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The map label for this gene is fabH

Identifier: 88658133

GI number: 88658133

Start: 425097

End: 426056

Strand: Direct

Name: fabH

Synonym: ECH_0448

Alternate gene names: 88658133

Gene position: 425097-426056 (Clockwise)

Preceding gene: 88657589

Following gene: 88657817

Centisome position: 36.14

GC content: 33.85

Gene sequence:

>960_bases
ATGAAAAGATCTACTATACTGGGAATAGGCTCATATTTGCCTAAAAAAATAGTAACAAATGATGAACTTGCTTTAACTGT
TGAAACTAGTGATGAGTGGATAGTAAAAAGGACTGGTATAAAGCAAAGGCATATTGCTGAGAATAATGAAATGACATCAG
ATATGGCAGCAAATGCAGCAAGGTTAGCTTTGACTGATGCTTGTGTTCATAAGGATGACATTGGGTTAATCATTGTTGCT
ACTACTACTCCAGATAGAACTTTTCCTAGTTGTGCTACTATAGTGCAAGATAAATTAGAATGTAAAAATGCATTTGCTTT
CGATATTCAAGCAGTATGTTCTGGGTTTGTATATGCAATATCTATTGCTGATAATTTTATTAAATCTGGTCAGGTAAATA
CAGCTTTAGTTATAGGGGCTGAAATTATGTCTAGAATTTTAGATTGGCAAGACAGATCAACGTGTGTTTTATTTGGTGAT
GGAGCAGGTGCAGTAGTTTTAGGTAACAATTCTGAAAAGGATAGTGGTATTATATCAACTATTTTACATTCTGATGGAGC
TTTTTGTGATTTATTGTATACCACTGGTGGTACTGCATATAATGGTCATGCTGGGACAATCTGTATGAATGGTACTATTG
TATTTGAACATGCAATTGAAAAATTGAGCGCTTCTATACTTGAAATTTTAGACCAAAATGATTTAGAAATAAATGATGTT
GATTGGTTTGTTTTACATCAGGCTAATATCCGTATTATTGAATTGGTAGCACGTAGACTGAAAATACCTTATGAAAAAAT
GGTTGTTAGTGTTAATTGGCACGGTAATACTTCTGCAGCATCAATTCCTTTAGCGCTATCTTATGCAAAGAGTTCTGGAA
AGTTAAAGAAACACGATATTGCTATATTGGCAGCAATAGGTGGTGGTTTTACTTGGGGAACATGTTTAGTACGTATTTAG

Upstream 100 bases:

>100_bases
TGATAAGGTAGCTTTTGCTCATGCTATTAAAGTGACTGTAAATGCTGTGCGTAATGATATCAATGCTAAAATTATTCATG
AATTAAGTTAATGTTATTCT

Downstream 100 bases:

>100_bases
CTGTTAGATTGTATTAAAAACAGTGATGTATTTTTGATTAGTGGAAATTAAGTTATCTATAAATTACTCTTTTCTTAGTT
TTTTAAAAAAATCTGTTATA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKRSTILGIGSYLPKKIVTNDELALTVETSDEWIVKRTGIKQRHIAENNEMTSDMAANAARLALTDACVHKDDIGLIIVA
TTTPDRTFPSCATIVQDKLECKNAFAFDIQAVCSGFVYAISIADNFIKSGQVNTALVIGAEIMSRILDWQDRSTCVLFGD
GAGAVVLGNNSEKDSGIISTILHSDGAFCDLLYTTGGTAYNGHAGTICMNGTIVFEHAIEKLSASILEILDQNDLEINDV
DWFVLHQANIRIIELVARRLKIPYEKMVVSVNWHGNTSAASIPLALSYAKSSGKLKKHDIAILAAIGGGFTWGTCLVRI

Sequences:

>Translated_319_residues
MKRSTILGIGSYLPKKIVTNDELALTVETSDEWIVKRTGIKQRHIAENNEMTSDMAANAARLALTDACVHKDDIGLIIVA
TTTPDRTFPSCATIVQDKLECKNAFAFDIQAVCSGFVYAISIADNFIKSGQVNTALVIGAEIMSRILDWQDRSTCVLFGD
GAGAVVLGNNSEKDSGIISTILHSDGAFCDLLYTTGGTAYNGHAGTICMNGTIVFEHAIEKLSASILEILDQNDLEINDV
DWFVLHQANIRIIELVARRLKIPYEKMVVSVNWHGNTSAASIPLALSYAKSSGKLKKHDIAILAAIGGGFTWGTCLVRI
>Mature_319_residues
MKRSTILGIGSYLPKKIVTNDELALTVETSDEWIVKRTGIKQRHIAENNEMTSDMAANAARLALTDACVHKDDIGLIIVA
TTTPDRTFPSCATIVQDKLECKNAFAFDIQAVCSGFVYAISIADNFIKSGQVNTALVIGAEIMSRILDWQDRSTCVLFGD
GAGAVVLGNNSEKDSGIISTILHSDGAFCDLLYTTGGTAYNGHAGTICMNGTIVFEHAIEKLSASILEILDQNDLEINDV
DWFVLHQANIRIIELVARRLKIPYEKMVVSVNWHGNTSAASIPLALSYAKSSGKLKKHDIAILAAIGGGFTWGTCLVRI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=46.6876971608833, Blast_Score=287, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_EHRCR (Q2GH17)

Other databases:

- EMBL:   CP000236
- RefSeq:   YP_507266.1
- ProteinModelPortal:   Q2GH17
- SMR:   Q2GH17
- STRING:   Q2GH17
- GeneID:   3927359
- GenomeReviews:   CP000236_GR
- KEGG:   ech:ECH_0448
- TIGR:   ECH_0448
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   Q2GH17
- ProtClustDB:   CLSK749163
- BioCyc:   ECHA205920:ECH_0448-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 34493; Mature: 34493

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 246-246 ACT_SITE 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSTILGIGSYLPKKIVTNDELALTVETSDEWIVKRTGIKQRHIAENNEMTSDMAANAA
CCCCEEEECHHHCCHHHCCCCCEEEEEECCCCEEEEECCCCHHHCCCCCCCCHHHHHCHH
RLALTDACVHKDDIGLIIVATTTPDRTFPSCATIVQDKLECKNAFAFDIQAVCSGFVYAI
HEEEHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHCCCEEEE
SIADNFIKSGQVNTALVIGAEIMSRILDWQDRSTCVLFGDGAGAVVLGNNSEKDSGIIST
EEHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCHHHHH
ILHSDGAFCDLLYTTGGTAYNGHAGTICMNGTIVFEHAIEKLSASILEILDQNDLEINDV
HHCCCCCEEEEEEECCCCEECCCCCEEEECCEEEEHHHHHHHHHHHHHHHCCCCCEECCC
DWFVLHQANIRIIELVARRLKIPYEKMVVSVNWHGNTSAASIPLALSYAKSSGKLKKHDI
EEEEEEECCCHHHHHHHHHHCCCHHHEEEEEEECCCCCCCEEEEEEEEECCCCCEEECCE
AILAAIGGGFTWGTCLVRI
EEEEEECCCCEEEEEEEEC
>Mature Secondary Structure
MKRSTILGIGSYLPKKIVTNDELALTVETSDEWIVKRTGIKQRHIAENNEMTSDMAANAA
CCCCEEEECHHHCCHHHCCCCCEEEEEECCCCEEEEECCCCHHHCCCCCCCCHHHHHCHH
RLALTDACVHKDDIGLIIVATTTPDRTFPSCATIVQDKLECKNAFAFDIQAVCSGFVYAI
HEEEHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHCCCEEEE
SIADNFIKSGQVNTALVIGAEIMSRILDWQDRSTCVLFGDGAGAVVLGNNSEKDSGIIST
EEHHHHHHCCCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEECCCCCCCCHHHHH
ILHSDGAFCDLLYTTGGTAYNGHAGTICMNGTIVFEHAIEKLSASILEILDQNDLEINDV
HHCCCCCEEEEEEECCCCEECCCCCEEEECCEEEEHHHHHHHHHHHHHHHCCCCCEECCC
DWFVLHQANIRIIELVARRLKIPYEKMVVSVNWHGNTSAASIPLALSYAKSSGKLKKHDI
EEEEEEECCCHHHHHHHHHHCCCHHHEEEEEEECCCCCCCEEEEEEEEECCCCCEEECCE
AILAAIGGGFTWGTCLVRI
EEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA