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The map label for this gene is lolC [H]

Identifier: 88608320

GI number: 88608320

Start: 111587

End: 112810

Strand: Direct

Name: lolC [H]

Synonym: NSE_0137

Alternate gene names: 88608320

Gene position: 111587-112810 (Clockwise)

Preceding gene: 88608719

Following gene: 88608287

Centisome position: 12.99

GC content: 41.67

Gene sequence:

>1224_bases
ATGTTTGTTATAAAGCTGGAGCTTGAGCTTGCGTTTAGTTATTTGATCTCCAAGAGTTTCAGAGGGCTTGTCACCTTTCT
TTCTCTTATTGGTGTAGCCATTGGAGTTGCCTCGTTAATAGTTGTCACGTCTGTCATGGACGGTTTCAAGGCGGAGCTCA
TTTCAAACATCGTGGGTATGAGTGGTCATGTGAACATTTGGTTTCAAAGAAGTACAAATGAAAATGAAGATGTGATGCGT
CTACGTTCCCTTGCGACCGGAATGCCTCATGTTGCTAAGGTAGTTCCAGCTCTTGAGGCGAGGGCAATCATTTCAAATGA
GCTGACAAACGTAGGTGTCCTTGTTAGAGGAATGGAGCTAAATGATTTTGAGAGGGAATCACTCGTTACGGAGAAAATTA
TCCAAGGAAAGGTTGCAGATTTTGAAGATGGTATCGTAATTGGTACGAGAATGGCCAAAGAGCTAGGAGTGAATGTGGGC
GATGAGGTGAGGTTTTTATCTGCGTCATACACCAATACAATCCTTGGTCCAATACCTAGGATGAAGCATTTGAAAGTAGC
AGCTATTTTTGCTCTTGGGCTTGTTGAATACGACAGTACACTTGTGTACATGCCATTTAACATAGCATCAACTTTTTTCC
GTTCTGAAATGAACACGGCAAGTATCTACCTAGACGATCCCTATTTTGCTTCTGACGTATCGGAGCGTATAAAAGAAAAG
CTTCCGAATTTACATGTAACTAACTGGCAAGATGTTGGTAATCCTTACTTTCGTGCTCTGAAGGTCGAAAAAGCAGTGAT
GTCGGTTGTTCTATTGATGATTGTGCTTGTAGCAGCATTCAATATCGTTTCAGGGTTATTCATGTTGGTGGACGAGAAAA
AGCAATCTGTTGCTATTTTGCGTACCATGGGTATGACGGGGGCAAGTATTGTTAGAATCTTTATTTTCTGCGGCAGCATA
ATAGGATTAGTTGGCACTGGTCTGGGTGTGATGTTTGGTCTTTTGATAGCTGTCAATATTAACAGGCTGAGATTTTTTAT
AGAGTGGCTTACCGGAGAGACTATCTTCGATCCGTCTGTGTATTTTGTTGATAAAATACCAGTTTTGCTTGACCCTGCAA
GTGTTGGGTTGATAGCTCTATTCACAATTTTAATAACGTTCTTTGCGACTATTCCCCCGGCTTACAAAGCCTCGAAACAA
AGTCCTGGATCTATTTTGCGCTGA

Upstream 100 bases:

>100_bases
ATCGTTTCTCGTTTTGCCGCTATAGCCCAGTGGTAGCGCGCTTCATTGGTAATGAAGAGGTCTCAAGTTCGATTCTTGAT
AGCGGCACCGCCTTCTGCAA

Downstream 100 bases:

>100_bases
GGTTCTCCTTAGGTTGTTTTTCGATAAAATTATGCTGTAACTTGCTCTGCATGAATAACACCTTCTTTGATCATCTGGGA
AAGGGATAGATGTGCGGGAT

Product: putative permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MFVIKLELELAFSYLISKSFRGLVTFLSLIGVAIGVASLIVVTSVMDGFKAELISNIVGMSGHVNIWFQRSTNENEDVMR
LRSLATGMPHVAKVVPALEARAIISNELTNVGVLVRGMELNDFERESLVTEKIIQGKVADFEDGIVIGTRMAKELGVNVG
DEVRFLSASYTNTILGPIPRMKHLKVAAIFALGLVEYDSTLVYMPFNIASTFFRSEMNTASIYLDDPYFASDVSERIKEK
LPNLHVTNWQDVGNPYFRALKVEKAVMSVVLLMIVLVAAFNIVSGLFMLVDEKKQSVAILRTMGMTGASIVRIFIFCGSI
IGLVGTGLGVMFGLLIAVNINRLRFFIEWLTGETIFDPSVYFVDKIPVLLDPASVGLIALFTILITFFATIPPAYKASKQ
SPGSILR

Sequences:

>Translated_407_residues
MFVIKLELELAFSYLISKSFRGLVTFLSLIGVAIGVASLIVVTSVMDGFKAELISNIVGMSGHVNIWFQRSTNENEDVMR
LRSLATGMPHVAKVVPALEARAIISNELTNVGVLVRGMELNDFERESLVTEKIIQGKVADFEDGIVIGTRMAKELGVNVG
DEVRFLSASYTNTILGPIPRMKHLKVAAIFALGLVEYDSTLVYMPFNIASTFFRSEMNTASIYLDDPYFASDVSERIKEK
LPNLHVTNWQDVGNPYFRALKVEKAVMSVVLLMIVLVAAFNIVSGLFMLVDEKKQSVAILRTMGMTGASIVRIFIFCGSI
IGLVGTGLGVMFGLLIAVNINRLRFFIEWLTGETIFDPSVYFVDKIPVLLDPASVGLIALFTILITFFATIPPAYKASKQ
SPGSILR
>Mature_407_residues
MFVIKLELELAFSYLISKSFRGLVTFLSLIGVAIGVASLIVVTSVMDGFKAELISNIVGMSGHVNIWFQRSTNENEDVMR
LRSLATGMPHVAKVVPALEARAIISNELTNVGVLVRGMELNDFERESLVTEKIIQGKVADFEDGIVIGTRMAKELGVNVG
DEVRFLSASYTNTILGPIPRMKHLKVAAIFALGLVEYDSTLVYMPFNIASTFFRSEMNTASIYLDDPYFASDVSERIKEK
LPNLHVTNWQDVGNPYFRALKVEKAVMSVVLLMIVLVAAFNIVSGLFMLVDEKKQSVAILRTMGMTGASIVRIFIFCGSI
IGLVGTGLGVMFGLLIAVNINRLRFFIEWLTGETIFDPSVYFVDKIPVLLDPASVGLIALFTILITFFATIPPAYKASKQ
SPGSILR

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=400, Percent_Identity=30, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1787362, Length=392, Percent_Identity=26.0204081632653, Blast_Score=118, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44772; Mature: 44772

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVIKLELELAFSYLISKSFRGLVTFLSLIGVAIGVASLIVVTSVMDGFKAELISNIVGM
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGHVNIWFQRSTNENEDVMRLRSLATGMPHVAKVVPALEARAIISNELTNVGVLVRGMEL
CCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
NDFERESLVTEKIIQGKVADFEDGIVIGTRMAKELGVNVGDEVRFLSASYTNTILGPIPR
CCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCC
MKHLKVAAIFALGLVEYDSTLVYMPFNIASTFFRSEMNTASIYLDDPYFASDVSERIKEK
HHHHHHHHHHHHHHHEECCEEEEECHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHH
LPNLHVTNWQDVGNPYFRALKVEKAVMSVVLLMIVLVAAFNIVSGLFMLVDEKKQSVAIL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RTMGMTGASIVRIFIFCGSIIGLVGTGLGVMFGLLIAVNINRLRFFIEWLTGETIFDPSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCE
YFVDKIPVLLDPASVGLIALFTILITFFATIPPAYKASKQSPGSILR
EEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MFVIKLELELAFSYLISKSFRGLVTFLSLIGVAIGVASLIVVTSVMDGFKAELISNIVGM
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGHVNIWFQRSTNENEDVMRLRSLATGMPHVAKVVPALEARAIISNELTNVGVLVRGMEL
CCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
NDFERESLVTEKIIQGKVADFEDGIVIGTRMAKELGVNVGDEVRFLSASYTNTILGPIPR
CCHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCC
MKHLKVAAIFALGLVEYDSTLVYMPFNIASTFFRSEMNTASIYLDDPYFASDVSERIKEK
HHHHHHHHHHHHHHHEECCEEEEECHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHH
LPNLHVTNWQDVGNPYFRALKVEKAVMSVVLLMIVLVAAFNIVSGLFMLVDEKKQSVAIL
CCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
RTMGMTGASIVRIFIFCGSIIGLVGTGLGVMFGLLIAVNINRLRFFIEWLTGETIFDPSV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCE
YFVDKIPVLLDPASVGLIALFTILITFFATIPPAYKASKQSPGSILR
EEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]