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The map label for this gene is purE [H]

Identifier: 88607251

GI number: 88607251

Start: 1349214

End: 1349711

Strand: Reverse

Name: purE [H]

Synonym: APH_1279

Alternate gene names: 88607251

Gene position: 1349711-1349214 (Counterclockwise)

Preceding gene: 88606924

Following gene: 88607380

Centisome position: 91.74

GC content: 45.78

Gene sequence:

>498_bases
ATGAATGAACCTAAATTGCCTCCTGTGCCCGTGGCTGTGATAATGGGTAGTAAATCAGATCTTCCTACTATGAGTGCAGC
AATTTCTGTGCTAGATGAGCTCATGATAGCCCATGAGGCGCTTGTTGTGTCTGCTCATAGAACACCTGAAAGGTTATTTA
ATTTCGCCAAGTCAGCTCATGAAACAGGGTTTAAGGTCATTATCGCCGGAGCAGGTGGAGCAGCTCACTTGCCCGGTATG
GTAGCAGCACTTACTCATATTCCAGTAATAGGTGTGCCTGTAATGAGTGAGTGTTTGAAAGGGATGGATAGCCTGCTTTC
TATAGTGCAAATGCCTAAGGGGACGCCTGTGGCAACTATGGCTATTGGCCCCGCAGGGGCTTTTAATGCTGCAGTACTTG
CCGCGTCTATTATTGGACTGTGGGATGAAAATGTCTCTTTGCGACTACAAAACTGGAAGCAGAAAATTACTGATTCTGTC
TCAATAACACCTTACTAG

Upstream 100 bases:

>100_bases
CCGTTTATTGCCATAATCGGGGATAATACTGCACCAATTACAAATGTATATAACAAGCGTGCGCTTTTTGCCGCAATAGC
GTCTGTATCGAAGGCTAACA

Downstream 100 bases:

>100_bases
ACCTGTTTTGTGTAGATAGTCCGGAAAGTATACTACCAAAGTTCCAGCGTGTGACAGCAAATGGTTCGGTTTATTGTGTG
TTGGTGCTGAAGTTGCAAGT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MNEPKLPPVPVAVIMGSKSDLPTMSAAISVLDELMIAHEALVVSAHRTPERLFNFAKSAHETGFKVIIAGAGGAAHLPGM
VAALTHIPVIGVPVMSECLKGMDSLLSIVQMPKGTPVATMAIGPAGAFNAAVLAASIIGLWDENVSLRLQNWKQKITDSV
SITPY

Sequences:

>Translated_165_residues
MNEPKLPPVPVAVIMGSKSDLPTMSAAISVLDELMIAHEALVVSAHRTPERLFNFAKSAHETGFKVIIAGAGGAAHLPGM
VAALTHIPVIGVPVMSECLKGMDSLLSIVQMPKGTPVATMAIGPAGAFNAAVLAASIIGLWDENVSLRLQNWKQKITDSV
SITPY
>Mature_165_residues
MNEPKLPPVPVAVIMGSKSDLPTMSAAISVLDELMIAHEALVVSAHRTPERLFNFAKSAHETGFKVIIAGAGGAAHLPGM
VAALTHIPVIGVPVMSECLKGMDSLLSIVQMPKGTPVATMAIGPAGAFNAAVLAASIIGLWDENVSLRLQNWKQKITDSV
SITPY

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=57.9617834394904, Blast_Score=154, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=54.6666666666667, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17247; Mature: 17247

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPKLPPVPVAVIMGSKSDLPTMSAAISVLDELMIAHEALVVSAHRTPERLFNFAKSAH
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
ETGFKVIIAGAGGAAHLPGMVAALTHIPVIGVPVMSECLKGMDSLLSIVQMPKGTPVATM
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
AIGPAGAFNAAVLAASIIGLWDENVSLRLQNWKQKITDSVSITPY
EECCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNEPKLPPVPVAVIMGSKSDLPTMSAAISVLDELMIAHEALVVSAHRTPERLFNFAKSAH
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
ETGFKVIIAGAGGAAHLPGMVAALTHIPVIGVPVMSECLKGMDSLLSIVQMPKGTPVATM
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
AIGPAGAFNAAVLAASIIGLWDENVSLRLQNWKQKITDSVSITPY
EECCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]