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The map label for this gene is bioA [H]

Identifier: 88658309

GI number: 88658309

Start: 676774

End: 678054

Strand: Reverse

Name: bioA [H]

Synonym: ECH_0666

Alternate gene names: 88658309

Gene position: 678054-676774 (Counterclockwise)

Preceding gene: 88657803

Following gene: 88658050

Centisome position: 57.65

GC content: 32.08

Gene sequence:

>1281_bases
ATGTATGCGGATTTTTGTACATGGTTTGATGAAGGGTATCAAAATATATGGATGCCTTATGCGCAAATGAAAAACTCGCC
TTTACCATTAAGGGTAAAATCTGCTAGTGGATGTTATATAACGTTAGAGGATAATACAAAATTACTTGATGGTATATCTA
GCTGGTGGAGTGTATGTCATGGATATTCTCACCCGCATATTGTTCAAAAAGTTCAGAATCAAGTTGCTAAGTTATCGCAT
GTTATGTTTTCTGGATTAGCACATGAACAAAGTTATGTTTTGGCATCTCGACTTGTTAAAATTTCGCCAAAGCAGAAAAT
GAGTAGAGTTTTCTTTTCAGATTCTGGATCCACTGCTGTTGAAGTAGCTATGAAAATGGCAGTTCAATATTACCAAAATT
TGGGGGATACAAATAAGTGTAGTTTTATATCTTTTGTTAATGGATATCATGGAGATACAATGGGGTGTATGTCAATATCT
GATCCTGAGAAAATTCATGGTACCAAGTTCAAAAAATATCACCCTTTACAATTCATTTTACGCTTACCGCAGACAGAAGA
AGAATTTAAGGATTTTACAGATATAGTATATTCTATAAAGGACCGTGTTGCTGCTATAATTTTAGAGCCAATCTTGCAAG
CAGCAGGTGGAATGTTAATTCATTCTGCAAGTACTGTAAAAAAGATTTGTGAGATTGCACGAGATAATAATATGTTATTT
ATAGCAGATGAAGTGGCAACAGGTTTTGGTAGACTTGGAACTATGTTTGGATGTAATCAAGCAGATATTGTGCCAGATAT
TATGGTAATAGGAAAAGCATTAACAGGTGGATTTTGTACATTGGCTGCAACTTTAACTACAGAAGAGGTTTATAATGCAT
TTTTATCAGATAATATAGATGATGCTTTTATGCATGGTCCAACTTTTATGGCAAATGCTTTAGCTTGTGCTGCAGCAAAT
GCTTCACTAGATCTTTTTGAAAATCAAGATTTAATACAAAATGTGAGTTTAATTGAAAATCAATTAATATCAGAATTAGA
GATATTTAGACAGTTAAGTTATGTTACTGATATTAGGGTAAAAGGTGCAACTGGGATAATAGAGTTAGAGAGTGGATTAA
TTAATAAGAATGATATTATAAGTAAAGGGGTTGAATTGAATATATGGATACGTCCTATTAATAATGTGATATATATTATG
CCACCTTTTGTGATCAATCGTAATGAACTTACTAAATTAATAACATCAATATATATTATCCTTAAAAACAACTATAGTTA
A

Upstream 100 bases:

>100_bases
ATTAGTGTATGTTTAATAATGGTGTTGACATATGTATGATTGTAGGTTGTATTTTTTTATAATATAATTTTTGTAGTGTA
ATCCTTTGTTATAAATAGTT

Downstream 100 bases:

>100_bases
TAGGTATAGTATAATGTCAGCATGGTGTGTATTTTTAATGCTATATTCTCTCCTTAGTGTGCTTACTATATAAGCATTTA
TCATGTTATTATTTTAGTCA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MYADFCTWFDEGYQNIWMPYAQMKNSPLPLRVKSASGCYITLEDNTKLLDGISSWWSVCHGYSHPHIVQKVQNQVAKLSH
VMFSGLAHEQSYVLASRLVKISPKQKMSRVFFSDSGSTAVEVAMKMAVQYYQNLGDTNKCSFISFVNGYHGDTMGCMSIS
DPEKIHGTKFKKYHPLQFILRLPQTEEEFKDFTDIVYSIKDRVAAIILEPILQAAGGMLIHSASTVKKICEIARDNNMLF
IADEVATGFGRLGTMFGCNQADIVPDIMVIGKALTGGFCTLAATLTTEEVYNAFLSDNIDDAFMHGPTFMANALACAAAN
ASLDLFENQDLIQNVSLIENQLISELEIFRQLSYVTDIRVKGATGIIELESGLINKNDIISKGVELNIWIRPINNVIYIM
PPFVINRNELTKLITSIYIILKNNYS

Sequences:

>Translated_426_residues
MYADFCTWFDEGYQNIWMPYAQMKNSPLPLRVKSASGCYITLEDNTKLLDGISSWWSVCHGYSHPHIVQKVQNQVAKLSH
VMFSGLAHEQSYVLASRLVKISPKQKMSRVFFSDSGSTAVEVAMKMAVQYYQNLGDTNKCSFISFVNGYHGDTMGCMSIS
DPEKIHGTKFKKYHPLQFILRLPQTEEEFKDFTDIVYSIKDRVAAIILEPILQAAGGMLIHSASTVKKICEIARDNNMLF
IADEVATGFGRLGTMFGCNQADIVPDIMVIGKALTGGFCTLAATLTTEEVYNAFLSDNIDDAFMHGPTFMANALACAAAN
ASLDLFENQDLIQNVSLIENQLISELEIFRQLSYVTDIRVKGATGIIELESGLINKNDIISKGVELNIWIRPINNVIYIM
PPFVINRNELTKLITSIYIILKNNYS
>Mature_426_residues
MYADFCTWFDEGYQNIWMPYAQMKNSPLPLRVKSASGCYITLEDNTKLLDGISSWWSVCHGYSHPHIVQKVQNQVAKLSH
VMFSGLAHEQSYVLASRLVKISPKQKMSRVFFSDSGSTAVEVAMKMAVQYYQNLGDTNKCSFISFVNGYHGDTMGCMSIS
DPEKIHGTKFKKYHPLQFILRLPQTEEEFKDFTDIVYSIKDRVAAIILEPILQAAGGMLIHSASTVKKICEIARDNNMLF
IADEVATGFGRLGTMFGCNQADIVPDIMVIGKALTGGFCTLAATLTTEEVYNAFLSDNIDDAFMHGPTFMANALACAAAN
ASLDLFENQDLIQNVSLIENQLISELEIFRQLSYVTDIRVKGATGIIELESGLINKNDIISKGVELNIWIRPINNVIYIM
PPFVINRNELTKLITSIYIILKNNYS

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=408, Percent_Identity=27.6960784313726, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI37574042, Length=427, Percent_Identity=27.1662763466042, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI13994255, Length=363, Percent_Identity=28.099173553719, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=27.3417721518987, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=26.9320843091335, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI24119277, Length=427, Percent_Identity=25.2927400468384, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI284507298, Length=312, Percent_Identity=27.8846153846154, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI188536080, Length=290, Percent_Identity=27.9310344827586, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679950, Length=290, Percent_Identity=27.9310344827586, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679946, Length=290, Percent_Identity=27.9310344827586, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=44.3645083932854, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI145693181, Length=384, Percent_Identity=31.7708333333333, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789016, Length=403, Percent_Identity=26.5508684863524, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789759, Length=354, Percent_Identity=26.8361581920904, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788044, Length=303, Percent_Identity=27.7227722772277, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787560, Length=225, Percent_Identity=29.3333333333333, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=403, Percent_Identity=26.302729528536, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=418, Percent_Identity=27.511961722488, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=277, Percent_Identity=27.0758122743682, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=24.4803695150115, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=35.9477124183007, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=26.9230769230769, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=368, Percent_Identity=27.9891304347826, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=27.5779376498801, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574759, Length=428, Percent_Identity=29.2056074766355, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=28.7383177570093, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21356575, Length=422, Percent_Identity=25.3554502369668, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47637; Mature: 47637

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYADFCTWFDEGYQNIWMPYAQMKNSPLPLRVKSASGCYITLEDNTKLLDGISSWWSVCH
CCCHHHHHHHHCHHHHCCCHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHC
GYSHPHIVQKVQNQVAKLSHVMFSGLAHEQSYVLASRLVKISPKQKMSRVFFSDSGSTAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
EVAMKMAVQYYQNLGDTNKCSFISFVNGYHGDTMGCMSISDPEKIHGTKFKKYHPLQFIL
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCCCCHHHHH
RLPQTEEEFKDFTDIVYSIKDRVAAIILEPILQAAGGMLIHSASTVKKICEIARDNNMLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCEEE
IADEVATGFGRLGTMFGCNQADIVPDIMVIGKALTGGFCTLAATLTTEEVYNAFLSDNID
EEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
DAFMHGPTFMANALACAAANASLDLFENQDLIQNVSLIENQLISELEIFRQLSYVTDIRV
HHHHCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
KGATGIIELESGLINKNDIISKGVELNIWIRPINNVIYIMPPFVINRNELTKLITSIYII
CCCCCEEEECCCCCCCCHHHHCCCEEEEEEEECCCEEEECCCEEECHHHHHHHHHHHEEE
LKNNYS
EECCCC
>Mature Secondary Structure
MYADFCTWFDEGYQNIWMPYAQMKNSPLPLRVKSASGCYITLEDNTKLLDGISSWWSVCH
CCCHHHHHHHHCHHHHCCCHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHHC
GYSHPHIVQKVQNQVAKLSHVMFSGLAHEQSYVLASRLVKISPKQKMSRVFFSDSGSTAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHH
EVAMKMAVQYYQNLGDTNKCSFISFVNGYHGDTMGCMSISDPEKIHGTKFKKYHPLQFIL
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEEECCCCHHHCCCCCCCCCCHHHHH
RLPQTEEEFKDFTDIVYSIKDRVAAIILEPILQAAGGMLIHSASTVKKICEIARDNNMLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHCCCCEEE
IADEVATGFGRLGTMFGCNQADIVPDIMVIGKALTGGFCTLAATLTTEEVYNAFLSDNID
EEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
DAFMHGPTFMANALACAAANASLDLFENQDLIQNVSLIENQLISELEIFRQLSYVTDIRV
HHHHCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
KGATGIIELESGLINKNDIISKGVELNIWIRPINNVIYIMPPFVINRNELTKLITSIYII
CCCCCEEEECCCCCCCCHHHHCCCEEEEEEEECCCEEEECCCEEECHHHHHHHHHHHEEE
LKNNYS
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]