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The map label for this gene is htpG

Identifier: 88608574

GI number: 88608574

Start: 407507

End: 409369

Strand: Direct

Name: htpG

Synonym: NSE_0495

Alternate gene names: 88608574

Gene position: 407507-409369 (Clockwise)

Preceding gene: 88608304

Following gene: 88608640

Centisome position: 47.44

GC content: 38.38

Gene sequence:

>1863_bases
ATGGAGAAAACAGAGCATAAGAACACCTATTCTTTTGATGCAGATGCATCGAAGGTTTTGAATTTGGTTATACATTCTCT
TTACAGACATAAGGACGTTTTTCTTAGAGAGCTCATCTCTAATGCATCTGATGCTCTAAATAAACTACGTGAGGCATCTT
ACTTTGATCAGGAATTACTTGAAGATAACCCTGAGCTTGAGATTCTTATCTCTCTTAATAAGGAGAAAAAAATATTAGAG
ATCTCCGATAATGGGATCGGAATGGACGAAAAAGAGCTTGTAGAAAATTTAGGAACAGTAGCCAGATCTGGGACTGAGAA
ATTTTTGGAATCACTTAAGGATAAAAAAGTCGATTTAATAGGGCAGTTTGGAGTTGGGTTTTATTCAGTCTTCATGGTGG
CAGATAAGGTTGAAGTGGAGACAAGAAAGGCAGGTACAAAAAAAGGTTATATTTGGGGGTCTCGTGGAAGAGATAGCTTC
TATGTTGATGAACTTGGTGAAAGTGTTTCTAGGGGAACAAAGATCAGAATCTATCTCAAGGATAATTCTGAGGAATTCTT
GGATAAGTTCAAACTAGAGCATGTTGTTGTGACAAATTCCAATCACATTGCCTTCCCAATATACCTGATCGATGAGAAAG
GTGAGAAAGATCAGATTAATTCTGCGAGTGCTATATGGACGAAGAACAAAACTGAAATTACTGATGAAGAACATCAAAAC
TTCTTCCGCGATGTTGCGCATGTAGGGGGAAAGCCATGGATGATCATCCACAATAAAAATGAGGGTAGCACTGAGTATAT
AAACTTGCTCTACGTGCCGTCTATAAAGCCGTTTGATCTCTACAATCCTGATAGGAGGGCTTCTGTAAAACTATACATAA
AAAAAGTTTTCATAACCGAAGAGAATGTACAGTTAATTCCTCAATACTTACGGTTCCTAAAGGGCGTAGTAGACTGCGCT
GATCTTCCGCTTAATATAAGCAGGGAAACGCTCCAGTATAATAATGCACTTGTTAAGATAAAGAAGTCCTTGACTAATAG
GGTGCTTAACGAGCTTAAAAAAAGGGCGGACAGCAATCCTGAAGAGTATATCTCTGGGTTTTGGAACAATTTTGGGGCTG
TTTTAAAAGAAGGCCTCTGTGAGGCTATGCCAACAGATGAGAGGGAGCGTTTATTTGCTTTGTGTCGTTTTTACTCTCTG
AAAAAGGAGAAGCTTATCAGCCTGGATGAATACATACAGGATATGCATCCGGAACAAAAAGAAATCTACTGTCTATGTAG
TACAAGCTTTGAGAGTGCTAAAAATAGTCCTCAGCTTGAGGGTTTTGTTAGCCGTGGATTGGATGTGTTGTTTTTTACTG
ATCCAGTAGACGATTTTTGGATAAGTGTTTCTCATGAATATAAGTCGTATAATATTAAATCGATTACTAGATCTAGCATT
GATCTTGATGCTTTTGCTGAACTTGAAAAAGCAGGACAGGAGGTTCAACAACATCATGATAAAGAGATAGATCGTTTGAT
AGCAAAAATGCAAGAAGTCTTGAAAGATGAAGTTGAGTCTGTAAGAATCTCGAAGAGGCTTACAGAAAGTCCTGTTTGTC
TTGCTGTTCCGGATGGTGCAATGGATATAAGGATGGAGAAGTTTATGCTTGAGCAGAAACAGCTTCATTCCAGATCAAAA
AAGATTTTGGAGATCAATGCTTCTCATCCTGTCATTGGAAAAATAATTGGGAAAGTCGATTCTCCTGAAGTAGAGGATTT
GATATTTCTTCTCTATGATCAGGCATGCATTCTACAAGGTGATGAGGTGAGAAATCCTGTGAGGATGTCTAAGGCACTAA
CCAGGTTGCTTTTAATGACGTGA

Upstream 100 bases:

>100_bases
TCTTGTATTTTCGATCCCATGGTAACGTGTTTGGGATTGAAATTGTGAAATAAGACACTTATATCTTCTCGAGTAGACTT
GGGACTTTGATAGCTAACTC

Downstream 100 bases:

>100_bases
AATAGATGGTTATCTTTGTAAGTCTGATAGATTAGGAGCAGTCTTAGGTGCTGAGTTTCTTGGTAGCATTTTTTTAAACT
GTTTTAGGTATAATTGGCGC

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MEKTEHKNTYSFDADASKVLNLVIHSLYRHKDVFLRELISNASDALNKLREASYFDQELLEDNPELEILISLNKEKKILE
ISDNGIGMDEKELVENLGTVARSGTEKFLESLKDKKVDLIGQFGVGFYSVFMVADKVEVETRKAGTKKGYIWGSRGRDSF
YVDELGESVSRGTKIRIYLKDNSEEFLDKFKLEHVVVTNSNHIAFPIYLIDEKGEKDQINSASAIWTKNKTEITDEEHQN
FFRDVAHVGGKPWMIIHNKNEGSTEYINLLYVPSIKPFDLYNPDRRASVKLYIKKVFITEENVQLIPQYLRFLKGVVDCA
DLPLNISRETLQYNNALVKIKKSLTNRVLNELKKRADSNPEEYISGFWNNFGAVLKEGLCEAMPTDERERLFALCRFYSL
KKEKLISLDEYIQDMHPEQKEIYCLCSTSFESAKNSPQLEGFVSRGLDVLFFTDPVDDFWISVSHEYKSYNIKSITRSSI
DLDAFAELEKAGQEVQQHHDKEIDRLIAKMQEVLKDEVESVRISKRLTESPVCLAVPDGAMDIRMEKFMLEQKQLHSRSK
KILEINASHPVIGKIIGKVDSPEVEDLIFLLYDQACILQGDEVRNPVRMSKALTRLLLMT

Sequences:

>Translated_620_residues
MEKTEHKNTYSFDADASKVLNLVIHSLYRHKDVFLRELISNASDALNKLREASYFDQELLEDNPELEILISLNKEKKILE
ISDNGIGMDEKELVENLGTVARSGTEKFLESLKDKKVDLIGQFGVGFYSVFMVADKVEVETRKAGTKKGYIWGSRGRDSF
YVDELGESVSRGTKIRIYLKDNSEEFLDKFKLEHVVVTNSNHIAFPIYLIDEKGEKDQINSASAIWTKNKTEITDEEHQN
FFRDVAHVGGKPWMIIHNKNEGSTEYINLLYVPSIKPFDLYNPDRRASVKLYIKKVFITEENVQLIPQYLRFLKGVVDCA
DLPLNISRETLQYNNALVKIKKSLTNRVLNELKKRADSNPEEYISGFWNNFGAVLKEGLCEAMPTDERERLFALCRFYSL
KKEKLISLDEYIQDMHPEQKEIYCLCSTSFESAKNSPQLEGFVSRGLDVLFFTDPVDDFWISVSHEYKSYNIKSITRSSI
DLDAFAELEKAGQEVQQHHDKEIDRLIAKMQEVLKDEVESVRISKRLTESPVCLAVPDGAMDIRMEKFMLEQKQLHSRSK
KILEINASHPVIGKIIGKVDSPEVEDLIFLLYDQACILQGDEVRNPVRMSKALTRLLLMT
>Mature_620_residues
MEKTEHKNTYSFDADASKVLNLVIHSLYRHKDVFLRELISNASDALNKLREASYFDQELLEDNPELEILISLNKEKKILE
ISDNGIGMDEKELVENLGTVARSGTEKFLESLKDKKVDLIGQFGVGFYSVFMVADKVEVETRKAGTKKGYIWGSRGRDSF
YVDELGESVSRGTKIRIYLKDNSEEFLDKFKLEHVVVTNSNHIAFPIYLIDEKGEKDQINSASAIWTKNKTEITDEEHQN
FFRDVAHVGGKPWMIIHNKNEGSTEYINLLYVPSIKPFDLYNPDRRASVKLYIKKVFITEENVQLIPQYLRFLKGVVDCA
DLPLNISRETLQYNNALVKIKKSLTNRVLNELKKRADSNPEEYISGFWNNFGAVLKEGLCEAMPTDERERLFALCRFYSL
KKEKLISLDEYIQDMHPEQKEIYCLCSTSFESAKNSPQLEGFVSRGLDVLFFTDPVDDFWISVSHEYKSYNIKSITRSSI
DLDAFAELEKAGQEVQQHHDKEIDRLIAKMQEVLKDEVESVRISKRLTESPVCLAVPDGAMDIRMEKFMLEQKQLHSRSK
KILEINASHPVIGKIIGKVDSPEVEDLIFLLYDQACILQGDEVRNPVRMSKALTRLLLMT

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI4507677, Length=666, Percent_Identity=33.6336336336336, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI155722983, Length=624, Percent_Identity=35.0961538461538, Blast_Score=335, Evalue=8e-92,
Organism=Homo sapiens, GI20149594, Length=415, Percent_Identity=30.6024096385542, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI154146191, Length=415, Percent_Identity=30.1204819277108, Blast_Score=191, Evalue=3e-48,
Organism=Homo sapiens, GI153792590, Length=415, Percent_Identity=29.6385542168675, Blast_Score=188, Evalue=1e-47,
Organism=Escherichia coli, GI1786679, Length=629, Percent_Identity=37.8378378378378, Blast_Score=435, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17542208, Length=670, Percent_Identity=33.2835820895522, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17559162, Length=670, Percent_Identity=32.9850746268657, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI115535205, Length=637, Percent_Identity=33.5949764521193, Blast_Score=290, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI115535167, Length=420, Percent_Identity=36.4285714285714, Blast_Score=244, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6323840, Length=676, Percent_Identity=32.9881656804734, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6325016, Length=418, Percent_Identity=30.8612440191388, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI21357739, Length=686, Percent_Identity=32.0699708454811, Blast_Score=338, Evalue=5e-93,
Organism=Drosophila melanogaster, GI24586016, Length=593, Percent_Identity=34.4013490725127, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI17647529, Length=416, Percent_Identity=31.7307692307692, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_NEOSM (Q2GDR7)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506379.1
- ProteinModelPortal:   Q2GDR7
- STRING:   Q2GDR7
- GeneID:   3932284
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0495
- TIGR:   NSE_0495
- eggNOG:   COG0326
- HOGENOM:   HBG631012
- OMA:   DAQELNK
- PhylomeDB:   Q2GDR7
- ProtClustDB:   PRK05218
- BioCyc:   NSEN222891:NSE_0495-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 71308; Mature: 71308

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTEHKNTYSFDADASKVLNLVIHSLYRHKDVFLRELISNASDALNKLREASYFDQELL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNPELEILISLNKEKKILEISDNGIGMDEKELVENLGTVARSGTEKFLESLKDKKVDLI
CCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHH
GQFGVGFYSVFMVADKVEVETRKAGTKKGYIWGSRGRDSFYVDELGESVSRGTKIRIYLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHHCCCEEEEEEE
DNSEEFLDKFKLEHVVVTNSNHIAFPIYLIDEKGEKDQINSASAIWTKNKTEITDEEHQN
CCCHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHH
FFRDVAHVGGKPWMIIHNKNEGSTEYINLLYVPSIKPFDLYNPDRRASVKLYIKKVFITE
HHHHHHHCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEC
ENVQLIPQYLRFLKGVVDCADLPLNISRETLQYNNALVKIKKSLTNRVLNELKKRADSNP
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EEYISGFWNNFGAVLKEGLCEAMPTDERERLFALCRFYSLKKEKLISLDEYIQDMHPEQK
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EIYCLCSTSFESAKNSPQLEGFVSRGLDVLFFTDPVDDFWISVSHEYKSYNIKSITRSSI
EEEEEEECCHHCCCCCCCHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHCCC
DLDAFAELEKAGQEVQQHHDKEIDRLIAKMQEVLKDEVESVRISKRLTESPVCLAVPDGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MDIRMEKFMLEQKQLHSRSKKILEINASHPVIGKIIGKVDSPEVEDLIFLLYDQACILQG
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHCCHHEECC
DEVRNPVRMSKALTRLLLMT
HHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKTEHKNTYSFDADASKVLNLVIHSLYRHKDVFLRELISNASDALNKLREASYFDQELL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNPELEILISLNKEKKILEISDNGIGMDEKELVENLGTVARSGTEKFLESLKDKKVDLI
CCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHH
GQFGVGFYSVFMVADKVEVETRKAGTKKGYIWGSRGRDSFYVDELGESVSRGTKIRIYLK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHHCCCEEEEEEE
DNSEEFLDKFKLEHVVVTNSNHIAFPIYLIDEKGEKDQINSASAIWTKNKTEITDEEHQN
CCCHHHHHHHCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHH
FFRDVAHVGGKPWMIIHNKNEGSTEYINLLYVPSIKPFDLYNPDRRASVKLYIKKVFITE
HHHHHHHCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEC
ENVQLIPQYLRFLKGVVDCADLPLNISRETLQYNNALVKIKKSLTNRVLNELKKRADSNP
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EEYISGFWNNFGAVLKEGLCEAMPTDERERLFALCRFYSLKKEKLISLDEYIQDMHPEQK
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EIYCLCSTSFESAKNSPQLEGFVSRGLDVLFFTDPVDDFWISVSHEYKSYNIKSITRSSI
EEEEEEECCHHCCCCCCCHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHCCC
DLDAFAELEKAGQEVQQHHDKEIDRLIAKMQEVLKDEVESVRISKRLTESPVCLAVPDGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
MDIRMEKFMLEQKQLHSRSKKILEINASHPVIGKIIGKVDSPEVEDLIFLLYDQACILQG
HHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHCCHHEECC
DEVRNPVRMSKALTRLLLMT
HHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA