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The map label for this gene is atpA [H]

Identifier: 88657691

GI number: 88657691

Start: 120796

End: 122325

Strand: Direct

Name: atpA [H]

Synonym: ECH_0132

Alternate gene names: 88657691

Gene position: 120796-122325 (Clockwise)

Preceding gene: 88658063

Following gene: 88657640

Centisome position: 10.27

GC content: 35.42

Gene sequence:

>1530_bases
ATGAATAATACTATATCTCCAGGTGAGGTGTTAAAAGTTATTAAGGAGCGTATTGAGAATTTTGATAACCAAGTAAAGTC
TGATAGTGTTGGTGAAGTGATATCTATTAAAGATGGTATAGCTTTAATATATGGCTTAGAAAAAGCAAAATTTGGAGAAG
TAGTAGTTTTTGCTAACGGTATTACAGGTATAGTATTAGGGTTAGATTGTGATACTGCTAGTGTTGTTGTATTTGGTGAT
GAAAGAAGTGTTGGGGAAGGTGATACTGCAAAATGTACAGGAAAATTGATGGATGTTCCTGTTGGGTTGGAGTTGCTAGG
AAGGGTAGTTGATGCATTAGGTAATCCTATTGATGGAGCTGGCAGCATTGATAGTAAAACTAGGTTGCCAGTGGAGATTA
AGGCTCCAGGTATTATCGCTAGACAATCCGTTACTGAGCCTCTGCAGACTGGTATTAAAATTATAGATATGTTAATACCA
ATAGGACGTGGGCAACGTGAGTTAATTATAGGTGATAGAAAGACAGGGAAGACTGCAATAGCAATTGATACTATCATTAA
TCAGAAAGCACATAATGATGTAGTGTCAGAAAAGGAAAAAGTTTACTGTATTTATGTTGCAATAGGACAAAAGAATTCTT
CTGTTGCAAGAATAGTTGATAAATTACGTGTAAGTGGAGCTTTAGAATACACAATTGTTGTTGCTGCTGGGGCTTCAGAT
ACTGTATCGTTCCAATATCTTGCGCCATATGCTGCTTGTGCAATGGGAGAATTTTTTAGGGATAATGGAATGCACTGCTT
GATTGTATATGATGATCTGTCAAAACATGCTGTTGCTTATAGACAAATGTCCTTGTTGTTAAGACGTCCTCCAGGTCGTG
AAGCATATCCTGGTGATGTATTTTTCTTACATTCTCGATTGTTAGAAAGAGCAGCTAAAATGTCTGACAAAGAAGGAGGT
GGTTCATTAACTGCTTTACCAATAATTGAAACACAAGCTGGTGATGTATCTGCGTATGTTCCAACTAATGTTATTTCAAT
TACTGATGGTCAGATTTTCCTTGAATCTGAAATTTTTTATAAAGGTTTACGTCCGGCTGTAAATGTTGGGTTATCTGTTT
CAAGGGTAGGTTCTGCTGCACAAACTAAATCGGTAAAAAAAGTTGCTGGTTCTGTAAAGTTGAGTTTAGCACAATATAGA
GAGTTAGAAGATTTTGCAAAATTTGGGTCTGATATTGATGTGCATTCTCAGAAGGTATTAGATAGAGGTAGAAGGATGAT
GGAATTGTTGAAACAAAAACAATATTCTCCATTATCTGTGCCGGAGCAAGTTGCTGTGATATTTGCTGGTACAAGTGGTT
GTTTGGATGGTGTTAGTGTAAGTGATATCAGTAGATTTGAAGAAATGCTCCTTAAAGAGCTTAATGAAAATTATCCAGAT
GTTTTAAGTAGTATATTGAATAATTTTACTGATGATGTAAAAGACTTATTATTAGAAATTATAGGTAAGGTTACTTCTAA
TTTTGAATAG

Upstream 100 bases:

>100_bases
TGACGTAATAGATGTATCTTTAAATAGTTATTTACAAAGTTTGCGAGAACTTAGTAAAATGGCTATACGTAGTAGTATAA
GTGAATAGTAGGGTACGGTA

Downstream 100 bases:

>100_bases
TTCTGTATTATGTAGGTATGACTTATGAATGACTATATGAATGCGAGATTTCCTATTACAAAAAATGGGTTTGCAAAACT
TGAGTTAGAGCTAGAGTCAT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MNNTISPGEVLKVIKERIENFDNQVKSDSVGEVISIKDGIALIYGLEKAKFGEVVVFANGITGIVLGLDCDTASVVVFGD
ERSVGEGDTAKCTGKLMDVPVGLELLGRVVDALGNPIDGAGSIDSKTRLPVEIKAPGIIARQSVTEPLQTGIKIIDMLIP
IGRGQRELIIGDRKTGKTAIAIDTIINQKAHNDVVSEKEKVYCIYVAIGQKNSSVARIVDKLRVSGALEYTIVVAAGASD
TVSFQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFFLHSRLLERAAKMSDKEGG
GSLTALPIIETQAGDVSAYVPTNVISITDGQIFLESEIFYKGLRPAVNVGLSVSRVGSAAQTKSVKKVAGSVKLSLAQYR
ELEDFAKFGSDIDVHSQKVLDRGRRMMELLKQKQYSPLSVPEQVAVIFAGTSGCLDGVSVSDISRFEEMLLKELNENYPD
VLSSILNNFTDDVKDLLLEIIGKVTSNFE

Sequences:

>Translated_509_residues
MNNTISPGEVLKVIKERIENFDNQVKSDSVGEVISIKDGIALIYGLEKAKFGEVVVFANGITGIVLGLDCDTASVVVFGD
ERSVGEGDTAKCTGKLMDVPVGLELLGRVVDALGNPIDGAGSIDSKTRLPVEIKAPGIIARQSVTEPLQTGIKIIDMLIP
IGRGQRELIIGDRKTGKTAIAIDTIINQKAHNDVVSEKEKVYCIYVAIGQKNSSVARIVDKLRVSGALEYTIVVAAGASD
TVSFQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFFLHSRLLERAAKMSDKEGG
GSLTALPIIETQAGDVSAYVPTNVISITDGQIFLESEIFYKGLRPAVNVGLSVSRVGSAAQTKSVKKVAGSVKLSLAQYR
ELEDFAKFGSDIDVHSQKVLDRGRRMMELLKQKQYSPLSVPEQVAVIFAGTSGCLDGVSVSDISRFEEMLLKELNENYPD
VLSSILNNFTDDVKDLLLEIIGKVTSNFE
>Mature_509_residues
MNNTISPGEVLKVIKERIENFDNQVKSDSVGEVISIKDGIALIYGLEKAKFGEVVVFANGITGIVLGLDCDTASVVVFGD
ERSVGEGDTAKCTGKLMDVPVGLELLGRVVDALGNPIDGAGSIDSKTRLPVEIKAPGIIARQSVTEPLQTGIKIIDMLIP
IGRGQRELIIGDRKTGKTAIAIDTIINQKAHNDVVSEKEKVYCIYVAIGQKNSSVARIVDKLRVSGALEYTIVVAAGASD
TVSFQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFFLHSRLLERAAKMSDKEGG
GSLTALPIIETQAGDVSAYVPTNVISITDGQIFLESEIFYKGLRPAVNVGLSVSRVGSAAQTKSVKKVAGSVKLSLAQYR
ELEDFAKFGSDIDVHSQKVLDRGRRMMELLKQKQYSPLSVPEQVAVIFAGTSGCLDGVSVSDISRFEEMLLKELNENYPD
VLSSILNNFTDDVKDLLLEIIGKVTSNFE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=62.4254473161034, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=62.4254473161034, Blast_Score=635, Evalue=0.0,
Organism=Homo sapiens, GI19913428, Length=326, Percent_Identity=27.6073619631902, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19913426, Length=359, Percent_Identity=26.4623955431755, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI32189394, Length=397, Percent_Identity=26.9521410579345, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI19913424, Length=264, Percent_Identity=25.3787878787879, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790172, Length=506, Percent_Identity=53.3596837944664, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI1788251, Length=313, Percent_Identity=27.1565495207668, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1790170, Length=372, Percent_Identity=25.5376344086022, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=480, Percent_Identity=64.1666666666667, Blast_Score=630, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=480, Percent_Identity=64.1666666666667, Blast_Score=629, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=480, Percent_Identity=59.7916666666667, Blast_Score=574, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17510931, Length=375, Percent_Identity=26.1333333333333, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=325, Percent_Identity=27.0769230769231, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=411, Percent_Identity=26.7639902676399, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=60, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=77, Percent_Identity=41.5584415584416, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=479, Percent_Identity=60.3340292275574, Blast_Score=615, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6319603, Length=349, Percent_Identity=29.512893982808, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322581, Length=405, Percent_Identity=26.6666666666667, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658560, Length=509, Percent_Identity=60.5108055009823, Blast_Score=628, Evalue=1e-180,
Organism=Drosophila melanogaster, GI281361666, Length=343, Percent_Identity=27.6967930029155, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24646341, Length=343, Percent_Identity=27.6967930029155, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI17136796, Length=343, Percent_Identity=27.6967930029155, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24638766, Length=374, Percent_Identity=25.668449197861, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574560, Length=400, Percent_Identity=25.75, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI20129479, Length=265, Percent_Identity=27.1698113207547, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583988, Length=275, Percent_Identity=25.4545454545455, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583986, Length=275, Percent_Identity=25.4545454545455, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583984, Length=275, Percent_Identity=25.4545454545455, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583992, Length=275, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55073; Mature: 55073

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTISPGEVLKVIKERIENFDNQVKSDSVGEVISIKDGIALIYGLEKAKFGEVVVFANG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCCCCCCEEEEECC
ITGIVLGLDCDTASVVVFGDERSVGEGDTAKCTGKLMDVPVGLELLGRVVDALGNPIDGA
CEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCC
GSIDSKTRLPVEIKAPGIIARQSVTEPLQTGIKIIDMLIPIGRGQRELIIGDRKTGKTAI
CCCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEE
AIDTIINQKAHNDVVSEKEKVYCIYVAIGQKNSSVARIVDKLRVSGALEYTIVVAAGASD
EHHHHHCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECCCC
TVSFQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDV
CEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
FFLHSRLLERAAKMSDKEGGGSLTALPIIETQAGDVSAYVPTNVISITDGQIFLESEIFY
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCCCEEEEECCCEEEEHHHHH
KGLRPAVNVGLSVSRVGSAAQTKSVKKVAGSVKLSLAQYRELEDFAKFGSDIDVHSQKVL
HCCCHHHHCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
DRGRRMMELLKQKQYSPLSVPEQVAVIFAGTSGCLDGVSVSDISRFEEMLLKELNENYPD
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
VLSSILNNFTDDVKDLLLEIIGKVTSNFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNNTISPGEVLKVIKERIENFDNQVKSDSVGEVISIKDGIALIYGLEKAKFGEVVVFANG
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCCCCCCEEEEECC
ITGIVLGLDCDTASVVVFGDERSVGEGDTAKCTGKLMDVPVGLELLGRVVDALGNPIDGA
CEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCCC
GSIDSKTRLPVEIKAPGIIARQSVTEPLQTGIKIIDMLIPIGRGQRELIIGDRKTGKTAI
CCCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEE
AIDTIINQKAHNDVVSEKEKVYCIYVAIGQKNSSVARIVDKLRVSGALEYTIVVAAGASD
EHHHHHCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECCCC
TVSFQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDV
CEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
FFLHSRLLERAAKMSDKEGGGSLTALPIIETQAGDVSAYVPTNVISITDGQIFLESEIFY
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCCCEEEEECCCEEEEHHHHH
KGLRPAVNVGLSVSRVGSAAQTKSVKKVAGSVKLSLAQYRELEDFAKFGSDIDVHSQKVL
HCCCHHHHCCEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
DRGRRMMELLKQKQYSPLSVPEQVAVIFAGTSGCLDGVSVSDISRFEEMLLKELNENYPD
HHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
VLSSILNNFTDDVKDLLLEIIGKVTSNFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA