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The map label for this gene is nadC [H]

Identifier: 88607335

GI number: 88607335

Start: 16610

End: 17437

Strand: Reverse

Name: nadC [H]

Synonym: APH_0016

Alternate gene names: 88607335

Gene position: 17437-16610 (Counterclockwise)

Preceding gene: 88607636

Following gene: 88607501

Centisome position: 1.19

GC content: 38.41

Gene sequence:

>828_bases
ATGTTCGAATATATTATTCAACGTGCATTAGAAGAGGACTTAGGCACCATTGGAGATATTACTACTGACTGTATTATTGG
AGATCAAAGGATTAAGTTCGAGGTAAATGCTAGAGAAGAACTTATAGTTTCTGGCATGCTGTTTATTTCTGATTTGGCAA
ACGTTCTACACAAAGAAGATATCTCTTTTTATCCTATGGAAGTCGATGGAACTCCAGTAAAATCTGGTACCTGTTTGCTT
AGAGGAGAAGGTAGTGCTTCGAAGATTTTATCTGTTGAGAGGGTTTTGCTTAACTTTATTCAACGTGCTTCAGGAATTTC
CTCTTTGACTAGACAGTTTGTCGAAATCATACACGGTACCAATGCAATCATTCGCAGTACTCGAAAAACATGTCCTGGTT
TGAGGAAGTTTGACCTGTATGCAGTGCATGTAGGGGGAGGAGAAAGTTTTAGGACTGGATTGTTTGATGGAGTATTGATA
AAAGACAACCATATAGCAAGCTGTAGCGGTATATCTGAATGTGTTCACAAGGTTAGGGCAAAATTGGGTAACGTCGTTAT
TCTAGTTGAGTGTGATACTACAGAGCAAGTTGAGGAATCTATTCTAAACAACGTGGATACAGTAATGCTGGATAACATGT
CTCTGGATAATATAAAAAAGTCAGTCAGCATCGTTAATTCACGTGCAAAAATAGAAGTTTCTGGTGGAATAAATCTGAAC
AACGTGCGACCTATTGCTGAATGCGGGGTAGACTATATATCCGTAGGCTGTATTACAAATGCAGTAAAATGCAAAGACAT
AGGCCTGGATGTTATAGAGCAGATATAG

Upstream 100 bases:

>100_bases
TATAAACACAGAGCCCCCATCACAAGCAAATTCACTAAATAGTACAAAGATGATACAATCTATATCGTGTTATTGTATAC
AATAGTTTGGAAAGTATACC

Downstream 100 bases:

>100_bases
CTAAAAAGGATCGCAACCTTTCCTAAGAGCTTATATCCTTCCAAATTCCTTTTATCTTTTGAAAGAATCCTGAGAATTTT
GGACTGCTATTCGCATTAGA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MFEYIIQRALEEDLGTIGDITTDCIIGDQRIKFEVNAREELIVSGMLFISDLANVLHKEDISFYPMEVDGTPVKSGTCLL
RGEGSASKILSVERVLLNFIQRASGISSLTRQFVEIIHGTNAIIRSTRKTCPGLRKFDLYAVHVGGGESFRTGLFDGVLI
KDNHIASCSGISECVHKVRAKLGNVVILVECDTTEQVEESILNNVDTVMLDNMSLDNIKKSVSIVNSRAKIEVSGGINLN
NVRPIAECGVDYISVGCITNAVKCKDIGLDVIEQI

Sequences:

>Translated_275_residues
MFEYIIQRALEEDLGTIGDITTDCIIGDQRIKFEVNAREELIVSGMLFISDLANVLHKEDISFYPMEVDGTPVKSGTCLL
RGEGSASKILSVERVLLNFIQRASGISSLTRQFVEIIHGTNAIIRSTRKTCPGLRKFDLYAVHVGGGESFRTGLFDGVLI
KDNHIASCSGISECVHKVRAKLGNVVILVECDTTEQVEESILNNVDTVMLDNMSLDNIKKSVSIVNSRAKIEVSGGINLN
NVRPIAECGVDYISVGCITNAVKCKDIGLDVIEQI
>Mature_275_residues
MFEYIIQRALEEDLGTIGDITTDCIIGDQRIKFEVNAREELIVSGMLFISDLANVLHKEDISFYPMEVDGTPVKSGTCLL
RGEGSASKILSVERVLLNFIQRASGISSLTRQFVEIIHGTNAIIRSTRKTCPGLRKFDLYAVHVGGGESFRTGLFDGVLI
KDNHIASCSGISECVHKVRAKLGNVVILVECDTTEQVEESILNNVDTVMLDNMSLDNIKKSVSIVNSRAKIEVSGGINLN
NVRPIAECGVDYISVGCITNAVKCKDIGLDVIEQI

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=197, Percent_Identity=31.4720812182741, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786299, Length=268, Percent_Identity=34.3283582089552, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6321162, Length=197, Percent_Identity=32.994923857868, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30051; Mature: 30051

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYIIQRALEEDLGTIGDITTDCIIGDQRIKFEVNAREELIVSGMLFISDLANVLHKED
CHHHHHHHHHHHHHCHHCCCHHHEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
ISFYPMEVDGTPVKSGTCLLRGEGSASKILSVERVLLNFIQRASGISSLTRQFVEIIHGT
CCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
NAIIRSTRKTCPGLRKFDLYAVHVGGGESFRTGLFDGVLIKDNHIASCSGISECVHKVRA
HHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
KLGNVVILVECDTTEQVEESILNNVDTVMLDNMSLDNIKKSVSIVNSRAKIEVSGGINLN
HHCCEEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCC
NVRPIAECGVDYISVGCITNAVKCKDIGLDVIEQI
CCCCHHHCCHHHEEHHHHCCCHHHHHCCHHHHHCC
>Mature Secondary Structure
MFEYIIQRALEEDLGTIGDITTDCIIGDQRIKFEVNAREELIVSGMLFISDLANVLHKED
CHHHHHHHHHHHHHCHHCCCHHHEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
ISFYPMEVDGTPVKSGTCLLRGEGSASKILSVERVLLNFIQRASGISSLTRQFVEIIHGT
CCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
NAIIRSTRKTCPGLRKFDLYAVHVGGGESFRTGLFDGVLIKDNHIASCSGISECVHKVRA
HHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
KLGNVVILVECDTTEQVEESILNNVDTVMLDNMSLDNIKKSVSIVNSRAKIEVSGGINLN
HHCCEEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCC
NVRPIAECGVDYISVGCITNAVKCKDIGLDVIEQI
CCCCHHHCCHHHEEHHHHCCCHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]