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The map label for this gene is dacC [H]

Identifier: 88607085

GI number: 88607085

Start: 1282486

End: 1283646

Strand: Reverse

Name: dacC [H]

Synonym: APH_1214

Alternate gene names: 88607085

Gene position: 1283646-1282486 (Counterclockwise)

Preceding gene: 88606886

Following gene: 88606695

Centisome position: 87.25

GC content: 41.6

Gene sequence:

>1161_bases
ATGCGAGCAAGTCTTGGTCTTCTTTTATTTAAAGCGTTTATTTGTGCTTTGATCTTCGTTCTACCCGCGCATCCAGATGC
ATCAGGGCTGCGTACGAAAGCGCCTCACGCTATTGTGTTTGAATGGGGTTCGAAAACAATACTTTTTGAACATGATGTAG
ATGCACCGACGCCTACTGCTTCCATGAGTAAGCTTATGACTCTGTACATAGTGCTGAAGAACTTGAAGGCAGGGAATATC
AAGCTTGAGGATAACTTGCGAGTTAGTGAAGGTGCCGCTTCTGCAGGTGCGCCAACAGCGTTTTTAAAGACTGGGCAACT
CATCTCTGTCAACGACCTTATAAAAGGTGCTGCTGTTGCTTCAGGGAATGACGCATGTATCACTCTTGCAGAAGGTTTGT
ATACGTCGCAAGAAAAGTTCGTTGAAGAAATGAACAGGGTAGCGAAAGAATTGGATCTCAAGAACAGCCGCTTTGTAAAT
GTTACAGGTTGGCCAGATGATAATATGATGTCGGTACGTGATCTACTTATCCTTTCAGCGCGGATATTACAAGACTTTCC
AGAATACTATTACTTTTTTGGCGAAAAGCAGTTTACCTATAATGGGATAACACAGAAGAATTATAATGCATTGTTGAATT
ACAATAATATAGAAGTTGATGGTATAAAAACTGGGCATACAAGAACAGGAGGTTACGGTATGGTAGCCTCAGCACTGAAA
GATGGACGACGCGTTTTAGTGGTAATCAATGGATTGAGCACCGAAACAGAACGTGCTTATGAGGCAAAAAAACTTATCTT
GTACGCCTTGAATCACTTCAGCACGAAAACAATATTTCCTGCAAATGGGGTCGTTGGGGAAATATCTGTGAAACACAAAA
AGGGCACATCTTTGCAAGTATTCCTAAAGGAAGATGCTGTAGTTACTTACCCAAAGGACTTAGAACATGAACTGCATGCG
TTCTTACTATCACAAGAGAGTTTAAAAGCACCAATCAAGAAAGGTCAACTAGTAGGGAGCTTGTTAGTTAAGACAAAAAA
CTCAGTCCAGTACTCTTTTCCCGTATATGCAGCAACCTCAGTGCGTGCTCCGTGTGCCGTGTGTGATTATATACGCTCTC
TCTACAGAACTTTGTATTCGCATTATACGTCTGATGATTAA

Upstream 100 bases:

>100_bases
GTAGTAGAAACACGGTGCGTCAGTTGCTAGGTTTTTGTTATTGACATTGCTCTGGGCATAGTACTAGTATGACTCCCCAA
TTCTGTTTCTTGTAAAATCT

Downstream 100 bases:

>100_bases
TCTGTAAGGCTTCGTAAGAGAAAGTCTGTCAGCTTAGCCTCGCTGAATATTTGAGGTATTGGTTCTGTTGTAGGCTTTCC
ATGCACATATAGCACGTAAA

Product: D-alanyl-D-alanine carboxypeptidase family protein

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRASLGLLLFKAFICALIFVLPAHPDASGLRTKAPHAIVFEWGSKTILFEHDVDAPTPTASMSKLMTLYIVLKNLKAGNI
KLEDNLRVSEGAASAGAPTAFLKTGQLISVNDLIKGAAVASGNDACITLAEGLYTSQEKFVEEMNRVAKELDLKNSRFVN
VTGWPDDNMMSVRDLLILSARILQDFPEYYYFFGEKQFTYNGITQKNYNALLNYNNIEVDGIKTGHTRTGGYGMVASALK
DGRRVLVVINGLSTETERAYEAKKLILYALNHFSTKTIFPANGVVGEISVKHKKGTSLQVFLKEDAVVTYPKDLEHELHA
FLLSQESLKAPIKKGQLVGSLLVKTKNSVQYSFPVYAATSVRAPCAVCDYIRSLYRTLYSHYTSDD

Sequences:

>Translated_386_residues
MRASLGLLLFKAFICALIFVLPAHPDASGLRTKAPHAIVFEWGSKTILFEHDVDAPTPTASMSKLMTLYIVLKNLKAGNI
KLEDNLRVSEGAASAGAPTAFLKTGQLISVNDLIKGAAVASGNDACITLAEGLYTSQEKFVEEMNRVAKELDLKNSRFVN
VTGWPDDNMMSVRDLLILSARILQDFPEYYYFFGEKQFTYNGITQKNYNALLNYNNIEVDGIKTGHTRTGGYGMVASALK
DGRRVLVVINGLSTETERAYEAKKLILYALNHFSTKTIFPANGVVGEISVKHKKGTSLQVFLKEDAVVTYPKDLEHELHA
FLLSQESLKAPIKKGQLVGSLLVKTKNSVQYSFPVYAATSVRAPCAVCDYIRSLYRTLYSHYTSDD
>Mature_386_residues
MRASLGLLLFKAFICALIFVLPAHPDASGLRTKAPHAIVFEWGSKTILFEHDVDAPTPTASMSKLMTLYIVLKNLKAGNI
KLEDNLRVSEGAASAGAPTAFLKTGQLISVNDLIKGAAVASGNDACITLAEGLYTSQEKFVEEMNRVAKELDLKNSRFVN
VTGWPDDNMMSVRDLLILSARILQDFPEYYYFFGEKQFTYNGITQKNYNALLNYNNIEVDGIKTGHTRTGGYGMVASALK
DGRRVLVVINGLSTETERAYEAKKLILYALNHFSTKTIFPANGVVGEISVKHKKGTSLQVFLKEDAVVTYPKDLEHELHA
FLLSQESLKAPIKKGQLVGSLLVKTKNSVQYSFPVYAATSVRAPCAVCDYIRSLYRTLYSHYTSDD

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=340, Percent_Identity=35.8823529411765, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786851, Length=356, Percent_Identity=33.1460674157303, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI87082022, Length=320, Percent_Identity=33.75, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87082054, Length=223, Percent_Identity=27.3542600896861, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42631; Mature: 42631

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASLGLLLFKAFICALIFVLPAHPDASGLRTKAPHAIVFEWGSKTILFEHDVDAPTPTA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCH
SMSKLMTLYIVLKNLKAGNIKLEDNLRVSEGAASAGAPTAFLKTGQLISVNDLIKGAAVA
HHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCCCCEECCCCEEEHHHHHCCCEEE
SGNDACITLAEGLYTSQEKFVEEMNRVAKELDLKNSRFVNVTGWPDDNMMSVRDLLILSA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RILQDFPEYYYFFGEKQFTYNGITQKNYNALLNYNNIEVDGIKTGHTRTGGYGMVASALK
HHHHHCHHHEEEECCCEEEECCCCCCCCCEEEECCCEEECCEECCCCCCCCHHHHHHHHH
DGRRVLVVINGLSTETERAYEAKKLILYALNHFSTKTIFPANGVVGEISVKHKKGTSLQV
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCEEEE
FLKEDAVVTYPKDLEHELHAFLLSQESLKAPIKKGQLVGSLLVKTKNSVQYSFPVYAATS
EEECCEEEECCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCCEEEECCEEEECC
VRAPCAVCDYIRSLYRTLYSHYTSDD
CCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRASLGLLLFKAFICALIFVLPAHPDASGLRTKAPHAIVFEWGSKTILFEHDVDAPTPTA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCH
SMSKLMTLYIVLKNLKAGNIKLEDNLRVSEGAASAGAPTAFLKTGQLISVNDLIKGAAVA
HHHHHHHHHHHHHCCCCCCEEECCCCEEECCCCCCCCCCCEECCCCEEEHHHHHCCCEEE
SGNDACITLAEGLYTSQEKFVEEMNRVAKELDLKNSRFVNVTGWPDDNMMSVRDLLILSA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RILQDFPEYYYFFGEKQFTYNGITQKNYNALLNYNNIEVDGIKTGHTRTGGYGMVASALK
HHHHHCHHHEEEECCCEEEECCCCCCCCCEEEECCCEEECCEECCCCCCCCHHHHHHHHH
DGRRVLVVINGLSTETERAYEAKKLILYALNHFSTKTIFPANGVVGEISVKHKKGTSLQV
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCCCEEEE
FLKEDAVVTYPKDLEHELHAFLLSQESLKAPIKKGQLVGSLLVKTKNSVQYSFPVYAATS
EEECCEEEECCHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCCEEEECCEEEECC
VRAPCAVCDYIRSLYRTLYSHYTSDD
CCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]