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The map label for this gene is nuoH

Identifier: 88608314

GI number: 88608314

Start: 46226

End: 47236

Strand: Direct

Name: nuoH

Synonym: NSE_0054

Alternate gene names: 88608314

Gene position: 46226-47236 (Clockwise)

Preceding gene: 88608010

Following gene: 88608109

Centisome position: 5.38

GC content: 42.53

Gene sequence:

>1011_bases
ATGCTTTATCTTGTTCTCTCTAAGCTTGTTTGGATAGTACTGCTTGCAATAGTCTTGATACTTTGTGTGGCCTACCTGAC
ATATGCAGAGAGAAAGGTAATAGCAGCAACACAACTTCGTGTCGGTCCCGACTTGGTAGGGCCGTTTGGACTTCTGCAAC
CGATTGCTGATGCTATAAAGGTTTTGCTTAAGGAGATAATTATTCCGAATGCTGCCAGCCCAAAACTGTTTTTATTCGCC
CCAGTAATCATATTTGTGTTGGCGTTGGTAGGGTGGGCAGTCATACCGTTTGGGACATCCGAAATAGACGGTGTAGAAGT
GCCAACTGTAATTGCAAATGTTAATCTCGGGGTTATGTATCTTCTTGGTGTTGCCGCGCTTGAGGTTTACGGAACGATCA
TTGCAGGTTGGGCAAGTAAATCTAGTTATTCATTTTTGGGAGCACTTAGGTCGGCTTCTCAGATGATTTCATATGAGATT
GTTATAGCGCCAGTAGTCATGACGGTTATACTGCTCACTGGCTCTCTTAACCTGGCCGAGATAGTGGTGATAAAGCACAG
TCTGCCATATTGGGTCGATATCTTGATGTTGCCCATGACTTTTATATTTTTTGTTTCGATTCTTGCAGAAACAAACAGAC
ATCCTTTCGATTTACCCGAGGCAGAAGCTGAGCTAGTTTCGGGTTACAATGTCGAGTATTCATCTATTCCTTTTGCGCTT
TTCTTTCTTGGGGAGTATGCAAATATGATATTGAGCAGTAGCATAATGGCGACGCTGTTTTTAGGTGGGTGGTATCCGCC
AATTAACTGGTGGGGTTTATCCATTGTTCCGGGCTTTATCTGGTTTATTCTGAAGATTGTATTTGTTTTGTTTTGTTTTC
TGATTGTCAGAGCAACGCTCCCACGTTACAGATATGACCAGTTAATGAGGTTGTGTTGGAAGGTATTTCTGCCGGTGACG
TTACTCTGGATAGTTGTTATAGGTGGATTGGTAGCTTTTAACATTGTTTGA

Upstream 100 bases:

>100_bases
TTTGCAGATGAAGTTATTTCATTTAAGAAAAGAAACTTTTATATGTCCGATGTGATCAGCAGGGCTTCTAGTACGATGGC
AAAGTGTAGTGAGGAGTTTA

Downstream 100 bases:

>100_bases
CGAGGAGTCGTAGGCCTCTATTCACACTTTGATAGTAGTATTGCGATTGTTTGGTGTTCTGCTATCTTTTACTTCCTGCT
CTCCCCTTTTGGAAATGCGT

Product: NADH dehydrogenase I subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLYLVLSKLVWIVLLAIVLILCVAYLTYAERKVIAATQLRVGPDLVGPFGLLQPIADAIKVLLKEIIIPNAASPKLFLFA
PVIIFVLALVGWAVIPFGTSEIDGVEVPTVIANVNLGVMYLLGVAALEVYGTIIAGWASKSSYSFLGALRSASQMISYEI
VIAPVVMTVILLTGSLNLAEIVVIKHSLPYWVDILMLPMTFIFFVSILAETNRHPFDLPEAEAELVSGYNVEYSSIPFAL
FFLGEYANMILSSSIMATLFLGGWYPPINWWGLSIVPGFIWFILKIVFVLFCFLIVRATLPRYRYDQLMRLCWKVFLPVT
LLWIVVIGGLVAFNIV

Sequences:

>Translated_336_residues
MLYLVLSKLVWIVLLAIVLILCVAYLTYAERKVIAATQLRVGPDLVGPFGLLQPIADAIKVLLKEIIIPNAASPKLFLFA
PVIIFVLALVGWAVIPFGTSEIDGVEVPTVIANVNLGVMYLLGVAALEVYGTIIAGWASKSSYSFLGALRSASQMISYEI
VIAPVVMTVILLTGSLNLAEIVVIKHSLPYWVDILMLPMTFIFFVSILAETNRHPFDLPEAEAELVSGYNVEYSSIPFAL
FFLGEYANMILSSSIMATLFLGGWYPPINWWGLSIVPGFIWFILKIVFVLFCFLIVRATLPRYRYDQLMRLCWKVFLPVT
LLWIVVIGGLVAFNIV
>Mature_336_residues
MLYLVLSKLVWIVLLAIVLILCVAYLTYAERKVIAATQLRVGPDLVGPFGLLQPIADAIKVLLKEIIIPNAASPKLFLFA
PVIIFVLALVGWAVIPFGTSEIDGVEVPTVIANVNLGVMYLLGVAALEVYGTIIAGWASKSSYSFLGALRSASQMISYEI
VIAPVVMTVILLTGSLNLAEIVVIKHSLPYWVDILMLPMTFIFFVSILAETNRHPFDLPEAEAELVSGYNVEYSSIPFAL
FFLGEYANMILSSSIMATLFLGGWYPPINWWGLSIVPGFIWFILKIVFVLFCFLIVRATLPRYRYDQLMRLCWKVFLPVT
LLWIVVIGGLVAFNIV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=300, Percent_Identity=41.6666666666667, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI1788618, Length=320, Percent_Identity=39.0625, Blast_Score=236, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_NEOSM (Q2GEZ1)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_505955.1
- STRING:   Q2GEZ1
- GeneID:   3931707
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0054
- TIGR:   NSE_0054
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q2GEZ1
- ProtClustDB:   CLSK2527841
- BioCyc:   NSEN222891:NSE_0054-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37257; Mature: 37257

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe45ee80)-; HASH(0x1021d6a8)-; HASH(0xf7ea964)-; HASH(0xf8aa270)-; HASH(0xfc4653c)-; HASH(0x1021d5ac)-; HASH(0xf7b2768)-; HASH(0x1021d6f0)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLVLSKLVWIVLLAIVLILCVAYLTYAERKVIAATQLRVGPDLVGPFGLLQPIADAIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLLKEIIIPNAASPKLFLFAPVIIFVLALVGWAVIPFGTSEIDGVEVPTVIANVNLGVMY
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHH
LLGVAALEVYGTIIAGWASKSSYSFLGALRSASQMISYEIVIAPVVMTVILLTGSLNLAE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVVIKHSLPYWVDILMLPMTFIFFVSILAETNRHPFDLPEAEAELVSGYNVEYSSIPFAL
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHCCCHHH
FFLGEYANMILSSSIMATLFLGGWYPPINWWGLSIVPGFIWFILKIVFVLFCFLIVRATL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRYRYDQLMRLCWKVFLPVTLLWIVVIGGLVAFNIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MLYLVLSKLVWIVLLAIVLILCVAYLTYAERKVIAATQLRVGPDLVGPFGLLQPIADAIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
VLLKEIIIPNAASPKLFLFAPVIIFVLALVGWAVIPFGTSEIDGVEVPTVIANVNLGVMY
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCHHHHH
LLGVAALEVYGTIIAGWASKSSYSFLGALRSASQMISYEIVIAPVVMTVILLTGSLNLAE
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVVIKHSLPYWVDILMLPMTFIFFVSILAETNRHPFDLPEAEAELVSGYNVEYSSIPFAL
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHCCCHHH
FFLGEYANMILSSSIMATLFLGGWYPPINWWGLSIVPGFIWFILKIVFVLFCFLIVRATL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRYRYDQLMRLCWKVFLPVTLLWIVVIGGLVAFNIV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA