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The map label for this gene is pth

Identifier: 88607642

GI number: 88607642

Start: 1368973

End: 1369524

Strand: Reverse

Name: pth

Synonym: APH_1301

Alternate gene names: 88607642

Gene position: 1369524-1368973 (Counterclockwise)

Preceding gene: 88607427

Following gene: 88607063

Centisome position: 93.08

GC content: 45.29

Gene sequence:

>552_bases
GTGTTGCTTTTAGTCGGGTTAGGCAATCCGGGGAAGCGGTATGCTGAGACGCGTCACAATGTTGGTTTTATGATCATTGA
TGCTGTGGCGCGTGGCTTTTTCTTTCCCGAATTTTGTAGTAAGCACGATGCTTTGGTATCTATTGGGAACATTGGTACCC
ACCGTGTGATGTTGATGAAGCCGCTTTTATACATGAATAGGTCTGGCACTTCGGTGTTGAGTTGTACTAGCATGCACAAA
ATAGCGCCGGAACATATCACGGTGTTTCATGATGATGTAGAATTGCAGCCAGGAACGATAAGAGTAAAGCTTGGTGGAGG
AAGTGGAGGACACAATGGTCTTCGTTCTATCGATTCCGCGATAGGTAAGGCATATTGGAGAGTCAGATTTGGGGTTGGAC
GGGCAGAACTCTGTAATTTGTCGGATTATGTGTTGTCAGATTTTGAAAATATTGCTCAAGTTACCGACCTAGTAAACAGT
GTAGCAGCGAATTTACAGATGCTCTTGGACGGAAATGCCGCAGGGTTCGTATCAAAAGTCACCTCAGTGTAG

Upstream 100 bases:

>100_bases
AATTGCTACTGTTGTTGCTTCTGGTGGGGGAATTTCTGAAGATGCAGAGGAAGCTGCTCCTGCTAGTGATATCCCAGAGG
CAGGTAAGTAGTATTCAACT

Downstream 100 bases:

>100_bases
TATACGCGAGCATTTTTCGCATATATCATCCTAGCATTTTGCTGTTGAGTTGTGCTAGCATGCAAAAACTGGAACGCATA
ACGGTGTTTCATGATGATAT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MLLLVGLGNPGKRYAETRHNVGFMIIDAVARGFFFPEFCSKHDALVSIGNIGTHRVMLMKPLLYMNRSGTSVLSCTSMHK
IAPEHITVFHDDVELQPGTIRVKLGGGSGGHNGLRSIDSAIGKAYWRVRFGVGRAELCNLSDYVLSDFENIAQVTDLVNS
VAANLQMLLDGNAAGFVSKVTSV

Sequences:

>Translated_183_residues
MLLLVGLGNPGKRYAETRHNVGFMIIDAVARGFFFPEFCSKHDALVSIGNIGTHRVMLMKPLLYMNRSGTSVLSCTSMHK
IAPEHITVFHDDVELQPGTIRVKLGGGSGGHNGLRSIDSAIGKAYWRVRFGVGRAELCNLSDYVLSDFENIAQVTDLVNS
VAANLQMLLDGNAAGFVSKVTSV
>Mature_183_residues
MLLLVGLGNPGKRYAETRHNVGFMIIDAVARGFFFPEFCSKHDALVSIGNIGTHRVMLMKPLLYMNRSGTSVLSCTSMHK
IAPEHITVFHDDVELQPGTIRVKLGGGSGGHNGLRSIDSAIGKAYWRVRFGVGRAELCNLSDYVLSDFENIAQVTDLVNS
VAANLQMLLDGNAAGFVSKVTSV

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=156, Percent_Identity=31.4102564102564, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1787455, Length=134, Percent_Identity=41.7910447761194, Blast_Score=79, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ANAPZ (Q2GII6)

Other databases:

- EMBL:   CP000235
- RefSeq:   YP_505815.1
- ProteinModelPortal:   Q2GII6
- SMR:   Q2GII6
- STRING:   Q2GII6
- GeneID:   3930906
- GenomeReviews:   CP000235_GR
- KEGG:   aph:APH_1301
- NMPDR:   fig|212042.5.peg.1249
- TIGR:   APH_1301
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- ProtClustDB:   PRK05426
- BioCyc:   APHA212042:APH_1301-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 19809; Mature: 19809

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLVGLGNPGKRYAETRHNVGFMIIDAVARGFFFPEFCSKHDALVSIGNIGTHRVMLMK
CEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCHHHHHHH
PLLYMNRSGTSVLSCTSMHKIAPEHITVFHDDVELQPGTIRVKLGGGSGGHNGLRSIDSA
HHHHHCCCCCCEEEEHHHHHCCCCCEEEEECCEEECCCEEEEEECCCCCCCHHHHHHHHH
IGKAYWRVRFGVGRAELCNLSDYVLSDFENIAQVTDLVNSVAANLQMLLDGNAAGFVSKV
HHHHHEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHH
TSV
HCC
>Mature Secondary Structure
MLLLVGLGNPGKRYAETRHNVGFMIIDAVARGFFFPEFCSKHDALVSIGNIGTHRVMLMK
CEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCHHHHHHH
PLLYMNRSGTSVLSCTSMHKIAPEHITVFHDDVELQPGTIRVKLGGGSGGHNGLRSIDSA
HHHHHCCCCCCEEEEHHHHHCCCCCEEEEECCEEECCCEEEEEECCCCCCCHHHHHHHHH
IGKAYWRVRFGVGRAELCNLSDYVLSDFENIAQVTDLVNSVAANLQMLLDGNAAGFVSKV
HHHHHEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHH
TSV
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA