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The map label for this gene is guaB

Identifier: 88608173

GI number: 88608173

Start: 451188

End: 452633

Strand: Direct

Name: guaB

Synonym: NSE_0525

Alternate gene names: 88608173

Gene position: 451188-452633 (Clockwise)

Preceding gene: 88608061

Following gene: 88608575

Centisome position: 52.52

GC content: 44.12

Gene sequence:

>1446_bases
ATGGAACAGGGATACACATTCGATGACGTACTGCTCGTCCCTAAATACTCAGAAGTTCTCCCGCGAGATGTAAGTACGGA
GACATACCTCACACAAGAGATAAAGCTTGGTGTCCCTATTGTCTCATCCGCTATGGATATGGTAACGGAGGCTCGTCTTG
CGATATGCCTAGCCAAGCATGGAGGAATTGGGATAATTCACCGAAATATGACTCCGGAGGCTCAGGCTCTGGAAATTCGC
AAGGTAAAGAAGTATGAGAGCTGGATTGTTTCTGATCCCGTAACAGTTTCCCCAGATGATAGATTGGAGAAAGTCTCAGC
ACTTAAAAAGCAACATGGCTATTCTGGTTTGCCTGTTGTAGATGAAAAGAACAGACTCATAGGAATACTGACAAACAGAG
ACGTGCGTTTTGTCGAAGATAGTTCCAGAAAGGTCTCGGAGCTTATGACAACAAAAAACCTGATCACAGTAAAAGAAGGA
ATAAGCTATGATGAGGCTAGGCTGTTGTTTCATAAACACAAAATAGAAAGACTGATCGTAGTTGATGAGGAATTTAGGTG
TGTTGGCTTAATAACAGTCAAAGATATCGCTAATACCAATGCTCACCCAAATGCCTGCAAAGATTCTAAGAGTAGGCTGA
GAGTGGGTGCAGCAGTTGGTGTGACAGGTAGCTTCTTGGAAAGAGTTGATTTATTGGTAAGAGAAAATGTAGACGTCGTT
GTGATAGATACAGCTCATGCACATACAAAAATCGTTGGTGACGCAATAAAGCAAATAAGAGGCCACTTTGGAAATATACA
GCTTATTGCTGGGAACATTGCAACCGCTGCAGCTGCAGAATACTTGATCAAAATGGGTGTGGATGGAGTCAAGGTTGGCA
TCGGTCCTGGGTCGATATGTACAACACGTGTAGTTACAGGAATCGGCGTCCCTCAGTTCACCGCTATTCTAAATGTTGCA
AGTGTATGTAAAAAAACAGGTGTTAAGGTCATTGCAGATGGTGGTATACGCTATTCAGGTGATATCGCTAAGGCGCTTGC
AGCTGGAGCGGATTGTGTGATGATTGGCTCCCTATTTGCTGGAACTGATGAATCTCCAGGGGAAGTAGTATTGTATAGGG
GACGTTCATATAAGAGCTATAGAGGAATGGGCTCTGTGGGTGCCATGAGCACTGGCTCCTCAGATAGGTACTTCCAGAAT
TCTTCAATGAAGCTTGTACCTGAAGGAGTCGAGGGGTTAGTGCCGCTCAAGGGTGCACTCAGTGAGACAGTATATCAGCT
TGTCGGCGGTGTAAGATCTTCTATGGGTTATGCTGGCTGCAAGGACGTCAACGAAATGAAAAACAACTGCAGTTTCATTC
ACATAACTACGGCTTCAAATAACGAGGGACATCCGCATGATATCGTTATAACTCAGGAATCTCCCAACTATTCCAAAACT
CACTAA

Upstream 100 bases:

>100_bases
GGCTCTCGCACGACTGTCAAGTATTTGGACTGTAGGATGATGCCGGAAAAGTAAGGTAGCCTTACTTTTATTTTCTTGAT
AAAAATGCTAGGAATTAGTG

Downstream 100 bases:

>100_bases
ATCAAATCTTTTGCCGTCTCTTTTAGCTCTCTTTAGTTTAACTTTTATATTATTTTAGATTTTTCATATCTATGTAATAT
ATCTTTTATAAAATTGTCTT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MEQGYTFDDVLLVPKYSEVLPRDVSTETYLTQEIKLGVPIVSSAMDMVTEARLAICLAKHGGIGIIHRNMTPEAQALEIR
KVKKYESWIVSDPVTVSPDDRLEKVSALKKQHGYSGLPVVDEKNRLIGILTNRDVRFVEDSSRKVSELMTTKNLITVKEG
ISYDEARLLFHKHKIERLIVVDEEFRCVGLITVKDIANTNAHPNACKDSKSRLRVGAAVGVTGSFLERVDLLVRENVDVV
VIDTAHAHTKIVGDAIKQIRGHFGNIQLIAGNIATAAAAEYLIKMGVDGVKVGIGPGSICTTRVVTGIGVPQFTAILNVA
SVCKKTGVKVIADGGIRYSGDIAKALAAGADCVMIGSLFAGTDESPGEVVLYRGRSYKSYRGMGSVGAMSTGSSDRYFQN
SSMKLVPEGVEGLVPLKGALSETVYQLVGGVRSSMGYAGCKDVNEMKNNCSFIHITTASNNEGHPHDIVITQESPNYSKT
H

Sequences:

>Translated_481_residues
MEQGYTFDDVLLVPKYSEVLPRDVSTETYLTQEIKLGVPIVSSAMDMVTEARLAICLAKHGGIGIIHRNMTPEAQALEIR
KVKKYESWIVSDPVTVSPDDRLEKVSALKKQHGYSGLPVVDEKNRLIGILTNRDVRFVEDSSRKVSELMTTKNLITVKEG
ISYDEARLLFHKHKIERLIVVDEEFRCVGLITVKDIANTNAHPNACKDSKSRLRVGAAVGVTGSFLERVDLLVRENVDVV
VIDTAHAHTKIVGDAIKQIRGHFGNIQLIAGNIATAAAAEYLIKMGVDGVKVGIGPGSICTTRVVTGIGVPQFTAILNVA
SVCKKTGVKVIADGGIRYSGDIAKALAAGADCVMIGSLFAGTDESPGEVVLYRGRSYKSYRGMGSVGAMSTGSSDRYFQN
SSMKLVPEGVEGLVPLKGALSETVYQLVGGVRSSMGYAGCKDVNEMKNNCSFIHITTASNNEGHPHDIVITQESPNYSKT
H
>Mature_481_residues
MEQGYTFDDVLLVPKYSEVLPRDVSTETYLTQEIKLGVPIVSSAMDMVTEARLAICLAKHGGIGIIHRNMTPEAQALEIR
KVKKYESWIVSDPVTVSPDDRLEKVSALKKQHGYSGLPVVDEKNRLIGILTNRDVRFVEDSSRKVSELMTTKNLITVKEG
ISYDEARLLFHKHKIERLIVVDEEFRCVGLITVKDIANTNAHPNACKDSKSRLRVGAAVGVTGSFLERVDLLVRENVDVV
VIDTAHAHTKIVGDAIKQIRGHFGNIQLIAGNIATAAAAEYLIKMGVDGVKVGIGPGSICTTRVVTGIGVPQFTAILNVA
SVCKKTGVKVIADGGIRYSGDIAKALAAGADCVMIGSLFAGTDESPGEVVLYRGRSYKSYRGMGSVGAMSTGSSDRYFQN
SSMKLVPEGVEGLVPLKGALSETVYQLVGGVRSSMGYAGCKDVNEMKNNCSFIHITTASNNEGHPHDIVITQESPNYSKT
H

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=478, Percent_Identity=40.3765690376569, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI34328928, Length=448, Percent_Identity=39.7321428571429, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI217035146, Length=448, Percent_Identity=39.7321428571429, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI34328930, Length=448, Percent_Identity=39.7321428571429, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI156616279, Length=448, Percent_Identity=39.7321428571429, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI217035152, Length=443, Percent_Identity=39.7291196388262, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI217035148, Length=448, Percent_Identity=38.8392857142857, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI217035150, Length=448, Percent_Identity=35.9375, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI50541954, Length=248, Percent_Identity=35.0806451612903, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI50541952, Length=248, Percent_Identity=35.0806451612903, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI50541948, Length=248, Percent_Identity=35.0806451612903, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI50541956, Length=248, Percent_Identity=35.0806451612903, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=36, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1788855, Length=479, Percent_Identity=54.9060542797495, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=35.2678571428571, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=496, Percent_Identity=34.6774193548387, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=36.6666666666667, Blast_Score=249, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI17560440, Length=269, Percent_Identity=33.8289962825279, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322012, Length=480, Percent_Identity=37.9166666666667, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6323585, Length=480, Percent_Identity=38.125, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=480, Percent_Identity=38.3333333333333, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=37.8698224852071, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=41.2280701754386, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=38.045738045738, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=38.045738045738, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.496583143508, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51952; Mature: 51952

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQGYTFDDVLLVPKYSEVLPRDVSTETYLTQEIKLGVPIVSSAMDMVTEARLAICLAKH
CCCCCCCCCEEECCCHHHHCCCCCCCHHEEEEHHEECCCHHHHHHHHHHHHHHHEEEECC
GGIGIIHRNMTPEAQALEIRKVKKYESWIVSDPVTVSPDDRLEKVSALKKQHGYSGLPVV
CCEEEEECCCCCCHHHHHHHHHHHHHHEEECCCEEECCHHHHHHHHHHHHHCCCCCCCEE
DEKNRLIGILTNRDVRFVEDSSRKVSELMTTKNLITVKEGISYDEARLLFHKHKIERLIV
CCCCCEEEEEECCCEEEEECCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCEEEE
VDEEFRCVGLITVKDIANTNAHPNACKDSKSRLRVGAAVGVTGSFLERVDLLVRENVDVV
ECCCCEEEEEEEEEECCCCCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHCCCCEE
VIDTAHAHTKIVGDAIKQIRGHFGNIQLIAGNIATAAAAEYLIKMGVDGVKVGIGPGSIC
EEECCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHH
TTRVVTGIGVPQFTAILNVASVCKKTGVKVIADGGIRYSGDIAKALAAGADCVMIGSLFA
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCCEEEEEHHHC
GTDESPGEVVLYRGRSYKSYRGMGSVGAMSTGSSDRYFQNSSMKLVPEGVEGLVPLKGAL
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHHH
SETVYQLVGGVRSSMGYAGCKDVNEMKNNCSFIHITTASNNEGHPHDIVITQESPNYSKT
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCC
H
C
>Mature Secondary Structure
MEQGYTFDDVLLVPKYSEVLPRDVSTETYLTQEIKLGVPIVSSAMDMVTEARLAICLAKH
CCCCCCCCCEEECCCHHHHCCCCCCCHHEEEEHHEECCCHHHHHHHHHHHHHHHEEEECC
GGIGIIHRNMTPEAQALEIRKVKKYESWIVSDPVTVSPDDRLEKVSALKKQHGYSGLPVV
CCEEEEECCCCCCHHHHHHHHHHHHHHEEECCCEEECCHHHHHHHHHHHHHCCCCCCCEE
DEKNRLIGILTNRDVRFVEDSSRKVSELMTTKNLITVKEGISYDEARLLFHKHKIERLIV
CCCCCEEEEEECCCEEEEECCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCEEEE
VDEEFRCVGLITVKDIANTNAHPNACKDSKSRLRVGAAVGVTGSFLERVDLLVRENVDVV
ECCCCEEEEEEEEEECCCCCCCCCCCCCCHHHEEEEEEECCCHHHHHHHHHHHHCCCCEE
VIDTAHAHTKIVGDAIKQIRGHFGNIQLIAGNIATAAAAEYLIKMGVDGVKVGIGPGSIC
EEECCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCHH
TTRVVTGIGVPQFTAILNVASVCKKTGVKVIADGGIRYSGDIAKALAAGADCVMIGSLFA
HHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCCEEEEEHHHC
GTDESPGEVVLYRGRSYKSYRGMGSVGAMSTGSSDRYFQNSSMKLVPEGVEGLVPLKGAL
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEEECCCCCCCCCCHHHH
SETVYQLVGGVRSSMGYAGCKDVNEMKNNCSFIHITTASNNEGHPHDIVITQESPNYSKT
HHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]