTKTCPK
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
GLNPAKAIAHIKQMMVRR
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA