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The map label for this gene is rnc

Identifier: 88608789

GI number: 88608789

Start: 815133

End: 815801

Strand: Reverse

Name: rnc

Synonym: NSE_0918

Alternate gene names: 88608789

Gene position: 815801-815133 (Counterclockwise)

Preceding gene: 88608845

Following gene: 88608482

Centisome position: 94.97

GC content: 41.7

Gene sequence:

>669_bases
ATGGAACTAGAAGAACTACAATCCTTACTTGGAGTGTATTTTAAAAACAAAGACTTACTTGTCGAAGCTTTAACGCATCC
AAGTGTTGAAAAGTGTCCATCTTACGAGAGATTAGAATTTCTTGGGGATGCAGTGTTAAATCTGGTTATTGCTTCGATGC
TTTACGATCTTTTTCCGGGTGATCCTGAAGGTAGACTTTCTCATAGGCAAAGTGCACTTATTTGCAAGAACACTCTCGCT
ATGCTTGCTCGTCAGATGAATTTAGGTGATTATATTCGCCTTTCAAGTTCGGAGGAAGCGGGCGGTGGACGGGACAAAAC
AAGTAATCTAGAGAATGTTTTAGAAGCCCTCGTAGGAGCTATTTTCCTGGATGCAGGTCTTGAAACAGTTACCTGCTTCA
TTAAGAAACGTTGGTATGGGTTGGCTGTTCAATCAGATTCTATTGAGCCAAATCCAAAAAGCACACTTCAAGAGCTGCTT
CAAGCAAAAGGAATGAAGCCACCGATATATAACGTCATAAATAGATCAGGGCCAGCACACCTACCCATTTTTGAAATAGA
AATCCGCGTAGATGGGAAAAAAAGGCGAGCTACTGGCAAAAGCAAAAAGCTAGGTGAGGAAAATGCAGCAAGGATGATGC
TTGAAGAATTGAAAGCGGAAACCCGGTAG

Upstream 100 bases:

>100_bases
AAGGCTACGACTTAGGTAATTGGGTGTTGATCGACATGGGTGAAGTTATAGTGCACATCTTTAAGGATGACGTCAGAAAG
TATTATGAAGTAGACGCTCT

Downstream 100 bases:

>100_bases
GAACAAACTGTTCCAAACCCGAGTTTCCATTTTTGCCCTCATGCAAGGAATGCTCCAAAGGTAGTTGAAACACCAATTTT
AACCGCGTGGGCAAAAAGAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MELEELQSLLGVYFKNKDLLVEALTHPSVEKCPSYERLEFLGDAVLNLVIASMLYDLFPGDPEGRLSHRQSALICKNTLA
MLARQMNLGDYIRLSSSEEAGGGRDKTSNLENVLEALVGAIFLDAGLETVTCFIKKRWYGLAVQSDSIEPNPKSTLQELL
QAKGMKPPIYNVINRSGPAHLPIFEIEIRVDGKKRRATGKSKKLGEENAARMMLEELKAETR

Sequences:

>Translated_222_residues
MELEELQSLLGVYFKNKDLLVEALTHPSVEKCPSYERLEFLGDAVLNLVIASMLYDLFPGDPEGRLSHRQSALICKNTLA
MLARQMNLGDYIRLSSSEEAGGGRDKTSNLENVLEALVGAIFLDAGLETVTCFIKKRWYGLAVQSDSIEPNPKSTLQELL
QAKGMKPPIYNVINRSGPAHLPIFEIEIRVDGKKRRATGKSKKLGEENAARMMLEELKAETR
>Mature_222_residues
MELEELQSLLGVYFKNKDLLVEALTHPSVEKCPSYERLEFLGDAVLNLVIASMLYDLFPGDPEGRLSHRQSALICKNTLA
MLARQMNLGDYIRLSSSEEAGGGRDKTSNLENVLEALVGAIFLDAGLETVTCFIKKRWYGLAVQSDSIEPNPKSTLQELL
QAKGMKPPIYNVINRSGPAHLPIFEIEIRVDGKKRRATGKSKKLGEENAARMMLEELKAETR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=207, Percent_Identity=28.5024154589372, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI155030234, Length=206, Percent_Identity=27.1844660194175, Blast_Score=77, Evalue=8e-15,
Organism=Escherichia coli, GI1788920, Length=195, Percent_Identity=41.025641025641, Blast_Score=130, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17506883, Length=210, Percent_Identity=28.0952380952381, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=210, Percent_Identity=28.0952380952381, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=30.5676855895196, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 24737; Mature: 24737

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEELQSLLGVYFKNKDLLVEALTHPSVEKCPSYERLEFLGDAVLNLVIASMLYDLFPG
CCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPEGRLSHRQSALICKNTLAMLARQMNLGDYIRLSSSEEAGGGRDKTSNLENVLEALVGA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IFLDAGLETVTCFIKKRWYGLAVQSDSIEPNPKSTLQELLQAKGMKPPIYNVINRSGPAH
HHHHCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
LPIFEIEIRVDGKKRRATGKSKKLGEENAARMMLEELKAETR
CCEEEEEEEECCCHHHCCCCHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELEELQSLLGVYFKNKDLLVEALTHPSVEKCPSYERLEFLGDAVLNLVIASMLYDLFPG
CCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPEGRLSHRQSALICKNTLAMLARQMNLGDYIRLSSSEEAGGGRDKTSNLENVLEALVGA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
IFLDAGLETVTCFIKKRWYGLAVQSDSIEPNPKSTLQELLQAKGMKPPIYNVINRSGPAH
HHHHCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCCC
LPIFEIEIRVDGKKRRATGKSKKLGEENAARMMLEELKAETR
CCEEEEEEEECCCHHHCCCCHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA