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The map label for this gene is fabH

Identifier: 88608629

GI number: 88608629

Start: 551656

End: 552591

Strand: Reverse

Name: fabH

Synonym: NSE_0630

Alternate gene names: 88608629

Gene position: 552591-551656 (Counterclockwise)

Preceding gene: 88608261

Following gene: 88608347

Centisome position: 64.33

GC content: 40.92

Gene sequence:

>936_bases
ATGAAGAAAACTAATTTCTTGAGTTTTGGTTGCTATCTACCAAAAAAAGTGCTTACTAATTTTGACCTTGAGGAGTTGGT
TGATACATCTGATGAATGGATTCTCAGGCGTACTGGGATTAAAACCAGGTATATAGCCGAGGAAGAGGACGTATGTGAGC
TTGCTTTTAGAGCGTCTTTGAACTGTCTTGAGAGGGCAATGCATTTTTCCCAAAAAGAGGTTGATGCGATAATCGTTGCG
ACCTGTACTGCTAATAAAAGGTTACCTGCAGTTGCAAATATGTTGCAGGCAAGATTAGGCATAGGGAGACACATTCTGTC
CTTTGATGTCAATGCTGCATGTACTGGATTTCTATATGCTCTCTCAATTGTTGATGCAATGATCGTGTCCGGTAAAGTTT
CTACAGTACTTTTAGTTGGAGCAGAAGCGATGTCCACAATTATTGATTGGAATGATCGAAATACTTGTGTTCTCTTTGGT
GATGGTGCAGGTGCCGTATTGGTTTCGGCTGGTGATTCTGGTGGGGTCTTATATGAACACATGGCTTGTGACTCTTCCCT
TGGAGAGGCACTCTTAGCAGAGGTTGGTGGAACGCTTAAAATGGATGGTCGAAGTGTATTTGAGGCAGCTATCAAAAGGT
TGACTCTTGCCATAGGTGAGGCGCTCAAAACAACTGGTATTAGTGTTGAAGAACTGGACTATTTTATAATGCACCAGGCA
AATATAAGAATTATAGAACTGATAGGTGAGAAGATAGGGATAGATCGCTCTAAAATCATTGTCACTGTGGATCGTTATGC
AAATACCTCTGCTGCATCCATACCAATTACACTAGCTTATATGGATTCTCATGGATCGATAAGAAAGGGTGCTAAGATAC
TTTTCGCAGCTATGGGTGCTGGATTTACCTATGGTGTAACAATTTTTGAGTACTAA

Upstream 100 bases:

>100_bases
GTTAGACGTGCACTTTCTTGTACCTTGTTGTAAATTTTATCCACCTCTGGAAGAGAAGTAGTATTCTACATGTATTCATA
GAGTTTTACACAGGATTATA

Downstream 100 bases:

>100_bases
AAGAATAGCTGTTCATGTTAGGATGGCTTTCTTACTACTGTATTATGGGTAAGATCTCTTATTTATTACTAGAGGATTGT
ATATCGAGAGGGTAACCGCG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKKTNFLSFGCYLPKKVLTNFDLEELVDTSDEWILRRTGIKTRYIAEEEDVCELAFRASLNCLERAMHFSQKEVDAIIVA
TCTANKRLPAVANMLQARLGIGRHILSFDVNAACTGFLYALSIVDAMIVSGKVSTVLLVGAEAMSTIIDWNDRNTCVLFG
DGAGAVLVSAGDSGGVLYEHMACDSSLGEALLAEVGGTLKMDGRSVFEAAIKRLTLAIGEALKTTGISVEELDYFIMHQA
NIRIIELIGEKIGIDRSKIIVTVDRYANTSAASIPITLAYMDSHGSIRKGAKILFAAMGAGFTYGVTIFEY

Sequences:

>Translated_311_residues
MKKTNFLSFGCYLPKKVLTNFDLEELVDTSDEWILRRTGIKTRYIAEEEDVCELAFRASLNCLERAMHFSQKEVDAIIVA
TCTANKRLPAVANMLQARLGIGRHILSFDVNAACTGFLYALSIVDAMIVSGKVSTVLLVGAEAMSTIIDWNDRNTCVLFG
DGAGAVLVSAGDSGGVLYEHMACDSSLGEALLAEVGGTLKMDGRSVFEAAIKRLTLAIGEALKTTGISVEELDYFIMHQA
NIRIIELIGEKIGIDRSKIIVTVDRYANTSAASIPITLAYMDSHGSIRKGAKILFAAMGAGFTYGVTIFEY
>Mature_311_residues
MKKTNFLSFGCYLPKKVLTNFDLEELVDTSDEWILRRTGIKTRYIAEEEDVCELAFRASLNCLERAMHFSQKEVDAIIVA
TCTANKRLPAVANMLQARLGIGRHILSFDVNAACTGFLYALSIVDAMIVSGKVSTVLLVGAEAMSTIIDWNDRNTCVLFG
DGAGAVLVSAGDSGGVLYEHMACDSSLGEALLAEVGGTLKMDGRSVFEAAIKRLTLAIGEALKTTGISVEELDYFIMHQA
NIRIIELIGEKIGIDRSKIIVTVDRYANTSAASIPITLAYMDSHGSIRKGAKILFAAMGAGFTYGVTIFEY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=39.1167192429022, Blast_Score=231, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_NEOSM (Q2GDD8)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506508.1
- ProteinModelPortal:   Q2GDD8
- SMR:   Q2GDD8
- STRING:   Q2GDD8
- GeneID:   3931433
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0630
- TIGR:   NSE_0630
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   DAGISAN
- PhylomeDB:   Q2GDD8
- ProtClustDB:   CLSK2528046
- BioCyc:   NSEN222891:NSE_0630-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33705; Mature: 33705

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 238-238 ACT_SITE 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTNFLSFGCYLPKKVLTNFDLEELVDTSDEWILRRTGIKTRYIAEEEDVCELAFRASL
CCCCCEEEECCCCCHHHHCCCCHHHHHCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHH
NCLERAMHFSQKEVDAIIVATCTANKRLPAVANMLQARLGIGRHILSFDVNAACTGFLYA
HHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
LSIVDAMIVSGKVSTVLLVGAEAMSTIIDWNDRNTCVLFGDGAGAVLVSAGDSGGVLYEH
HHHHHHHHHCCCCEEEEEECHHHHHHHEECCCCCEEEEEECCCCEEEEEECCCCCEEEEE
MACDSSLGEALLAEVGGTLKMDGRSVFEAAIKRLTLAIGEALKTTGISVEELDYFIMHQA
HHCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEECC
NIRIIELIGEKIGIDRSKIIVTVDRYANTSAASIPITLAYMDSHGSIRKGAKILFAAMGA
CEEEEEEEHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHEEEEECCC
GFTYGVTIFEY
CEEEEEEEEEC
>Mature Secondary Structure
MKKTNFLSFGCYLPKKVLTNFDLEELVDTSDEWILRRTGIKTRYIAEEEDVCELAFRASL
CCCCCEEEECCCCCHHHHCCCCHHHHHCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHH
NCLERAMHFSQKEVDAIIVATCTANKRLPAVANMLQARLGIGRHILSFDVNAACTGFLYA
HHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
LSIVDAMIVSGKVSTVLLVGAEAMSTIIDWNDRNTCVLFGDGAGAVLVSAGDSGGVLYEH
HHHHHHHHHCCCCEEEEEECHHHHHHHEECCCCCEEEEEECCCCEEEEEECCCCCEEEEE
MACDSSLGEALLAEVGGTLKMDGRSVFEAAIKRLTLAIGEALKTTGISVEELDYFIMHQA
HHCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEEEECC
NIRIIELIGEKIGIDRSKIIVTVDRYANTSAASIPITLAYMDSHGSIRKGAKILFAAMGA
CEEEEEEEHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHEEEEECCC
GFTYGVTIFEY
CEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA