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The map label for this gene is gap [H]

Identifier: 88606948

GI number: 88606948

Start: 1413112

End: 1414119

Strand: Reverse

Name: gap [H]

Synonym: APH_1349

Alternate gene names: 88606948

Gene position: 1414119-1413112 (Counterclockwise)

Preceding gene: 88606749

Following gene: 88607446

Centisome position: 96.11

GC content: 40.67

Gene sequence:

>1008_bases
ATGATTAGAGTGGGAATAAATGGCCTTGGTAGGATAGGTCGCTGTTTGTTTAGGTTGTTATGCAGTTTAGATAGTTCTTC
AAAGATTGAGCTTGCTGCAGTGAATGGTTCTTCAAGTATAGATTTGCATAGGCATTTGCTAAAAAATGACTCAGTGCATG
GTGTATATGAGCACGCGATAGAAAAGATAGGAGAAGACTTTTTTTCGGTTAATGGGAAGAAAATAAAGTTTTTCTGCGAA
AGAGACCCTGAAAATGTCCCTTGGGATTCATGTGGGGTGGATGTCGTTTTTGAGTGTACGGGTAAGTTTAATAAGAAGCC
TCTCGCAGCAAAGCATATTAGGGGTACTGTAAAAAAGGTTATAGTTTCCGCTCCTGTGGATGGTGCTGATTTACAAGTGA
TCTATGGTATAAATGAGGGCAGTATCACCAACGATCATAAGGTTATTTCCGTAGGATCATGCACTACAAACTGTGCTGCT
CATGTTGTGGGAGCTATTGATCGTGAATTTGGAATAGATGGTGGTTTTATAACCACTGTTCATGCGTACACTAATGACCA
GAATCATGTAGATGGAAGCCATAAGGACTTCCGTAGAGCTAGAGCATGTGGTTTGTCCATGATACCTACTTCTACCGGTG
CATCTAAGGCATTATCACTACTTTTCCCTCACTTAGATGGCAAAATTTCCGTTGCTGCGGTAAGGGTTCCTACTCCTAAT
GTATCTATGGTTGATTTCACTTTTGTTCCTTCTGTAAAAGTGCCACGCTCCTCCATAAATGATGCATTATCGAAAGCTGC
TGATATTAGGAAAGATGTGCTCTTAGCCACTGAGGAGATGTTAGTGTCAGTGGATTTTAATCACACTACTTATAGTGCAA
TTTTTGATCTCTGCGAAACTCACGTAAATGATGCCAACTTCTCTCGCGTGGTTGCTTGGTATGATAACGAGTGGGCTTTT
GCTAATAGAATGCTGGATGTCGCCCTAATAGCGCAGAAATTTTTATAA

Upstream 100 bases:

>100_bases
GTTACTGCAAAAATTTACCCCGTGTTGAGATGTATAATTAGTTGCATAAACATTGTGTGAGTGGCAGACTAAAATGTTAT
CTAGTTGTTAATAATTTGTG

Downstream 100 bases:

>100_bases
ATTCCATATGTACTTTAAACATTGTTGGAATTTCTGAGCGAATTGTGCTAAAAGGTAGTGGGCAGTGCGAGCGGGTTTCG
TGTGAAGTCGGTCAGGTTAG

Product: glyceraldehyde-3-phosphate dehydrogenase, type I

Products: NA

Alternate protein names: NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase; GAPDH [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MIRVGINGLGRIGRCLFRLLCSLDSSSKIELAAVNGSSSIDLHRHLLKNDSVHGVYEHAIEKIGEDFFSVNGKKIKFFCE
RDPENVPWDSCGVDVVFECTGKFNKKPLAAKHIRGTVKKVIVSAPVDGADLQVIYGINEGSITNDHKVISVGSCTTNCAA
HVVGAIDREFGIDGGFITTVHAYTNDQNHVDGSHKDFRRARACGLSMIPTSTGASKALSLLFPHLDGKISVAAVRVPTPN
VSMVDFTFVPSVKVPRSSINDALSKAADIRKDVLLATEEMLVSVDFNHTTYSAIFDLCETHVNDANFSRVVAWYDNEWAF
ANRMLDVALIAQKFL

Sequences:

>Translated_335_residues
MIRVGINGLGRIGRCLFRLLCSLDSSSKIELAAVNGSSSIDLHRHLLKNDSVHGVYEHAIEKIGEDFFSVNGKKIKFFCE
RDPENVPWDSCGVDVVFECTGKFNKKPLAAKHIRGTVKKVIVSAPVDGADLQVIYGINEGSITNDHKVISVGSCTTNCAA
HVVGAIDREFGIDGGFITTVHAYTNDQNHVDGSHKDFRRARACGLSMIPTSTGASKALSLLFPHLDGKISVAAVRVPTPN
VSMVDFTFVPSVKVPRSSINDALSKAADIRKDVLLATEEMLVSVDFNHTTYSAIFDLCETHVNDANFSRVVAWYDNEWAF
ANRMLDVALIAQKFL
>Mature_335_residues
MIRVGINGLGRIGRCLFRLLCSLDSSSKIELAAVNGSSSIDLHRHLLKNDSVHGVYEHAIEKIGEDFFSVNGKKIKFFCE
RDPENVPWDSCGVDVVFECTGKFNKKPLAAKHIRGTVKKVIVSAPVDGADLQVIYGINEGSITNDHKVISVGSCTTNCAA
HVVGAIDREFGIDGGFITTVHAYTNDQNHVDGSHKDFRRARACGLSMIPTSTGASKALSLLFPHLDGKISVAAVRVPTPN
VSMVDFTFVPSVKVPRSSINDALSKAADIRKDVLLATEEMLVSVDFNHTTYSAIFDLCETHVNDANFSRVVAWYDNEWAF
ANRMLDVALIAQKFL

Specific function: More active in anabolism [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=330, Percent_Identity=38.7878787878788, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI7657116, Length=336, Percent_Identity=37.202380952381, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1788079, Length=328, Percent_Identity=42.0731707317073, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789295, Length=330, Percent_Identity=37.8787878787879, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17534679, Length=334, Percent_Identity=42.2155688622754, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17534677, Length=334, Percent_Identity=41.9161676646707, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=41.1764705882353, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=41.1764705882353, Blast_Score=218, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6321631, Length=330, Percent_Identity=40.3030303030303, Blast_Score=232, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322409, Length=334, Percent_Identity=40.1197604790419, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322468, Length=330, Percent_Identity=40, Blast_Score=229, Evalue=6e-61,
Organism=Drosophila melanogaster, GI17933600, Length=337, Percent_Identity=40.6528189910979, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI18110149, Length=337, Percent_Identity=40.6528189910979, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI85725000, Length=341, Percent_Identity=39.8826979472141, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI22023983, Length=341, Percent_Identity=39.8826979472141, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI19922412, Length=337, Percent_Identity=37.0919881305638, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.59 [H]

Molecular weight: Translated: 36583; Mature: 36583

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVGINGLGRIGRCLFRLLCSLDSSSKIELAAVNGSSSIDLHRHLLKNDSVHGVYEHAI
CEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHH
EKIGEDFFSVNGKKIKFFCERDPENVPWDSCGVDVVFECTGKFNKKPLAAKHIRGTVKKV
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
IVSAPVDGADLQVIYGINEGSITNDHKVISVGSCTTNCAAHVVGAIDREFGIDGGFITTV
EEECCCCCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEE
HAYTNDQNHVDGSHKDFRRARACGLSMIPTSTGASKALSLLFPHLDGKISVAAVRVPTPN
EEEECCCCCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCC
VSMVDFTFVPSVKVPRSSINDALSKAADIRKDVLLATEEMLVSVDFNHTTYSAIFDLCET
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCHHHHHHHHHHHH
HVNDANFSRVVAWYDNEWAFANRMLDVALIAQKFL
HCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRVGINGLGRIGRCLFRLLCSLDSSSKIELAAVNGSSSIDLHRHLLKNDSVHGVYEHAI
CEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHH
EKIGEDFFSVNGKKIKFFCERDPENVPWDSCGVDVVFECTGKFNKKPLAAKHIRGTVKKV
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
IVSAPVDGADLQVIYGINEGSITNDHKVISVGSCTTNCAAHVVGAIDREFGIDGGFITTV
EEECCCCCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEE
HAYTNDQNHVDGSHKDFRRARACGLSMIPTSTGASKALSLLFPHLDGKISVAAVRVPTPN
EEEECCCCCCCCCHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCCEEEEEEEEECCCC
VSMVDFTFVPSVKVPRSSINDALSKAADIRKDVLLATEEMLVSVDFNHTTYSAIFDLCET
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCHHHHHHHHHHHH
HVNDANFSRVVAWYDNEWAFANRMLDVALIAQKFL
HCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10799476 [H]