Click here to switch to the map view.

The map label for this gene is dnaX [H]

Identifier: 88607446

GI number: 88607446

Start: 1411570

End: 1412940

Strand: Reverse

Name: dnaX [H]

Synonym: APH_1348

Alternate gene names: 88607446

Gene position: 1412940-1411570 (Counterclockwise)

Preceding gene: 88606948

Following gene: 88606805

Centisome position: 96.03

GC content: 40.7

Gene sequence:

>1371_bases
GTGAATTTGGCGCTAAAGTACAGGCCGAGCAACTTTGATGATCTTGTTGGTCAGGATGTCTTGGTCCGGATACTGAGAAA
TTCTTTTTCCGTCGGAAATCTTAATACTCCTTTATTAATGGTGGGTGCTAGTGGCGTTGGTAAGACTACGTGCGCAAGGA
TAGTCTCGCTGTGTCTTAATTGTGAGAATGGGCCTACTTCGTCTCCCTGTGGGACATGCGCTACTTGTACTTCTATTAAA
AACTCTCATAACCCAGATGTTGTGGAGATGGATGCTGCTAGTAATACCAGTGTGGATGATATTAGAGTGATCTTGGAGAG
TTCCAACTATCTCCCGGTAAGCTCTAGGTTTAAAGTCTATATCATAGACGAAGTGCATATGCTCTCCACTAGCGCATTTA
ATGCGTTATTAAAGACTTTGGAAAGTCCAGCTCAGCATGCAAAGTTTATTATGGCTACTACGGAAGTTAGAAAGGTTCCT
GTAACCGTAGCTTCTAGGTGTTTAAGATTGGATCTGGGTAAGCTACCGATAAAACAGTTATACGATCATCTTGTAAAAAT
ATCGGCTAAGGAGAATATAGCTCATGATGAAAGTAGTCTGATGCTTATAGCTGAGAATTCTTCTGGTTCTGTTAGAAATT
CTCTTTTCCTGCTAGAGCAGGCTCTTATTTATTCTAACAATAAAATTTCCCTGCAGGAAGTTAGGGAGTTGCTTGGTTGT
GTTGATAAGAAGATTCTTGAGGGCATTGTAAGAGATATTATAAGTAGTGATGTCAAAAGCGCTATAGATGGCTTTAGAGA
GTTATGTAATGCTAGTACGCCGGTCATAATTTTTGAGGGGATGCAGAAGGTCGTTTATGGGCTTTGTATGTATTCTATTG
ATAAGGATTTTCACCATGGTCTAGGGGAAGAGTTATTTACTGCTGAAAAGTCTGGTTCTACTCCTTTTCTTTCTAGATTG
TGGCAGTTGGTTCTACATGGAATTCAGGAGATTAAGAGTTCTGAGAGTCCGGAGCAAGCTGGTGAGATGCTAATAGTTAG
GTTATGTTACTTGAGTGATTTACCTTCTCCTCAAAAGATAGCTTCTTCTATATCTTCGAAGTATGGGGATATGCCTCCTT
CTGGAGGGCAAGGAAGGAGTGAATCTTTAAATGCAGGAAGTATGTCTGCGCGCAGTAGACCTTGTTTTATGGGAGCTGCT
AGTAGTCCTACAAATGCTGTAGGTGGTATTTCTGTTTTAGGAGATAAGAAAAATAATGATGTCAATGACCGGGGTAAGGT
GTACAATCCGGATGATGATGAGGCTGTAGTTGATGTTGTGAAAAACTTCGATGGTGCTTCTGTTGTGAGCTTTAAGAGTT
TTGATGTCTGA

Upstream 100 bases:

>100_bases
CGGGTTTCGTGTGAAGTCGGTCAGGTTAGAAATAAAGCAGCCGTAGCATTGAGTATTCGGGTTGCACTGTCCACTGGGTT
CTGCTAAGGGTGGTGCACTG

Downstream 100 bases:

>100_bases
GGGGTATCTTTATGTCTTTTGATGATCAGAAATTTGCAGATTTGCAAGATGCTCTGAAGAAAAAGCTGTCTGAGCTAAAA
GTGTATCAGGAGCCGAAGTC

Product: DNA polymerase III, subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MNLALKYRPSNFDDLVGQDVLVRILRNSFSVGNLNTPLLMVGASGVGKTTCARIVSLCLNCENGPTSSPCGTCATCTSIK
NSHNPDVVEMDAASNTSVDDIRVILESSNYLPVSSRFKVYIIDEVHMLSTSAFNALLKTLESPAQHAKFIMATTEVRKVP
VTVASRCLRLDLGKLPIKQLYDHLVKISAKENIAHDESSLMLIAENSSGSVRNSLFLLEQALIYSNNKISLQEVRELLGC
VDKKILEGIVRDIISSDVKSAIDGFRELCNASTPVIIFEGMQKVVYGLCMYSIDKDFHHGLGEELFTAEKSGSTPFLSRL
WQLVLHGIQEIKSSESPEQAGEMLIVRLCYLSDLPSPQKIASSISSKYGDMPPSGGQGRSESLNAGSMSARSRPCFMGAA
SSPTNAVGGISVLGDKKNNDVNDRGKVYNPDDDEAVVDVVKNFDGASVVSFKSFDV

Sequences:

>Translated_456_residues
MNLALKYRPSNFDDLVGQDVLVRILRNSFSVGNLNTPLLMVGASGVGKTTCARIVSLCLNCENGPTSSPCGTCATCTSIK
NSHNPDVVEMDAASNTSVDDIRVILESSNYLPVSSRFKVYIIDEVHMLSTSAFNALLKTLESPAQHAKFIMATTEVRKVP
VTVASRCLRLDLGKLPIKQLYDHLVKISAKENIAHDESSLMLIAENSSGSVRNSLFLLEQALIYSNNKISLQEVRELLGC
VDKKILEGIVRDIISSDVKSAIDGFRELCNASTPVIIFEGMQKVVYGLCMYSIDKDFHHGLGEELFTAEKSGSTPFLSRL
WQLVLHGIQEIKSSESPEQAGEMLIVRLCYLSDLPSPQKIASSISSKYGDMPPSGGQGRSESLNAGSMSARSRPCFMGAA
SSPTNAVGGISVLGDKKNNDVNDRGKVYNPDDDEAVVDVVKNFDGASVVSFKSFDV
>Mature_456_residues
MNLALKYRPSNFDDLVGQDVLVRILRNSFSVGNLNTPLLMVGASGVGKTTCARIVSLCLNCENGPTSSPCGTCATCTSIK
NSHNPDVVEMDAASNTSVDDIRVILESSNYLPVSSRFKVYIIDEVHMLSTSAFNALLKTLESPAQHAKFIMATTEVRKVP
VTVASRCLRLDLGKLPIKQLYDHLVKISAKENIAHDESSLMLIAENSSGSVRNSLFLLEQALIYSNNKISLQEVRELLGC
VDKKILEGIVRDIISSDVKSAIDGFRELCNASTPVIIFEGMQKVVYGLCMYSIDKDFHHGLGEELFTAEKSGSTPFLSRL
WQLVLHGIQEIKSSESPEQAGEMLIVRLCYLSDLPSPQKIASSISSKYGDMPPSGGQGRSESLNAGSMSARSRPCFMGAA
SSPTNAVGGISVLGDKKNNDVNDRGKVYNPDDDEAVVDVVKNFDGASVVSFKSFDV

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=296, Percent_Identity=23.6486486486486, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI194306571, Length=296, Percent_Identity=23.6486486486486, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI194306567, Length=296, Percent_Identity=23.6486486486486, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786676, Length=240, Percent_Identity=45.8333333333333, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17554730, Length=280, Percent_Identity=23.9285714285714, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322528, Length=329, Percent_Identity=24.9240121580547, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324039, Length=288, Percent_Identity=23.9583333333333, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17647857, Length=262, Percent_Identity=24.8091603053435, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859927, Length=253, Percent_Identity=23.3201581027668, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 49405; Mature: 49405

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLALKYRPSNFDDLVGQDVLVRILRNSFSVGNLNTPLLMVGASGVGKTTCARIVSLCLN
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
CENGPTSSPCGTCATCTSIKNSHNPDVVEMDAASNTSVDDIRVILESSNYLPVSSRFKVY
CCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHEEECCCCCCCCCCEEEE
IIDEVHMLSTSAFNALLKTLESPAQHAKFIMATTEVRKVPVTVASRCLRLDLGKLPIKQL
EECCHHHHHHHHHHHHHHHHHCHHHHHHHHEEEHHHHHCCHHHHHHHHHHCCCCCCHHHH
YDHLVKISAKENIAHDESSLMLIAENSSGSVRNSLFLLEQALIYSNNKISLQEVRELLGC
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VDKKILEGIVRDIISSDVKSAIDGFRELCNASTPVIIFEGMQKVVYGLCMYSIDKDFHHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCHHHHHC
LGEELFTAEKSGSTPFLSRLWQLVLHGIQEIKSSESPEQAGEMLIVRLCYLSDLPSPQKI
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
ASSISSKYGDMPPSGGQGRSESLNAGSMSARSRPCFMGAASSPTNAVGGISVLGDKKNND
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEECCCCCCC
VNDRGKVYNPDDDEAVVDVVKNFDGASVVSFKSFDV
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCC
>Mature Secondary Structure
MNLALKYRPSNFDDLVGQDVLVRILRNSFSVGNLNTPLLMVGASGVGKTTCARIVSLCLN
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHC
CENGPTSSPCGTCATCTSIKNSHNPDVVEMDAASNTSVDDIRVILESSNYLPVSSRFKVY
CCCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHEEECCCCCCCCCCEEEE
IIDEVHMLSTSAFNALLKTLESPAQHAKFIMATTEVRKVPVTVASRCLRLDLGKLPIKQL
EECCHHHHHHHHHHHHHHHHHCHHHHHHHHEEEHHHHHCCHHHHHHHHHHCCCCCCHHHH
YDHLVKISAKENIAHDESSLMLIAENSSGSVRNSLFLLEQALIYSNNKISLQEVRELLGC
HHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VDKKILEGIVRDIISSDVKSAIDGFRELCNASTPVIIFEGMQKVVYGLCMYSIDKDFHHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCHHHHHC
LGEELFTAEKSGSTPFLSRLWQLVLHGIQEIKSSESPEQAGEMLIVRLCYLSDLPSPQKI
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHH
ASSISSKYGDMPPSGGQGRSESLNAGSMSARSRPCFMGAASSPTNAVGGISVLGDKKNND
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEECCCCCCC
VNDRGKVYNPDDDEAVVDVVKNFDGASVVSFKSFDV
CCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]