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The map label for this gene is serS

Identifier: 88608228

GI number: 88608228

Start: 493675

End: 494922

Strand: Reverse

Name: serS

Synonym: NSE_0569

Alternate gene names: 88608228

Gene position: 494922-493675 (Counterclockwise)

Preceding gene: 88608118

Following gene: 88608354

Centisome position: 57.62

GC content: 40.62

Gene sequence:

>1248_bases
ATGAATGATCTCGAATATATAGTCTCTAATCCAGAAGGGTTCACTGAGATGATGAAGAGGCGAGGTGTAAGGTTTGATCC
TCTGCCTCTAATTACACTGTATGAAGAACGAAAAAGTTGCGTTACTTCACTCAATAATCTTCAAGCGAGCAAAAATGAAT
TGACCAGATCTTTTCAGGTTATTCAGGAGAACAAAAGTGAGCTTTTTGAAAAAGCCAAAGTGATAGATAAGGAGATTTTA
AGAGTTAAGAAGCATCTCCAAAAAATTTGTGAGCAGCTTGAGTTAATTGTGTTAGATTTACCTAACATCTTAGCTGAGGA
TGTCCCAATAGGTGAAGATGAGAGATCTAACGTTGTAGTAAAGTCGTGGGGTGCAGTTAGGGATTTTGGGTTTGAACCTA
AAGCCCATGATGAACTTGGTGTCGCTCTTGGTATATTGGATTTTTTAAATGTTGCTAAGGTTTCAGGGGCGAGATTTTCG
GGATTCATTGGCAGTGGGGCAAGGCTGTTTAGAGTGCTCAAAGATTTCATGCTTGAGCATAATACGGAGCATGGTCACCG
TGAATATTTTCTACCGTACCTGGTGAAAGAAGATGCCATGTATAAAGCTGGGCAGTTACCGAAGTTTTCTCAAGAGTCAT
TTAAAGTGGATGGCGGAATGCGCTTGGTTCCGACAAGTGAAGTTTCTCTGCTAAACTTTGTGTCTGATAATTTCTATGGG
GAGACTGAGCTACCACTTAGGATGACCTCCTACAGTGAATGTTTCCGTTCTGAGGCGGGGAGCAGCGGTAAGGATACTAA
AGGCATAATAAGGCAACATCAGTTCGGCAAGGTCGAGCTTTTGTCGGTAACGGAGCCGGAAAAATCGGATGATGAACTCG
AGCGAATGTTGTGTATAGCTGAGGGTTTATTACAGAAGCTGAAGCTGCCATACCGAGTTGTTAATTTATGTTCGGGTGAT
ATTGGTTTCTGTTCAAAAAAAACATATGACATAGAAGTGTGGATTCCGTCTCAATGCTGTTATAGAGAGATTTCTAGTTG
CTCTAACTGCGGAGATTTTCAGTCTAGAAGGTTAGCGATCAAGTATAAATTCAAGAAAAAAAAGGGCTTTTTGCATACAC
TGAACGCGAGCTCTCTTGCTATTGGTAGAACTATTGTTGCAATTTTGGAGAATTATCAGATGCATGATGGTTCTATTGAA
GTTCCAGAAGTCTTGAGAAGTAGGTTCGGTGCTGATTTTATCAAGTAA

Upstream 100 bases:

>100_bases
AGTGCTTCTGATGTTGTGTTACTGCGAACCGTGCCCAAAGAGTACAAAGTGACTACGTTAGGCGATATATTCTCATTGAA
TCACACAGGCAAAATGAACG

Downstream 100 bases:

>100_bases
GTGAGTTGTCTGCTGCAACGGTCCCTATGAGATGGGAGTAGTGTACCTTTTAACTTGCAAATGTTAGTGACATGCGGTGT
TCAAAGATAACCGGGATGGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNDLEYIVSNPEGFTEMMKRRGVRFDPLPLITLYEERKSCVTSLNNLQASKNELTRSFQVIQENKSELFEKAKVIDKEIL
RVKKHLQKICEQLELIVLDLPNILAEDVPIGEDERSNVVVKSWGAVRDFGFEPKAHDELGVALGILDFLNVAKVSGARFS
GFIGSGARLFRVLKDFMLEHNTEHGHREYFLPYLVKEDAMYKAGQLPKFSQESFKVDGGMRLVPTSEVSLLNFVSDNFYG
ETELPLRMTSYSECFRSEAGSSGKDTKGIIRQHQFGKVELLSVTEPEKSDDELERMLCIAEGLLQKLKLPYRVVNLCSGD
IGFCSKKTYDIEVWIPSQCCYREISSCSNCGDFQSRRLAIKYKFKKKKGFLHTLNASSLAIGRTIVAILENYQMHDGSIE
VPEVLRSRFGADFIK

Sequences:

>Translated_415_residues
MNDLEYIVSNPEGFTEMMKRRGVRFDPLPLITLYEERKSCVTSLNNLQASKNELTRSFQVIQENKSELFEKAKVIDKEIL
RVKKHLQKICEQLELIVLDLPNILAEDVPIGEDERSNVVVKSWGAVRDFGFEPKAHDELGVALGILDFLNVAKVSGARFS
GFIGSGARLFRVLKDFMLEHNTEHGHREYFLPYLVKEDAMYKAGQLPKFSQESFKVDGGMRLVPTSEVSLLNFVSDNFYG
ETELPLRMTSYSECFRSEAGSSGKDTKGIIRQHQFGKVELLSVTEPEKSDDELERMLCIAEGLLQKLKLPYRVVNLCSGD
IGFCSKKTYDIEVWIPSQCCYREISSCSNCGDFQSRRLAIKYKFKKKKGFLHTLNASSLAIGRTIVAILENYQMHDGSIE
VPEVLRSRFGADFIK
>Mature_415_residues
MNDLEYIVSNPEGFTEMMKRRGVRFDPLPLITLYEERKSCVTSLNNLQASKNELTRSFQVIQENKSELFEKAKVIDKEIL
RVKKHLQKICEQLELIVLDLPNILAEDVPIGEDERSNVVVKSWGAVRDFGFEPKAHDELGVALGILDFLNVAKVSGARFS
GFIGSGARLFRVLKDFMLEHNTEHGHREYFLPYLVKEDAMYKAGQLPKFSQESFKVDGGMRLVPTSEVSLLNFVSDNFYG
ETELPLRMTSYSECFRSEAGSSGKDTKGIIRQHQFGKVELLSVTEPEKSDDELERMLCIAEGLLQKLKLPYRVVNLCSGD
IGFCSKKTYDIEVWIPSQCCYREISSCSNCGDFQSRRLAIKYKFKKKKGFLHTLNASSLAIGRTIVAILENYQMHDGSIE
VPEVLRSRFGADFIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=434, Percent_Identity=30.6451612903226, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI225579074, Length=436, Percent_Identity=30.2752293577982, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI16306548, Length=356, Percent_Identity=34.5505617977528, Blast_Score=186, Evalue=5e-47,
Organism=Escherichia coli, GI1787120, Length=420, Percent_Identity=44.047619047619, Blast_Score=351, Evalue=5e-98,
Organism=Caenorhabditis elegans, GI17539260, Length=333, Percent_Identity=33.033033033033, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17542084, Length=319, Percent_Identity=31.6614420062696, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320226, Length=421, Percent_Identity=33.2541567695962, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=380, Percent_Identity=31.0526315789474, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24581334, Length=362, Percent_Identity=34.2541436464088, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI17737985, Length=301, Percent_Identity=33.8870431893688, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47178; Mature: 47178

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLEYIVSNPEGFTEMMKRRGVRFDPLPLITLYEERKSCVTSLNNLQASKNELTRSFQV
CCCCCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQENKSELFEKAKVIDKEILRVKKHLQKICEQLELIVLDLPNILAEDVPIGEDERSNVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEE
KSWGAVRDFGFEPKAHDELGVALGILDFLNVAKVSGARFSGFIGSGARLFRVLKDFMLEH
ECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
NTEHGHREYFLPYLVKEDAMYKAGQLPKFSQESFKVDGGMRLVPTSEVSLLNFVSDNFYG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCEEEECCCCHHHHHHHHHCCCC
ETELPLRMTSYSECFRSEAGSSGKDTKGIIRQHQFGKVELLSVTEPEKSDDELERMLCIA
CCCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
EGLLQKLKLPYRVVNLCSGDIGFCSKKTYDIEVWIPSQCCYREISSCSNCGDFQSRRLAI
HHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCCHHHCEEEE
KYKFKKKKGFLHTLNASSLAIGRTIVAILENYQMHDGSIEVPEVLRSRFGADFIK
EEEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNDLEYIVSNPEGFTEMMKRRGVRFDPLPLITLYEERKSCVTSLNNLQASKNELTRSFQV
CCCCCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQENKSELFEKAKVIDKEILRVKKHLQKICEQLELIVLDLPNILAEDVPIGEDERSNVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCEEE
KSWGAVRDFGFEPKAHDELGVALGILDFLNVAKVSGARFSGFIGSGARLFRVLKDFMLEH
ECCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHC
NTEHGHREYFLPYLVKEDAMYKAGQLPKFSQESFKVDGGMRLVPTSEVSLLNFVSDNFYG
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCCEEEECCCCHHHHHHHHHCCCC
ETELPLRMTSYSECFRSEAGSSGKDTKGIIRQHQFGKVELLSVTEPEKSDDELERMLCIA
CCCCCEEEHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
EGLLQKLKLPYRVVNLCSGDIGFCSKKTYDIEVWIPSQCCYREISSCSNCGDFQSRRLAI
HHHHHHHCCCHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCCHHHCEEEE
KYKFKKKKGFLHTLNASSLAIGRTIVAILENYQMHDGSIEVPEVLRSRFGADFIK
EEEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA