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The map label for this gene is atpB

Identifier: 88658166

GI number: 88658166

Start: 1113510

End: 1114241

Strand: Direct

Name: atpB

Synonym: ECH_1086

Alternate gene names: 88658166

Gene position: 1113510-1114241 (Clockwise)

Preceding gene: 88658408

Following gene: 88658098

Centisome position: 94.67

GC content: 34.56

Gene sequence:

>732_bases
ATGTCAGCAAACCCCTTAGATCAGTTTAAAATTTCGACTATATTTAAGTTGCCTAGTATTGGTGGGTACAATATAGATTT
CACCAATGCATCACTGTTTATGGTGTTATCTACACTTATAATCTCCCTTTTCTGCTATATTGGATTAAGGAAAGAAAATA
TCCTTCCAAATAGTATGCAACTAATCATTGAAGCAATCTACAATTTTATCGTTTCAACAATAGAAAGTAATGTAGGAAGA
AAAGGATTACAATATATCCCCTTGGTTTTCACAATATTCACATTCATTGCAACATGTAACCTATTAGGTGTCCTACCACT
AGGATTTACCGTTACTAGTCACATTGCCGTAACATTCGCAATATCCATGGTTGTATTTATCAGCGTTACAGCAATAGGGT
TTAAGCATCAGGGAATACATTTTCTACGTATACTATTACCAAAAGGTACCCCAGGTTGGCTAGCTCCAATGATGGTATTT
ATTGAGTTGTTTGCATATTGTGCACGTCCTGTAAGCTTATCAATACGTCTTGCTGCTAATATGATAGCAGGACATACCAT
AATCAAAGTAATAGCAGGATTCGTAATAAAAATGAACATATTTCTCACCCCTTTGCCTATGGCTTTCATTATCATTTTAA
TTGGGTTTGAAATATTTGTTGCAATATTACAAGCATACATATTTACAGTGCTAACTTGCGTATACTTATCAGATGCGATC
AACGAGCACTAA

Upstream 100 bases:

>100_bases
TAATTTTTTATAGTCACATAACTCCAATTGACTAACTGTCTGCAATTGATATGATTAAGTATAATATTCTTTAATAATAT
CGTGTTTGTATGGAGCATAA

Downstream 100 bases:

>100_bases
ATTTTATCAATTGACTTCACATGTTGATGTACTTATAATACGTTTAACTTTTTATAAAGGTAGGAGTATATGGAATCTTT
GAAGTTTATTGCTGTAGGGT

Product: F0F1 ATP synthase subunit A

Products: ATP; H+; H2O [C]

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSANPLDQFKISTIFKLPSIGGYNIDFTNASLFMVLSTLIISLFCYIGLRKENILPNSMQLIIEAIYNFIVSTIESNVGR
KGLQYIPLVFTIFTFIATCNLLGVLPLGFTVTSHIAVTFAISMVVFISVTAIGFKHQGIHFLRILLPKGTPGWLAPMMVF
IELFAYCARPVSLSIRLAANMIAGHTIIKVIAGFVIKMNIFLTPLPMAFIIILIGFEIFVAILQAYIFTVLTCVYLSDAI
NEH

Sequences:

>Translated_243_residues
MSANPLDQFKISTIFKLPSIGGYNIDFTNASLFMVLSTLIISLFCYIGLRKENILPNSMQLIIEAIYNFIVSTIESNVGR
KGLQYIPLVFTIFTFIATCNLLGVLPLGFTVTSHIAVTFAISMVVFISVTAIGFKHQGIHFLRILLPKGTPGWLAPMMVF
IELFAYCARPVSLSIRLAANMIAGHTIIKVIAGFVIKMNIFLTPLPMAFIIILIGFEIFVAILQAYIFTVLTCVYLSDAI
NEH
>Mature_242_residues
SANPLDQFKISTIFKLPSIGGYNIDFTNASLFMVLSTLIISLFCYIGLRKENILPNSMQLIIEAIYNFIVSTIESNVGRK
GLQYIPLVFTIFTFIATCNLLGVLPLGFTVTSHIAVTFAISMVVFISVTAIGFKHQGIHFLRILLPKGTPGWLAPMMVFI
ELFAYCARPVSLSIRLAANMIAGHTIIKVIAGFVIKMNIFLTPLPMAFIIILIGFEIFVAILQAYIFTVLTCVYLSDAIN
EH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=161, Percent_Identity=35.4037267080745, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1790176, Length=206, Percent_Identity=30.5825242718447, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6226527, Length=250, Percent_Identity=32, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_EHRCR (Q2GFB2)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507871.1
- ProteinModelPortal:   Q2GFB2
- SMR:   Q2GFB2
- STRING:   Q2GFB2
- GeneID:   3927577
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_1086
- TIGR:   ECH_1086
- eggNOG:   COG0356
- HOGENOM:   HBG734175
- OMA:   TSHFLIT
- PhylomeDB:   Q2GFB2
- ProtClustDB:   PRK05815
- BioCyc:   ECHA205920:ECH_1086-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14 [C]

Molecular weight: Translated: 26910; Mature: 26779

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d96f634)-; HASH(0x1e0ed13c)-; HASH(0x1da683f0)-; HASH(0x1e4d3118)-; HASH(0x1d7ea390)-; HASH(0x1de287fc)-; HASH(0x1deb56d4)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANPLDQFKISTIFKLPSIGGYNIDFTNASLFMVLSTLIISLFCYIGLRKENILPNSMQ
CCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LIIEAIYNFIVSTIESNVGRKGLQYIPLVFTIFTFIATCNLLGVLPLGFTVTSHIAVTFA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISMVVFISVTAIGFKHQGIHFLRILLPKGTPGWLAPMMVFIELFAYCARPVSLSIRLAAN
HHHHHHHHHHHHCCCCCCHHEEHEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MIAGHTIIKVIAGFVIKMNIFLTPLPMAFIIILIGFEIFVAILQAYIFTVLTCVYLSDAI
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEH
CCH
>Mature Secondary Structure 
SANPLDQFKISTIFKLPSIGGYNIDFTNASLFMVLSTLIISLFCYIGLRKENILPNSMQ
CCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LIIEAIYNFIVSTIESNVGRKGLQYIPLVFTIFTFIATCNLLGVLPLGFTVTSHIAVTFA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISMVVFISVTAIGFKHQGIHFLRILLPKGTPGWLAPMMVFIELFAYCARPVSLSIRLAAN
HHHHHHHHHHHHCCCCCCHHEEHEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MIAGHTIIKVIAGFVIKMNIFLTPLPMAFIIILIGFEIFVAILQAYIFTVLTCVYLSDAI
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEH
CCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ADP; H+; Phosphate [C]

Specific reaction: ADP + (4) H+ + Phosphate <==> ATP + (3) H+ + H2O [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA