Click here to switch to the map view.

The map label for this gene is fabD [H]

Identifier: 88657851

GI number: 88657851

Start: 215951

End: 216922

Strand: Direct

Name: fabD [H]

Synonym: ECH_0227

Alternate gene names: 88657851

Gene position: 215951-216922 (Clockwise)

Preceding gene: 88658127

Following gene: 88658326

Centisome position: 18.36

GC content: 35.39

Gene sequence:

>972_bases
ATGATTTTTATGTTTCCTGGTCAGGGGTCTCAATTTGTGTCTATGGGGAAGAATATATATGACAACTTTGCTGTTGCTCG
GTATGTTTTTCATGAAGTAGATGACATATTGAATAAAAAGTTATCTAAAATAATGTTTGAAGGTTCTATCGAAAATTTAA
CTTCAACAGATAATGCACAGTTGGCATTGATGGTTACTTCTATTGCAACATTACGTGCTATAGAGTATGTTTTAGGTAAG
CCAGTACATTTATTTAATAATATAAAGTATATGGCAGGGCATTCGGTAGGTGAATGTGTAGCATTGTGTGCATCTGGAGC
ATTAACTTTGTATGAAGTTACACAACTTTTGCTTGTAAGAAGCCAAGCTATGTATGATGCAGTGCCTCTAGGATATGGAG
GGATGTGTGCTTTAATAGGTGGCAGCTTAAGTGATGTAGAAAATGTTGTGAAAATGGCTCAAGAGTATGGAATATGTGAA
ATTGCTAATGATAATTGTGATGGTCAGGTTGTTGTTAGTGGTGTTAAAGCCGCTCTTGAAAAATTGCCAGATTTAATTAA
AGATACTGGTATAAAAAAAGTTATAAAGTTACAAGTTAGTGGACCATTCCATTCATCATTGATGAGTTCTGCGTGTGAGA
AACTACAGGAATTTATTGAGAGTGTTAGAAATATGAAAATGCCGTCAGTTAAGGTTGTATCTAATGTATCTGCAAGAGAA
TATACTGATTGTTTCATGATTAAGAATTTAATAGCGAAACAACTAGTAAGTAGAGTTCGGTGGCGTGAAAGTATTTTGTA
CATGATAAGTCAAGGTTGTACTCACTTTATTGAAGTTGGTGCTGGTACTACGTTGTCAGGTTTGGTGAAGAGGATTAGTT
CGGATGTTTCTGCAGTTAGCATTAACACGGCAGATTGTATAGATTCTATAACGCGACATTTCACGGTAAGTACGGATCTT
GTTGATGCATAG

Upstream 100 bases:

>100_bases
CAATTATATATAGGGCTTTTAATGGTTATGTAAATTCTTTTGACTAATTTACCATAACAGTATATCATAAAAATAGGTAG
ACAGTCGAGGATATATACAG

Downstream 100 bases:

>100_bases
ATATAGTATATACTTGTAACTATCTTTGTTATTTTCTCCTACAGTTTTTAATTATATTTTTGTGCAGTAGTTTTAGCTAG
AAATTTTTAGGTTACTAAAG

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MIFMFPGQGSQFVSMGKNIYDNFAVARYVFHEVDDILNKKLSKIMFEGSIENLTSTDNAQLALMVTSIATLRAIEYVLGK
PVHLFNNIKYMAGHSVGECVALCASGALTLYEVTQLLLVRSQAMYDAVPLGYGGMCALIGGSLSDVENVVKMAQEYGICE
IANDNCDGQVVVSGVKAALEKLPDLIKDTGIKKVIKLQVSGPFHSSLMSSACEKLQEFIESVRNMKMPSVKVVSNVSARE
YTDCFMIKNLIAKQLVSRVRWRESILYMISQGCTHFIEVGAGTTLSGLVKRISSDVSAVSINTADCIDSITRHFTVSTDL
VDA

Sequences:

>Translated_323_residues
MIFMFPGQGSQFVSMGKNIYDNFAVARYVFHEVDDILNKKLSKIMFEGSIENLTSTDNAQLALMVTSIATLRAIEYVLGK
PVHLFNNIKYMAGHSVGECVALCASGALTLYEVTQLLLVRSQAMYDAVPLGYGGMCALIGGSLSDVENVVKMAQEYGICE
IANDNCDGQVVVSGVKAALEKLPDLIKDTGIKKVIKLQVSGPFHSSLMSSACEKLQEFIESVRNMKMPSVKVVSNVSARE
YTDCFMIKNLIAKQLVSRVRWRESILYMISQGCTHFIEVGAGTTLSGLVKRISSDVSAVSINTADCIDSITRHFTVSTDL
VDA
>Mature_323_residues
MIFMFPGQGSQFVSMGKNIYDNFAVARYVFHEVDDILNKKLSKIMFEGSIENLTSTDNAQLALMVTSIATLRAIEYVLGK
PVHLFNNIKYMAGHSVGECVALCASGALTLYEVTQLLLVRSQAMYDAVPLGYGGMCALIGGSLSDVENVVKMAQEYGICE
IANDNCDGQVVVSGVKAALEKLPDLIKDTGIKKVIKLQVSGPFHSSLMSSACEKLQEFIESVRNMKMPSVKVVSNVSARE
YTDCFMIKNLIAKQLVSRVRWRESILYMISQGCTHFIEVGAGTTLSGLVKRISSDVSAVSINTADCIDSITRHFTVSTDL
VDA

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=302, Percent_Identity=31.1258278145695, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1787334, Length=300, Percent_Identity=34.3333333333333, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71984332, Length=297, Percent_Identity=29.2929292929293, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=307, Percent_Identity=24.7557003257329, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24665753, Length=313, Percent_Identity=31.629392971246, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 35229; Mature: 35229

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFMFPGQGSQFVSMGKNIYDNFAVARYVFHEVDDILNKKLSKIMFEGSIENLTSTDNAQ
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCE
LALMVTSIATLRAIEYVLGKPVHLFNNIKYMAGHSVGECVALCASGALTLYEVTQLLLVR
EEHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHH
SQAMYDAVPLGYGGMCALIGGSLSDVENVVKMAQEYGICEIANDNCDGQVVVSGVKAALE
HHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHH
KLPDLIKDTGIKKVIKLQVSGPFHSSLMSSACEKLQEFIESVRNMKMPSVKVVSNVSARE
HHHHHHHHCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHH
YTDCFMIKNLIAKQLVSRVRWRESILYMISQGCTHFIEVGAGTTLSGLVKRISSDVSAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
INTADCIDSITRHFTVSTDLVDA
CCHHHHHHHHHHHEECCHHCCCC
>Mature Secondary Structure
MIFMFPGQGSQFVSMGKNIYDNFAVARYVFHEVDDILNKKLSKIMFEGSIENLTSTDNAQ
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCE
LALMVTSIATLRAIEYVLGKPVHLFNNIKYMAGHSVGECVALCASGALTLYEVTQLLLVR
EEHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHH
SQAMYDAVPLGYGGMCALIGGSLSDVENVVKMAQEYGICEIANDNCDGQVVVSGVKAALE
HHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHH
KLPDLIKDTGIKKVIKLQVSGPFHSSLMSSACEKLQEFIESVRNMKMPSVKVVSNVSARE
HHHHHHHHCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHH
YTDCFMIKNLIAKQLVSRVRWRESILYMISQGCTHFIEVGAGTTLSGLVKRISSDVSAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
INTADCIDSITRHFTVSTDLVDA
CCHHHHHHHHHHHEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]