Click here to switch to the map view.

The map label for this gene is pccB

Identifier: 88608690

GI number: 88608690

Start: 706523

End: 708079

Strand: Direct

Name: pccB

Synonym: NSE_0796

Alternate gene names: 88608690

Gene position: 706523-708079 (Clockwise)

Preceding gene: 88608051

Following gene: 88608418

Centisome position: 82.25

GC content: 44.38

Gene sequence:

>1557_bases
TTGACCGTAAATAGATCAATTAGGTATAATACAACCTGTCTGTCAGGCACCTTTAGCATGCAAAAGTCTCTTCAGCTTTC
CCTAGATGAGTCAACAAAAGCACAAGCTACAACTTCCAAACTTACTGCCCGTGAAAGATTGGAAATCCTGTTCGATGATG
GGAAATTTGTGGAGATTGATAGCCTAGTTCGCCACAGGTGTACCAATTTCGGACTCGAAAAAAAATCTGTGGATGGAGAT
GGTGTAATTGCAGCACATGGTCAAATCAATGGGAGAAGTGTCTTTGCGTATTCACAGGATTTTTCAGTGTTTGGCGGGTC
ACTCAGTGAAAGGAATGCTGCGAAGATCTGCAAAATCATGGACCTTGCAGCCAAGACTCGTGCCCCTATCATCGGGATAA
ATGACTCTGGCGGTGCAAGGATACAAGAAGGTGTTGACTCCTTAGGTGGATACGGAGAGATATTCTTGCGCAATGTCCGA
CTCTCCGGTGTTGTGCCACAAATTTCACTGATTATGGGGCCATGTGCTGGTGGTGCTGTGTACTCACCCGCATTGACCGA
CTTTATTTTCATGGTTAAAGAGACGAGCTATATGTTCGTTACCGGACCAAAAGTCGTAAAGACTGTTCTCAAGGAAGATC
TTACACAAAATGAGCTTGGTGGTTCCGAGATACACACGAAAAAATCAGGCGTATGCGACAGAGCATTTGAAAATTCTGTT
GAGCTGCTTATTGCGGTGAGAAATTTTCTTGATTTTCTACCGCAAAACAACACCGAAACCCCACGTCAGAGAGAGTGCAC
CGACCCCGTCTGCAGGCAGATCGAATGGCTAGATCGTGCTACTCCGGTAGTATCAAACTTACCGTATGATATGAGCAATA
TCATAAGGGCAATAGTCGATGATGGGGAGTTCTTTGAACTTTCGCCTGATTTTGCAAAAAACGTATTGACTGGTTTTGCT
CATATTGGCGGGATTCGTATAGGTATCGTTGCAAACCAACCATCTGTTCTAGCAGGTTGCCTTGATATCAATTCTTCCAG
GAAAGCAGCGCGCTTTGTTCGTTTCTGTGATGCCTTTAACATCCCGATCCTTACGCTCGTCGATGTACCAGGTTTCTTGC
CTGGATCTTCTCAGGAGCAAAATGCCATTATAAAACACGGAGCAAAATTGCTTTATGCATATGCCGAAGCAACGGTCCCA
AAAGTGACACTCATCATAAAAAAAGCTTATGGTGGTGCCTACATAGTGATGGGATCGAAACATCTTGGTGGAGACGTGAA
CTTTTCATGGCCGAATGCAGAAGTTGCTGTGATGGGGCCGGAAGCAGCTGTAGAAATCGTATTTAGGCGAGAAATCGATA
CACCAAACAAAATCGCGGAATTAGCAGCAGATTACAGAACACAGATTGCAAATCCAAGAGTACCCGCTGCACGTGGATAT
TTGGACGATATAATCAAACCTTCGGATAGCAGAAAAAAAATAGTAGAAGCCTTCAGAATGCTGGCTAGCAAGACGATGGA
AAAACCATGGAAAAAACACGACAACCTTCCACTCTAG

Upstream 100 bases:

>100_bases
CACACGCTACTTGTAGGTTAGGAAAACGCAAAGCACAGATAAGGTTGATATTATTATATTTATTTTGATAATTTATTATT
ACACCTTTTAAACTGCCTTA

Downstream 100 bases:

>100_bases
CCAGCACCATAGGTCAAACGAACCGATGAAGTTATGACAGACCGTAACGTCTGTATGAAACCCGAATTATACTCTAGTTA
GTTTTTATGTGATAGCATTG

Product: propionyl-CoA carboxylase subunit beta

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MTVNRSIRYNTTCLSGTFSMQKSLQLSLDESTKAQATTSKLTARERLEILFDDGKFVEIDSLVRHRCTNFGLEKKSVDGD
GVIAAHGQINGRSVFAYSQDFSVFGGSLSERNAAKICKIMDLAAKTRAPIIGINDSGGARIQEGVDSLGGYGEIFLRNVR
LSGVVPQISLIMGPCAGGAVYSPALTDFIFMVKETSYMFVTGPKVVKTVLKEDLTQNELGGSEIHTKKSGVCDRAFENSV
ELLIAVRNFLDFLPQNNTETPRQRECTDPVCRQIEWLDRATPVVSNLPYDMSNIIRAIVDDGEFFELSPDFAKNVLTGFA
HIGGIRIGIVANQPSVLAGCLDINSSRKAARFVRFCDAFNIPILTLVDVPGFLPGSSQEQNAIIKHGAKLLYAYAEATVP
KVTLIIKKAYGGAYIVMGSKHLGGDVNFSWPNAEVAVMGPEAAVEIVFRREIDTPNKIAELAADYRTQIANPRVPAARGY
LDDIIKPSDSRKKIVEAFRMLASKTMEKPWKKHDNLPL

Sequences:

>Translated_518_residues
MTVNRSIRYNTTCLSGTFSMQKSLQLSLDESTKAQATTSKLTARERLEILFDDGKFVEIDSLVRHRCTNFGLEKKSVDGD
GVIAAHGQINGRSVFAYSQDFSVFGGSLSERNAAKICKIMDLAAKTRAPIIGINDSGGARIQEGVDSLGGYGEIFLRNVR
LSGVVPQISLIMGPCAGGAVYSPALTDFIFMVKETSYMFVTGPKVVKTVLKEDLTQNELGGSEIHTKKSGVCDRAFENSV
ELLIAVRNFLDFLPQNNTETPRQRECTDPVCRQIEWLDRATPVVSNLPYDMSNIIRAIVDDGEFFELSPDFAKNVLTGFA
HIGGIRIGIVANQPSVLAGCLDINSSRKAARFVRFCDAFNIPILTLVDVPGFLPGSSQEQNAIIKHGAKLLYAYAEATVP
KVTLIIKKAYGGAYIVMGSKHLGGDVNFSWPNAEVAVMGPEAAVEIVFRREIDTPNKIAELAADYRTQIANPRVPAARGY
LDDIIKPSDSRKKIVEAFRMLASKTMEKPWKKHDNLPL
>Mature_517_residues
TVNRSIRYNTTCLSGTFSMQKSLQLSLDESTKAQATTSKLTARERLEILFDDGKFVEIDSLVRHRCTNFGLEKKSVDGDG
VIAAHGQINGRSVFAYSQDFSVFGGSLSERNAAKICKIMDLAAKTRAPIIGINDSGGARIQEGVDSLGGYGEIFLRNVRL
SGVVPQISLIMGPCAGGAVYSPALTDFIFMVKETSYMFVTGPKVVKTVLKEDLTQNELGGSEIHTKKSGVCDRAFENSVE
LLIAVRNFLDFLPQNNTETPRQRECTDPVCRQIEWLDRATPVVSNLPYDMSNIIRAIVDDGEFFELSPDFAKNVLTGFAH
IGGIRIGIVANQPSVLAGCLDINSSRKAARFVRFCDAFNIPILTLVDVPGFLPGSSQEQNAIIKHGAKLLYAYAEATVPK
VTLIIKKAYGGAYIVMGSKHLGGDVNFSWPNAEVAVMGPEAAVEIVFRREIDTPNKIAELAADYRTQIANPRVPAARGYL
DDIIKPSDSRKKIVEAFRMLASKTMEKPWKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=487, Percent_Identity=59.1375770020534, Blast_Score=605, Evalue=1e-173,
Organism=Homo sapiens, GI295821216, Length=507, Percent_Identity=56.8047337278106, Blast_Score=592, Evalue=1e-169,
Organism=Homo sapiens, GI11545863, Length=508, Percent_Identity=29.1338582677165, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI38679960, Length=408, Percent_Identity=24.5098039215686, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI134142062, Length=382, Percent_Identity=23.8219895287958, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679974, Length=408, Percent_Identity=24.5098039215686, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI38679971, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38679977, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI38679967, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788655, Length=250, Percent_Identity=25.6, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147359, Length=498, Percent_Identity=56.2248995983936, Blast_Score=588, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI25147362, Length=498, Percent_Identity=56.2248995983936, Blast_Score=588, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17552936, Length=515, Percent_Identity=30.4854368932039, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=347, Percent_Identity=25.6484149855908, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24586065, Length=492, Percent_Identity=29.0650406504065, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56741; Mature: 56610

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVNRSIRYNTTCLSGTFSMQKSLQLSLDESTKAQATTSKLTARERLEILFDDGKFVEID
CCCCCCEEECCEEECCCHHHHHCEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCEEEHH
SLVRHRCTNFGLEKKSVDGDGVIAAHGQINGRSVFAYSQDFSVFGGSLSERNAAKICKIM
HHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHH
DLAAKTRAPIIGINDSGGARIQEGVDSLGGYGEIFLRNVRLSGVVPQISLIMGPCAGGAV
HHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCC
YSPALTDFIFMVKETSYMFVTGPKVVKTVLKEDLTQNELGGSEIHTKKSGVCDRAFENSV
CCHHHHHHHHHEECCCEEEEECHHHHHHHHHHHCHHCCCCCCHHCCCCCCCHHHHHHHHH
ELLIAVRNFLDFLPQNNTETPRQRECTDPVCRQIEWLDRATPVVSNLPYDMSNIIRAIVD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHC
DGEFFELSPDFAKNVLTGFAHIGGIRIGIVANQPSVLAGCLDINSSRKAARFVRFCDAFN
CCCEEEECHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCC
IPILTLVDVPGFLPGSSQEQNAIIKHGAKLLYAYAEATVPKVTLIIKKAYGGAYIVMGSK
CCEEEEECCCCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCC
HLGGDVNFSWPNAEVAVMGPEAAVEIVFRREIDTPNKIAELAADYRTQIANPRVPAARGY
CCCCCCEECCCCCEEEEECCHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
LDDIIKPSDSRKKIVEAFRMLASKTMEKPWKKHDNLPL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVNRSIRYNTTCLSGTFSMQKSLQLSLDESTKAQATTSKLTARERLEILFDDGKFVEID
CCCCCEEECCEEECCCHHHHHCEEEECCCCCCHHHHHHHHHHHHHEEEEECCCCEEEHH
SLVRHRCTNFGLEKKSVDGDGVIAAHGQINGRSVFAYSQDFSVFGGSLSERNAAKICKIM
HHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHH
DLAAKTRAPIIGINDSGGARIQEGVDSLGGYGEIFLRNVRLSGVVPQISLIMGPCAGGAV
HHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEEECCCCCCC
YSPALTDFIFMVKETSYMFVTGPKVVKTVLKEDLTQNELGGSEIHTKKSGVCDRAFENSV
CCHHHHHHHHHEECCCEEEEECHHHHHHHHHHHCHHCCCCCCHHCCCCCCCHHHHHHHHH
ELLIAVRNFLDFLPQNNTETPRQRECTDPVCRQIEWLDRATPVVSNLPYDMSNIIRAIVD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHC
DGEFFELSPDFAKNVLTGFAHIGGIRIGIVANQPSVLAGCLDINSSRKAARFVRFCDAFN
CCCEEEECHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCC
IPILTLVDVPGFLPGSSQEQNAIIKHGAKLLYAYAEATVPKVTLIIKKAYGGAYIVMGSK
CCEEEEECCCCCCCCCCCCCHHHHHHCHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCC
HLGGDVNFSWPNAEVAVMGPEAAVEIVFRREIDTPNKIAELAADYRTQIANPRVPAARGY
CCCCCCEECCCCCEEEEECCHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHHH
LDDIIKPSDSRKKIVEAFRMLASKTMEKPWKKHDNLPL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]